DE102004063223A1 - Chinolinderivat, dessen Verwendung, Herstellung und dieses enthaltendes Arzneimittel - Google Patents

Chinolinderivat, dessen Verwendung, Herstellung und dieses enthaltendes Arzneimittel Download PDF

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Publication number
DE102004063223A1
DE102004063223A1 DE102004063223A DE102004063223A DE102004063223A1 DE 102004063223 A1 DE102004063223 A1 DE 102004063223A1 DE 102004063223 A DE102004063223 A DE 102004063223A DE 102004063223 A DE102004063223 A DE 102004063223A DE 102004063223 A1 DE102004063223 A1 DE 102004063223A1
Authority
DE
Germany
Prior art keywords
alkyl
alkoxy
general formula
aryl
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE102004063223A
Other languages
German (de)
English (en)
Inventor
Wolfgang Schwede
Stefan Jaroch
Benjamin Bader
Roman Hillig
Antonius Ter Laak
Dieter Zopf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE102004063223A priority Critical patent/DE102004063223A1/de
Priority to AT05850343T priority patent/ATE445617T1/de
Priority to MX2007007645A priority patent/MX2007007645A/es
Priority to CA002592009A priority patent/CA2592009A1/en
Priority to BRPI0519267-6A priority patent/BRPI0519267A2/pt
Priority to KR1020077016907A priority patent/KR20070097540A/ko
Priority to ES05850343T priority patent/ES2334453T3/es
Priority to CNA2005800444603A priority patent/CN101087788A/zh
Priority to JP2007547384A priority patent/JP4988592B2/ja
Priority to EP05850343A priority patent/EP1833830B1/de
Priority to PCT/EP2005/013955 priority patent/WO2006066955A1/de
Priority to DE502005008351T priority patent/DE502005008351D1/de
Priority to GT200500381A priority patent/GT200500381A/es
Priority to US11/312,635 priority patent/US20060167035A1/en
Priority to PA20058657701A priority patent/PA8657701A1/es
Priority to UY29308A priority patent/UY29308A1/es
Priority to ARP050105485A priority patent/AR052544A1/es
Priority to TW094145873A priority patent/TW200634013A/zh
Priority to SV2005002357A priority patent/SV2007002357A/es
Publication of DE102004063223A1 publication Critical patent/DE102004063223A1/de
Priority to IL183636A priority patent/IL183636A0/en
Priority to CR9182A priority patent/CR9182A/es
Priority to NO20073839A priority patent/NO20073839L/no
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE102004063223A 2004-12-22 2004-12-22 Chinolinderivat, dessen Verwendung, Herstellung und dieses enthaltendes Arzneimittel Ceased DE102004063223A1 (de)

Priority Applications (22)

Application Number Priority Date Filing Date Title
DE102004063223A DE102004063223A1 (de) 2004-12-22 2004-12-22 Chinolinderivat, dessen Verwendung, Herstellung und dieses enthaltendes Arzneimittel
CA002592009A CA2592009A1 (en) 2004-12-22 2005-12-19 Quinoline derivative, its use, production and pharmaceutical agents containing the latter
MX2007007645A MX2007007645A (es) 2004-12-22 2005-12-19 Derivado de quinolina, su uso, preparacion y medicamento que lo contiene.
PCT/EP2005/013955 WO2006066955A1 (de) 2004-12-22 2005-12-19 Chinolinderivat, dessen verwendung, herstellung und dieses enthalten­des arzneimittel
BRPI0519267-6A BRPI0519267A2 (pt) 2004-12-22 2005-12-19 derivado de quinolina, seu uso, produÇço e medicamento contendo o mesmo
KR1020077016907A KR20070097540A (ko) 2004-12-22 2005-12-19 퀴놀린 유도체, 그것의 용도 및 제조, 그것을 함유하는제약제
ES05850343T ES2334453T3 (es) 2004-12-22 2005-12-19 Derivado de quinolina, su utilizacion, su preparacion y medicamentos que contienen a este.
CNA2005800444603A CN101087788A (zh) 2004-12-22 2005-12-19 喹啉衍生物、其应用、制备以及包含该化合物的药物
JP2007547384A JP4988592B2 (ja) 2004-12-22 2005-12-19 キノリン誘導体、その使用、製造およびそれを含む医薬剤
EP05850343A EP1833830B1 (de) 2004-12-22 2005-12-19 Chinolinderivat, dessen verwendung, herstellung und dieses enthaltendes arzneimittel
DE502005008351T DE502005008351D1 (de) 2004-12-22 2005-12-19 Chinolinderivat, dessen verwendung, herstellung und dieses enthaltendes arzneimittel
AT05850343T ATE445617T1 (de) 2004-12-22 2005-12-19 Chinolinderivat, dessen verwendung, herstellung und dieses enthaltendes arzneimittel
US11/312,635 US20060167035A1 (en) 2004-12-22 2005-12-21 Quinoline derivative, its use, production and pharmaceutical agents containing the latter
GT200500381A GT200500381A (es) 2004-12-22 2005-12-21 Derivado de quinolina, su uso, preparacion y medicamento que lo contiene
TW094145873A TW200634013A (en) 2004-12-22 2005-12-22 Quinoline derivative, its use, production and pharmaceutical agents containing the derivative
UY29308A UY29308A1 (es) 2004-12-22 2005-12-22 Derivado de quinolina, su uso, preparación y medicamento que lo contiene
ARP050105485A AR052544A1 (es) 2004-12-22 2005-12-22 Derivado de quinolina, su uso, preparacion y medicamento que lo contiene
PA20058657701A PA8657701A1 (es) 2004-12-22 2005-12-22 Derivado de quinolina, su uso, preparacion y medicamento que lo contiene
SV2005002357A SV2007002357A (es) 2004-12-22 2005-12-22 Derivado de quinolina, su uso, preparacion y medicamento que lo contiene ref. p-sv-79232/ug
IL183636A IL183636A0 (en) 2004-12-22 2007-06-04 Quinoline derivative, use and production thereof, and drug containing the same
CR9182A CR9182A (es) 2004-12-22 2007-06-13 Derivado de quinolina, su uso, preparacion y medicamento que lo contiene
NO20073839A NO20073839L (no) 2004-12-22 2007-07-20 Kinolinderivat, fremgangsmate for fremstilling og anvendelse av dette, og legemiddel inneholdende dette

