DE1770062C3 - Tetrahydroisochinolylpenicilline, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen - Google Patents

Tetrahydroisochinolylpenicilline, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen

Info

Publication number
DE1770062C3
DE1770062C3 DE1770062A DE1770062A DE1770062C3 DE 1770062 C3 DE1770062 C3 DE 1770062C3 DE 1770062 A DE1770062 A DE 1770062A DE 1770062 A DE1770062 A DE 1770062A DE 1770062 C3 DE1770062 C3 DE 1770062C3
Authority
DE
Germany
Prior art keywords
acid
benzyl
penicillin
tetrahydroisoquinaldic
carbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1770062A
Other languages
German (de)
English (en)
Other versions
DE1770062A1 (de
DE1770062B2 (de
Inventor
Daniel Dr.-Ing. Montrouge Bertin
Andre Noisy-Le-Sec Pierdet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of DE1770062A1 publication Critical patent/DE1770062A1/de
Publication of DE1770062B2 publication Critical patent/DE1770062B2/de
Application granted granted Critical
Publication of DE1770062C3 publication Critical patent/DE1770062C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE1770062A 1967-03-29 1968-03-26 Tetrahydroisochinolylpenicilline, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen Expired DE1770062C3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR100617A FR1525186A (fr) 1967-03-29 1967-03-29 Nouvelles pénicillines et procédé de préparation
FR138141A FR7155M (https=) 1967-03-29 1968-01-31

Publications (3)

Publication Number Publication Date
DE1770062A1 DE1770062A1 (de) 1971-09-16
DE1770062B2 DE1770062B2 (de) 1978-11-30
DE1770062C3 true DE1770062C3 (de) 1979-08-02

Family

ID=26175147

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1770062A Expired DE1770062C3 (de) 1967-03-29 1968-03-26 Tetrahydroisochinolylpenicilline, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen

Country Status (8)

Country Link
US (1) US3494917A (https=)
CH (1) CH491958A (https=)
DE (1) DE1770062C3 (https=)
DK (1) DK118021B (https=)
FR (2) FR1525186A (https=)
GB (2) GB1209669A (https=)
IL (1) IL29661A (https=)
NL (1) NL144944B (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8531615D0 (en) * 1985-12-23 1986-02-05 Zambeletti Spa L Compounds
HU212427B (en) * 1991-12-19 1996-06-28 Gyogyszerkutato Intezet Process for producing dl-, d- and l-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acids and their derivatives containing urethane-type n-protecting groups
KR101937514B1 (ko) 2011-10-14 2019-01-10 브리스톨-마이어스 스큅 컴퍼니 인자 xia 억제제로서의 치환된 테트라히드로이소퀴놀린 화합물
ES2579832T3 (es) 2011-10-14 2016-08-17 Bristol-Myers Squibb Company Compuestos de tetrahidroisoquinolina sustituida como inhibidores del factor XIa
EP2766345B1 (en) 2011-10-14 2016-03-16 Bristol-Myers Squibb Company Substituted tetrahydroisoquinoline compounds as factor xia inhibitors
TR201807316T4 (tr) 2012-10-12 2018-06-21 Bristol Myers Squibb Co Bir faktör XIa inhibitörünün kristalli formları.
WO2014059214A1 (en) 2012-10-12 2014-04-17 Bristol-Myers Squibb Company Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
EP2906552B1 (en) 2012-10-12 2017-11-22 Bristol-Myers Squibb Company Guanidine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
ES2712699T3 (es) 2013-03-25 2019-05-14 Bristol Myers Squibb Co Tetrahidroisoquinolinas que contienen azoles sustituidos como inhibidores del factor XIa
CN116987080A (zh) 2014-01-31 2023-11-03 百时美施贵宝公司 作为因子xia抑制剂的具有杂环p2′基团的大环化合物
NO2760821T3 (https=) 2014-01-31 2018-03-10
CN107074821B (zh) 2014-09-04 2020-05-22 百时美施贵宝公司 为fxia抑制剂的二酰胺大环化合物
US9453018B2 (en) 2014-10-01 2016-09-27 Bristol-Myers Squibb Company Pyrimidinones as factor XIa inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3174964A (en) * 1959-12-10 1965-03-23 Pfizer & Co C Derivatives of 6-aminopenicillanic acid
US3043831A (en) * 1960-07-18 1962-07-10 Doyle Frank Peter Synthetic penicillins

Also Published As

Publication number Publication date
NL6804392A (https=) 1968-09-30
GB1209668A (en) 1970-10-21
DE1770062A1 (de) 1971-09-16
DE1770062B2 (de) 1978-11-30
NL144944B (nl) 1975-02-17
US3494917A (en) 1970-02-10
DK118021B (da) 1970-06-29
FR7155M (https=) 1969-08-04
FR1525186A (fr) 1968-05-17
GB1209669A (en) 1970-10-21
IL29661A (en) 1972-01-27
CH491958A (fr) 1970-06-15

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Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
EHJ Ceased/non-payment of the annual fee