DE131595C - - Google Patents
Info
- Publication number
- DE131595C DE131595C DENDAT131595D DE131595DA DE131595C DE 131595 C DE131595 C DE 131595C DE NDAT131595 D DENDAT131595 D DE NDAT131595D DE 131595D A DE131595D A DE 131595DA DE 131595 C DE131595 C DE 131595C
- Authority
- DE
- Germany
- Prior art keywords
- hydrochloric acid
- quinine
- cinnamylquinine
- salt
- benzene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 claims description 9
- 235000001258 Cinchona calisaya Nutrition 0.000 claims description 5
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 claims description 5
- 229960000948 quinine Drugs 0.000 claims description 5
- IWTYTFSSTWXZFU-QPJJXVBHSA-N [(e)-3-chloroprop-1-enyl]benzene Chemical compound ClC\C=C\C1=CC=CC=C1 IWTYTFSSTWXZFU-QPJJXVBHSA-N 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- 150000003839 salts Chemical class 0.000 description 4
- 239000000243 solution Substances 0.000 description 3
- 239000007795 chemical reaction product Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- UOXLNYIYPISSFF-KBCVXPAYSA-N [(r)-[(2s,4s,5r)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methyl] benzoate Chemical compound O([C@H](C1=CC=NC2=CC=C(C=C21)OC)[C@H]1N2CC[C@H]([C@H](C2)C=C)C1)C(=O)C1=CC=CC=C1 UOXLNYIYPISSFF-KBCVXPAYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- -1 alkyl quinine carboxylates Chemical class 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- PASDCCFISLVPSO-UHFFFAOYSA-N benzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1 PASDCCFISLVPSO-UHFFFAOYSA-N 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE131595C true DE131595C (enrdf_load_stackoverflow) |
Family
ID=399915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT131595D Active DE131595C (enrdf_load_stackoverflow) |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE131595C (enrdf_load_stackoverflow) |
-
0
- DE DENDAT131595D patent/DE131595C/de active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2536145A1 (de) | Verfahren zur herstellung von cyclopropanderivaten | |
| DE69020155T2 (de) | Procede et appareil pour tester des circuits integres a grande integration. | |
| DE131595C (enrdf_load_stackoverflow) | ||
| DE2442706A1 (de) | Substituierte imidazolderivate | |
| DE2324390C2 (de) | Verfahren zur Herstellung von Derivaten des 2,2-Dichlor- bzw. 2,2-Dibromcyclopropans | |
| DE961087C (de) | Verfahren zur Herstellung von N-ª-Benzoyl-dl-lysin | |
| DE1301312B (de) | Verfahren zur Herstellung von Pyrryl-(2)-acetonitrilen | |
| DE1239696B (de) | Verfahren zur Herstellung von omega-Aminocarbon-saeuren | |
| EP1375490A1 (de) | Verfahren zur Herstellung von 2-Acetyl-2-chlor-gamma-butyrolacton | |
| DE2153356A1 (de) | Verfahren zur Herstellung von alpha Amlinocarbonsauren und ihren Derivaten | |
| DE2251556B2 (de) | a-(l-Chlor-2-naphthyloxy)-propionsäurederivate, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel | |
| EP0244613B1 (de) | Trifluormethylgruppen enthaltende Cyclopropylamine | |
| DE2651371A1 (de) | Quaternaere ammoniumsalze | |
| DE69905369T2 (de) | Verfahren zum Herstellen von Derivaten von Alpha-Ketocarbonsäuren | |
| DE1468344A1 (de) | Ungesaettigte saeuren und verfahren zu ihrer herstellung | |
| DE3605882A1 (de) | Verfahren zur herstellung von (alpha)-ketosaeuren | |
| DE160834C (enrdf_load_stackoverflow) | ||
| EP0732321B1 (de) | Verfahren zur Herstellung von 2-Aryl-2-chlormalonsäurediestern | |
| DE69021155T4 (de) | Verfahren zur Herstellung von 2-Chlor-4-Fluorphenol. | |
| DE292846C (enrdf_load_stackoverflow) | ||
| EP0336185B1 (de) | 1-(N-Formylamino)-2,4-dicyanobutan und ein Verfahren zu dessen Herstellung | |
| DE191547C (enrdf_load_stackoverflow) | ||
| DE2925012C2 (de) | Verfahren zur Herstellung von Pentachlor-3-butensäureestern | |
| DE69319113T2 (de) | Verbessertes verfahren zur herstellung von n-phenyl-n-methoxyacetyl-dl-alanin-methylesterderivaten | |
| DE157840C (enrdf_load_stackoverflow) |