ES2306483T5 - Prote�?na inhibidora de la ruta de señalización de wnt. - Google Patents

Prote�?na inhibidora de la ruta de señalización de wnt. Download PDF

Info

Publication number
ES2306483T5
ES2306483T5 ES98959767T ES98959767T ES2306483T5 ES 2306483 T5 ES2306483 T5 ES 2306483T5 ES 98959767 T ES98959767 T ES 98959767T ES 98959767 T ES98959767 T ES 98959767T ES 2306483 T5 ES2306483 T5 ES 2306483T5
Authority
ES
Spain
Prior art keywords
dna
protein
wnt
immunization
signaling pathway
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98959767T
Other languages
English (en)
Spanish (es)
Other versions
ES2306483T3 (es
Inventor
Christof Niehrs
Andrei Glinka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deutsches Krebsforschungszentrum DKFZ
Original Assignee
Deutsches Krebsforschungszentrum DKFZ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7846765&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2306483(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Deutsches Krebsforschungszentrum DKFZ filed Critical Deutsches Krebsforschungszentrum DKFZ
Application granted granted Critical
Publication of ES2306483T3 publication Critical patent/ES2306483T3/es
Publication of ES2306483T5 publication Critical patent/ES2306483T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES98959767T 1997-10-27 1998-10-27 Prote�?na inhibidora de la ruta de señalización de wnt. Expired - Lifetime ES2306483T5 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19747418A DE19747418C1 (de) 1997-10-27 1997-10-27 Inhibitor-Protein des wnt-Signalwegs
DE19747418 1997-10-27
PCT/DE1998/003155 WO1999022000A1 (de) 1997-10-27 1998-10-27 Inhibitor-protein des wnt-signalwegs

Publications (2)

Publication Number Publication Date
ES2306483T3 ES2306483T3 (es) 2008-11-01
ES2306483T5 true ES2306483T5 (es) 2012-03-16

Family

ID=7846765

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98959767T Expired - Lifetime ES2306483T5 (es) 1997-10-27 1998-10-27 Prote�?na inhibidora de la ruta de señalización de wnt.

Country Status (9)

