DE19747418C1 - Inhibitor-Protein des wnt-Signalwegs - Google Patents

Inhibitor-Protein des wnt-Signalwegs

Info

Publication number
DE19747418C1
DE19747418C1 DE19747418A DE19747418A DE19747418C1 DE 19747418 C1 DE19747418 C1 DE 19747418C1 DE 19747418 A DE19747418 A DE 19747418A DE 19747418 A DE19747418 A DE 19747418A DE 19747418 C1 DE19747418 C1 DE 19747418C1
Authority
DE
Germany
Prior art keywords
dna
protein
wnt
signaling pathway
wnt signaling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE19747418A
Other languages
German (de)
English (en)
Inventor
Christof Dr Niehrs
Andrei Dr Glinka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deutsches Krebsforschungszentrum DKFZ
Original Assignee
Deutsches Krebsforschungszentrum DKFZ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7846765&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE19747418(C1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Deutsches Krebsforschungszentrum DKFZ filed Critical Deutsches Krebsforschungszentrum DKFZ
Priority to DE19747418A priority Critical patent/DE19747418C1/de
Priority to EP08002377A priority patent/EP1923465A1/de
Priority to DE59814214T priority patent/DE59814214D1/de
Priority to EP98959767A priority patent/EP1027440B2/de
Priority to JP2000518092A priority patent/JP2001520886A/ja
Priority to AT98959767T priority patent/ATE391782T1/de
Priority to PCT/DE1998/003155 priority patent/WO1999022000A1/de
Priority to PT98959767T priority patent/PT1027440E/pt
Priority to US09/530,219 priority patent/US6844422B1/en
Priority to DK98959767T priority patent/DK1027440T3/da
Priority to ES98959767T priority patent/ES2306483T5/es
Publication of DE19747418C1 publication Critical patent/DE19747418C1/de
Application granted granted Critical
Priority to US10/960,235 priority patent/US7138508B2/en
Priority to US11/561,826 priority patent/US8536311B2/en
Priority to US12/930,858 priority patent/US8461309B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19747418A 1997-10-27 1997-10-27 Inhibitor-Protein des wnt-Signalwegs Expired - Fee Related DE19747418C1 (de)

Priority Applications (14)

Application Number Priority Date Filing Date Title
DE19747418A DE19747418C1 (de) 1997-10-27 1997-10-27 Inhibitor-Protein des wnt-Signalwegs
US09/530,219 US6844422B1 (en) 1997-10-27 1998-10-27 Inhibitor protein of the wnt signal pathway
ES98959767T ES2306483T5 (es) 1997-10-27 1998-10-27 Prote�?na inhibidora de la ruta de señalización de wnt.
EP98959767A EP1027440B2 (de) 1997-10-27 1998-10-27 Inhibitor-protein des wnt-signalwegs
JP2000518092A JP2001520886A (ja) 1997-10-27 1998-10-27 ｗｎｔシグナル経路の阻害タンパク質
AT98959767T ATE391782T1 (de) 1997-10-27 1998-10-27 Inhibitor-protein des wnt-signalwegs
PCT/DE1998/003155 WO1999022000A1 (de) 1997-10-27 1998-10-27 Inhibitor-protein des wnt-signalwegs
PT98959767T PT1027440E (pt) 1997-10-27 1998-10-27 Proteína inibidora da via de sinal wnt
EP08002377A EP1923465A1 (de) 1997-10-27 1998-10-27 Inhibitor-Protein des WNT-Signalwegs
DK98959767T DK1027440T3 (da) 1997-10-27 1998-10-27 Inhibitorprotein af wnt-signalbanen
DE59814214T DE59814214D1 (de) 1997-10-27 1998-10-27 Inhibitor-protein des wnt-signalwegs
US10/960,235 US7138508B2 (en) 1997-10-27 2004-10-06 Inhibitor protein of the wnt signal pathway
US11/561,826 US8536311B2 (en) 1997-10-27 2006-11-20 Inhibitor protein of the wnt signal pathway
US12/930,858 US8461309B2 (en) 1997-10-27 2011-01-19 Inhibitor protein of the wnt signal pathway

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19747418A DE19747418C1 (de) 1997-10-27 1997-10-27 Inhibitor-Protein des wnt-Signalwegs

Publications (1)

Publication Number Publication Date
DE19747418C1 true DE19747418C1 (de) 1999-07-15

Family

ID=7846765

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19747418A Expired - Fee Related DE19747418C1 (de) 1997-10-27 1997-10-27 Inhibitor-Protein des wnt-Signalwegs
DE59814214T Expired - Lifetime DE59814214D1 (de) 1997-10-27 1998-10-27 Inhibitor-protein des wnt-signalwegs

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59814214T Expired - Lifetime DE59814214D1 (de) 1997-10-27 1998-10-27 Inhibitor-protein des wnt-signalwegs

Country Status (9)

