DE2111467A1 - Verfahren zur Bindung von Heparin an Polyaethylenterephthalat - Google Patents
Verfahren zur Bindung von Heparin an PolyaethylenterephthalatInfo
- Publication number
- DE2111467A1 DE2111467A1 DE19712111467 DE2111467A DE2111467A1 DE 2111467 A1 DE2111467 A1 DE 2111467A1 DE 19712111467 DE19712111467 DE 19712111467 DE 2111467 A DE2111467 A DE 2111467A DE 2111467 A1 DE2111467 A1 DE 2111467A1
- Authority
- DE
- Germany
- Prior art keywords
- heparin
- polyethylene terephthalate
- dry heat
- binding
- active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920000669 heparin Polymers 0.000 title claims description 23
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title claims description 21
- 229960002897 heparin Drugs 0.000 title claims description 21
- -1 polyethylene terephthalate Polymers 0.000 title claims description 13
- 238000000034 method Methods 0.000 title claims description 12
- 229920000139 polyethylene terephthalate Polymers 0.000 title claims description 11
- 239000005020 polyethylene terephthalate Substances 0.000 title claims description 11
- 239000004094 surface-active agent Substances 0.000 claims description 8
- 150000001412 amines Chemical class 0.000 claims description 6
- 125000002091 cationic group Chemical group 0.000 claims description 5
- DVBJBNKEBPCGSY-UHFFFAOYSA-M cetylpyridinium bromide Chemical group [Br-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 DVBJBNKEBPCGSY-UHFFFAOYSA-M 0.000 claims description 3
- 239000000835 fiber Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 229910017464 nitrogen compound Inorganic materials 0.000 claims description 3
- 230000001453 nonthrombogenic effect Effects 0.000 claims description 3
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 3
- 239000006185 dispersion Substances 0.000 claims description 2
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 claims description 2
- RWSOTUBLDIXVET-UHFFFAOYSA-O sulfonium Chemical compound [SH3+] RWSOTUBLDIXVET-UHFFFAOYSA-O 0.000 claims description 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 2
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- KKEYFWRCBNTPAC-UHFFFAOYSA-N Terephthalic acid Chemical class OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 description 3
- 239000004744 fabric Substances 0.000 description 3
- 125000001165 hydrophobic group Chemical group 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000002473 artificial blood Substances 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 150000002830 nitrogen compounds Chemical class 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- FTBVOJZWVWWLFB-UHFFFAOYSA-N 2-(octan-2-ylamino)ethanol Chemical compound CCCCCCC(C)NCCO FTBVOJZWVWWLFB-UHFFFAOYSA-N 0.000 description 1
- HGPNKTHAVDVUNT-UHFFFAOYSA-N 2-dodecylpyridine;hydrochloride Chemical compound [Cl-].CCCCCCCCCCCCC1=CC=CC=[NH+]1 HGPNKTHAVDVUNT-UHFFFAOYSA-N 0.000 description 1
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- REYJJPSVUYRZGE-UHFFFAOYSA-N Octadecylamine Chemical compound CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000003872 anastomosis Effects 0.000 description 1
- 230000002429 anti-coagulating effect Effects 0.000 description 1
- 238000011888 autopsy Methods 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000009918 complex formation Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 150000002357 guanidines Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 150000002429 hydrazines Chemical class 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 150000004714 phosphonium salts Chemical class 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- SZEMGTQCPRNXEG-UHFFFAOYSA-M trimethyl(octadecyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C SZEMGTQCPRNXEG-UHFFFAOYSA-M 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0017—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using a surface active agent
