DE19855963A1 - Amphiphile Glycerylnucleotide, Verfahren zu ihrer Herstellung und ihre Verwendung - Google Patents

Amphiphile Glycerylnucleotide, Verfahren zu ihrer Herstellung und ihre Verwendung

Info

Publication number
DE19855963A1
DE19855963A1 DE19855963A DE19855963A DE19855963A1 DE 19855963 A1 DE19855963 A1 DE 19855963A1 DE 19855963 A DE19855963 A DE 19855963A DE 19855963 A DE19855963 A DE 19855963A DE 19855963 A1 DE19855963 A1 DE 19855963A1
Authority
DE
Germany
Prior art keywords
formula
hydroxyl
hydrogen
nucleoside derivative
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19855963A
Other languages
German (de)
English (en)
Inventor
Herbert Schott
Peter Stephan Ludwig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE19855963A priority Critical patent/DE19855963A1/de
Priority to DK99958161T priority patent/DK1135401T3/da
Priority to AT99958161T priority patent/ATE243220T1/de
Priority to US09/856,165 priority patent/US6787525B1/en
Priority to JP2000586741A priority patent/JP4879398B2/ja
Priority to PCT/EP1999/009461 priority patent/WO2000034298A1/de
Priority to ES99958161T priority patent/ES2201805T3/es
Priority to AU15588/00A priority patent/AU1558800A/en
Priority to EP99958161A priority patent/EP1135401B1/de
Priority to DE59906041T priority patent/DE59906041D1/de
Priority to CA002352229A priority patent/CA2352229C/en
Publication of DE19855963A1 publication Critical patent/DE19855963A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE19855963A 1998-12-04 1998-12-04 Amphiphile Glycerylnucleotide, Verfahren zu ihrer Herstellung und ihre Verwendung Withdrawn DE19855963A1 (de)

Priority Applications (11)

Application Number Priority Date Filing Date Title
DE19855963A DE19855963A1 (de) 1998-12-04 1998-12-04 Amphiphile Glycerylnucleotide, Verfahren zu ihrer Herstellung und ihre Verwendung
DK99958161T DK1135401T3 (da) 1998-12-04 1999-12-03 Glycerylnucleotider, fremgangsmåder til deres fremstilling og deres anvendelse
AT99958161T ATE243220T1 (de) 1998-12-04 1999-12-03 Glycerylnucleotide, verfahren zu ihrer herstellung und ihre verwendung
US09/856,165 US6787525B1 (en) 1998-12-04 1999-12-03 Glyceryl nucleotides, method for the production thereof and their use
JP2000586741A JP4879398B2 (ja) 1998-12-04 1999-12-03 グリセリルヌクレオチド、それらの製造法および使用
PCT/EP1999/009461 WO2000034298A1 (de) 1998-12-04 1999-12-03 Glycerylnucleotide, verfahren zu ihrer herstellung und ihre verwendung
ES99958161T ES2201805T3 (es) 1998-12-04 1999-12-03 Nuevos gliceril-nucleotidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
AU15588/00A AU1558800A (en) 1998-12-04 1999-12-03 Glyceryl nucleotides, method for the production thereof and their use
EP99958161A EP1135401B1 (de) 1998-12-04 1999-12-03 Glycerylnucleotide, verfahren zu ihrer herstellung und ihre verwendung
DE59906041T DE59906041D1 (de) 1998-12-04 1999-12-03 Glycerylnucleotide, verfahren zu ihrer herstellung und ihre verwendung
CA002352229A CA2352229C (en) 1998-12-04 1999-12-03 Glyceryl nucleotides, method for the production thereof and their use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19855963A DE19855963A1 (de) 1998-12-04 1998-12-04 Amphiphile Glycerylnucleotide, Verfahren zu ihrer Herstellung und ihre Verwendung

Publications (1)

Publication Number Publication Date
DE19855963A1 true DE19855963A1 (de) 2000-06-08

Family

ID=7889957

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19855963A Withdrawn DE19855963A1 (de) 1998-12-04 1998-12-04 Amphiphile Glycerylnucleotide, Verfahren zu ihrer Herstellung und ihre Verwendung
DE59906041T Expired - Lifetime DE59906041D1 (de) 1998-12-04 1999-12-03 Glycerylnucleotide, verfahren zu ihrer herstellung und ihre verwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59906041T Expired - Lifetime DE59906041D1 (de) 1998-12-04 1999-12-03 Glycerylnucleotide, verfahren zu ihrer herstellung und ihre verwendung

Country Status (10)

