DE102006009279A1 - Verfahren zur Herstellung von 1-Formamido-3,5-dimethyladamantan - Google Patents

Verfahren zur Herstellung von 1-Formamido-3,5-dimethyladamantan Download PDF

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Publication number
DE102006009279A1
DE102006009279A1 DE102006009279A DE102006009279A DE102006009279A1 DE 102006009279 A1 DE102006009279 A1 DE 102006009279A1 DE 102006009279 A DE102006009279 A DE 102006009279A DE 102006009279 A DE102006009279 A DE 102006009279A DE 102006009279 A1 DE102006009279 A1 DE 102006009279A1
Authority
DE
Germany
Prior art keywords
dimethyladamantane
formamido
preparation
acid
formamidation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE102006009279A
Other languages
German (de)
English (en)
Inventor
Peter R. Prof. Dr. Schreiner
Andrey A. Prof. Dr. Fokin
Lukas Wanka
Derek M. Wolfe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merz Pharma GmbH and Co KGaA
Original Assignee
Justus Liebig Universitaet Giessen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Justus Liebig Universitaet Giessen filed Critical Justus Liebig Universitaet Giessen
Priority to DE102006009279A priority Critical patent/DE102006009279A1/de
Priority to EP07722859A priority patent/EP1989175B1/de
Priority to US12/224,575 priority patent/US8138375B2/en
Priority to JP2008556686A priority patent/JP5345403B2/ja
Priority to PCT/EP2007/001433 priority patent/WO2007101536A1/de
Priority to RU2008138891/04A priority patent/RU2455281C2/ru
Priority to ES07722859T priority patent/ES2392550T3/es
Publication of DE102006009279A1 publication Critical patent/DE102006009279A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE102006009279A 2006-03-01 2006-03-01 Verfahren zur Herstellung von 1-Formamido-3,5-dimethyladamantan Ceased DE102006009279A1 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE102006009279A DE102006009279A1 (de) 2006-03-01 2006-03-01 Verfahren zur Herstellung von 1-Formamido-3,5-dimethyladamantan
EP07722859A EP1989175B1 (de) 2006-03-01 2007-02-20 Verfahren zur herstellung von 1-formamido-3,5-dimethyladamantan
US12/224,575 US8138375B2 (en) 2006-03-01 2007-02-20 Method for producing 1-formamido-3,5-dimethyladamantane
JP2008556686A JP5345403B2 (ja) 2006-03-01 2007-02-20 １−ホルムアミド−３，５−ジメチルアダマンタンの製造方法
PCT/EP2007/001433 WO2007101536A1 (de) 2006-03-01 2007-02-20 Verfahren zur herstellung von 1-formamido-3,5-dimethyladamantan
RU2008138891/04A RU2455281C2 (ru) 2006-03-01 2007-02-20 Способ получения 1-формамидо-3,5-диметиладамантана
ES07722859T ES2392550T3 (es) 2006-03-01 2007-02-20 Procedimiento para la producción de 1-formamido-3,5-dimetiladamantano

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102006009279A DE102006009279A1 (de) 2006-03-01 2006-03-01 Verfahren zur Herstellung von 1-Formamido-3,5-dimethyladamantan

Publications (1)

Publication Number Publication Date
DE102006009279A1 true DE102006009279A1 (de) 2007-09-06

Family

ID=38197988

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102006009279A Ceased DE102006009279A1 (de) 2006-03-01 2006-03-01 Verfahren zur Herstellung von 1-Formamido-3,5-dimethyladamantan

Country Status (7)

Country Link
US (1) US8138375B2 (https=)
EP (1) EP1989175B1 (https=)
JP (1) JP5345403B2 (https=)
DE (1) DE102006009279A1 (https=)
ES (1) ES2392550T3 (https=)
RU (1) RU2455281C2 (https=)
WO (1) WO2007101536A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011015265A2 (en) 2009-08-04 2011-02-10 Merck Patent Gmbh Electronic devices comprising multi cyclic hydrocarbons
RU2478611C2 (ru) * 2008-03-20 2013-04-10 Мерц Фарма Гмбх Унд Ко. Кгаа Способ получения мемантина и промежуточного продукта