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M16/00—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Surgery (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Textile Engineering (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2112670A | 1970-03-19 | 1970-03-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2111467A1 true DE2111467A1 (de) | 1971-10-07 |
Family
ID=21802477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19712111467 Pending DE2111467A1 (de) | 1970-03-19 | 1971-03-10 | Verfahren zur Bindung von Heparin an Polyaethylenterephthalat |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE764487A (OSRAM) |
| CA (1) | CA960583A (OSRAM) |
| DE (1) | DE2111467A1 (OSRAM) |
| FR (1) | FR2084813A5 (OSRAM) |
| GB (1) | GB1294788A (OSRAM) |
| NL (1) | NL7103642A (OSRAM) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE425372B (sv) * | 1977-07-18 | 1982-09-27 | Ird Biomaterial Ab | Sett att heparinisera en elektriskt laddad yta pa en medecinsk artikel avsedd att komma i kontakt med blod och medel for utforande av settet |
-
1971
- 1971-03-10 CA CA107,354A patent/CA960583A/en not_active Expired
- 1971-03-10 DE DE19712111467 patent/DE2111467A1/de active Pending
- 1971-03-18 FR FR7109511A patent/FR2084813A5/fr not_active Expired
- 1971-03-18 NL NL7103642A patent/NL7103642A/xx unknown
- 1971-03-18 BE BE764487A patent/BE764487A/xx unknown
- 1971-04-19 GB GB2349371A patent/GB1294788A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1294788A (en) | 1972-11-01 |
| NL7103642A (OSRAM) | 1971-09-21 |
| BE764487A (fr) | 1971-09-20 |
| FR2084813A5 (OSRAM) | 1971-12-17 |
| CA960583A (en) | 1975-01-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69019512T2 (de) | Verhinderung von verkalkung in bioprosthetischen implantaten. | |
| DE3608158C2 (OSRAM) | ||
| DE2841749A1 (de) | Verfahren zum nachweis eines impraegnierungsmittels und mit einem nachweismittel versehene stoffe | |
| DE2831360A1 (de) | Verfahren und mittel zur heparinisierung einer geladenen oberflaeche eines medizinischen gegenstandes | |
| DE2025714C3 (de) | Verfahren zum Erzeugen von heparinhattigen, auf Blut antikoagulierend wirkenden Oberflächen auf Gegenständen aus Kunststoff, Glas und Metallen | |
| EP0010621A1 (de) | Verfahren zur Herstellung eines Kunststoffverweilkatheters mit negativ geladener Oberfläche und danach hergestellter Verweilkatheter | |
| DE3503127A1 (de) | Kollagenbeschichteter synthetischer gefaessersatz | |
| DE2742588B2 (de) | Verfahren zur Sterilisation eines Dialysators mit semipermeabler Membran | |
| DE1806115A1 (de) | Verfahren zur Verhinderung von Blutgerinnung an Oberflaechen von kuenstlichen Gegenstaenden | |
| DE2840765A1 (de) | Verfahren zur behandlung von synthetischen fasern | |
| DE910950C (de) | Verfahren zur Herstellung von kuenstlichen Gebilden durch Verformung von Loesungen von Casein oder aehnlichen Proteinsubstanzen | |
| DE2111467A1 (de) | Verfahren zur Bindung von Heparin an Polyaethylenterephthalat | |
| DE2601289C3 (de) | Verfahren zum Abdichten von synthetischen Velours-Gefäßprothesen | |
| CH370235A (de) | Verfahren zur Herstellung von künstlichen Schwämmen aus regenerierter Cellulose und so hergestellter Schwamm | |
| EP0606866A1 (de) | Verfahren zur Verhinderung des Reissens von Bambusrohren (chemisch) | |
| DE2154542A1 (de) | Antithrombogene Kunststoffkörper | |
| DE659116C (de) | Verfahren zum Veredeln von Wollfasern | |
| DE966194C (de) | Verfahren zum Verhindern des Haftens von Daermen an der Wurstmasse | |
| DE1944596A1 (de) | Verfahren zum Faerben von keratinoesen Fasern | |
| DE1141612B (de) | Verfahren zur chemischen Modifizierung von cellulosehaltigen Materialien | |
| DE2116067A1 (de) | Dialysenmembranen und Verfahren zu ihrer Herstellung | |
| DE679829C (de) | Verfahren zur Herstellung eines schaum- und backfaehigen Eiweissproduktes | |
| DE2914018A1 (de) | Verfahren zur herstellung von biovertraeglichen materialien des polyamidtyps und die dabei erhaltenen gegenstaende | |
| EP0069156B1 (de) | Verfahren zur Herstellung von Skleroproteintransplantaten mit erhöhter biologischer Stabilität | |
| DE2118464C3 (OSRAM) |