CH551428A - Verfahren zur herstellung von neuen indolderivaten. - Google Patents

Verfahren zur herstellung von neuen indolderivaten.

Info

Publication number
CH551428A
CH551428A CH515172A CH515172A CH551428A CH 551428 A CH551428 A CH 551428A CH 515172 A CH515172 A CH 515172A CH 515172 A CH515172 A CH 515172A CH 551428 A CH551428 A CH 551428A
Authority
CH
Switzerland
Prior art keywords
new
production
indolder derivatives
indolder
derivatives
Prior art date
Application number
CH515172A
Other languages
English (en)
Original Assignee
Wyeth John & Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth John & Brother Ltd filed Critical Wyeth John & Brother Ltd
Publication of CH551428A publication Critical patent/CH551428A/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
CH515172A 1963-10-17 1968-05-21 Verfahren zur herstellung von neuen indolderivaten. CH551428A (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US317072A US3238215A (en) 1963-10-17 1963-10-17 1-[(3-, 2-, and 1-indolyl)-lower-alkyl-, lower-alkenyl-, and lower-alkynyl]piperidines
GB00096/68A GB1218570A (en) 1963-10-17 1967-05-24 Indoles
GB2425667 1967-05-24

Publications (1)

Publication Number Publication Date
CH551428A true CH551428A (de) 1974-07-15

Family

ID=27256462

Family Applications (5)

Application Number Title Priority Date Filing Date
CH752268A CH542221A (de) 1963-10-17 1968-05-21 Verfahren zur Herstellung von neuen Indolderivaten
CH515172A CH551428A (de) 1963-10-17 1968-05-21 Verfahren zur herstellung von neuen indolderivaten.
CH1615670A CH540916A (de) 1963-10-17 1968-05-21 Verfahren zur Herstellung von neuen Indolderivaten
CH1615370A CH528525A (de) 1963-10-17 1968-05-21 Verfahren zur Herstellung von neuen Indolderivaten
CH1615470A CH553796A (de) 1963-10-17 1968-05-21 Verfahren zur herstellung von neuen indolderivaten.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CH752268A CH542221A (de) 1963-10-17 1968-05-21 Verfahren zur Herstellung von neuen Indolderivaten

Family Applications After (3)

Application Number Title Priority Date Filing Date
CH1615670A CH540916A (de) 1963-10-17 1968-05-21 Verfahren zur Herstellung von neuen Indolderivaten
CH1615370A CH528525A (de) 1963-10-17 1968-05-21 Verfahren zur Herstellung von neuen Indolderivaten
CH1615470A CH553796A (de) 1963-10-17 1968-05-21 Verfahren zur herstellung von neuen indolderivaten.

Country Status (10)

