DE102005030292A1 - Nichtsteroidale Progesteronrezeptor-Modulatoren - Google Patents

Nichtsteroidale Progesteronrezeptor-Modulatoren Download PDF

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Publication number
DE102005030292A1
DE102005030292A1 DE102005030292A DE102005030292A DE102005030292A1 DE 102005030292 A1 DE102005030292 A1 DE 102005030292A1 DE 102005030292 A DE102005030292 A DE 102005030292A DE 102005030292 A DE102005030292 A DE 102005030292A DE 102005030292 A1 DE102005030292 A1 DE 102005030292A1
Authority
DE
Germany
Prior art keywords
methyl
compounds according
ethynyl
alkyl
alkynyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE102005030292A
Other languages
German (de)
English (en)
Inventor
Alexander Hillisch
Ulrich Bothe
Peter Droescher
Günter Kaufmann
Lothar Sobek
Ulrike Fuhrmann
Norbert Schmess
Carsten Möller
Wolfgang Schwede
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE102005030292A priority Critical patent/DE102005030292A1/de
Priority to CNA2006800308707A priority patent/CN101248066A/zh
Priority to EA200702524A priority patent/EA200702524A1/ru
Priority to BRPI0611903-4A priority patent/BRPI0611903A2/pt
Priority to AU2006261048A priority patent/AU2006261048A1/en
Priority to MX2008000072A priority patent/MX2008000072A/es
Priority to PCT/EP2006/006531 priority patent/WO2006136461A2/en
Priority to EP06762404A priority patent/EP1902049A2/en
Priority to KR1020087001793A priority patent/KR20080030622A/ko
Priority to JP2008517444A priority patent/JP2008543910A/ja
Priority to CA002611897A priority patent/CA2611897A1/en
Priority to US11/473,325 priority patent/US20070010514A1/en
Priority to TW095122742A priority patent/TW200740778A/zh
Priority to DO2006000148A priority patent/DOP2006000148A/es
Priority to PE2006000733A priority patent/PE20070125A1/es
Priority to UY29624A priority patent/UY29624A1/es
Priority to ARP060102750A priority patent/AR054519A1/es
Priority to GT200600271A priority patent/GT200600271A/es
Publication of DE102005030292A1 publication Critical patent/DE102005030292A1/de
Priority to IL188021A priority patent/IL188021A0/en
Priority to CR9598A priority patent/CR9598A/es
Priority to EC2007008044A priority patent/ECSP078044A/es
Priority to ZA200800690A priority patent/ZA200800690B/xx
Priority to NO20080440A priority patent/NO20080440L/no
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE102005030292A 2005-06-24 2005-06-24 Nichtsteroidale Progesteronrezeptor-Modulatoren Ceased DE102005030292A1 (de)

Priority Applications (23)

Application Number Priority Date Filing Date Title
DE102005030292A DE102005030292A1 (de) 2005-06-24 2005-06-24 Nichtsteroidale Progesteronrezeptor-Modulatoren
CNA2006800308707A CN101248066A (zh) 2005-06-24 2006-06-22 非甾体黄体酮受体调节剂
EA200702524A EA200702524A1 (ru) 2005-06-24 2006-06-22 Нестероидные модуляторы рецептора прогестерона
BRPI0611903-4A BRPI0611903A2 (pt) 2005-06-24 2006-06-22 moduladores de receptor de progesterona não-esteroidal
AU2006261048A AU2006261048A1 (en) 2005-06-24 2006-06-22 Non-steroidal progesterone receptor modulators
MX2008000072A MX2008000072A (es) 2005-06-24 2006-06-22 Moduladores no esteroides de receptor de progesterona.
PCT/EP2006/006531 WO2006136461A2 (en) 2005-06-24 2006-06-22 Non-steroidal progesterone receptor modulators
EP06762404A EP1902049A2 (en) 2005-06-24 2006-06-22 Non-steroidal progesterone receptor modulators
KR1020087001793A KR20080030622A (ko) 2005-06-24 2006-06-22 비스테로이드성 프로게스테론 수용체 조절자
JP2008517444A JP2008543910A (ja) 2005-06-24 2006-06-22 非ステロイド性プロゲステロン受容体モジュレーター
CA002611897A CA2611897A1 (en) 2005-06-24 2006-06-22 Non-steroidal progesterone receptor modulators
US11/473,325 US20070010514A1 (en) 2005-06-24 2006-06-23 Non-steroidal progesterone receptor modulators
TW095122742A TW200740778A (en) 2005-06-24 2006-06-23 Non-steroidal progesterone receptor modulators
DO2006000148A DOP2006000148A (es) 2005-06-24 2006-06-26 Moduladores no esteroides de receptores de progesterona
PE2006000733A PE20070125A1 (es) 2005-06-24 2006-06-26 Moduladores no esteroides de receptor de progesterona
UY29624A UY29624A1 (es) 2005-06-24 2006-06-26 Moduladores no esteroides de receptor de progesterona
ARP060102750A AR054519A1 (es) 2005-06-24 2006-06-27 Moduladores no esteroides de receptor de progesterona
GT200600271A GT200600271A (es) 2005-06-24 2006-06-28 Moduladores no esterides de receptores de progesterona
IL188021A IL188021A0 (en) 2005-06-24 2007-12-10 Non-steroidal progesterone receptor modulators
CR9598A CR9598A (es) 2005-06-24 2007-12-17 Moduladores no esteroides de receptor de progesterona
EC2007008044A ECSP078044A (es) 2005-06-24 2007-12-21 Moduladores no esteroides de receptor de progesterona
ZA200800690A ZA200800690B (en) 2005-06-24 2008-01-23 Non-steroidal progesterone receptor modulators
NO20080440A NO20080440L (no) 2005-06-24 2008-01-23 Ikke-steroide progesteronreseptormodulatorer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005030292A DE102005030292A1 (de) 2005-06-24 2005-06-24 Nichtsteroidale Progesteronrezeptor-Modulatoren

