DE1804796A1 - Verfahren zur Herstellung von polycyclischen Verbindungen - Google Patents

Verfahren zur Herstellung von polycyclischen Verbindungen

Info

Publication number
DE1804796A1
DE1804796A1 DE19681804796 DE1804796A DE1804796A1 DE 1804796 A1 DE1804796 A1 DE 1804796A1 DE 19681804796 DE19681804796 DE 19681804796 DE 1804796 A DE1804796 A DE 1804796A DE 1804796 A1 DE1804796 A1 DE 1804796A1
Authority
DE
Germany
Prior art keywords
hydrogen
general formula
methyl
compound
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19681804796
Other languages
German (de)
English (en)
Inventor
Gabriel Saucy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE1804796A1 publication Critical patent/DE1804796A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D315/00—Heterocyclic compounds containing rings having one oxygen atom as the only ring hetero atom according to more than one of groups C07D303/00 - C07D313/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/12—Saturated ethers containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/74—Naphthothiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/16—Benz[e]indenes; Hydrogenated benz[e]indenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19681804796 1967-11-02 1968-10-24 Verfahren zur Herstellung von polycyclischen Verbindungen Pending DE1804796A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67998967A 1967-11-02 1967-11-02

Publications (1)

Publication Number Publication Date
DE1804796A1 true DE1804796A1 (de) 1969-06-26

Family

ID=24729197

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19681804796 Pending DE1804796A1 (de) 1967-11-02 1968-10-24 Verfahren zur Herstellung von polycyclischen Verbindungen
DE19681806410 Pending DE1806410A1 (de) 1967-11-02 1968-10-31 Verfahren zur Herstellung von Steroiden

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE19681806410 Pending DE1806410A1 (de) 1967-11-02 1968-10-31 Verfahren zur Herstellung von Steroiden

Country Status (11)

Country Link
BE (2) BE723188A (es)
BR (1) BR6803655D0 (es)
CH (2) CH503050A (es)
DE (2) DE1804796A1 (es)
DK (1) DK126041B (es)
ES (1) ES359765A1 (es)
FR (2) FR1590470A (es)
GB (2) GB1207048A (es)
IL (1) IL30982A0 (es)
NL (3) NL6815381A (es)
SE (2) SE356297B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH568336A5 (es) * 1969-04-04 1975-10-31 Hoffmann La Roche

Also Published As

Publication number Publication date
GB1207048A (en) 1970-09-30
DE1806410A1 (de) 1969-06-19
CH503713A (de) 1971-02-28
IL30982A0 (en) 1969-01-29
NL6815555A (es) 1969-05-06
BE723187A (es) 1969-04-30
CH503050A (de) 1971-02-15
BE723188A (es) 1969-04-30
DK126041B (da) 1973-06-04
FR1590470A (es) 1970-04-13
ES359765A1 (es) 1970-06-16
SE356297B (es) 1973-05-21
FR1586571A (es) 1970-02-20
BR6803655D0 (pt) 1973-03-15
NL6815381A (es) 1969-05-06
GB1207047A (en) 1970-09-30
SE355804B (es) 1973-05-07
NL6815622A (es) 1969-05-06

Similar Documents

Publication Publication Date Title
DE2115718A1 (de) Verfahren zur Herstellung von penta cyclischen Alkaloiden
DE2412517A1 (de) Verfahren zur herstellung von alkoholen
DE2008878A1 (de) Neue Cycloalkenonester
DE1811693A1 (de) Verfahren zur Herstellung von polycyclischen Verbindungen
DE1958600A1 (de) Neue Isoxazolderivate und deren Herstellung
DE1803157A1 (de) Verfahren zur Herstellung von polycyclischen Verbindungen
DE2023458A1 (de) Tetrahydropyranole
DE2121387A1 (es)
DE1804796A1 (de) Verfahren zur Herstellung von polycyclischen Verbindungen
CH648282A5 (de) Verfahren zur herstellung von oxocyclopentenen.
DE1172670B (de) Verfahren zur Herstellung von 3-substituierten D-Homo-18-nor-androst-13(17a)-en-17-on-derivaten
DE2142808A1 (de) Tricychsche Verbindungen und ihre Herstellung
DE1618862A1 (de) Verfahren zur Herstellung von Cyanhydrinen
DE2729634A1 (de) Verfahren zur herstellung von 1alpha-hydroxy-cholesterinderivaten
DE2212589B2 (de) Verfahren zur Herstellung von 13 beta-R-4,9,11-gonatrienen und 13 beta-R-4,5-seco-9,l 1-gonadiene als Zwischenprodukte
DE2015800C3 (de) Verfahren zur Herstellung von 19-Norsteroiden sowie d 5 (10), 9 (U)-4-Oxasteroide als Zwischenprodukte
DE2226067C3 (de) Verfahren zur Herstellung von 16beta-Methyl-17alpha -hydroxy-1,4,9(11 )pregnatrien-3,20-dion(1)
DE2023401A1 (de) Polycyclische Verbindungen
DE1813974A1 (de) Benzomorphanderivate
DE954248C (de) Verfahren zur Herstellung neuer tricyclischer Ketone
DE2165320C2 (de) Verfahren zur Herstellung von Bicycloalkan-thio-Derivaten
DE2102623A1 (es)
DE896806C (de) Verfahren zur Herstellung von 3ª‡, 11ª‰-Dioxypregnan-20-on
DE2710062A1 (de) Neue cholesterinderivate
DE1568052C3 (de) 3beta-Acetoxy-5alpha-hydroxy-17 alpha-brompregnan-6, 20-dion sowie Verfahren zur Herstellung von 3beta, 5alpha-Dihydroxy-17alpha-methyl-17 beta-Carbo-methoxyandrostan-6-on