DE1770460C3 - In 3-Stellung durch einen heterocyclisch substituierten Alkyl- oder Acylrest substituierte bleiverbindungen und Verfahren zu ihrer Herstellung - Google Patents

In 3-Stellung durch einen heterocyclisch substituierten Alkyl- oder Acylrest substituierte bleiverbindungen und Verfahren zu ihrer Herstellung

Info

Publication number
DE1770460C3
DE1770460C3 DE1770460A DE1770460A DE1770460C3 DE 1770460 C3 DE1770460 C3 DE 1770460C3 DE 1770460 A DE1770460 A DE 1770460A DE 1770460 A DE1770460 A DE 1770460A DE 1770460 C3 DE1770460 C3 DE 1770460C3
Authority
DE
Germany
Prior art keywords
nhcor
ethyl
indole
compound
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1770460A
Other languages
German (de)
English (en)
Other versions
DE1770460A1 (de
DE1770460B2 (de
Inventor
John Leheup Windsor Berkshire Archibald
John Lambert Nottingham Jackson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Wyeth and Brother Ltd
Original Assignee
John Wyeth and Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by John Wyeth and Brother Ltd filed Critical John Wyeth and Brother Ltd
Publication of DE1770460A1 publication Critical patent/DE1770460A1/de
Publication of DE1770460B2 publication Critical patent/DE1770460B2/de
Application granted granted Critical
Publication of DE1770460C3 publication Critical patent/DE1770460C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
DE1770460A 1963-10-17 1968-05-20 In 3-Stellung durch einen heterocyclisch substituierten Alkyl- oder Acylrest substituierte bleiverbindungen und Verfahren zu ihrer Herstellung Expired DE1770460C3 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US317072A US3238215A (en) 1963-10-17 1963-10-17 1-[(3-, 2-, and 1-indolyl)-lower-alkyl-, lower-alkenyl-, and lower-alkynyl]piperidines
GB2425667 1967-05-24
GB00096/68A GB1218570A (en) 1963-10-17 1967-05-24 Indoles

Publications (3)

Publication Number Publication Date
DE1770460A1 DE1770460A1 (de) 1972-05-10
DE1770460B2 DE1770460B2 (de) 1978-07-13
DE1770460C3 true DE1770460C3 (de) 1979-03-22

Family

ID=27256462

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1770460A Expired DE1770460C3 (de) 1963-10-17 1968-05-20 In 3-Stellung durch einen heterocyclisch substituierten Alkyl- oder Acylrest substituierte bleiverbindungen und Verfahren zu ihrer Herstellung

Country Status (10)

Country Link
US (2) US3238215A (OSRAM)
BE (1) BE715545A (OSRAM)
CH (5) CH553796A (OSRAM)
DE (1) DE1770460C3 (OSRAM)
FR (2) FR7787M (OSRAM)
GB (1) GB1218570A (OSRAM)
IE (1) IE32083B1 (OSRAM)
IN (1) IN115974B (OSRAM)
MY (1) MY7100196A (OSRAM)
NL (1) NL161359C (OSRAM)

