DE2110115B2 - 16-methylen 17alpha-acyloxy-9beta, 10alpha-pregn-4-en (oder pregna-4,6-dien)- 3,20-dion verbindungen, verfahren zu ihrer herstellung sowie diese enthaltende pharmaceutische praeparate - Google Patents
16-methylen 17alpha-acyloxy-9beta, 10alpha-pregn-4-en (oder pregna-4,6-dien)- 3,20-dion verbindungen, verfahren zu ihrer herstellung sowie diese enthaltende pharmaceutische praeparateInfo
- Publication number
- DE2110115B2 DE2110115B2 DE19712110115 DE2110115A DE2110115B2 DE 2110115 B2 DE2110115 B2 DE 2110115B2 DE 19712110115 DE19712110115 DE 19712110115 DE 2110115 A DE2110115 A DE 2110115A DE 2110115 B2 DE2110115 B2 DE 2110115B2
- Authority
- DE
- Germany
- Prior art keywords
- methylene
- pregna
- dione
- compound
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 235000019445 benzyl alcohol Nutrition 0.000 description 1
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- 230000002357 endometrial effect Effects 0.000 description 1
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- ZGEGCLOFRBLKSE-UHFFFAOYSA-N methylene hexane Natural products CCCCCC=C ZGEGCLOFRBLKSE-UHFFFAOYSA-N 0.000 description 1
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- PVWOIHVRPOBWPI-UHFFFAOYSA-N n-propyl iodide Chemical compound CCCI PVWOIHVRPOBWPI-UHFFFAOYSA-N 0.000 description 1
- 229960002446 octanoic acid Drugs 0.000 description 1
- 239000012053 oil suspension Substances 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
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- 230000016087 ovulation Effects 0.000 description 1
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- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 235000011056 potassium acetate Nutrition 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 201000000484 premenstrual tension Diseases 0.000 description 1
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- 210000002307 prostate Anatomy 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
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- 239000012176 shellac wax Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 1
- 229910000342 sodium bisulfate Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000011121 vaginal smear Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
- C07J5/0084—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkylene group
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7003060A NL7003060A (enExample) | 1970-03-04 | 1970-03-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2110115A1 DE2110115A1 (de) | 1971-09-16 |
| DE2110115B2 true DE2110115B2 (de) | 1976-09-30 |
Family
ID=19809486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19712110115 Pending DE2110115B2 (de) | 1970-03-04 | 1971-03-03 | 16-methylen 17alpha-acyloxy-9beta, 10alpha-pregn-4-en (oder pregna-4,6-dien)- 3,20-dion verbindungen, verfahren zu ihrer herstellung sowie diese enthaltende pharmaceutische praeparate |
Country Status (5)
| Country | Link |
|---|---|
| DE (1) | DE2110115B2 (enExample) |
| FR (1) | FR2085667B1 (enExample) |
| GB (1) | GB1346326A (enExample) |
| NL (1) | NL7003060A (enExample) |
| SE (1) | SE374268B (enExample) |
-
1970
- 1970-03-04 NL NL7003060A patent/NL7003060A/xx unknown
-
1971
- 1971-03-01 SE SE7102586A patent/SE374268B/xx unknown
- 1971-03-03 DE DE19712110115 patent/DE2110115B2/de active Pending
- 1971-03-04 FR FR7107520A patent/FR2085667B1/fr not_active Expired
- 1971-04-19 GB GB2284571A patent/GB1346326A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2085667B1 (enExample) | 1974-08-02 |
| SE374268B (enExample) | 1975-03-03 |
| NL7003060A (enExample) | 1971-09-07 |
| DE2110115A1 (de) | 1971-09-16 |
| FR2085667A1 (enExample) | 1971-12-31 |
| GB1346326A (en) | 1974-02-06 |
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