Country Link
US (2) US3238215A (de)
BE (1) BE715545A (de)
CH (5) CH542221A (de)
DE (1) DE1770460C3 (de)
FR (2) FR7787M (de)
GB (1) GB1218570A (de)
IE (1) IE32083B1 (de)
IN (1) IN115974B (de)
MY (1) MY7100196A (de)
NL (1) NL161359C (de)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3238215A (en) * 1963-10-17 1966-03-01 Sterling Drug Inc 1-[(3-, 2-, and 1-indolyl)-lower-alkyl-, lower-alkenyl-, and lower-alkynyl]piperidines
BE665245A (de) * 1964-06-11
US3412097A (en) * 1964-09-07 1968-11-19 Koninklijke Pharma Fab Nv Indole derivatives
US3471499A (en) * 1965-12-03 1969-10-07 American Home Prod 1,4-bis-(2-indol-3-yl-ethyl)piperazines
US3984437A (en) * 1969-09-03 1976-10-05 Mitsubishi Chemical Industries Ltd. Basic dyestuff
SU516354A3 (ru) * 1970-03-07 1976-05-30 Краковски Заклады Фармацеутичне"Польфа" (Инопредприятие) Способ получени пиридиламидов фуранкарбоновой кислоты или их солей
US4028365A (en) * 1970-09-03 1977-06-07 John Wyeth & Brother Limited Benz[g]indolyl compounds
GB1374414A (en) * 1972-06-12 1974-11-20 Sterling Drug Inc 1-acyl-3-amino-alkyl-indoles and their preparation
US4160862A (en) * 1972-06-12 1979-07-10 Sterling Drug Inc. 1-Acyl-3-(amino-lower-alkyl)indoles
US4061758A (en) * 1972-06-30 1977-12-06 John Wyeth & Brother Limited Treating hypertension and central nervous system abnormalities
US4024147A (en) * 1972-06-30 1977-05-17 John Wyeth & Brother Limited Heterocyclic compounds
US3869463A (en) * 1973-01-17 1975-03-04 Wyeth John & Brother Ltd N-phenyl derivatives of alkanoylamido piperidines
DE2322470A1 (de) * 1973-05-04 1974-11-21 Boehringer Sohn Ingelheim Neue indolyl-piperidino-(bzw. 1,2,5,6tetrahydro-pyridyl-)butyrophenone und verfahren zu ihrer herstellung
GB1413708A (en) * 1973-06-19 1975-11-12 Wyeth John & Brother Ltd Indole derivative
US4061641A (en) * 1973-10-10 1977-12-06 John Wyeth & Brother Limited Ureidopiperidino-ketoalkyl indoles
US4177279A (en) * 1973-10-10 1979-12-04 John Wyeth & Brother Ltd. 1-[(3-Indolyl)-alkyl]-piperidyl ureas and hypotensive compositions
GB1459506A (en) * 1974-02-18 1976-12-22 Wyeth John & Brother Ltd Piperidine derivatives
US3936464A (en) * 1974-10-25 1976-02-03 American Cyanamid Company 1-Acyl-3-[2-(4-phenyl-1-piperidinyl)ethyl]indolines
US4026938A (en) * 1974-12-27 1977-05-31 Sterling Drug Inc. 1-Phenyl-3-azacarbocyclic-ureas
ZA76475B (en) * 1975-03-10 1977-08-31 Ciba Geigy Ag Indolyalkylpiperidines
GB1498884A (en) * 1975-04-15 1978-01-25 Wyeth John & Brother Ltd Aminoacetamide-pyridyl-tetrahydropyridyl and-piperidyl derivatives
US4147786A (en) * 1976-02-02 1979-04-03 Ciba-Geigy Corporation 1-Indolylalkyl-3-or 4-trimethyleneurido-piperidines
US4163789A (en) * 1976-02-17 1979-08-07 Anphar, S.A. Anti-psychotic (cycloalkenylalkylpiperidino) benzamides
GB1542137A (en) * 1976-03-12 1979-03-14 Wyeth John & Brother Ltd Process for preparing 3(piperidinoalkyl)indoles
GB1581620A (en) * 1977-02-23 1980-12-17 Sekisui Chemical Co Ltd Gas combustion system
EP0007399B1 (de) 1978-06-24 1982-01-20 MERCK PATENT GmbH Indolalkylamine, diese enthaltende pharmazeutische Zubereitungen und Verfahren zu ihrer Herstellung
US4242347A (en) * 1979-06-18 1980-12-30 Ciba-Geigy Corporation Hypotensive indolylalkylpiperidyl guanidines and isoureas
US4428954A (en) 1980-11-01 1984-01-31 John Wyeth And Brother Limited Method for treatment of cerebrovascular disorders
ZA822995B (en) * 1981-05-21 1983-12-28 Wyeth John & Brother Ltd Slow release pharmaceutical composition
FR2530632A1 (fr) * 1982-07-26 1984-01-27 Bouchara Emile Nouveaux derives substitues du 2,5-diamino 1,4-diazole, leurs procedes de preparation et les compositions pharmaceutiques en renfermant
DE3301758A1 (de) * 1983-01-20 1984-07-26 Merck Patent Gmbh, 6100 Darmstadt Indolderivate
JPS6084281A (ja) * 1983-09-14 1985-05-13 Yoshitomi Pharmaceut Ind Ltd ３−インド−ルカルボキサミド類
JPS60123485A (ja) * 1983-12-08 1985-07-02 Yoshitomi Pharmaceut Ind Ltd インド−ル−３−カルボキサミド誘導体
JPS60142981A (ja) * 1983-12-28 1985-07-29 Yoshitomi Pharmaceut Ind Ltd ３−インド−ルカルボキサミド誘導体
GB8406089D0 (en) * 1984-03-08 1984-04-11 Wyeth John & Brother Ltd Treatment/prevention of atherosclerotic disorders &c
US4569933A (en) * 1984-04-13 1986-02-11 Cornu Pierre Jean Antihypertensive substituted derivatives of 2,5-diamino 1,4-diazole
