DE2108403A1 - Verfahren zur Herstellung von festen Ein heitsdosierpackungen fur die Verabreichung von Medikamenten und die dabei erhaltenen Pro dukte - Google Patents
Verfahren zur Herstellung von festen Ein heitsdosierpackungen fur die Verabreichung von Medikamenten und die dabei erhaltenen Pro dukteInfo
- Publication number
- DE2108403A1 DE2108403A1 DE19712108403 DE2108403A DE2108403A1 DE 2108403 A1 DE2108403 A1 DE 2108403A1 DE 19712108403 DE19712108403 DE 19712108403 DE 2108403 A DE2108403 A DE 2108403A DE 2108403 A1 DE2108403 A1 DE 2108403A1
- Authority
- DE
- Germany
- Prior art keywords
- sugar
- mixture
- incorporated
- substance
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- 239000003814 drug Substances 0.000 title claims description 13
- 239000007787 solid Substances 0.000 title claims description 13
- 230000008569 process Effects 0.000 title description 7
- 238000004519 manufacturing process Methods 0.000 title description 6
- 239000000203 mixture Substances 0.000 claims description 25
- 239000000126 substance Substances 0.000 claims description 20
- 239000013078 crystal Substances 0.000 claims description 17
- 235000005911 diet Nutrition 0.000 claims description 9
- 230000000378 dietary effect Effects 0.000 claims description 9
- 229940079593 drug Drugs 0.000 claims description 9
- 238000007669 thermal treatment Methods 0.000 claims description 8
- 235000015961 tonic Nutrition 0.000 claims description 8
- 230000001256 tonic effect Effects 0.000 claims description 8
- 238000000265 homogenisation Methods 0.000 claims description 6
- 229960000716 tonics Drugs 0.000 claims description 5
- 239000011261 inert gas Substances 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 229920003023 plastic Polymers 0.000 claims description 4
- 239000004033 plastic Substances 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 230000009471 action Effects 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 239000000047 product Substances 0.000 description 14
- 238000009423 ventilation Methods 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 3
- 239000012298 atmosphere Substances 0.000 description 3
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- 241000282414 Homo sapiens Species 0.000 description 2
- 238000005054 agglomeration Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 239000003443 antiviral agent Substances 0.000 description 2
- HJJPJSXJAXAIPN-UHFFFAOYSA-N arecoline Chemical compound COC(=O)C1=CCCN(C)C1 HJJPJSXJAXAIPN-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000008298 dragée Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- -1 for example Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 239000007937 lozenge Substances 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- CQMVUTWTFBRWMW-MYINAIGISA-N 1-[(2s,4s,5r)-4-hydroxy-5-(hydroxymethyl)-2-iodooxolan-2-yl]pyrimidine-2,4-dione Chemical compound C1[C@H](O)[C@@H](CO)O[C@@]1(I)N1C(=O)NC(=O)C=C1 CQMVUTWTFBRWMW-MYINAIGISA-N 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- SWDXALWLRYIJHK-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;piperazine Chemical compound C1CNCCN1.OC(=O)CC(O)(C(O)=O)CC(O)=O SWDXALWLRYIJHK-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- OVCDSSHSILBFBN-UHFFFAOYSA-N Amodiaquine Chemical compound C1=C(O)C(CN(CC)CC)=CC(NC=2C3=CC=C(Cl)C=C3N=CC=2)=C1 OVCDSSHSILBFBN-UHFFFAOYSA-N 0.000 description 1
- 229930186147 Cephalosporin Natural products 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010028347 Muscle twitching Diseases 0.000 description 1
- 229930193140 Neomycin Natural products 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 241000589614 Pseudomonas stutzeri Species 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- TUFPZQHDPZYIEX-UHFFFAOYSA-N alpha-Santonin Natural products C1CC2(C)C=CC(=O)C=C2C2C1C(C)C(=O)O2 TUFPZQHDPZYIEX-UHFFFAOYSA-N 0.000 description 1
- XJHDMGJURBVLLE-BOCCBSBMSA-N alpha-santonin Chemical compound C([C@]1(C)CC2)=CC(=O)C(C)=C1[C@@H]1[C@@H]2[C@H](C)C(=O)O1 XJHDMGJURBVLLE-BOCCBSBMSA-N 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003096 antiparasitic agent Substances 0.000 description 1
- 229940125687 antiparasitic agent Drugs 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- 239000008122 artificial sweetener Substances 0.000 description 1
