DE2018107A1 - Verfahren zur Gewinnung von nativem Albumin und bzw. oder Globulin aus wässrigen Lösungen - Google Patents
Verfahren zur Gewinnung von nativem Albumin und bzw. oder Globulin aus wässrigen LösungenInfo
- Publication number
- DE2018107A1 DE2018107A1 DE19702018107 DE2018107A DE2018107A1 DE 2018107 A1 DE2018107 A1 DE 2018107A1 DE 19702018107 DE19702018107 DE 19702018107 DE 2018107 A DE2018107 A DE 2018107A DE 2018107 A1 DE2018107 A1 DE 2018107A1
- Authority
- DE
- Germany
- Prior art keywords
- albumins
- solution
- globulins
- value
- proteins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000009027 Albumins Human genes 0.000 title claims description 31
- 108010088751 Albumins Proteins 0.000 title claims description 31
- 238000000034 method Methods 0.000 title claims description 29
- 102000006395 Globulins Human genes 0.000 title claims description 24
- 108010044091 Globulins Proteins 0.000 title claims description 24
- 239000007864 aqueous solution Substances 0.000 title claims description 7
- 102000004169 proteins and genes Human genes 0.000 claims description 26
- 108090000623 proteins and genes Proteins 0.000 claims description 26
- 239000000243 solution Substances 0.000 claims description 23
- 239000002253 acid Substances 0.000 claims description 9
- 239000007858 starting material Substances 0.000 claims description 6
- 238000004925 denaturation Methods 0.000 claims description 5
- 230000036425 denaturation Effects 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 3
- 150000007514 bases Chemical class 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000012670 alkaline solution Substances 0.000 claims 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 24
- 239000005862 Whey Substances 0.000 description 16
- 102000007544 Whey Proteins Human genes 0.000 description 16
- 108010046377 Whey Proteins Proteins 0.000 description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 11
- 235000011121 sodium hydroxide Nutrition 0.000 description 8
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- 239000007788 liquid Substances 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 239000000047 product Substances 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000005189 flocculation Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 229910052742 iron Inorganic materials 0.000 description 3
- 235000021317 phosphate Nutrition 0.000 description 3
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 230000016615 flocculation Effects 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 235000002918 Fraxinus excelsior Nutrition 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 102000004407 Lactalbumin Human genes 0.000 description 1
- 108090000942 Lactalbumin Proteins 0.000 description 1
- 229920000388 Polyphosphate Polymers 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 239000002956 ash Substances 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 150000002505 iron Chemical class 0.000 description 1
- -1 iron (IIl) chloride Chemical class 0.000 description 1
- 150000002506 iron compounds Chemical class 0.000 description 1
- 235000014413 iron hydroxide Nutrition 0.000 description 1
- 159000000014 iron salts Chemical class 0.000 description 1
- NCNCGGDMXMBVIA-UHFFFAOYSA-L iron(ii) hydroxide Chemical compound [OH-].[OH-].[Fe+2] NCNCGGDMXMBVIA-UHFFFAOYSA-L 0.000 description 1
- 229910052901 montmorillonite Inorganic materials 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 238000013021 overheating Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 description 1
- 229940099402 potassium metaphosphate Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C21/00—Whey; Whey preparations
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/06—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from blood
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
- A23J1/205—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey from whey, e.g. lactalbumine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/833—Whey; cheese
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Peptides Or Proteins (AREA)
- Dairy Products (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL6906198A NL6906198A (enExample) | 1969-04-22 | 1969-04-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2018107A1 true DE2018107A1 (de) | 1970-11-05 |
Family
ID=19806758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19702018107 Pending DE2018107A1 (de) | 1969-04-22 | 1970-04-15 | Verfahren zur Gewinnung von nativem Albumin und bzw. oder Globulin aus wässrigen Lösungen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3687928A (enExample) |