PH23498A (en) * 1984-08-06 1989-08-16 Sterling Drug Inc 3-carbonyl-1-aminoalkyl-1h-indoles,composition and use thereof
GB8422924D0 (en) * 1984-09-11 1984-10-17 Wyeth John & Brother Ltd Prevention of hypertension
EP0187619A3 (de) * 1985-01-03 1987-08-26 Ciba-Geigy Ag 1,3-disubstituierte Tetrahydropyridine
EP0187122A3 (de) * 1985-01-03 1987-12-16 Ciba-Geigy Ag 1,3,4-Trisubstituierte Azacycloalkane bzw. Azacycloalkene
GB8531666D0 (en) * 1985-12-23 1986-02-05 Wyeth John & Brother Ltd Indole derivatives
GB8531665D0 (en) * 1985-12-23 1986-02-05 Wyeth John & Brother Ltd Indole derivatives
US4757079A (en) * 1986-06-24 1988-07-12 Dynamac Corporaton Anti-hypertensive piperidine compounds
US5004812A (en) * 1987-06-26 1991-04-02 E. I. Du Pont De Nemours And Company Direct positive dimethine cyanine dyes containing 1-aryl-2-heteroaryl indole nucleus
GB8903036D0 (en) * 1989-02-10 1989-03-30 Glaxo Group Ltd Chemical compounds
IL101243A (en) * 1991-03-20 1999-12-22 Merck & Co Inc Pharmaceutical preparations for the treatment of benign prostatic hyperplasia containing steroid history
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
AU3162695A (en) * 1994-08-03 1996-03-04 Asta Medica Aktiengesellschaft Indol, indazol, pyridopyrrol and pyridopyrazol derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunomodulating effects
JP3842043B2 (ja) * 1998-04-28 2006-11-08 エルビオン アクチエンゲゼルシャフト 新規ヒドロキシインドール、ホスホジエステラーゼ４のインヒビタとしてのその使用及びその製法
CN1572299A (zh) 1998-09-30 2005-02-02 武田药品工业株式会社 改善膀胱排泄能力的药物
US20020065286A1 (en) * 2000-08-21 2002-05-30 Davies Michael John Treatment of wounds
US20020091129A1 (en) * 2000-11-20 2002-07-11 Mitradev Boolell Treatment of premature ejaculation
GB0130219D0 (en) * 2001-12-18 2002-02-06 Pfizer Ltd Compounds for the treatment of sexual dysfunction
US20030229001A1 (en) * 2002-01-31 2003-12-11 Pfizer Inc. Treatment of male sexual dysfunction
CN1681495B (zh) 2002-08-19 2010-05-12 辉瑞产品公司 用于治疗过度增生性疾病的组合物
GB0219961D0 (en) 2002-08-28 2002-10-02 Pfizer Ltd Oxytocin inhibitors
US7323462B2 (en) * 2002-12-10 2008-01-29 Pfizer Inc. Morpholine dopamine agonists
CA2451267A1 (en) * 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
PA8597401A1 (es) * 2003-03-14 2005-05-24 Pfizer Derivados del acido 3-(1-[3-(1,3-benzotiazol-6-il) propilcarbamoil] cicloalquil) propanoico como inhibidores de nep
US20040220186A1 (en) * 2003-04-30 2004-11-04 Pfizer Inc. PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
KR20110117731A (ko) 2003-05-30 2011-10-27 랜박시 래보러터리스 리미티드 치환된 피롤 유도체와 ｈｍｇ―ｃｏ 억제제로서의 이의 용도
US20050065158A1 (en) * 2003-07-16 2005-03-24 Pfizer Inc. Treatment of sexual dysfunction
US7291640B2 (en) * 2003-09-22 2007-11-06 Pfizer Inc. Substituted triazole derivatives as oxytocin antagonists
US20050267096A1 (en) * 2004-05-26 2005-12-01 Pfizer Inc New indazole and indolone derivatives and their use pharmaceuticals
US20050288270A1 (en) * 2004-05-27 2005-12-29 Pfizer Inc New aminopyridine derivatives and their use as pharmaceuticals
US20060063803A1 (en) * 2004-09-23 2006-03-23 Pfizer Inc 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds
DE602006003416D1 (de) * 2005-03-21 2008-12-11 Pfizer Ltd Substituierte triazolderivate als oxytocinantagonisten
JP2008533193A (ja) * 2005-03-21 2008-08-21 ファイザー・リミテッド オキシトシン拮抗薬としての置換トリアゾール誘導体
JP2009504628A (ja) * 2005-08-10 2009-02-05 ファイザー・リミテッド オキシトシン拮抗薬としての置換トリアゾール誘導体
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
AU2006313430B2 (en) 2005-11-08 2012-09-06 Ranbaxy Laboratories Limited Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US8383660B2 (en) 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
JP5498168B2 (ja) 2006-12-01 2014-05-21 ブリストル−マイヤーズ スクイブ カンパニー アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体
WO2010127452A1 (en) 2009-05-04 2010-11-11 The Royal Institution For The Advancement Of Learning/Mcgill University 5-oxo-ete receptor antagonist compounds
EP2986599A1 (de) 2013-04-17 2016-02-24 Pfizer Inc. N-piperidin-3-ylbenzamid-derivate zur behandlung von herz-kreislauf-erkrankungen
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
US11993571B2 (en) * 2017-03-10 2024-05-28 Rutgers, The State University Of New Jersey Indole derivatives as efflux pump inhibitors
BR112021013807A2 (pt) 2019-01-18 2021-11-30 Astrazeneca Ab Inibidores de pcsk9 e seus métodos de uso

