DE19575040I2 - 2-Beta-morpholino androstanderivate und Verfahren zu ihrer Herstellung - Google Patents

2-Beta-morpholino androstanderivate und Verfahren zu ihrer Herstellung

Info

Publication number
DE19575040I2
DE19575040I2 DE1995175040 DE19575040C DE19575040I2 DE 19575040 I2 DE19575040 I2 DE 19575040I2 DE 1995175040 DE1995175040 DE 1995175040 DE 19575040 C DE19575040 C DE 19575040C DE 19575040 I2 DE19575040 I2 DE 19575040I2
Authority
DE
Germany
Prior art keywords
beta
androstanderivate
morpholino
preparation
cpds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE1995175040
Other languages
German (de)
English (en)
Inventor
David Samuel Savage
Thomas Sleig
Ian Graig Carlyle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Application granted granted Critical
Publication of DE19575040I2 publication Critical patent/DE19575040I2/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Underground Structures, Protecting, Testing And Restoring Foundations (AREA)
  • Measurement Of Velocity Or Position Using Acoustic Or Ultrasonic Waves (AREA)
DE1995175040 1987-04-14 1988-04-05 2-Beta-morpholino androstanderivate und Verfahren zu ihrer Herstellung Active DE19575040I2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878708886A GB8708886D0 (en) 1987-04-14 1987-04-14 2beta-morpholino-androstane derivatives

Publications (1)

Publication Number Publication Date
DE19575040I2 true DE19575040I2 (de) 2003-09-18

Family

ID=10615781

Family Applications (2)

Application Number Title Priority Date Filing Date
DE1995175040 Active DE19575040I2 (de) 1987-04-14 1988-04-05 2-Beta-morpholino androstanderivate und Verfahren zu ihrer Herstellung
DE8888200621T Expired - Lifetime DE3873803T2 (de) 1987-04-14 1988-04-05 2-beta-morpholino-androstanderivate und verfahren zu ihrer herstellung.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8888200621T Expired - Lifetime DE3873803T2 (de) 1987-04-14 1988-04-05 2-beta-morpholino-androstanderivate und verfahren zu ihrer herstellung.

Country Status (19)