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2507085T3 (es) * 2008-03-20 2014-10-14 Merz Pharma Gmbh & Co. Kgaa Proceso para la fabricación de Memantina y producto intermedio
EP2373612B1 (en) 2008-12-17 2013-04-17 Merz Pharma GmbH & Co. KGaA Method for producing memantine
EP2389351A1 (en) * 2009-01-21 2011-11-30 Merz Pharma GmbH & Co. KGaA A process for preparing memantine
JP2013180983A (ja) * 2012-03-01 2013-09-12 Tokyo Univ Of Agriculture & Technology Ｎ置換アミド化合物の製造方法
RU2549901C1 (ru) * 2013-12-30 2015-05-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный университет" (ФГБОУ ВПО "КубГУ") Способ получения n-адамантилированных амидов
EP4005565A1 (en) 2020-11-30 2022-06-01 Merz Pharmaceuticals GmbH Novel uses of adamantane derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2318461A1 (de) 1973-04-12 1974-10-31 Merz & Co Verfahren zur herstellung von 1,3,5trisubstituierten adamanta-verbindungen
JPS63159330A (ja) * 1986-12-23 1988-07-02 Kawasaki Steel Corp １，３−ジメチルアダマンタンの製造方法
JPS63295519A (ja) * 1987-05-27 1988-12-01 Kawasaki Steel Corp １，３−ジメチルアダマンタンの製造方法
SU1643528A1 (ru) * 1988-10-03 1991-04-23 Научно-производственное объединение "Комплекс" Способ получени 1-ацетаминоадамантана
ES2059602T3 (es) * 1989-04-14 1994-11-16 Merz & Co Gmbh & Co Uso de derivados de adamantano para la prevencion y tratamiento de isquemia cerebral.
US5117056A (en) 1990-12-21 1992-05-26 Air Products And Chemicals, Inc. Preparation of N-(1-alkoxyalkyl)formamide and bis formamides
RU2246482C2 (ru) * 2002-12-25 2005-02-20 ООО "Циклан" Способ получения гидрохлорида 1-амино-3,5-диметиладамантана
CN100345819C (zh) * 2003-07-01 2007-10-31 北京德众万全药物技术开发有限公司 一种取代的金刚烷胺类化合物或其盐的制备方法
EP1789380A1 (de) 2004-07-23 2007-05-30 Justus-Liebig-Universität Giessen Aminoadamantan-derivate, verfahren zu ihrer herstellung und ihre verwendung

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Chem. Abstr. 132:107719 (1999) *
Chem. Abstr. 83:163721 (1975) *
Chem. Abstr. 92:198012 (1980) *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2478611C2 (ru) * 2008-03-20 2013-04-10 Мерц Фарма Гмбх Унд Ко. Кгаа Способ получения мемантина и промежуточного продукта
WO2011015265A2 (en) 2009-08-04 2011-02-10 Merck Patent Gmbh Electronic devices comprising multi cyclic hydrocarbons

Also Published As

Publication number Publication date
WO2007101536A1 (de) 2007-09-13
US20090299097A1 (en) 2009-12-03
EP1989175A1 (de) 2008-11-12
US8138375B2 (en) 2012-03-20
EP1989175B1 (de) 2012-09-19
RU2455281C2 (ru) 2012-07-10
RU2008138891A (ru) 2010-04-10
ES2392550T3 (es) 2012-12-11
JP5345403B2 (ja) 2013-11-20
JP2009528309A (ja) 2009-08-06

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8127 New person/name/address of the applicant

Owner name: MERZ PHARMA GMBH & CO. KGAA, 60318 FRANKFURT, DE

R002 Refusal decision in examination/registration proceedings
R003 Refusal decision now final

Effective date: 20140503