DE19746583A1 - Mikromischer - Google Patents

Mikromischer

Info

Publication number
DE19746583A1
DE19746583A1 DE19746583A DE19746583A DE19746583A1 DE 19746583 A1 DE19746583 A1 DE 19746583A1 DE 19746583 A DE19746583 A DE 19746583A DE 19746583 A DE19746583 A DE 19746583A DE 19746583 A1 DE19746583 A1 DE 19746583A1
Authority
DE
Germany
Prior art keywords
housing part
channel
grooves
micromixer according
channel grooves
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19746583A
Other languages
German (de)
English (en)
Inventor
Ulrich Dr Koop
Michael Schmelz
Andreas Beirau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Priority to DE19746583A priority Critical patent/DE19746583A1/de
Priority to US09/529,970 priority patent/US6457854B1/en
Priority to JP2000516764A priority patent/JP2001520112A/ja
Priority to DE59805556T priority patent/DE59805556D1/de
Priority to EP98951514A priority patent/EP1047489B1/de
Priority to KR10-2000-7004186A priority patent/KR100518060B1/ko
Priority to PCT/EP1998/006462 priority patent/WO1999020379A1/de
Publication of DE19746583A1 publication Critical patent/DE19746583A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/432—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/10—Mixing gases with gases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/47—Mixing liquids with liquids; Emulsifying involving high-viscosity liquids, e.g. asphalt
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00824—Ceramic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00831—Glass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00833—Plastic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
DE19746583A 1997-10-22 1997-10-22 Mikromischer Withdrawn DE19746583A1 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE19746583A DE19746583A1 (de) 1997-10-22 1997-10-22 Mikromischer
US09/529,970 US6457854B1 (en) 1997-10-22 1998-10-12 Micromixer
JP2000516764A JP2001520112A (ja) 1997-10-22 1998-10-12 マイクロミキサー
DE59805556T DE59805556D1 (de) 1997-10-22 1998-10-12 Mikromischer
EP98951514A EP1047489B1 (de) 1997-10-22 1998-10-12 Mikromischer
KR10-2000-7004186A KR100518060B1 (ko) 1997-10-22 1998-10-12 마이크로믹서
PCT/EP1998/006462 WO1999020379A1 (de) 1997-10-22 1998-10-12 Mikromischer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19746583A DE19746583A1 (de) 1997-10-22 1997-10-22 Mikromischer

Publications (1)

Publication Number Publication Date
DE19746583A1 true DE19746583A1 (de) 1999-04-29

Family

ID=7846245

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19746583A Withdrawn DE19746583A1 (de) 1997-10-22 1997-10-22 Mikromischer
DE59805556T Expired - Fee Related DE59805556D1 (de) 1997-10-22 1998-10-12 Mikromischer

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59805556T Expired - Fee Related DE59805556D1 (de) 1997-10-22 1998-10-12 Mikromischer

Country Status (6)

Country Link
US (1) US6457854B1 (enExample)
EP (1) EP1047489B1 (enExample)
JP (1) JP2001520112A (enExample)
KR (1) KR100518060B1 (enExample)
DE (2) DE19746583A1 (enExample)
WO (1) WO1999020379A1 (enExample)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999036238A1 (en) * 1998-01-16 1999-07-22 The Sherwin-Williams Company Mixing block for mixing multi-component reactive material coating systems and an apparatus using same
EP1031375A3 (de) * 1999-02-24 2000-09-13 CPC Cellular Process Chemistry Systems GmbH Mikroreaktor
WO2000054890A1 (de) 1999-03-17 2000-09-21 Merck Patent Gmbh Verpackungssystem für kosmetische formulierungen
GB2355414A (en) * 1999-10-20 2001-04-25 Univ Sheffield Static micro-mixer for fluids comprising opposed fluid flows
EP1161221A1 (de) * 1999-03-17 2001-12-12 MERCK PATENT GmbH Verfahren zur herstellung von kosmetischen oder pharmazeutischen formulierungen durch mikromischung unmittelbar vor der verwendung
DE10159985A1 (de) * 2001-12-06 2003-06-26 Accoris Gmbh Mikroemulgator
DE10254534A1 (de) * 2002-11-22 2004-06-09 Henkel Kgaa Vorrichtung zum Vermischen von wenigstens zwei Flüssigkeiten
DE10333924B3 (de) * 2003-07-25 2004-10-07 Wella Ag Mehrkomponentenverpackung, Mischverfahren und Verwendung von statischen Mikromischern
US7098344B2 (en) * 2000-01-14 2006-08-29 Merck Patent Gmbh Reaction of carbonyl compounds with organometallic reagents
DE102005012415A1 (de) * 2005-03-17 2006-09-28 Syntics Gmbh Verfahrenstechnisches Funktionselement aus einem Folienstapel
EP2172261A1 (en) * 2008-09-29 2010-04-07 Corning Incorporated Multiple flow path microfluidic devices
CN105056821A (zh) * 2015-08-17 2015-11-18 江苏大学 一种对称椭圆弧挡板的十字微混合器
CN109092225A (zh) * 2018-11-02 2018-12-28 南京正源搪瓷设备制造有限公司 红心k型微反应器
EP4559568A1 (en) * 2023-11-24 2025-05-28 Sartorius BIA Separations d.o.o. Mixing unit, a mixing system comprising two or more mixing units , a method for mixing two or more fluids and a lysis system