Country Link
US (1) US4894369A (https=)
EP (1) EP0287150B1 (https=)
JP (1) JPH0753751B2 (https=)
KR (2) KR0130208B1 (https=)
AT (1) ATE79631T1 (https=)
AU (1) AU608313B2 (https=)
CA (1) CA1291117C (https=)
DE (2) DE19575040I2 (https=)
DK (1) DK174743B1 (https=)
ES (1) ES2043781T3 (https=)
FI (1) FI89057C (https=)
GB (1) GB8708886D0 (https=)
GR (1) GR3006275T3 (https=)
HU (1) HU198738B (https=)
IE (1) IE63672B1 (https=)
NL (1) NL940010I2 (https=)
NZ (1) NZ224228A (https=)
PT (1) PT87250B (https=)
ZA (1) ZA882481B (https=)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8709565D0 (en) * 1987-04-23 1987-05-28 Akzo Nv 2beta,16beta-diaminoandrostanes
HU210076B (en) * 1992-11-02 1995-01-30 Tuba Process for producing androstane derivatives substituted with quaternisaeted amino group in 16-position and for producing pharmaceutical compositions containing them
GB9302455D0 (en) * 1993-02-08 1993-03-24 Lab Inpharm N V Process for preparing a pharmaceutical preparation having neuromuscular blocking activity
CZ300694A3 (en) * 1993-12-02 1996-05-15 Akzo Nobel Nv Substituted 2beta-morpholinandrostane derivatives, process of their preparation, their use for preparing pharmaceutical preparations and pharmaceutical compositions containing thereof
IT1277700B1 (it) * 1995-12-22 1997-11-11 Poli Ind Chimica Spa Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura
EP2316468A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
DE112005000178T5 (de) * 2004-01-15 2007-01-25 Chemagis Ltd. Verfahren zur Herstellung von Rocuroniumbromid und Zwischenprodukte davon
US20060058276A1 (en) * 2004-07-15 2006-03-16 Oded Friedman Processes for the preparation and purification of rocuronium bromide
US20060058275A1 (en) * 2004-07-15 2006-03-16 Oded Friedman Processes for preparing stabilized, highly pure rocuronium bromide
US20060009485A1 (en) * 2005-06-23 2006-01-12 Chemagis Ltd Method of reprocessing quaternary ammonium-containing neuromuscular blocking agents
BRPI0605937A2 (pt) * 2005-09-13 2009-05-26 Sicor Inc processo para a sìntese de brometo de rocurÈnio
GB2445746A (en) * 2007-01-17 2008-07-23 Texcontor Ets Use of carbonated water as a solvent for freeze drying, and method of purification comprising dissolution of material in carbonated water and freeze drying
CN101125878B (zh) * 2007-09-30 2011-01-12 浙江仙琚制药股份有限公司 甾体类肌松药物罗库溴铵的制备方法
CN101863948B (zh) * 2009-04-17 2013-07-24 重庆医药工业研究院有限责任公司 高纯度(2β,3α,5α,16β,17β)-2-(4-吗啉基)-16-(1-吡咯烷基)-雄甾烷-3,17-二醇或其组合物及其制备方法
CN101824066B (zh) * 2010-04-08 2012-06-13 浙江仙琚制药股份有限公司 制备罗库溴铵中间体化合物结晶物的方法
WO2012100411A1 (zh) 2011-01-26 2012-08-02 浙江华海药业股份有限公司 罗库溴铵的制备方法
EP2703408B1 (en) 2011-04-25 2015-08-26 Zhejiang Huahai Pharmaceutical Co., Ltd. Method for purifying rocuronium bromide
ES2794529T3 (es) 2013-07-01 2020-11-18 Maruishi Pharma Preparado de rocuronio que causa menos dolor vascular, método para producirlo y método para reducir y/o aliviar el dolor vascular al usarlo
CN105566433A (zh) * 2016-01-15 2016-05-11 安徽悦康凯悦制药有限公司 一种罗库溴铵的生产工艺
CN108570090B (zh) * 2018-05-25 2021-02-02 江苏盈科生物制药有限公司 一种高纯度罗库溴铵的制备方法
CN110734468B (zh) 2018-07-20 2021-04-16 济南高德医药科技有限公司 罗库溴铵粗品的精制方法
CN110240624B (zh) * 2019-08-01 2020-06-09 天津红日药业股份有限公司 一种雄甾烷衍生物及其制备方法与应用
CN111057122B (zh) * 2019-12-25 2021-04-30 武汉华龙生物制药有限公司 一种罗库溴铵的制备方法
CN112110880B (zh) * 2020-09-29 2022-09-09 天津红日药业股份有限公司 雄甾烷衍生物及其制备方法与应用
WO2022078483A1 (zh) * 2020-10-15 2022-04-21 江苏恩华络康药物研发有限公司 甾体季铵化合物及其制备方法、制剂和用途
CN114088842B (zh) * 2021-11-19 2023-03-21 江苏正济药业股份有限公司 一种罗库溴铵中间体及杂质的检测方法
CN116925171B (zh) * 2023-07-10 2025-06-27 时森海(杭州)医药科技有限公司 含环丙甲基甾体类季铵盐化合物、中间体及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1138605A (en) * 1965-02-19 1969-01-01 Organon Labor Ltd Improvements in or relating to new 2-ß,16-ß-diamino-androstanes
GB1454749A (en) * 1972-11-29 1976-11-03 Akzo Nv 2beta, 16beta-diamino-androstanes and their preparation
IE53463B1 (en) * 1981-06-15 1988-11-23 Akzo Nv Mono-and bisquaternary ammonium derivatives of 2 beta,16 beta-d-amino-5 alpha-androstane derivatives and pharmaceutical preparations containing same
GB8709565D0 (en) * 1987-04-23 1987-05-28 Akzo Nv 2beta,16beta-diaminoandrostanes

Also Published As

Publication number Publication date
US4894369A (en) 1990-01-16
DK174743B1 (da) 2003-10-13
EP0287150B1 (en) 1992-08-19
FI89057C (fi) 1993-08-10
IE63672B1 (en) 1995-05-31
ES2043781T3 (es) 1994-01-01
FI89057B (fi) 1993-04-30
HU198738B (en) 1989-11-28
DK202888D0 (da) 1988-04-13
DK202888A (da) 1988-10-15
KR100221116B1 (ko) 1999-10-01
KR880012632A (ko) 1988-11-28
NL940010I1 (nl) 1994-07-18
IE881017L (en) 1988-10-14
KR19980078895A (ko) 1998-11-25
AU608313B2 (en) 1991-03-28
DE3873803D1 (de) 1992-09-24
GR3006275T3 (https=) 1993-06-21
ZA882481B (en) 1988-09-29
AU1457088A (en) 1988-10-20
KR0130208B1 (ko) 1998-04-03
NL940010I2 (nl) 1997-10-01
PT87250A (pt) 1988-05-01
ATE79631T1 (de) 1992-09-15
DE3873803T2 (de) 1993-06-24
JPS63277693A (ja) 1988-11-15
FI881707A7 (fi) 1988-10-15
FI881707A0 (fi) 1988-04-13
EP0287150A1 (en) 1988-10-19
CA1291117C (en) 1991-10-22
NZ224228A (en) 1990-03-27
JPH0753751B2 (ja) 1995-06-07
PT87250B (pt) 1992-08-31
GB8708886D0 (en) 1987-05-20
HUT47595A (en) 1989-03-28

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