Country Link
US (1) US6787525B1 (enExample)
EP (1) EP1135401B1 (enExample)
JP (1) JP4879398B2 (enExample)
AT (1) ATE243220T1 (enExample)
AU (1) AU1558800A (enExample)
CA (1) CA2352229C (enExample)
DE (2) DE19855963A1 (enExample)
DK (1) DK1135401T3 (enExample)
ES (1) ES2201805T3 (enExample)
WO (1) WO2000034298A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9243022B2 (en) 2012-12-21 2016-01-26 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9422323B2 (en) 2012-05-25 2016-08-23 Janssen Sciences Ireland Uc Uracyl spirooxetane nucleosides
US9862743B2 (en) 2013-10-11 2018-01-09 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10228059B4 (de) * 2002-06-19 2005-12-29 Eberhard-Karls-Universität Tübingen Verwendung von amphiphilen Nucleosid-Phosphonoameisensäure-Derivaten zur Behandlung von viralen Infektionskrankheiten
US7593913B2 (en) * 2006-01-11 2009-09-22 Siemens Medical Solutions Usa, Inc. Systems and method for integrative medical decision support
CA2812962C (en) 2010-09-22 2020-03-31 Alios Biopharma, Inc. Azido nucleosides and nucleotide analogs
EP2794627B1 (en) 2011-12-22 2018-09-26 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03236396A (ja) * 1990-02-10 1991-10-22 Tosoh Corp 修飾オリゴデオキシヌクレオチド及びそれを含むｄｎａ
JPH0421694A (ja) * 1990-05-16 1992-01-24 Asahi Chem Ind Co Ltd 新規なヌクレオシド―リン脂質複合体
DE69119074T2 (de) * 1990-06-15 1996-12-12 University Of North Carolina At Chapel Hill, Chapel Hill, N.C. Kovalente-ther lipidnukleosid-konjugate
CA2129986C (en) 1992-02-13 2003-12-09 Albert Reto Schwendener Amphiphile nucleosidphosphatanaloga
DE4418690A1 (de) * 1994-05-28 1996-01-11 Boehringer Mannheim Gmbh Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
DE69535758D1 (de) * 1994-08-29 2008-07-03 Univ Wake Forest Lipid-analoge zur behandlung von viralen infektionen
AU3120797A (en) 1996-05-08 1998-07-31 Weider Nutrition Group, Inc. Structured glycerols and structured phosphatides
US6686462B2 (en) * 1997-02-28 2004-02-03 The Regents Of The University Of California Antiviral compounds and methods of administration

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10301347B2 (en) 2012-05-25 2019-05-28 Janssen Sciences Ireland Unlimited Company Uracyl spirooxetane nucleosides
US10774106B2 (en) 2012-05-25 2020-09-15 Janssen Sciences Ireland Unlimited Company Uracyl spirooxetane nucleosides
US9422323B2 (en) 2012-05-25 2016-08-23 Janssen Sciences Ireland Uc Uracyl spirooxetane nucleosides
US9845336B2 (en) 2012-05-25 2017-12-19 Janssen Sciences Ireland Uc Uracyl spirooxetane nucleosides
US10544184B2 (en) 2012-05-25 2020-01-28 Janssen Sciences Ireland Unlimited Company Uracyl spirooxetane nucleosides
US10040814B2 (en) 2012-05-25 2018-08-07 Janssen Sciences Ireland Uc Uracyl spirooxetane nucleosides
US10683320B2 (en) 2012-12-21 2020-06-16 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US10144755B2 (en) 2012-12-21 2018-12-04 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US10112966B2 (en) 2012-12-21 2018-10-30 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US10487104B2 (en) 2012-12-21 2019-11-26 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9243022B2 (en) 2012-12-21 2016-01-26 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9249174B2 (en) 2012-12-21 2016-02-02 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US10793591B2 (en) 2012-12-21 2020-10-06 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US11485753B2 (en) 2012-12-21 2022-11-01 Janssen Pharmaceutica Nv Substituted nucleosides, nucleotides and analogs thereof
US12173025B2 (en) 2012-12-21 2024-12-24 Janssen Pharmaceuticals, Inc. Substituted nucleosides, nucleotides and analogs thereof
US10370401B2 (en) 2013-10-11 2019-08-06 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9862743B2 (en) 2013-10-11 2018-01-09 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof

Also Published As

Publication number Publication date
AU1558800A (en) 2000-06-26
JP4879398B2 (ja) 2012-02-22
ATE243220T1 (de) 2003-07-15
DE59906041D1 (de) 2003-07-24
CA2352229A1 (en) 2000-06-15
JP2002531573A (ja) 2002-09-24
US6787525B1 (en) 2004-09-07
EP1135401B1 (de) 2003-06-18
WO2000034298A1 (de) 2000-06-15
DK1135401T3 (da) 2003-10-06
EP1135401A1 (de) 2001-09-26
ES2201805T3 (es) 2004-03-16
CA2352229C (en) 2009-06-09

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Legal Events

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8122 Nonbinding interest in granting licences declared
8139 Disposal/non-payment of the annual fee