DE112022003796T5 - Verfahren und Reagenzien zur Erhöhung des chemilumineszenten Signals - Google Patents

Verfahren und Reagenzien zur Erhöhung des chemilumineszenten Signals Download PDF

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Publication number
DE112022003796T5
DE112022003796T5 DE112022003796.2T DE112022003796T DE112022003796T5 DE 112022003796 T5 DE112022003796 T5 DE 112022003796T5 DE 112022003796 T DE112022003796 T DE 112022003796T DE 112022003796 T5 DE112022003796 T5 DE 112022003796T5
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DE
Germany
Prior art keywords
chloride
compound
alkyl
acridinium
chemiluminescence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE112022003796.2T
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German (de)
English (en)
Inventor
Matthias Theuser
Lars Komorowski
Antje Dammermann
Kathrin Baumert
Mareike Holste
Marcel Hinkelammert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euroimmun Medizinische Labordiagnostika AG
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Euroimmun Medizinische Labordiagnostika AG
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Publication date
Application filed by Euroimmun Medizinische Labordiagnostika AG filed Critical Euroimmun Medizinische Labordiagnostika AG
Publication of DE112022003796T5 publication Critical patent/DE112022003796T5/de
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B15/00—Acridine dyes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
    • C09B67/0033—Blends of pigments; Mixtured crystals; Solid solutions
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
    • C09B67/0033—Blends of pigments; Mixtured crystals; Solid solutions
    • C09B67/0034—Mixtures of two or more pigments or dyes of the same type
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/06—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials
    • C09K11/07—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials having chemically-interreactive components, e.g. reactive chemiluminescent compositions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1003—Carbocyclic compounds
    • C09K2211/1007—Non-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1018—Heterocyclic compounds

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE112022003796.2T 2021-07-29 2022-07-21 Verfahren und Reagenzien zur Erhöhung des chemilumineszenten Signals Pending DE112022003796T5 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21188638 2021-07-29
EP21188638.7 2021-07-29
PCT/EP2022/070522 WO2023006581A1 (en) 2021-07-29 2022-07-21 A method and reagents for enhancing the chemiluminescent signal

Publications (1)

Publication Number Publication Date
DE112022003796T5 true DE112022003796T5 (de) 2024-06-20

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE112022003796.2T Pending DE112022003796T5 (de) 2021-07-29 2022-07-21 Verfahren und Reagenzien zur Erhöhung des chemilumineszenten Signals

Country Status (9)

Country Link
US (1) US20240353412A1 (https=)
EP (1) EP4146765B1 (https=)
JP (1) JP2024527110A (https=)
CN (1) CN117769588B (https=)
CA (1) CA3221813A1 (https=)
DE (1) DE112022003796T5 (https=)
ES (1) ES2952362T3 (https=)
PL (1) PL4146765T3 (https=)
WO (1) WO2023006581A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115980332B (zh) * 2023-03-20 2023-07-04 广州科方生物技术股份有限公司 一种可提高免疫诊断试剂灵敏度的增强液及其制配方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US915527A (en) 1908-04-14 1909-03-16 James C Wood Potato-planter.
US4927769A (en) 1987-07-08 1990-05-22 Ciba Corning Diagnostics Corp. Method for enhancement of chemiluminescence
EP1539702B1 (en) 2002-08-20 2012-04-11 Quest Diagnostics Investments Incorporated Hydrophilic chemiluminescent acridinium labeling reagents
EP1273917B1 (en) 2001-07-03 2014-05-07 Siemens Healthcare Diagnostics Inc. Acridinium ester labels having hydrophilic modifiers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2233451B (en) * 1989-06-27 1993-09-15 Tropix Inc Chemiluminescence enhancement
US5451347A (en) * 1993-06-24 1995-09-19 Lumigen, Inc. Methods and compositions providing enhanced chemiluminescence from chemiluminescent compounds using dicationic surfactants
US5879885A (en) * 1995-06-07 1999-03-09 Gen-Probe Incorporated Compositions for detecting and quantifying biological samples
CN102311730B (zh) * 2010-06-30 2014-09-24 深圳迈瑞生物医疗电子股份有限公司 化学发光液,增强化学发光的试剂和方法
CN102311731B (zh) * 2010-06-30 2016-08-03 深圳迈瑞生物医疗电子股份有限公司 增强化学发光的试剂、方法和化学发光液
US20130168620A1 (en) * 2011-12-30 2013-07-04 Maggilume, LLC Chemiluminescent system
ES2769887T3 (es) * 2013-05-14 2020-06-29 Siemens Healthcare Diagnostics Inc Tensioactivos catiónicos degradables y su uso para la mejora de la quimioluminiscencia
CN109425741A (zh) * 2017-08-31 2019-03-05 苏州长光华医生物医学工程有限公司 一种适用于吖啶酯发光体系的化学发光底物液

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US915527A (en) 1908-04-14 1909-03-16 James C Wood Potato-planter.
US4927769A (en) 1987-07-08 1990-05-22 Ciba Corning Diagnostics Corp. Method for enhancement of chemiluminescence
EP1273917B1 (en) 2001-07-03 2014-05-07 Siemens Healthcare Diagnostics Inc. Acridinium ester labels having hydrophilic modifiers
EP1539702B1 (en) 2002-08-20 2012-04-11 Quest Diagnostics Investments Incorporated Hydrophilic chemiluminescent acridinium labeling reagents

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
Cinquanta et al., „Chemiluminescent immunoassay technology: what does it change in autoantibody detection?", Auto Immun Highlights, 8:9, 24. Juni 2017
Division of the American Chemical Society sind über https://www.cas.org
Division of the American Chemical Society sind über https://www.cas.org oder https://commonchemistry.cas.org zugänglich
Kruger, N. J., Detection of Polypeptides on Blots Using Secondary Antibodies, in The Protein Protocols Handbook (Hrsg. J. M. Walker), Seite 967, Band 1996, Springer
Natrajan et al., „A comparison of chemiluminescent acridinium dimethylphenyl ester labels with different conjugation sites", Org Biomol Chem, 13(9):2622-337, März 2015
Natrajan et al., „Effect of surfactants on the chemiluminescence of acridinium dimethylphenyl ester labels and their conjugates", Org. Biomol. Chem., 9, Seiten 5092 bis 5103, 13. April 2011
Tannous et al., „Combined flash and glow-type chemiluminescent reactions for high-throughput genotyping of biallelic polymorphisms", Analytical Biochemistry, Band 320, Ausgabe 2, Seiten 266 bis 272, 15. September 2003

Also Published As

Publication number Publication date
EP4146765A1 (en) 2023-03-15
WO2023006581A1 (en) 2023-02-02
EP4146765C0 (en) 2023-07-05
US20240353412A1 (en) 2024-10-24
ES2952362T3 (es) 2023-10-31
CA3221813A1 (en) 2023-02-02
CN117769588A (zh) 2024-03-26
PL4146765T3 (pl) 2023-12-11
CN117769588B (zh) 2025-02-21
EP4146765B1 (en) 2023-07-05
JP2024527110A (ja) 2024-07-19

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