DE2034708C3 - Verfahren zur Herstellung eines antihypertensiv wirksamen Extraktes der Anacardium occidentale L.-Rinde - Google Patents
Verfahren zur Herstellung eines antihypertensiv wirksamen Extraktes der Anacardium occidentale L.-RindeInfo
- Publication number
- DE2034708C3 DE2034708C3 DE2034708A DE2034708A DE2034708C3 DE 2034708 C3 DE2034708 C3 DE 2034708C3 DE 2034708 A DE2034708 A DE 2034708A DE 2034708 A DE2034708 A DE 2034708A DE 2034708 C3 DE2034708 C3 DE 2034708C3
- Authority
- DE
- Germany
- Prior art keywords
- rat
- extract
- bark
- antihypertensive
- injection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000284 extract Substances 0.000 title claims description 23
- 244000226021 Anacardium occidentale Species 0.000 title claims description 11
- 235000001274 Anacardium occidentale Nutrition 0.000 title claims description 10
- 230000003276 anti-hypertensive effect Effects 0.000 title claims description 10
- 238000000034 method Methods 0.000 title claims description 10
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- 230000008569 process Effects 0.000 title claims description 4
- 238000002803 maceration Methods 0.000 claims description 5
- 241000700159 Rattus Species 0.000 description 50
- 239000007924 injection Substances 0.000 description 18
- 238000002347 injection Methods 0.000 description 18
- 230000000694 effects Effects 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- 210000003734 kidney Anatomy 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 239000000047 product Substances 0.000 description 6
- 235000000346 sugar Nutrition 0.000 description 6
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 5
- 241000693997 Anacardium Species 0.000 description 4
- 235000001271 Anacardium Nutrition 0.000 description 4
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 239000002244 precipitate Substances 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 206010020772 Hypertension Diseases 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 230000007717 exclusion Effects 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 238000004108 freeze drying Methods 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 229940098465 tincture Drugs 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 229940024606 amino acid Drugs 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 229940030600 antihypertensive agent Drugs 0.000 description 2
- 239000002220 antihypertensive agent Substances 0.000 description 2
- 230000004872 arterial blood pressure Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 150000002019 disulfides Chemical class 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 2
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000000419 plant extract Substances 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 150000003573 thiols Chemical class 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- QIJRTFXNRTXDIP-UHFFFAOYSA-N (1-carboxy-2-sulfanylethyl)azanium;chloride;hydrate Chemical compound O.Cl.SCC(N)C(O)=O QIJRTFXNRTXDIP-UHFFFAOYSA-N 0.000 description 1
- DNXIKVLOVZVMQF-UHFFFAOYSA-N (3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 DNXIKVLOVZVMQF-UHFFFAOYSA-N 0.000 description 1
- MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 description 1
- BGNGWHSBYQYVRX-UHFFFAOYSA-N 4-(dimethylamino)benzaldehyde Chemical compound CN(C)C1=CC=C(C=O)C=C1 BGNGWHSBYQYVRX-UHFFFAOYSA-N 0.000 description 1
- 241000003910 Baronia <angiosperm> Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 206010024229 Leprosy Diseases 0.000 description 1
- 241000238633 Odonata Species 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 235000008075 Pistacia terebinthus Nutrition 0.000 description 1
- 240000006705 Pistacia terebinthus Species 0.000 description 1
- 235000003447 Pistacia vera Nutrition 0.000 description 1
- 240000006711 Pistacia vera Species 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- LCQMZZCPPSWADO-UHFFFAOYSA-N Reserpilin Natural products COC(=O)C1COCC2CN3CCc4c([nH]c5cc(OC)c(OC)cc45)C3CC12 LCQMZZCPPSWADO-UHFFFAOYSA-N 0.000 description 1
- QEVHRUUCFGRFIF-SFWBKIHZSA-N Reserpine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cc(OC)cc3 QEVHRUUCFGRFIF-SFWBKIHZSA-N 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000012675 alcoholic extract Substances 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 230000002558 anti-leprotic effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000013736 caramel Nutrition 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 235000020226 cashew nut Nutrition 0.000 description 1