Country Link
US (4) US6844422B1 (enExample)
EP (2) EP1923465A1 (enExample)
JP (1) JP2001520886A (enExample)
AT (1) ATE391782T1 (enExample)
DE (2) DE19747418C1 (enExample)
DK (1) DK1027440T3 (enExample)
ES (1) ES2306483T5 (enExample)
PT (1) PT1027440E (enExample)
WO (1) WO1999022000A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7446181B2 (en) 1998-01-15 2008-11-04 Millennium Pharmaceuticals, Inc. Antibodies that bind human Dickkopf-1 proteins
US7579168B2 (en) 1997-04-16 2009-08-25 Millennium Pharmaceuticals, Inc. Human Dickkopf-related nucleic acid molecules
US7700101B2 (en) 2001-05-17 2010-04-20 Wyeth Reagents and method for modulating Dkk-mediated interactions
US7723478B2 (en) 1998-09-25 2010-05-25 Amgen Inc. DKR polypeptides

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE505543T1 (de) * 1997-04-16 2011-04-15 Millennium Pharm Inc Zusammensetzung, umfassend einen antikörper, der selektiv an ein cysteinreiches sekretiertes protein (crsp) bindet
DE19747418C1 (de) 1997-10-27 1999-07-15 Deutsches Krebsforsch Inhibitor-Protein des wnt-Signalwegs
AU3510200A (en) * 1999-03-05 2000-09-21 Millennium Pharmaceuticals, Inc. Human dickkopf-related protein and nucleic acid molecules and uses therefor
JP2003501395A (ja) * 1999-06-08 2003-01-14 ローランティス・リミテッド 治療的使用
DE60101305D1 (de) * 2000-02-24 2004-01-08 Oxford Glycosciences Uk Ltd Dpi-6, ein therapeutischer biomarker in neurologischen krankheiten
EP1222933A1 (en) * 2001-01-15 2002-07-17 Academisch Ziekenhuis Leiden h.o.d.n., Leids Universitair Medisch Centrum Generation and/or reduction of new lung tissue in an affected lung, by modulation of the Wnt-pathway
US7736654B2 (en) 2001-04-10 2010-06-15 Agensys, Inc. Nucleic acids and corresponding proteins useful in the detection and treatment of various cancers
US7927597B2 (en) 2001-04-10 2011-04-19 Agensys, Inc. Methods to inhibit cell growth
US7713526B2 (en) * 2001-05-01 2010-05-11 The Regents Of The University Of California Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
IL149404A0 (en) * 2002-04-29 2002-11-10 Yissum Res Dev Co METHODS AND COMPOSITIONS FOR MODULATING β-CATENIN PHOSPHORYLATION
CA2501235A1 (en) * 2002-10-04 2004-04-22 The Regents Of The University Of California Methods for treating cancer by inhibiting wnt signaling
US9046537B2 (en) 2003-09-22 2015-06-02 Enzo Biochem, Inc. Method for treating inflammation by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain
US8367822B2 (en) 2003-09-22 2013-02-05 Enzo Therapeutics, Inc. Compositions and methods for bone formation and remodeling
US8461155B2 (en) * 2003-09-22 2013-06-11 University Of Connecticut Sclerostin and the inhibition of WNT signaling and bone formation
US8637506B2 (en) * 2003-09-22 2014-01-28 Enzo Biochem, Inc. Compositions and methods for bone formation and remodeling
US7622553B2 (en) 2003-11-17 2009-11-24 Merck & Co., Inc. Rhesus monkey dickkopf-1, nucleotides encoding same, and uses thereof
WO2005049797A2 (en) 2003-11-17 2005-06-02 Merck & Co., Inc. Cynomolgus monkey dickkopf-4, nucleotides encoding same, and uses thereof
WO2005095448A2 (en) * 2004-03-23 2005-10-13 Oscient Pharmaceuticals Corporation Method of synthesizing and purifying dkk proteins and dkk proteins obtained thereby
US20060040883A1 (en) * 2004-05-14 2006-02-23 The Regents Of The University Of California Methods for treating cancer using anti-Wnt2 monoclonal antibodies and siRNA
US8343922B2 (en) * 2004-05-19 2013-01-01 Enzo Biochem, Inc. Compositions and methods for the stimulation or enhancement of bone formation and the self-renewal of cells
US9052324B2 (en) 2004-05-19 2015-06-09 Enzo Biochem, Inc. Compounds and assays for controlling Wnt activity
US7618936B2 (en) * 2004-05-21 2009-11-17 The Regents Of The University Of California Methods for treating and diagnosing cancer with WNT inhibitory Factor-1 (WIF-1)
AU2005267722B2 (en) * 2004-08-04 2009-10-08 Amgen Inc. Antibodies to Dkk-1
NZ555216A (en) * 2004-11-10 2010-05-28 Hubrecht Lab Treatment of an intestinal adenoma and/or adenocarcinoma by inhibition of notch pathway activation
WO2006061717A2 (en) * 2004-12-09 2006-06-15 Neuro Therapeutics Ab Materials and methods related to dickkopfs (dkk) and neurogenesis
EP1795198A1 (en) * 2005-12-09 2007-06-13 Hubrecht Laboratorium Treatment of Barret's esophagus
AR060017A1 (es) 2006-01-13 2008-05-21 Novartis Ag Composiciones y metodos de uso para anticuerpos de dickkopf -1
EP2121755A1 (en) * 2007-02-08 2009-11-25 Merck & Co., Inc. Antibodies specific for dkk-1
US20090074668A1 (en) * 2007-09-14 2009-03-19 Farjo Rafal A Vldlr-/- mouse models and related methods
AR075989A1 (es) 2009-04-10 2011-05-11 Lilly Co Eli Anticuerpo dkk -1 (dickkopf-1) humano disenado por ingenieria
US20120165270A1 (en) * 2009-04-27 2012-06-28 Yeon Sook Choi Inhibition of hair follicle growth by the wnt inhibitor dkk1
SA110310369B1 (ar) 2009-05-12 2014-09-02 Pfizer أجسام مضادة تخص dkk-1 واستخداماتها
US9133272B2 (en) 2011-03-01 2015-09-15 Amgen Inc. Bispecific binding agents
HUE039849T2 (hu) 2011-03-16 2019-02-28 Argenx Bvba CD70 elleni ellenanyagok
WO2013155447A1 (en) * 2012-04-13 2013-10-17 Children's Medical Center Corporation Tiki inhibitors
UY35148A (es) 2012-11-21 2014-05-30 Amgen Inc Immunoglobulinas heterodiméricas
US10391168B1 (en) 2014-08-22 2019-08-27 University Of Bern Anti-CD70 combination therapy
GB201800649D0 (en) 2018-01-16 2018-02-28 Argenx Bvba CD70 Combination Therapy
TWI848030B (zh) 2018-12-18 2024-07-11 比利時商阿根思公司 Ｃｄ７０組合治療