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2701797A (en) * 1955-02-08 - indolylmethyl
US2708197A (en) * 1952-05-24 1955-05-10 Upjohn Co Preparation of (hydroxy-3-indole)-alkylamines
US3014043A (en) * 1957-02-08 1961-12-19 Merck & Co Inc Serotonin antagonists
US3075986A (en) * 1958-01-09 1963-01-29 Rhone Poulenc Sa (1-piperdidylalkyl) derivatives of 3-indole
US3155668A (en) * 1960-04-11 1964-11-03 Sterling Drug Inc 1-[3-, 2-, and 1-indolyl)-lower-alkyl]-tertiary amines and intermediates therefor
US3183235A (en) * 1961-06-27 1965-05-11 Sterling Drug Inc 1-[3-, 2-, and 1-indolyl-lower-alkanoyl] piperidines
US3198807A (en) * 1961-07-25 1965-08-03 Substitutes carboxamide indoles and indolines
US3238215A (en) * 1963-10-17 1966-03-01 Sterling Drug Inc 1-[(3-, 2-, and 1-indolyl)-lower-alkyl-, lower-alkenyl-, and lower-alkynyl]piperidines
US3471499A (en) * 1965-12-03 1969-10-07 American Home Prod 1,4-bis-(2-indol-3-yl-ethyl)piperazines

Also Published As

Publication number Publication date
US3527761A (en) 1970-09-08
IE32083L (en) 1968-11-24
IE32083B1 (en) 1973-04-04
NL6807187A (de) 1968-11-25
GB1218570A (en) 1971-01-06
DE1770460B2 (de) 1978-07-13
BE715545A (de) 1968-11-22
IN115974B (de) 1975-08-16
MY7100196A (en) 1971-12-31
CH528525A (de) 1972-09-30
DE1770460C3 (de) 1979-03-22
NL161359B (nl) 1979-09-17
NL161359C (nl) 1980-02-15
CH540916A (de) 1973-10-15
CH553796A (de) 1974-09-13
FR1582086A (de) 1969-09-26
US3238215A (en) 1966-03-01
CH542221A (de) 1973-11-15
DE1770460A1 (de) 1972-05-10
FR7787M (de) 1970-03-31

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Legal Events

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PL Patent ceased