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DE3301758A1 (de) * 1983-01-20 1984-07-26 Merck Patent Gmbh, 6100 Darmstadt Indolderivate
JPS6084281A (ja) * 1983-09-14 1985-05-13 Yoshitomi Pharmaceut Ind Ltd ３−インド−ルカルボキサミド類
JPS60123485A (ja) * 1983-12-08 1985-07-02 Yoshitomi Pharmaceut Ind Ltd インド−ル−３−カルボキサミド誘導体
JPS60142981A (ja) * 1983-12-28 1985-07-29 Yoshitomi Pharmaceut Ind Ltd ３−インド−ルカルボキサミド誘導体
GB8406089D0 (en) * 1984-03-08 1984-04-11 Wyeth John & Brother Ltd Treatment/prevention of atherosclerotic disorders &c
US4569933A (en) * 1984-04-13 1986-02-11 Cornu Pierre Jean Antihypertensive substituted derivatives of 2,5-diamino 1,4-diazole
PH23498A (en) * 1984-08-06 1989-08-16 Sterling Drug Inc 3-carbonyl-1-aminoalkyl-1h-indoles,composition and use thereof
GB8422924D0 (en) * 1984-09-11 1984-10-17 Wyeth John & Brother Ltd Prevention of hypertension
EP0187122A3 (de) * 1985-01-03 1987-12-16 Ciba-Geigy Ag 1,3,4-Trisubstituierte Azacycloalkane bzw. Azacycloalkene
EP0187619A3 (de) * 1985-01-03 1987-08-26 Ciba-Geigy Ag 1,3-disubstituierte Tetrahydropyridine
GB8531665D0 (en) * 1985-12-23 1986-02-05 Wyeth John & Brother Ltd Indole derivatives
GB8531666D0 (en) * 1985-12-23 1986-02-05 Wyeth John & Brother Ltd Indole derivatives
US4757079A (en) * 1986-06-24 1988-07-12 Dynamac Corporaton Anti-hypertensive piperidine compounds
US5004812A (en) * 1987-06-26 1991-04-02 E. I. Du Pont De Nemours And Company Direct positive dimethine cyanine dyes containing 1-aryl-2-heteroaryl indole nucleus
GB8903036D0 (en) * 1989-02-10 1989-03-30 Glaxo Group Ltd Chemical compounds
NZ241979A (en) * 1991-03-20 1996-01-26 Merck & Co Inc Treatment of benign prostatic hyperplasia using 5alpha-reductase inhibitor and an alpha1-adrenergic recepter blocker
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
US5965582A (en) * 1994-08-03 1999-10-12 Asta Medica Aktiengesellschaft N-benzylindole and benzopyrazole derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunemodulating effect
ES2262072T3 (es) * 1998-04-28 2006-11-16 Elbion Ag Derivados de indol y su utilizacion como inhibidores de la fosfodiesterasa 4.
AU758802B2 (en) 1998-09-30 2003-03-27 Takeda Pharmaceutical Company Limited Drugs for improving vesical excretory strength
US20020065286A1 (en) * 2000-08-21 2002-05-30 Davies Michael John Treatment of wounds
US20020091129A1 (en) * 2000-11-20 2002-07-11 Mitradev Boolell Treatment of premature ejaculation
GB0130219D0 (en) * 2001-12-18 2002-02-06 Pfizer Ltd Compounds for the treatment of sexual dysfunction
US20030229001A1 (en) * 2002-01-31 2003-12-11 Pfizer Inc. Treatment of male sexual dysfunction
EP1545519B1 (en) 2002-08-19 2011-03-23 Pfizer Inc. Combination therapy for hyperproliferative diseases
GB0219961D0 (en) 2002-08-28 2002-10-02 Pfizer Ltd Oxytocin inhibitors
US7323462B2 (en) * 2002-12-10 2008-01-29 Pfizer Inc. Morpholine dopamine agonists
CA2451267A1 (en) * 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
PA8597401A1 (es) * 2003-03-14 2005-05-24 Pfizer Derivados del acido 3-(1-[3-(1,3-benzotiazol-6-il) propilcarbamoil] cicloalquil) propanoico como inhibidores de nep
US20040220186A1 (en) * 2003-04-30 2004-11-04 Pfizer Inc. PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
KR20110117731A (ko) 2003-05-30 2011-10-27 랜박시 래보러터리스 리미티드 치환된 피롤 유도체와 ｈｍｇ―ｃｏ 억제제로서의 이의 용도