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US7905653B2 (en) * 2001-07-31 2011-03-15 Mega Fluid Systems, Inc. Method and apparatus for blending process materials
DE10218280C1 (de) * 2002-04-19 2003-11-20 Fraunhofer Ges Forschung Integriertes Misch- und Schaltsystem für die Mikroreaktionstechnik
WO2004007346A2 (en) * 2002-07-16 2004-01-22 Mixtek System, Llc Aerosol mixing system with columns
KR100472058B1 (ko) * 2002-11-02 2005-03-11 한국전자통신연구원 미소유체 혼합을 위한 미소 유체제어 소자
US7094354B2 (en) 2002-12-19 2006-08-22 Bayer Healthcare Llc Method and apparatus for separation of particles in a microfluidic device
US7125711B2 (en) 2002-12-19 2006-10-24 Bayer Healthcare Llc Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
CA2526965C (en) * 2003-05-16 2011-10-11 Velocys Inc. Process for forming an emulsion using microchannel process technology
US7485671B2 (en) * 2003-05-16 2009-02-03 Velocys, Inc. Process for forming an emulsion using microchannel process technology
US7435381B2 (en) 2003-05-29 2008-10-14 Siemens Healthcare Diagnostics Inc. Packaging of microfluidic devices
US20040265171A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method for uniform application of fluid into a reactive reagent area
US7347617B2 (en) 2003-08-19 2008-03-25 Siemens Healthcare Diagnostics Inc. Mixing in microfluidic devices
JP4581380B2 (ja) * 2003-11-17 2010-11-17 パナソニック株式会社 核酸増幅反応容器およびその製造方法
TWI230683B (en) * 2004-04-19 2005-04-11 Jing-Tang Yang The micromixer with overlapping-crisscross entrance
KR100658361B1 (ko) * 2005-09-12 2006-12-15 주식회사 스펙 마이크로 채널 리액터
US7314060B2 (en) * 2005-04-23 2008-01-01 Industrial Technology Research Institute Fluid flow conducting module
US20060280029A1 (en) * 2005-06-13 2006-12-14 President And Fellows Of Harvard College Microfluidic mixer
US20060285433A1 (en) * 2005-06-20 2006-12-21 Jing-Tang Yang Fluidic mixer of serpentine channel incorporated with staggered sudden-expansion and convergent cross sections
US20070047388A1 (en) * 2005-08-25 2007-03-01 Rockwell Scientific Licensing, Llc Fluidic mixing structure, method for fabricating same, and mixing method
DE102005060280B4 (de) * 2005-12-16 2018-12-27 Ehrfeld Mikrotechnik Bts Gmbh Integrierbarer Mikromischer sowie dessen Verwendung
JP4931065B2 (ja) * 2007-03-29 2012-05-16 財団法人 岡山県産業振興財団 衝突型マイクロミキサー
KR100898065B1 (ko) 2007-10-19 2009-05-15 송상섭 마이크로 리액터
KR101113727B1 (ko) * 2008-02-18 2012-02-27 주식회사 올메디쿠스 수직 적층식 마이크로 믹서 및 그 제조방법
JP4683066B2 (ja) * 2008-04-14 2011-05-11 コニカミノルタホールディングス株式会社 液体混合機構
KR101005676B1 (ko) * 2008-11-27 2011-01-05 인하대학교 산학협력단 수동형 미세혼합기
US8696193B2 (en) 2009-03-06 2014-04-15 Ehrfeld Mikrotechnik Bts Gmbh Coaxial compact static mixer and use thereof
JP2011050936A (ja) * 2009-09-04 2011-03-17 Nisso Engineering Co Ltd 流通式管型反応装置
WO2011078790A1 (en) 2009-12-23 2011-06-30 Agency For Science, Technology And Research Microfluidic mixing apparatus and method
KR101176175B1 (ko) 2010-07-30 2013-05-09 광주과학기술원 마이크로 믹서 및 이의 제조 방법
US9079140B2 (en) 2011-04-13 2015-07-14 Microfluidics International Corporation Compact interaction chamber with multiple cross micro impinging jets
JP5963410B2 (ja) * 2011-08-11 2016-08-03 キヤノン株式会社 流路デバイスおよび流体の混合方法
JP5781414B2 (ja) * 2011-10-11 2015-09-24 株式会社日立ハイテクノロジーズ 流体混合器及び流体混合方法
CN102401760B (zh) * 2011-11-04 2014-05-07 华中科技大学 十字型三维水力聚焦微混合装置
CN102513011B (zh) * 2011-11-24 2013-10-30 华中科技大学 一种基于三维水力聚焦的微混合装置
KR101666425B1 (ko) * 2013-11-25 2016-10-14 주식회사 엘지화학 미세 유로 반응기
WO2015184302A1 (en) 2014-05-30 2015-12-03 Microfluidics Corporation Interaction chambers with reduced cavitation
EP3031518B1 (en) * 2014-12-08 2021-01-20 Lonza Ltd Fluid mixing structure, continuous reaction unit, continuous reaction reactor and method of using the same
AU2016222746A1 (en) 2015-02-24 2017-09-07 The University Of British Columbia Continuous flow microfluidic system
US10035113B2 (en) * 2015-02-26 2018-07-31 Tokyo Electron Limited Method and system for a spiral mixer
WO2016176505A1 (en) 2015-04-28 2016-11-03 The University Of British Columbia Disposable microfluidic cartridge
EP3797860B1 (en) 2016-01-06 2025-07-30 The University of British Columbia Bifurcating mixers and methods of their use and manufacture
KR101736797B1 (ko) * 2016-01-29 2017-05-17 인하대학교 산학협력단 미세 유체 혼합기
CN105771765B (zh) * 2016-03-30 2018-02-27 江苏大学 一种内置周期性阻块和挡板的被动式微混合器
CN106268471B (zh) * 2016-08-05 2019-02-05 江苏大学 一种渐缩弯管串联式微混合器
US10603647B2 (en) * 2016-12-01 2020-03-31 Imagine Tf, Llc Microstructure flow mixing devices
KR102371209B1 (ko) * 2017-03-24 2022-03-07 (주)아모레퍼시픽 순간 유화 화장품 제조 장치 및 제조 방법
CN110634723B (zh) * 2018-06-21 2022-07-05 中微半导体设备(上海)股份有限公司 一种耐腐蚀的气体混合装置及等离子体处理设备
CN109647307A (zh) * 2019-01-28 2019-04-19 北京理工大学 Y型组合式微通道结构
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GB202303464D0 (en) * 2023-03-09 2023-04-26 Univ Dublin A microfluidic chip for synthesis of nanoparticles
CN117899778B (zh) * 2024-03-04 2025-06-17 广东省科学院新材料研究所 一种微通道反应器及其制备方法