Country Link
US (4) US6844422B1 (enExample)
EP (2) EP1923465A1 (enExample)
JP (1) JP2001520886A (enExample)
AT (1) ATE391782T1 (enExample)
DE (2) DE19747418C1 (enExample)
DK (1) DK1027440T3 (enExample)
ES (1) ES2306483T5 (enExample)
PT (1) PT1027440E (enExample)
WO (1) WO1999022000A1 (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7057017B2 (en) 1997-04-16 2006-06-06 Millennium Pharmaceuticals, Inc. Human dickkopf-related protein and nucleic acid molecules and uses therefor
ATE505543T1 (de) * 1997-04-16 2011-04-15 Millennium Pharm Inc Zusammensetzung, umfassend einen antikörper, der selektiv an ein cysteinreiches sekretiertes protein (crsp) bindet
DE19747418C1 (de) 1997-10-27 1999-07-15 Deutsches Krebsforsch Inhibitor-Protein des wnt-Signalwegs
US7446181B2 (en) * 1998-01-15 2008-11-04 Millennium Pharmaceuticals, Inc. Antibodies that bind human Dickkopf-1 proteins
US6344541B1 (en) 1998-09-25 2002-02-05 Amgen Inc. DKR polypeptides
AU3510200A (en) * 1999-03-05 2000-09-21 Millennium Pharmaceuticals, Inc. Human dickkopf-related protein and nucleic acid molecules and uses therefor
JP2003501395A (ja) * 1999-06-08 2003-01-14 ローランティス・リミテッド 治療的使用
DE60101305D1 (de) * 2000-02-24 2004-01-08 Oxford Glycosciences Uk Ltd Dpi-6, ein therapeutischer biomarker in neurologischen krankheiten
EP1222933A1 (en) * 2001-01-15 2002-07-17 Academisch Ziekenhuis Leiden h.o.d.n., Leids Universitair Medisch Centrum Generation and/or reduction of new lung tissue in an affected lung, by modulation of the Wnt-pathway
US7736654B2 (en) 2001-04-10 2010-06-15 Agensys, Inc. Nucleic acids and corresponding proteins useful in the detection and treatment of various cancers
US7927597B2 (en) 2001-04-10 2011-04-19 Agensys, Inc. Methods to inhibit cell growth
US7713526B2 (en) * 2001-05-01 2010-05-11 The Regents Of The University Of California Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
US20040038860A1 (en) * 2002-05-17 2004-02-26 Allen Kristina M. Reagents and methods for modulating dkk-mediated interactions
IL149404A0 (en) * 2002-04-29 2002-11-10 Yissum Res Dev Co METHODS AND COMPOSITIONS FOR MODULATING β-CATENIN PHOSPHORYLATION
CA2501235A1 (en) * 2002-10-04 2004-04-22 The Regents Of The University Of California Methods for treating cancer by inhibiting wnt signaling
US9046537B2 (en) 2003-09-22 2015-06-02 Enzo Biochem, Inc. Method for treating inflammation by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain
US8367822B2 (en) 2003-09-22 2013-02-05 Enzo Therapeutics, Inc. Compositions and methods for bone formation and remodeling
US8461155B2 (en) * 2003-09-22 2013-06-11 University Of Connecticut Sclerostin and the inhibition of WNT signaling and bone formation
US8637506B2 (en) * 2003-09-22 2014-01-28 Enzo Biochem, Inc. Compositions and methods for bone formation and remodeling
US7622553B2 (en) 2003-11-17 2009-11-24 Merck & Co., Inc. Rhesus monkey dickkopf-1, nucleotides encoding same, and uses thereof
WO2005049797A2 (en) 2003-11-17 2005-06-02 Merck & Co., Inc. Cynomolgus monkey dickkopf-4, nucleotides encoding same, and uses thereof
WO2005095448A2 (en) * 2004-03-23 2005-10-13 Oscient Pharmaceuticals Corporation Method of synthesizing and purifying dkk proteins and dkk proteins obtained thereby
US20060040883A1 (en) * 2004-05-14 2006-02-23 The Regents Of The University Of California Methods for treating cancer using anti-Wnt2 monoclonal antibodies and siRNA
US8343922B2 (en) * 2004-05-19 2013-01-01 Enzo Biochem, Inc. Compositions and methods for the stimulation or enhancement of bone formation and the self-renewal of cells
US9052324B2 (en) 2004-05-19 2015-06-09 Enzo Biochem, Inc. Compounds and assays for controlling Wnt activity
US7618936B2 (en) * 2004-05-21 2009-11-17 The Regents Of The University Of California Methods for treating and diagnosing cancer with WNT inhibitory Factor-1 (WIF-1)
AU2005267722B2 (en) * 2004-08-04 2009-10-08 Amgen Inc. Antibodies to Dkk-1
NZ555216A (en) * 2004-11-10 2010-05-28 Hubrecht Lab Treatment of an intestinal adenoma and/or adenocarcinoma by inhibition of notch pathway activation
WO2006061717A2 (en) * 2004-12-09 2006-06-15 Neuro Therapeutics Ab Materials and methods related to dickkopfs (dkk) and neurogenesis
EP1795198A1 (en) * 2005-12-09 2007-06-13 Hubrecht Laboratorium Treatment of Barret's esophagus
AR060017A1 (es) 2006-01-13 2008-05-21 Novartis Ag Composiciones y metodos de uso para anticuerpos de dickkopf -1
EP2121755A1 (en) * 2007-02-08 2009-11-25 Merck & Co., Inc. Antibodies specific for dkk-1
US20090074668A1 (en) * 2007-09-14 2009-03-19 Farjo Rafal A Vldlr-/- mouse models and related methods
AR075989A1 (es) 2009-04-10 2011-05-11 Lilly Co Eli Anticuerpo dkk -1 (dickkopf-1) humano disenado por ingenieria
US20120165270A1 (en) * 2009-04-27 2012-06-28 Yeon Sook Choi Inhibition of hair follicle growth by the wnt inhibitor dkk1
SA110310369B1 (ar) 2009-05-12 2014-09-02 Pfizer أجسام مضادة تخص dkk-1 واستخداماتها
US9133272B2 (en) 2011-03-01 2015-09-15 Amgen Inc. Bispecific binding agents
HUE039849T2 (hu) 2011-03-16 2019-02-28 Argenx Bvba CD70 elleni ellenanyagok
WO2013155447A1 (en) * 2012-04-13 2013-10-17 Children's Medical Center Corporation Tiki inhibitors
UY35148A (es) 2012-11-21 2014-05-30 Amgen Inc Immunoglobulinas heterodiméricas
US10391168B1 (en) 2014-08-22 2019-08-27 University Of Bern Anti-CD70 combination therapy
GB201800649D0 (en) 2018-01-16 2018-02-28 Argenx Bvba CD70 Combination Therapy
TWI848030B (zh) 2018-12-18 2024-07-11 比利時商阿根思公司 Ｃｄ７０組合治療