Publications (1)

Publication Number Publication Date
DE102005030292A1 true DE102005030292A1 (de) 2007-01-11

Family

ID=37199176

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102005030292A Ceased DE102005030292A1 (de) 2005-06-24 2005-06-24 Nichtsteroidale Progesteronrezeptor-Modulatoren

Country Status (22)

Country Link
EP (1) EP1902049A2 (pt)
JP (1) JP2008543910A (pt)
KR (1) KR20080030622A (pt)
CN (1) CN101248066A (pt)
AR (1) AR054519A1 (pt)
AU (1) AU2006261048A1 (pt)
BR (1) BRPI0611903A2 (pt)
CA (1) CA2611897A1 (pt)
CR (1) CR9598A (pt)
DE (1) DE102005030292A1 (pt)
DO (1) DOP2006000148A (pt)
EA (1) EA200702524A1 (pt)
EC (1) ECSP078044A (pt)
GT (1) GT200600271A (pt)
IL (1) IL188021A0 (pt)
MX (1) MX2008000072A (pt)
NO (1) NO20080440L (pt)
PE (1) PE20070125A1 (pt)
TW (1) TW200740778A (pt)
UY (1) UY29624A1 (pt)
WO (1) WO2006136461A2 (pt)
ZA (1) ZA200800690B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY30805A1 (es) * 2006-12-21 2008-07-31 Bayer Schering Pharma Ag Moduladores no esteroides de receptores de progesterona
DE102007032800A1 (de) * 2007-07-10 2009-01-15 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
DE102007058747A1 (de) 2007-12-05 2009-06-10 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
WO2010002075A1 (en) * 2008-07-02 2010-01-07 Pharmacostech Co., Ltd. Methods for preparing amide derivatives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1133486B1 (de) * 1998-11-27 2004-12-22 Schering Aktiengesellschaft Nichtsteroidale entzündungshemmer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1344776A1 (en) * 2002-03-11 2003-09-17 Schering Aktiengesellschaft 5- 2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino -phtalide and 6- 2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino -4-methyl-2,3-benzoxazin-1-one derivatives with progesterone receptor modulating activity for use in fertility control, hormone replacement therapy and the treatment of gynecological disorders
MXPA06000169A (es) * 2003-07-01 2006-04-27 Schering Ag Derivados de pentanol heterociclicamente sustituidos, procedimiento para su preparacion y su uso como anti-inflamatorios.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1133486B1 (de) * 1998-11-27 2004-12-22 Schering Aktiengesellschaft Nichtsteroidale entzündungshemmer

Also Published As

Publication number Publication date
ECSP078044A (es) 2008-01-23
AU2006261048A1 (en) 2006-12-28
EA200702524A1 (ru) 2008-06-30
TW200740778A (en) 2007-11-01
IL188021A0 (en) 2008-03-20
WO2006136461A2 (en) 2006-12-28
WO2006136461A3 (en) 2007-03-15
MX2008000072A (es) 2008-03-24
PE20070125A1 (es) 2007-02-14
CR9598A (es) 2008-04-09
GT200600271A (es) 2007-02-05
BRPI0611903A2 (pt) 2010-10-05
DOP2006000148A (es) 2007-07-15
ZA200800690B (en) 2009-09-30
NO20080440L (no) 2008-03-25
UY29624A1 (es) 2007-01-31
CA2611897A1 (en) 2006-12-28
KR20080030622A (ko) 2008-04-04
EP1902049A2 (en) 2008-03-26
JP2008543910A (ja) 2008-12-04
CN101248066A (zh) 2008-08-20
AR054519A1 (es) 2007-06-27

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8127 New person/name/address of the applicant

Owner name: BAYER SCHERING PHARMA AG, 13353 BERLIN, DE

8127 New person/name/address of the applicant

Owner name: BAYER SCHERING PHARMA AKIENGESELLSCHAFT, 13353, DE

8131 Rejection