- 229940083181 centrally acting adntiadrenergic agent methyldopa Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 229960001305 cysteine hydrochloride Drugs 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000035487 diastolic blood pressure Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 238000013059 nephrectomy Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
- 235000020233 pistachio Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 description 1
- 206010038464 renal hypertension Diseases 0.000 description 1
- BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 description 1
- 229960003147 reserpine Drugs 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 210000002820 sympathetic nervous system Anatomy 0.000 description 1
- 230000035488 systolic blood pressure Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/22—Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3642769 | 1969-07-19 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2034708A1 DE2034708A1 (de) | 1971-02-04 |
| DE2034708B2 DE2034708B2 (de) | 1980-02-07 |
| DE2034708C3 true DE2034708C3 (de) | 1980-10-09 |
Family
ID=10388045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2034708A Expired DE2034708C3 (de) | 1969-07-19 | 1970-07-13 | Verfahren zur Herstellung eines antihypertensiv wirksamen Extraktes der Anacardium occidentale L.-Rinde |
Country Status (19)
| Country | Link |
|---|---|
| JP (1) | JPS5414166B1 (enEXAMPLES) |
| AT (1) | AT300185B (enEXAMPLES) |
| BE (1) | BE752966A (enEXAMPLES) |
| CA (1) | CA940454A (enEXAMPLES) |
| CH (1) | CH523688A (enEXAMPLES) |
| CS (1) | CS150633B2 (enEXAMPLES) |
| DE (1) | DE2034708C3 (enEXAMPLES) |
| DK (1) | DK125624B (enEXAMPLES) |
| ES (1) | ES381750A1 (enEXAMPLES) |
| FI (1) | FI50297C (enEXAMPLES) |
| GB (1) | GB1303817A (enEXAMPLES) |
| IL (1) | IL34901A (enEXAMPLES) |
| LU (1) | LU61356A1 (enEXAMPLES) |
| NL (1) | NL7010735A (enEXAMPLES) |
| NO (1) | NO132022C (enEXAMPLES) |
| OA (1) | OA03643A (enEXAMPLES) |
| RO (1) | RO58857A (enEXAMPLES) |
| SE (1) | SE360563B (enEXAMPLES) |
| ZA (1) | ZA704836B (enEXAMPLES) |
-
1969
- 1969-07-19 GB GB3642769A patent/GB1303817A/en not_active Expired
-
1970
- 1970-07-03 BE BE752966D patent/BE752966A/xx unknown
- 1970-07-04 NO NO2645/70A patent/NO132022C/no unknown
- 1970-07-13 IL IL34901A patent/IL34901A/xx unknown
- 1970-07-13 DE DE2034708A patent/DE2034708C3/de not_active Expired
- 1970-07-14 ZA ZA704836A patent/ZA704836B/xx unknown
- 1970-07-14 CA CA088,102A patent/CA940454A/en not_active Expired
- 1970-07-14 ES ES381750A patent/ES381750A1/es not_active Expired
- 1970-07-16 AT AT647370A patent/AT300185B/de active
- 1970-07-16 CH CH1093870A patent/CH523688A/fr not_active IP Right Cessation
- 1970-07-16 CS CS5022A patent/CS150633B2/cs unknown
- 1970-07-16 OA OA53982A patent/OA03643A/xx unknown
- 1970-07-17 SE SE09929/70A patent/SE360563B/xx unknown
- 1970-07-17 FI FI702015A patent/FI50297C/fi active
- 1970-07-17 DK DK371370AA patent/DK125624B/da unknown
- 1970-07-17 LU LU61356D patent/LU61356A1/xx unknown
- 1970-07-18 JP JP6275670A patent/JPS5414166B1/ja active Pending
- 1970-07-18 RO RO63965A patent/RO58857A/ro unknown
- 1970-07-20 NL NL7010735A patent/NL7010735A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AT300185B (de) | 1972-07-10 |
| NO132022B (enEXAMPLES) | 1975-06-02 |
| SE360563B (enEXAMPLES) | 1973-10-01 |
| NO132022C (enEXAMPLES) | 1975-09-10 |
| BE752966A (fr) | 1970-12-16 |
| ES381750A1 (es) | 1972-11-16 |
| FI50297B (enEXAMPLES) | 1975-10-31 |
| NL7010735A (enEXAMPLES) | 1971-01-21 |
| DE2034708B2 (de) | 1980-02-07 |
| CH523688A (fr) | 1972-06-15 |
| IL34901A (en) | 1973-03-30 |
| DK125624B (da) | 1973-03-19 |
| JPS5414166B1 (enEXAMPLES) | 1979-06-05 |
| DE2034708A1 (de) | 1971-02-04 |
| RO58857A (enEXAMPLES) | 1975-10-15 |
| ZA704836B (en) | 1971-04-28 |
| LU61356A1 (enEXAMPLES) | 1970-09-21 |
| CA940454A (en) | 1974-01-22 |
| GB1303817A (enEXAMPLES) | 1973-01-24 |
| OA03643A (fr) | 1971-12-24 |
| CS150633B2 (enEXAMPLES) | 1973-09-04 |
| FI50297C (fi) | 1976-02-10 |
| IL34901A0 (en) | 1970-09-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| 8339 | Ceased/non-payment of the annual fee |