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6133232A (en) * 1996-06-20 2000-10-17 The Regents Of The University Of California Endoderm, cardiac and neural inducing factors
WO1998027932A2 (en) 1996-12-20 1998-07-02 Human Genome Sciences, Inc. Cerebellum and embryo specific protein
ATE505543T1 (de) * 1997-04-16 2011-04-15 Millennium Pharm Inc Zusammensetzung, umfassend einen antikörper, der selektiv an ein cysteinreiches sekretiertes protein (crsp) bindet
US7057017B2 (en) * 1997-04-16 2006-06-06 Millennium Pharmaceuticals, Inc. Human dickkopf-related protein and nucleic acid molecules and uses therefor
DE19747418C1 (de) 1997-10-27 1999-07-15 Deutsches Krebsforsch Inhibitor-Protein des wnt-Signalwegs
US7446181B2 (en) * 1998-01-15 2008-11-04 Millennium Pharmaceuticals, Inc. Antibodies that bind human Dickkopf-1 proteins

Also Published As

Publication number Publication date
EP1923465A1 (de) 2008-05-21
EP1027440A1 (de) 2000-08-16
PT1027440E (pt) 2008-07-14
US8536311B2 (en) 2013-09-17
WO1999022000A1 (de) 1999-05-06
US20050079173A1 (en) 2005-04-14
JP2001520886A (ja) 2001-11-06
US8461309B2 (en) 2013-06-11
ATE391782T1 (de) 2008-04-15
DE59814214D1 (de) 2008-05-21
US20110118445A1 (en) 2011-05-19
EP1027440B2 (de) 2011-09-14
US20070077244A1 (en) 2007-04-05
EP1027440B1 (de) 2008-04-09
US6844422B1 (en) 2005-01-18
DE19747418C1 (de) 1999-07-15
ES2306483T3 (es) 2008-11-01
DK1027440T3 (da) 2008-08-04
US7138508B2 (en) 2006-11-21

Similar Documents

Publication Publication Date Title
ES2306483T5 (es) Prote�?na inhibidora de la ruta de señalización de wnt.
ES2208676T3 (es) Factor 10 de crecimiento de fibroblasto.
US7141417B1 (en) Compositions, kits, and methods relating to the human FEZ1 gene, a novel tumor suppressor gene
JP2002502589A (ja) ４５個のヒト分泌タンパク質
JP2000078991A (ja) ヒト・ナトリウム依存性リン酸輸送体（ｉｐｔ―１）
WO1996013514A1 (en) Tcl-1 gene and protein and related methods and compositions
JPH10510986A (ja) メタロプロテイナーゼ−４のヒト組織インヒビター
JP2002501738A (ja) ６７個のヒト分泌タンパク質
ES2296412T3 (es) Gen y proteina mn.
Chow et al. DENN, a novel human gene differentially expressed in normal and neoplastic cells
JP2003525566A (ja) １２５個のヒト分泌タンパク質
JP2003508011A (ja) ヒトｆｅｚ１遺伝子である新規ガン抑制遺伝子に関する組成物、キットおよび方法
ES2255076T3 (es) Proteina con actividad adnasa.
US20040005688A1 (en) Isolated dishevelled associated kinases, polynucleotides encoding the kinases, and methods of use thereof
US6312688B1 (en) Tyrosine-phosphatase-related protein
ES2264142T3 (es) Proteina analoga a transcetolasa.
ES2235363T3 (es) Proteina relacionada con la proteasa.
JPH10201491A (ja) タンパク質ホスファターゼ１結合タンパク質ｒ５
US20020115069A1 (en) Eh domain containing genes and proteins
JP2002504361A (ja) ３６個のヒト分泌タンパク質
US6171818B1 (en) Protein having an anti-tumoral effect
WO2001038371A1 (en) A NOVEL POLYPEPTIDE-HUMAN GLUTAMATE tRNA SYNTHETASE 58 AND THE POLYNUCLEOTIDE ENCODING SAID POLYPEPTIDE
JPH119288A (ja) 新規ｈａｓ２スプライシング変種ｈｏｅｆｃ１１：慢性腎不全、炎症性疾患および心筋虚血における標的
JP2001509667A (ja) Ｓｒｃｒドメイン含有タンパク質
JP2002527053A (ja) 骨形成蛋白質誘導性遺伝子およびポリペプチド、並びに診断および治療方法におけるそれらの使用