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004063223A DE102004063223A1 (de) 2004-12-22 2004-12-22 Chinolinderivat, dessen Verwendung, Herstellung und dieses enthaltendes Arzneimittel

Publications (1)

Publication Number Publication Date
DE102004063223A1 true DE102004063223A1 (de) 2006-07-13

Family

ID=36599298

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102004063223A Ceased DE102004063223A1 (de) 2004-12-22 2004-12-22 Chinolinderivat, dessen Verwendung, Herstellung und dieses enthaltendes Arzneimittel

Country Status (7)

Country Link
CN (1) CN101087788A (es)
AR (1) AR052544A1 (es)
DE (1) DE102004063223A1 (es)
GT (1) GT200500381A (es)
PA (1) PA8657701A1 (es)
SV (1) SV2007002357A (es)
UY (1) UY29308A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113150009A (zh) * 2020-01-07 2021-07-23 爱科诺生物医药股份有限公司 一类具有程序性细胞坏死通路抑制活性的杂环化合物及其应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103382206B (zh) * 2012-05-04 2016-09-28 上海恒瑞医药有限公司 喹啉或喹唑啉类衍生物、其制备方法及其在医药上的应用
CN106565823B (zh) * 2016-11-10 2020-09-11 珠海诺贝尔国际生物医药研究院有限公司 一种Eph受体小分子抑制剂及其制备方法
WO2019233458A1 (zh) * 2018-06-08 2019-12-12 江苏威凯尔医药科技有限公司 Vegfr抑制剂及其制备方法和应用
CN110577546B (zh) * 2018-06-08 2021-09-07 江苏威凯尔医药科技有限公司 Vegfr抑制剂及其制备方法和应用
CN113061142A (zh) * 2020-01-02 2021-07-02 爱科诺生物医药股份有限公司 一类具有程序性细胞坏死通路抑制活性的杂环化合物及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2427409A1 (de) * 1973-06-06 1975-01-09 Morton Norwich Products Inc 9-(substituierte amino) imidazo eckige klammer auf 4,5-f eckige klammer zu chinoline und verfahren zu deren herstellung
EP0187705A2 (en) * 1985-01-08 1986-07-16 Norwich Eaton Pharmaceuticals, Inc. Imidazo(4,5-f)quinolines useful as immunomodulating agents
US5506235A (en) * 1991-08-02 1996-04-09 Pfizer Inc. Quinoline derivatives as immunostimulants

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2427409A1 (de) * 1973-06-06 1975-01-09 Morton Norwich Products Inc 9-(substituierte amino) imidazo eckige klammer auf 4,5-f eckige klammer zu chinoline und verfahren zu deren herstellung
EP0187705A2 (en) * 1985-01-08 1986-07-16 Norwich Eaton Pharmaceuticals, Inc. Imidazo(4,5-f)quinolines useful as immunomodulating agents
US5506235A (en) * 1991-08-02 1996-04-09 Pfizer Inc. Quinoline derivatives as immunostimulants

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113150009A (zh) * 2020-01-07 2021-07-23 爱科诺生物医药股份有限公司 一类具有程序性细胞坏死通路抑制活性的杂环化合物及其应用
CN113150009B (zh) * 2020-01-07 2023-05-23 爱科诺生物医药(香港)有限公司 一类具有程序性细胞坏死通路抑制活性的杂环化合物及其应用

Also Published As

Publication number Publication date
AR052544A1 (es) 2007-03-21
CN101087788A (zh) 2007-12-12
PA8657701A1 (es) 2006-09-08
UY29308A1 (es) 2006-06-30
SV2007002357A (es) 2007-02-16
GT200500381A (es) 2006-08-03

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8127 New person/name/address of the applicant

Owner name: BAYER SCHERING PHARMA AG, 13353 BERLIN, DE

8127 New person/name/address of the applicant

Owner name: BAYER SCHERING PHARMA AKIENGESELLSCHAFT, 13353, DE

8131 Rejection