- 235000021311 artificial sweeteners Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 229960005091 chloramphenicol Drugs 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 229960002949 fluorouracil Drugs 0.000 description 1
- GWOFUCIGLDBNKM-UHFFFAOYSA-N glafenine Chemical compound OCC(O)COC(=O)C1=CC=CC=C1NC1=CC=NC2=CC(Cl)=CC=C12 GWOFUCIGLDBNKM-UHFFFAOYSA-N 0.000 description 1
- 229960001650 glafenine Drugs 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229940079866 intestinal antibiotic Drugs 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 229960000718 piperazine citrate Drugs 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 229940074353 santonin Drugs 0.000 description 1
- 230000008786 sensory perception of smell Effects 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR707006340A FR2077890B1 (enrdf_load_stackoverflow) | 1970-02-23 | 1970-02-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2108403A1 true DE2108403A1 (de) | 1971-09-09 |
Family
ID=9051078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19712108403 Ceased DE2108403A1 (de) | 1970-02-23 | 1971-02-22 | Verfahren zur Herstellung von festen Ein heitsdosierpackungen fur die Verabreichung von Medikamenten und die dabei erhaltenen Pro dukte |
Country Status (11)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1509866A (en) * | 1975-06-10 | 1978-05-04 | Johnson & Johnson | Enteric coated digestive enzyme compositions |
| GB2132890B (en) * | 1983-01-06 | 1986-12-03 | Andrew Macarthy Reynolds | Oral veterinary drug |
| US5262172A (en) * | 1992-06-19 | 1993-11-16 | Digestive Care Inc. | Compositions of gastric acid-resistant microspheres containing buffered bile acids |
| US5260074A (en) * | 1992-06-22 | 1993-11-09 | Digestive Care Inc. | Compositions of digestive enzymes and salts of bile acids and process for preparation thereof |
| US5460812A (en) * | 1992-06-22 | 1995-10-24 | Digestive Care Inc. | Compositions of digestive enzymes and salts of bile acids and process for preparation thereof |
| US5415872A (en) * | 1992-06-22 | 1995-05-16 | Digestive Care Inc. | Compositions of gastric acid-resistant microspheres containing salts of bile acids |
| US5578304A (en) * | 1992-06-22 | 1996-11-26 | Digestive Care Inc. | Compositions of digestive enzymes and salts of bile acids and process for preparation thereof |
| US5352682A (en) * | 1993-03-08 | 1994-10-04 | Digestive Care Inc. | Compositions containing salts of bile acid-aminosalicylate conjugates |
| US5750104A (en) * | 1996-05-29 | 1998-05-12 | Digestive Care Inc. | High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith |
| PT1910579E (pt) * | 2005-07-29 | 2014-03-27 | Saint Louis Sucre | Pedaços de açúcar fortificados com pelo menos uma substância com interesse, processo de fabrico |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE463169A (enrdf_load_stackoverflow) * | ||||
| FR1322121A (fr) * | 1960-02-04 | 1963-03-29 | Sucre biologique et son procédé d'obtention |
-
1970
- 1970-02-23 FR FR707006340A patent/FR2077890B1/fr not_active Expired
-
1971
- 1971-02-09 BE BE762716A patent/BE762716A/xx not_active IP Right Cessation
- 1971-02-15 SE SE01917/71A patent/SE368772B/xx unknown
- 1971-02-15 ZA ZA710951A patent/ZA71951B/xx unknown
- 1971-02-22 NL NL7102349A patent/NL7102349A/xx unknown
- 1971-02-22 NO NO626/71A patent/NO134974C/no unknown
- 1971-02-22 CA CA105,972A patent/CA999524A/fr not_active Expired
- 1971-02-22 DE DE19712108403 patent/DE2108403A1/de not_active Ceased
- 1971-02-23 JP JP46008443A patent/JPS519004B1/ja active Pending
- 1971-02-23 DK DK81871AA patent/DK128052B/da not_active IP Right Cessation
- 1971-04-19 GB GB1296944D patent/GB1296944A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE762716A (fr) | 1971-07-16 |
| SE368772B (enrdf_load_stackoverflow) | 1974-07-22 |
| FR2077890B1 (enrdf_load_stackoverflow) | 1973-03-16 |
| FR2077890A1 (enrdf_load_stackoverflow) | 1971-11-05 |
| NO134974C (enrdf_load_stackoverflow) | 1977-01-19 |
| NL7102349A (enrdf_load_stackoverflow) | 1971-08-25 |
| JPS519004B1 (enrdf_load_stackoverflow) | 1976-03-23 |
| NO134974B (enrdf_load_stackoverflow) | 1976-10-11 |
| DK128052B (da) | 1974-02-25 |
| GB1296944A (enrdf_load_stackoverflow) | 1972-11-22 |
| CA999524A (fr) | 1976-11-09 |
| ZA71951B (en) | 1971-11-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8131 | Rejection |