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Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999036238A1 (en) * 1998-01-16 1999-07-22 The Sherwin-Williams Company Mixing block for mixing multi-component reactive material coating systems and an apparatus using same
US6105880A (en) * 1998-01-16 2000-08-22 The Sherwin-Williams Company Mixing block for mixing multi-component reactive material coating systems and an apparatus using same
EP1031375A3 (de) * 1999-02-24 2000-09-13 CPC Cellular Process Chemistry Systems GmbH Mikroreaktor
WO2000054890A1 (de) 1999-03-17 2000-09-21 Merck Patent Gmbh Verpackungssystem für kosmetische formulierungen
EP1161221A1 (de) * 1999-03-17 2001-12-12 MERCK PATENT GmbH Verfahren zur herstellung von kosmetischen oder pharmazeutischen formulierungen durch mikromischung unmittelbar vor der verwendung
GB2355414A (en) * 1999-10-20 2001-04-25 Univ Sheffield Static micro-mixer for fluids comprising opposed fluid flows
US7098344B2 (en) * 2000-01-14 2006-08-29 Merck Patent Gmbh Reaction of carbonyl compounds with organometallic reagents
DE10159985A1 (de) * 2001-12-06 2003-06-26 Accoris Gmbh Mikroemulgator
DE10159985B4 (de) * 2001-12-06 2008-02-28 Schwesinger, Norbert, Prof.Dr.-Ing. Mikroemulgator
DE10254534A1 (de) * 2002-11-22 2004-06-09 Henkel Kgaa Vorrichtung zum Vermischen von wenigstens zwei Flüssigkeiten
DE10333924B3 (de) * 2003-07-25 2004-10-07 Wella Ag Mehrkomponentenverpackung, Mischverfahren und Verwendung von statischen Mikromischern
WO2005018785A1 (de) 2003-07-25 2005-03-03 Wella Aktiengesellschaft Mehrkomponentenverpackung mit statischem mikromischer
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DE59805556D1 (de) 2002-10-17
EP1047489B1 (de) 2002-09-11
KR100518060B1 (ko) 2005-09-28
WO1999020379A1 (de) 1999-04-29
JP2001520112A (ja) 2001-10-30
US6457854B1 (en) 2002-10-01
EP1047489A1 (en) 2000-11-02
KR20010024538A (ko) 2001-03-26

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