DE19856052A1 - Konjugat zur Anreicherung in neuronalen Zellen - Google Patents

Konjugat zur Anreicherung in neuronalen Zellen

Info

Publication number
DE19856052A1
DE19856052A1 DE19856052A DE19856052A DE19856052A1 DE 19856052 A1 DE19856052 A1 DE 19856052A1 DE 19856052 A DE19856052 A DE 19856052A DE 19856052 A DE19856052 A DE 19856052A DE 19856052 A1 DE19856052 A1 DE 19856052A1
Authority
DE
Germany
Prior art keywords
toxin
heavy chain
conjugate
protein
conjugate according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19856052A
Other languages
German (de)
English (en)
Inventor
Achim Loehr
Manfred Schwab
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deutsches Krebsforschungszentrum DKFZ
Original Assignee
Deutsches Krebsforschungszentrum DKFZ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforschungszentrum DKFZ filed Critical Deutsches Krebsforschungszentrum DKFZ
Priority to DE19856052A priority Critical patent/DE19856052A1/de
Priority to PCT/DE1999/003924 priority patent/WO2000033880A2/fr
Publication of DE19856052A1 publication Critical patent/DE19856052A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE19856052A 1998-12-04 1998-12-04 Konjugat zur Anreicherung in neuronalen Zellen Withdrawn DE19856052A1 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE19856052A DE19856052A1 (de) 1998-12-04 1998-12-04 Konjugat zur Anreicherung in neuronalen Zellen
PCT/DE1999/003924 WO2000033880A2 (fr) 1998-12-04 1999-12-03 Conjugue pour l'administration dans des cellules neuronales

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19856052A DE19856052A1 (de) 1998-12-04 1998-12-04 Konjugat zur Anreicherung in neuronalen Zellen

Publications (1)

Publication Number Publication Date
DE19856052A1 true DE19856052A1 (de) 2000-06-08

Family

ID=7890019

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19856052A Withdrawn DE19856052A1 (de) 1998-12-04 1998-12-04 Konjugat zur Anreicherung in neuronalen Zellen

Country Status (2)

Country Link
DE (1) DE19856052A1 (fr)
WO (1) WO2000033880A2 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005056752A2 (fr) 2003-10-24 2005-06-23 Gencia Corporation Procedes et compositions permettant de distribuer des polynucleotides
US8062891B2 (en) 2003-10-24 2011-11-22 Gencia Corporation Nonviral vectors for delivering polynucleotides to plants
US8133733B2 (en) 2003-10-24 2012-03-13 Gencia Corporation Nonviral vectors for delivering polynucleotides to target tissues
US8507277B2 (en) 2003-10-24 2013-08-13 Gencia Corporation Nonviral vectors for delivering polynucleotides
US8927691B2 (en) 2003-10-24 2015-01-06 Gencia Corporation Transducible polypeptides for modifying metabolism

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9410871D0 (en) 1994-05-31 1994-07-20 Imperial College Modification of tetanus toxin for use as a transport protein
US7838008B2 (en) 1999-12-07 2010-11-23 Allergan, Inc. Methods for treating diverse cancers
US7838007B2 (en) 1999-12-07 2010-11-23 Allergan, Inc. Methods for treating mammary gland disorders
DE102004035606A1 (de) * 2004-07-22 2006-03-30 Biotecon Therapeutics Gmbh Carrier für Arzneimittel zur Gewinnung der oralen Bioverfügbarkeit
GB0725321D0 (en) * 2007-12-31 2008-02-06 Syntaxin Ltd Delivery vehicles

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995032738A1 (fr) * 1994-05-31 1995-12-07 Allergan, Inc. Modification de toxines de clostridium utilisees comme proteines de transport

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4594336A (en) * 1982-09-28 1986-06-10 Institut Pasteur Thiolated polypeptide compound derived from a tetanus toxin fragment, the process for obtaining and its application
DE68917126T2 (de) * 1988-02-01 1995-02-02 Praxis Biolog Inc T-zellen-epitope als träger für einen konjugierten impfstoff.
GB9524807D0 (en) * 1995-12-05 1996-02-07 Smithkline Beecham Plc Novel compounds
GB9824282D0 (en) * 1998-11-05 1998-12-30 Microbiological Research Agenc Delivery of superoxide dismutase to neuronal cells

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995032738A1 (fr) * 1994-05-31 1995-12-07 Allergan, Inc. Modification de toxines de clostridium utilisees comme proteines de transport

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BEAUDE, P. et al.: "Retrograde axonal transport of an exogenous enzyme covalenty linked to B-IIb fragment of tetanus toxin", Biochem.J. (1990) 271, S. 87-91 *
JOHNSTONE, S.R. et al.: "The heavy chain of tetanus toxin can medate the cytotoxic gelonin into intact cells", FEBS Letters 265 (1990) 1-2, S. 101-103 *

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005056752A2 (fr) 2003-10-24 2005-06-23 Gencia Corporation Procedes et compositions permettant de distribuer des polynucleotides
EP1687017A2 (fr) * 2003-10-24 2006-08-09 Gencia Corporation Procedes et compositions permettant de distribuer des polynucleotides
EP1687017A4 (fr) * 2003-10-24 2009-08-19 Gencia Corp Procedes et compositions permettant de distribuer des polynucleotides
AU2004297533B2 (en) * 2003-10-24 2010-04-29 Gencia Corporation Methods and compositions for delivering polynucleotides
US8039587B2 (en) 2003-10-24 2011-10-18 Gencia Corporation Methods and compositions for delivering polynucleotides
US8062891B2 (en) 2003-10-24 2011-11-22 Gencia Corporation Nonviral vectors for delivering polynucleotides to plants
US8133733B2 (en) 2003-10-24 2012-03-13 Gencia Corporation Nonviral vectors for delivering polynucleotides to target tissues
EP2418281A3 (fr) * 2003-10-24 2012-09-19 Gencia Corporation Procédés et compositions pour l'administration de polynucléotides
US8470972B2 (en) 2003-10-24 2013-06-25 Gencia Corporation Nonviral vectors for delivering polynucleotides to plants
US8507277B2 (en) 2003-10-24 2013-08-13 Gencia Corporation Nonviral vectors for delivering polynucleotides
US8541550B2 (en) 2003-10-24 2013-09-24 Gencia Corporation Methods and compositions for delivering polynucleotides
US8927691B2 (en) 2003-10-24 2015-01-06 Gencia Corporation Transducible polypeptides for modifying metabolism
US8952133B2 (en) 2003-10-24 2015-02-10 Gencia Corporation Nonviral vectors for delivering polynucleotides to target tissue

Also Published As

Publication number Publication date
WO2000033880A3 (fr) 2000-10-12
WO2000033880A2 (fr) 2000-06-15

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8139 Disposal/non-payment of the annual fee