| AU (1) | AU1389570A (enExample) |
| BE (1) | BE749322A (enExample) |
| DE (1) | DE2018107A1 (enExample) |
| FR (1) | FR2039347A1 (enExample) |
| IT (1) | IT990488B (enExample) |
| LU (1) | LU60765A1 (enExample) |
| NL (1) | NL6906198A (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4007115A (en) * | 1974-04-12 | 1977-02-08 | Eli Lilly And Company | Process for treating spent monensic acid antibiotic fermentation broth containing relatively high concentrations of fatty and proteinaceous residues |
| GB1473824A (en) * | 1975-05-30 | 1977-05-18 | Stauffer Chemical Co | Process for forming an egg white substitute |
| US4267100A (en) * | 1975-05-30 | 1981-05-12 | Stauffer Chemical Company | Process for forming an egg white substitute |
| US4111803A (en) * | 1977-06-03 | 1978-09-05 | The United States Of America As Represented By The Secretary Of Agriculture | Process for recovering proteinaceous matter from acid whey and tannery unhairing effluents |
| SE8006102L (sv) * | 1980-09-02 | 1982-03-03 | Gambro Ab | Sett att utvinna en peptidinnehallande forening samt medel for genomforande av settet |
| US4376072A (en) * | 1980-11-17 | 1983-03-08 | New Zealand Milk Products, Inc. | Method of producing milk protein isolates and milk protein/vegetable protein isolates and compositions of same |
| US5198213A (en) * | 1985-04-15 | 1993-03-30 | Protein Technology, Inc. | Method of disease treatment utilizing an immunologically whey fraction |
| US4816252A (en) * | 1985-04-15 | 1989-03-28 | Protein Technology, Inc. | Product and process for transferring passive immunity to newborn domestic animals using ultrafiltered whey containing immunoglobulins |
| US4834974A (en) * | 1986-01-13 | 1989-05-30 | Protein Technologies, Inc. | Immunologically active whey fraction and recovery process |
| US5219578A (en) * | 1991-02-25 | 1993-06-15 | Innovet, Inc. | Composition and method for immunostimulation in mammals |
| US5707678A (en) * | 1995-04-12 | 1998-01-13 | Galagen Inc. | Method for microfiltration of milk or colostral whey |
| US5670196A (en) * | 1995-04-12 | 1997-09-23 | Galagen Inc. | Method for microfiltration of milk or colostral whey |
| US20030166866A1 (en) * | 2002-01-28 | 2003-09-04 | Land O' Lakes, Inc. | Method of processing a proteinaceous material to recover K-casein macropeptide and polymers of a-lactalbumin and B-lactoglobulin |
| CN106417613A (zh) * | 2015-08-07 | 2017-02-22 | 内蒙古伊利实业集团股份有限公司 | 一种富含α-乳白蛋白的乳清粉及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2684960A (en) * | 1954-07-27 | Method of isolating protein from | ||
| US2450810A (en) * | 1948-10-05 | X p process for the recovery of protein | ||
| US669361A (en) * | 1900-09-08 | 1901-03-05 | Georg Deycke | Process of obtaining albumen. |
| US1428820A (en) * | 1921-12-12 | 1922-09-12 | Thomson David | Process for the extraction of proteids and lactose from whey |
| US2219791A (en) * | 1937-06-28 | 1940-10-29 | Rare Chemicals Inc | Process for obtaining proteohormones with albumen character |
| US2391559A (en) * | 1941-12-18 | 1945-12-25 | June E Faulkner | Beverage |
| US2460550A (en) * | 1945-08-10 | 1949-02-01 | John S Sharpe Res Foundation O | Modified globin and method for its preparation |
| US2923665A (en) * | 1956-11-07 | 1960-02-02 | American Cyanamid Co | Processes for preparing human plasminogen from human placenta sources |
| US3018280A (en) * | 1958-07-08 | 1962-01-23 | Borden Co | Seedmeal protein composition |
| US3476739A (en) * | 1968-03-04 | 1969-11-04 | Erving S Sternberg | Recovery of protein and oil from oilcontaining seeds by treatment with a saturated solution of calcium hydroxide |
-
1969
- 1969-04-22 NL NL6906198A patent/NL6906198A/xx unknown
-
1970
- 1970-04-15 DE DE19702018107 patent/DE2018107A1/de active Pending
- 1970-04-15 AU AU13895/70A patent/AU1389570A/en not_active Expired
- 1970-04-20 FR FR7014261A patent/FR2039347A1/fr not_active Withdrawn
- 1970-04-21 US US30601A patent/US3687928A/en not_active Expired - Lifetime
- 1970-04-21 IT IT68352/70A patent/IT990488B/it active
- 1970-04-21 LU LU60765D patent/LU60765A1/xx unknown
- 1970-04-22 BE BE749322D patent/BE749322A/nl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2039347A1 (enExample) | 1971-01-15 |
| BE749322A (nl) | 1970-10-22 |
| LU60765A1 (enExample) | 1970-06-26 |
| NL6906198A (enExample) | 1970-10-26 |
| AU1389570A (en) | 1971-10-21 |
| US3687928A (en) | 1972-08-29 |
| IT990488B (it) | 1975-06-20 |
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