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6133232A (en) * 1996-06-20 2000-10-17 The Regents Of The University Of California Endoderm, cardiac and neural inducing factors
WO1998027932A2 (en) 1996-12-20 1998-07-02 Human Genome Sciences, Inc. Cerebellum and embryo specific protein
ATE505543T1 (de) * 1997-04-16 2011-04-15 Millennium Pharm Inc Zusammensetzung, umfassend einen antikörper, der selektiv an ein cysteinreiches sekretiertes protein (crsp) bindet
US7057017B2 (en) * 1997-04-16 2006-06-06 Millennium Pharmaceuticals, Inc. Human dickkopf-related protein and nucleic acid molecules and uses therefor
DE19747418C1 (de) 1997-10-27 1999-07-15 Deutsches Krebsforsch Inhibitor-Protein des wnt-Signalwegs
US7446181B2 (en) * 1998-01-15 2008-11-04 Millennium Pharmaceuticals, Inc. Antibodies that bind human Dickkopf-1 proteins

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Science 275, 1997, S.1752-1753 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7579168B2 (en) 1997-04-16 2009-08-25 Millennium Pharmaceuticals, Inc. Human Dickkopf-related nucleic acid molecules
US7645451B2 (en) 1997-04-16 2010-01-12 Millennium Pharmaceuticals, Inc. Human dickkopf-related protein and nucleic acid molecules and uses therefor
US8202966B2 (en) 1997-04-16 2012-06-19 Millennium Pharmaceuticals, Inc. Human Dickkopf-related protein and nucleic acid molecules and uses therefor
US7446181B2 (en) 1998-01-15 2008-11-04 Millennium Pharmaceuticals, Inc. Antibodies that bind human Dickkopf-1 proteins
US7723478B2 (en) 1998-09-25 2010-05-25 Amgen Inc. DKR polypeptides
US7700101B2 (en) 2001-05-17 2010-04-20 Wyeth Reagents and method for modulating Dkk-mediated interactions

Also Published As

Publication number Publication date
EP1923465A1 (de) 2008-05-21
EP1027440A1 (de) 2000-08-16
PT1027440E (pt) 2008-07-14
ES2306483T5 (es) 2012-03-16
US8536311B2 (en) 2013-09-17
WO1999022000A1 (de) 1999-05-06
US20050079173A1 (en) 2005-04-14
JP2001520886A (ja) 2001-11-06
US8461309B2 (en) 2013-06-11
ATE391782T1 (de) 2008-04-15
DE59814214D1 (de) 2008-05-21
US20110118445A1 (en) 2011-05-19
EP1027440B2 (de) 2011-09-14
US20070077244A1 (en) 2007-04-05
EP1027440B1 (de) 2008-04-09
US6844422B1 (en) 2005-01-18
ES2306483T3 (es) 2008-11-01
DK1027440T3 (da) 2008-08-04
US7138508B2 (en) 2006-11-21

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Legal Events

Date Code Title Description
8100 Publication of patent without earlier publication of application
D1 Grant (no unexamined application published) patent law 81
8364 No opposition during term of opposition
R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee