CN117769588B - 增强化学发光信号的方法和试剂 - Google Patents

增强化学发光信号的方法和试剂 Download PDF

Info

Publication number
CN117769588B
CN117769588B CN202280051022.3A CN202280051022A CN117769588B CN 117769588 B CN117769588 B CN 117769588B CN 202280051022 A CN202280051022 A CN 202280051022A CN 117769588 B CN117769588 B CN 117769588B
Authority
CN
China
Prior art keywords
chemiluminescent
ammonium chloride
compound
alkyl
alkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202280051022.3A
Other languages
English (en)
Chinese (zh)
Other versions
CN117769588A (zh
Inventor
M·瑟乌色
L·科莫罗斯基
A·达默曼
K·鲍莫特
M·霍斯特
M·海英科拉莫特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euroimmun Medizinische Labordiagnostika AG
Original Assignee
Euroimmun Medizinische Labordiagnostika AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euroimmun Medizinische Labordiagnostika AG filed Critical Euroimmun Medizinische Labordiagnostika AG
Publication of CN117769588A publication Critical patent/CN117769588A/zh
Application granted granted Critical
Publication of CN117769588B publication Critical patent/CN117769588B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B15/00—Acridine dyes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
    • C09B67/0033—Blends of pigments; Mixtured crystals; Solid solutions
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
    • C09B67/0033—Blends of pigments; Mixtured crystals; Solid solutions
    • C09B67/0034—Mixtures of two or more pigments or dyes of the same type
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/06—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials
    • C09K11/07—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials having chemically-interreactive components, e.g. reactive chemiluminescent compositions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1003—Carbocyclic compounds
    • C09K2211/1007—Non-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1018—Heterocyclic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN202280051022.3A 2021-07-29 2022-07-21 增强化学发光信号的方法和试剂 Active CN117769588B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21188638 2021-07-29
EP21188638.7 2021-07-29
PCT/EP2022/070522 WO2023006581A1 (en) 2021-07-29 2022-07-21 A method and reagents for enhancing the chemiluminescent signal

Publications (2)

Publication Number Publication Date
CN117769588A CN117769588A (zh) 2024-03-26
CN117769588B true CN117769588B (zh) 2025-02-21

Family

ID=77155594

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280051022.3A Active CN117769588B (zh) 2021-07-29 2022-07-21 增强化学发光信号的方法和试剂

Country Status (9)

Country Link
US (1) US20240353412A1 (https=)
EP (1) EP4146765B1 (https=)
JP (1) JP2024527110A (https=)
CN (1) CN117769588B (https=)
CA (1) CA3221813A1 (https=)
DE (1) DE112022003796T5 (https=)
ES (1) ES2952362T3 (https=)
PL (1) PL4146765T3 (https=)
WO (1) WO2023006581A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115980332B (zh) * 2023-03-20 2023-07-04 广州科方生物技术股份有限公司 一种可提高免疫诊断试剂灵敏度的增强液及其制配方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102311730A (zh) * 2010-06-30 2012-01-11 深圳迈瑞生物医疗电子股份有限公司 化学发光液,增强化学发光的试剂和方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US915527A (en) 1908-04-14 1909-03-16 James C Wood Potato-planter.
US4927769A (en) 1987-07-08 1990-05-22 Ciba Corning Diagnostics Corp. Method for enhancement of chemiluminescence
GB2233451B (en) * 1989-06-27 1993-09-15 Tropix Inc Chemiluminescence enhancement
US5451347A (en) * 1993-06-24 1995-09-19 Lumigen, Inc. Methods and compositions providing enhanced chemiluminescence from chemiluminescent compounds using dicationic surfactants
US5879885A (en) * 1995-06-07 1999-03-09 Gen-Probe Incorporated Compositions for detecting and quantifying biological samples
US6664043B2 (en) 2001-07-03 2003-12-16 Bayer Corporation Acridinium ester labels having hydrophilic modifiers
ATE553089T1 (de) 2002-08-20 2012-04-15 Quest Diagnostics Invest Inc Hydrophile, chemilumineszente acridiniummarkierungsreagenzien
CN102311731B (zh) * 2010-06-30 2016-08-03 深圳迈瑞生物医疗电子股份有限公司 增强化学发光的试剂、方法和化学发光液
US20130168620A1 (en) * 2011-12-30 2013-07-04 Maggilume, LLC Chemiluminescent system
ES2769887T3 (es) * 2013-05-14 2020-06-29 Siemens Healthcare Diagnostics Inc Tensioactivos catiónicos degradables y su uso para la mejora de la quimioluminiscencia
CN109425741A (zh) * 2017-08-31 2019-03-05 苏州长光华医生物医学工程有限公司 一种适用于吖啶酯发光体系的化学发光底物液

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102311730A (zh) * 2010-06-30 2012-01-11 深圳迈瑞生物医疗电子股份有限公司 化学发光液,增强化学发光的试剂和方法

Also Published As

Publication number Publication date
EP4146765A1 (en) 2023-03-15
WO2023006581A1 (en) 2023-02-02
EP4146765C0 (en) 2023-07-05
US20240353412A1 (en) 2024-10-24
ES2952362T3 (es) 2023-10-31
DE112022003796T5 (de) 2024-06-20
CA3221813A1 (en) 2023-02-02
CN117769588A (zh) 2024-03-26
PL4146765T3 (pl) 2023-12-11
EP4146765B1 (en) 2023-07-05
JP2024527110A (ja) 2024-07-19

Similar Documents

Publication Publication Date Title
JP3117459B2 (ja) 螢光化合物からの発光信号増幅方法
US6184042B1 (en) Method for reducing hook effect in an immunoassay
US7314711B2 (en) Assays employing electrochemiluminescent labels and electrochemiluminescence quenchers
CN114910633B (zh) 一种免疫复合物及其应用
JP2013532275A (ja) 高感度のホモジニアス化学発光アッセイ方法
JP6979941B2 (ja) Ｐｅｇ化分析物特異的結合剤を用いた粒子に基づくイムノアッセイ
EP3295174B1 (en) Method for re-using test probe and reagents in an immunoassay
EP3111218B1 (en) Protein l based bioassay method for determining presence of soluble antibodies in a sample and kit therefor
JP2013513107A (ja) 自己抗体抗原結合を阻害するためのペプチド試薬及び方法
CN108391432B (zh) 杂环化合物的生物偶联分子
EP3425394B1 (en) Kit for quantitatively determining bile acid in biological sample and method for quantitatively determining bile acid in biological sample
WO2001063265A1 (en) Measuring method using long life fluorescence of excitation type
JP6386591B2 (ja) 新規な試料内検出対象物の検出方法及びこれを利用した検出キット
JP2024045268A (ja) 新規抗チミジンキナーゼ抗体
CN117769588B (zh) 增强化学发光信号的方法和试剂
Gai et al. Digital Immunoassays
CN119470884A (zh) 抑制干扰的药代动力学免疫测定
JP2016520193A (ja) 受容体含有安定化液剤
CN110514648A (zh) 一种化学发光分析poct检测装置及其应用
JPH0348765A (ja) 免疫的検出用物質及び免疫的検出法
JP2024518541A (ja) 補体成分１ｑ（Ｃ１ｑ）に対する抗体の結合を判定するための方法
US20040214217A1 (en) Chemiluminescent compounds and use thereof
Ricchiuti IMMUNOASSAY-BASED TECHNOL-OGIES FOR THE MEASUREMENT OF BIOLOGICAL MATERIALS USED FOR BIOMARKERS DISCOVERY
Diamandis et al. MC-1 A new generation of time-resolved fluoroimmunoassays with europium chelates as labels

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant