DE102004063223A1 - Chinolinderivat, dessen Verwendung, Herstellung und dieses enthaltendes Arzneimittel - Google Patents
Chinolinderivat, dessen Verwendung, Herstellung und dieses enthaltendes Arzneimittel Download PDFInfo
- Publication number
- DE102004063223A1 DE102004063223A1 DE102004063223A DE102004063223A DE102004063223A1 DE 102004063223 A1 DE102004063223 A1 DE 102004063223A1 DE 102004063223 A DE102004063223 A DE 102004063223A DE 102004063223 A DE102004063223 A DE 102004063223A DE 102004063223 A1 DE102004063223 A1 DE 102004063223A1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- alkoxy
- general formula
- aryl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 *Nc1ccnc2ccc(C=C*3)c3c12 Chemical compound *Nc1ccnc2ccc(C=C*3)c3c12 0.000 description 24
- RNSJERLHDFUEGF-UHFFFAOYSA-N CCNNc1ccnc(cc2)c1c1c2OCC1 Chemical compound CCNNc1ccnc(cc2)c1c1c2OCC1 RNSJERLHDFUEGF-UHFFFAOYSA-N 0.000 description 1
- ZEADAFJQIXLSDL-UHFFFAOYSA-N Cc(ccc(O)c1)c1Nc1c(c([s]cc2)c2cc2)c2ncc1 Chemical compound Cc(ccc(O)c1)c1Nc1c(c([s]cc2)c2cc2)c2ncc1 ZEADAFJQIXLSDL-UHFFFAOYSA-N 0.000 description 1
- ZAQIONKYMZGYFO-UHFFFAOYSA-N Cc1nc(c2c(cc3)nccc2NC)c3[s]1 Chemical compound Cc1nc(c2c(cc3)nccc2NC)c3[s]1 ZAQIONKYMZGYFO-UHFFFAOYSA-N 0.000 description 1
- QZSGEZHBLGBBCU-UHFFFAOYSA-N Cc1nc(c2c(cc3)nccc2Nc2c(C)ccc(O)c2)c3[s]1 Chemical compound Cc1nc(c2c(cc3)nccc2Nc2c(C)ccc(O)c2)c3[s]1 QZSGEZHBLGBBCU-UHFFFAOYSA-N 0.000 description 1
- XBCBZMFTDPTUEE-UHFFFAOYSA-N Clc1ccnc2ccc3[s]ccc3c12 Chemical compound Clc1ccnc2ccc3[s]ccc3c12 XBCBZMFTDPTUEE-UHFFFAOYSA-N 0.000 description 1
- DFDHRDMIGBAQNO-UHFFFAOYSA-N Nc1c(c(C=CC2)c2cc2)c2ncc1 Chemical compound Nc1c(c(C=CC2)c2cc2)c2ncc1 DFDHRDMIGBAQNO-UHFFFAOYSA-N 0.000 description 1
- FLPOLTKFKUFUEL-UHFFFAOYSA-N Nc1ccnc2c1c([nH]cc1)c1cc2 Chemical compound Nc1ccnc2c1c([nH]cc1)c1cc2 FLPOLTKFKUFUEL-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004063223A DE102004063223A1 (de) | 2004-12-22 | 2004-12-22 | Chinolinderivat, dessen Verwendung, Herstellung und dieses enthaltendes Arzneimittel |
PCT/EP2005/013955 WO2006066955A1 (de) | 2004-12-22 | 2005-12-19 | Chinolinderivat, dessen verwendung, herstellung und dieses enthaltendes arzneimittel |
ES05850343T ES2334453T3 (es) | 2004-12-22 | 2005-12-19 | Derivado de quinolina, su utilizacion, su preparacion y medicamentos que contienen a este. |
AT05850343T ATE445617T1 (de) | 2004-12-22 | 2005-12-19 | Chinolinderivat, dessen verwendung, herstellung und dieses enthaltendes arzneimittel |
CA002592009A CA2592009A1 (en) | 2004-12-22 | 2005-12-19 | Quinoline derivative, its use, production and pharmaceutical agents containing the latter |
CNA2005800444603A CN101087788A (zh) | 2004-12-22 | 2005-12-19 | 喹啉衍生物、其应用、制备以及包含该化合物的药物 |
EP05850343A EP1833830B1 (de) | 2004-12-22 | 2005-12-19 | Chinolinderivat, dessen verwendung, herstellung und dieses enthaltendes arzneimittel |
MX2007007645A MX2007007645A (es) | 2004-12-22 | 2005-12-19 | Derivado de quinolina, su uso, preparacion y medicamento que lo contiene. |
KR1020077016907A KR20070097540A (ko) | 2004-12-22 | 2005-12-19 | 퀴놀린 유도체, 그것의 용도 및 제조, 그것을 함유하는제약제 |
BRPI0519267-6A BRPI0519267A2 (pt) | 2004-12-22 | 2005-12-19 | derivado de quinolina, seu uso, produÇço e medicamento contendo o mesmo |
DE502005008351T DE502005008351D1 (de) | 2004-12-22 | 2005-12-19 | Chinolinderivat, dessen verwendung, herstellung und dieses enthaltendes arzneimittel |
JP2007547384A JP4988592B2 (ja) | 2004-12-22 | 2005-12-19 | キノリン誘導体、その使用、製造およびそれを含む医薬剤 |
GT200500381A GT200500381A (es) | 2004-12-22 | 2005-12-21 | Derivado de quinolina, su uso, preparacion y medicamento que lo contiene |
US11/312,635 US20060167035A1 (en) | 2004-12-22 | 2005-12-21 | Quinoline derivative, its use, production and pharmaceutical agents containing the latter |
PA20058657701A PA8657701A1 (es) | 2004-12-22 | 2005-12-22 | Derivado de quinolina, su uso, preparacion y medicamento que lo contiene |
UY29308A UY29308A1 (es) | 2004-12-22 | 2005-12-22 | Derivado de quinolina, su uso, preparación y medicamento que lo contiene |
TW094145873A TW200634013A (en) | 2004-12-22 | 2005-12-22 | Quinoline derivative, its use, production and pharmaceutical agents containing the derivative |
SV2005002357A SV2007002357A (es) | 2004-12-22 | 2005-12-22 | Derivado de quinolina, su uso, preparacion y medicamento que lo contiene ref. p-sv-79232/ug |
ARP050105485A AR052544A1 (es) | 2004-12-22 | 2005-12-22 | Derivado de quinolina, su uso, preparacion y medicamento que lo contiene |
IL183636A IL183636A0 (en) | 2004-12-22 | 2007-06-04 | Quinoline derivative, use and production thereof, and drug containing the same |
CR9182A CR9182A (es) | 2004-12-22 | 2007-06-13 | Derivado de quinolina, su uso, preparacion y medicamento que lo contiene |
NO20073839A NO20073839L (no) | 2004-12-22 | 2007-07-20 | Kinolinderivat, fremgangsmate for fremstilling og anvendelse av dette, og legemiddel inneholdende dette |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004063223A DE102004063223A1 (de) | 2004-12-22 | 2004-12-22 | Chinolinderivat, dessen Verwendung, Herstellung und dieses enthaltendes Arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
DE102004063223A1 true DE102004063223A1 (de) | 2006-07-13 |
Family
ID=36599298
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE102004063223A Ceased DE102004063223A1 (de) | 2004-12-22 | 2004-12-22 | Chinolinderivat, dessen Verwendung, Herstellung und dieses enthaltendes Arzneimittel |
Country Status (7)
Country | Link |
---|---|
CN (1) | CN101087788A (es) |
AR (1) | AR052544A1 (es) |
DE (1) | DE102004063223A1 (es) |
GT (1) | GT200500381A (es) |
PA (1) | PA8657701A1 (es) |
SV (1) | SV2007002357A (es) |
UY (1) | UY29308A1 (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113150009A (zh) * | 2020-01-07 | 2021-07-23 | 爱科诺生物医药股份有限公司 | 一类具有程序性细胞坏死通路抑制活性的杂环化合物及其应用 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103382206B (zh) * | 2012-05-04 | 2016-09-28 | 上海恒瑞医药有限公司 | 喹啉或喹唑啉类衍生物、其制备方法及其在医药上的应用 |
CN106565823B (zh) * | 2016-11-10 | 2020-09-11 | 珠海诺贝尔国际生物医药研究院有限公司 | 一种Eph受体小分子抑制剂及其制备方法 |
CN110577546B (zh) * | 2018-06-08 | 2021-09-07 | 江苏威凯尔医药科技有限公司 | Vegfr抑制剂及其制备方法和应用 |
WO2019233458A1 (zh) * | 2018-06-08 | 2019-12-12 | 江苏威凯尔医药科技有限公司 | Vegfr抑制剂及其制备方法和应用 |
CN113061142A (zh) * | 2020-01-02 | 2021-07-02 | 爱科诺生物医药股份有限公司 | 一类具有程序性细胞坏死通路抑制活性的杂环化合物及其应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2427409A1 (de) * | 1973-06-06 | 1975-01-09 | Morton Norwich Products Inc | 9-(substituierte amino) imidazo eckige klammer auf 4,5-f eckige klammer zu chinoline und verfahren zu deren herstellung |
EP0187705A2 (en) * | 1985-01-08 | 1986-07-16 | Norwich Eaton Pharmaceuticals, Inc. | Imidazo(4,5-f)quinolines useful as immunomodulating agents |
US5506235A (en) * | 1991-08-02 | 1996-04-09 | Pfizer Inc. | Quinoline derivatives as immunostimulants |
-
2004
- 2004-12-22 DE DE102004063223A patent/DE102004063223A1/de not_active Ceased
-
2005
- 2005-12-19 CN CNA2005800444603A patent/CN101087788A/zh active Pending
- 2005-12-21 GT GT200500381A patent/GT200500381A/es unknown
- 2005-12-22 UY UY29308A patent/UY29308A1/es not_active Application Discontinuation
- 2005-12-22 SV SV2005002357A patent/SV2007002357A/es not_active Application Discontinuation
- 2005-12-22 PA PA20058657701A patent/PA8657701A1/es unknown
- 2005-12-22 AR ARP050105485A patent/AR052544A1/es not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2427409A1 (de) * | 1973-06-06 | 1975-01-09 | Morton Norwich Products Inc | 9-(substituierte amino) imidazo eckige klammer auf 4,5-f eckige klammer zu chinoline und verfahren zu deren herstellung |
EP0187705A2 (en) * | 1985-01-08 | 1986-07-16 | Norwich Eaton Pharmaceuticals, Inc. | Imidazo(4,5-f)quinolines useful as immunomodulating agents |
US5506235A (en) * | 1991-08-02 | 1996-04-09 | Pfizer Inc. | Quinoline derivatives as immunostimulants |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113150009A (zh) * | 2020-01-07 | 2021-07-23 | 爱科诺生物医药股份有限公司 | 一类具有程序性细胞坏死通路抑制活性的杂环化合物及其应用 |
CN113150009B (zh) * | 2020-01-07 | 2023-05-23 | 爱科诺生物医药(香港)有限公司 | 一类具有程序性细胞坏死通路抑制活性的杂环化合物及其应用 |
Also Published As
Publication number | Publication date |
---|---|
GT200500381A (es) | 2006-08-03 |
UY29308A1 (es) | 2006-06-30 |
AR052544A1 (es) | 2007-03-21 |
CN101087788A (zh) | 2007-12-12 |
SV2007002357A (es) | 2007-02-16 |
PA8657701A1 (es) | 2006-09-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
OP8 | Request for examination as to paragraph 44 patent law | ||
8127 | New person/name/address of the applicant |
Owner name: BAYER SCHERING PHARMA AG, 13353 BERLIN, DE |
|
8127 | New person/name/address of the applicant |
Owner name: BAYER SCHERING PHARMA AKIENGESELLSCHAFT, 13353, DE |
|
8131 | Rejection |