US20050065158A1 (en) * 2003-07-16 2005-03-24 Pfizer Inc. Treatment of sexual dysfunction
US7291640B2 (en) * 2003-09-22 2007-11-06 Pfizer Inc. Substituted triazole derivatives as oxytocin antagonists
US20050267096A1 (en) * 2004-05-26 2005-12-01 Pfizer Inc New indazole and indolone derivatives and their use pharmaceuticals
US20050288270A1 (en) * 2004-05-27 2005-12-29 Pfizer Inc New aminopyridine derivatives and their use as pharmaceuticals
US20060063803A1 (en) * 2004-09-23 2006-03-23 Pfizer Inc 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds
US7618972B2 (en) * 2005-03-21 2009-11-17 Pfizer Inc Substituted triazole derivatives as oxytocin antagonists
EP1863484A1 (en) * 2005-03-21 2007-12-12 Pfizer Limited Substituted triazole derivatives as oxytocin antagonists
CA2618103A1 (en) * 2005-08-10 2007-02-15 Pfizer Limited Substituted triazole derivatives as oxytocin antagonists
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
AU2006313430B2 (en) 2005-11-08 2012-09-06 Ranbaxy Laboratories Limited Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
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EP2094643B1 (en) 2006-12-01 2012-02-29 Bristol-Myers Squibb Company N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
EP2427430B1 (en) * 2009-05-04 2014-09-10 The Royal Institution for the Advancement of Learning/McGill University 5-oxo-ete receptor antagonist compounds
KR101695582B1 (ko) 2013-04-17 2017-01-13 화이자 인코포레이티드 심혈관 질환을 치료하기 위한 n-피페리딘-3-일벤즈아미드 유도체
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CA3061238A1 (en) * 2017-03-10 2018-09-13 Rutgers, The State University Of New Jersey Indole derivatives as efflux pump inhibitors
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US3014043A (en) * 1957-02-08 1961-12-19 Merck & Co Inc Serotonin antagonists
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US3155668A (en) * 1960-04-11 1964-11-03 Sterling Drug Inc 1-[3-, 2-, and 1-indolyl)-lower-alkyl]-tertiary amines and intermediates therefor
US3183235A (en) * 1961-06-27 1965-05-11 Sterling Drug Inc 1-[3-, 2-, and 1-indolyl-lower-alkanoyl] piperidines
US3198807A (en) * 1961-07-25 1965-08-03 Substitutes carboxamide indoles and indolines
US3238215A (en) * 1963-10-17 1966-03-01 Sterling Drug Inc 1-[(3-, 2-, and 1-indolyl)-lower-alkyl-, lower-alkenyl-, and lower-alkynyl]piperidines
US3445472A (en) * 1965-12-03 1969-05-20 American Home Prod Mono- and di-aroyl pyridylethyl and piperidylethyl indoles

Also Published As

Publication number Publication date
CH553796A (de) 1974-09-13
NL161359C (nl) 1980-02-15
US3238215A (en) 1966-03-01
CH528525A (de) 1972-09-30
BE715545A (OSRAM) 1968-11-22
DE1770460A1 (de) 1972-05-10
NL6807187A (OSRAM) 1968-11-25
US3527761A (en) 1970-09-08
IE32083L (en) 1968-11-24
DE1770460B2 (de) 1978-07-13
IN115974B (OSRAM) 1975-08-16
FR1582086A (OSRAM) 1969-09-26
CH540916A (de) 1973-10-15
FR7787M (OSRAM) 1970-03-31
IE32083B1 (en) 1973-04-04
NL161359B (nl) 1979-09-17
MY7100196A (en) 1971-12-31
CH542221A (de) 1973-11-15
CH551428A (de) 1974-07-15
GB1218570A (en) 1971-01-06

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Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
8328 Change in the person/name/address of the agent

Free format text: SCHWABE, H., DIPL.-ING. SANDMAIR, K., DIPL.-CHEM. DR.JUR. DR.RER.NAT. MARX, L., DIPL.-PHYS. DR.RER.NAT., PAT.-ANW., 8000 MUENCHEN