SU516354A3 - Способ получени пиридиламидов фуранкарбоновой кислоты или их солей - Google Patents
Способ получени пиридиламидов фуранкарбоновой кислоты или их солейInfo
- Publication number
- SU516354A3 SU516354A3 SU1628615A SU1628615A SU516354A3 SU 516354 A3 SU516354 A3 SU 516354A3 SU 1628615 A SU1628615 A SU 1628615A SU 1628615 A SU1628615 A SU 1628615A SU 516354 A3 SU516354 A3 SU 516354A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- pyridylamide
- furan
- hydrochloride
- carboxylic acid
- boetins
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Claims (1)
- т. пл. 2-пиридиламида фуран-2-карбоновой кислоты 90-9 ГС. Пример 2. 13 г хлорангидрида фуран-2карбоновой кислоты раствор ли в 20 мл безводного диоксана. К раствору порци ми добавл ли 9,4 г 4-аминопиридина, растворенного в 30 мл безводного диоксана. Смесь нагревали 3 час на бане при 105-110°С, после чего смесь оставл ли дл кристаллизации. В результате получали 20,8 г 93% хлористоводородной соли 4-пиридиламида фуран-2карбоновой кислоты, 250-254°С (Boetins). Дл очистки хлоргидрата нодвергалн рекристаллизации из 96%-пого этанола. При этом получали 16,8 г хлоргидрата 4-пиридиламида фуран - 2 - карбоновой кислоты, 256-258°С (Boetins). Хлоргидрат 4-пиридиламида фуран-2-карбоыовой кислоты превращали в амид посредством подщелачивани с помощью охлажденного раствора аммиака водного раствора хлоргидрата . Т. пл. 4-пиридиламида фурап-2-карбоновой кислоты 161 -162°С (Boetins). Пример 3. 13 г хлорангидрида фуран-2карбоновой кислоты раствор ли в 15 мл безводного диоксапа. К раствору част ми добавл ли 10,8 г 4-метил-2-аминопиридина, растворенного в 40 мл безводного диоксана. Смесь нагревали в течение 3 час в ванне при температуре 105-110°С, а затем ее оставл ли дл кристаллизации. При этом получили 20,2 г хлоргидрата 4-метил-2-пиридиламида фуран-2-карбоновой кислоты, 215-220°С (Boetins), что составл ет 85% от теоретического выхода. Дл очистки хлоргидрат подвергали рекристаллизации из 96% этанола. В результате получили 15 г хлоргидрата 4-метнл-2-пиридиламида фурац-2-карбоновой кислоты , т. пл. 224-226°С (Boetins). Хлоргидрат 4-метил-2-пиридиламида фуран-2-карбоновой кислоты превращали в амид посредством подщелачивани с помощью охлажденного раствора аммиака водного раствора хлоргидрата. Т. пл. 4-метил-2-пиридиламида фуран-2-карбоновой кислоты 104-106°С (Boetins). Формула изобретени Способ получени пиридиламидов фуранкарбоповой кислоты общей формулы Г со-ш ч где R - водород, низший алкил с Ci-С, или их солей. отличающийс тем, что аминопиридип или его производные общей формулы , где R имеет вышеуказанные значени , подвергают взаимодействию с хлорангидридом фуранкарбоновой кислоты общей формулы (.К в среде органического растворител с последующим выделением полученного хлоргидрита пиридиламида фуран-карбоновой кислоты или обработкой ее щелочью. Приоритет по признакам: 07.03.70, при R - водород. 26.08.70, при R - низкий алкил с Ci-С4.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL13926670A PL70910B1 (ru) | 1970-03-07 | 1970-03-07 | |
PL14522470A PL82188A6 (ru) | 1970-08-26 | 1970-08-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
SU516354A3 true SU516354A3 (ru) | 1976-05-30 |
Family
ID=26652834
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU1628615A SU516354A3 (ru) | 1970-03-07 | 1971-03-05 | Способ получени пиридиламидов фуранкарбоновой кислоты или их солей |
Country Status (6)
Country | Link |
---|---|
US (1) | US3758485A (ru) |
JP (1) | JPS5310067B1 (ru) |
DE (1) | DE2110537C3 (ru) |
FR (1) | FR2085684B1 (ru) |
GB (1) | GB1329493A (ru) |
SU (1) | SU516354A3 (ru) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4021433A (en) * | 1973-03-08 | 1977-05-03 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Derivative of nicotinic acid with amides |
IT1056031B (it) * | 1973-03-08 | 1982-01-30 | Sigma Tau Ind Farmaceuti | Redivati ammidici dell acido nicotininico |
US3959299A (en) * | 1973-07-03 | 1976-05-25 | Shell Oil Company | Herbicidal amide derivatives |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3238215A (en) * | 1963-10-17 | 1966-03-01 | Sterling Drug Inc | 1-[(3-, 2-, and 1-indolyl)-lower-alkyl-, lower-alkenyl-, and lower-alkynyl]piperidines |
-
1971
- 1971-03-05 DE DE2110537A patent/DE2110537C3/de not_active Expired
- 1971-03-05 SU SU1628615A patent/SU516354A3/ru active
- 1971-03-08 FR FR7107933A patent/FR2085684B1/fr not_active Expired
- 1971-03-08 US US00122022A patent/US3758485A/en not_active Expired - Lifetime
- 1971-03-08 JP JP1188671A patent/JPS5310067B1/ja active Pending
- 1971-04-19 GB GB2314071*A patent/GB1329493A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE2110537A1 (de) | 1971-12-16 |
DE2110537B2 (de) | 1977-10-20 |
GB1329493A (en) | 1973-09-12 |
DE2110537C3 (de) | 1978-06-15 |
US3758485A (en) | 1973-09-11 |
JPS5310067B1 (ru) | 1978-04-11 |
FR2085684B1 (ru) | 1975-06-06 |
FR2085684A1 (ru) | 1971-12-31 |
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