DE10199054I1 - Hypoglycemisches Agens - Google Patents
Hypoglycemisches AgensInfo
- Publication number
- DE10199054I1 DE10199054I1 DE2001199054 DE10199054C DE10199054I1 DE 10199054 I1 DE10199054 I1 DE 10199054I1 DE 2001199054 DE2001199054 DE 2001199054 DE 10199054 C DE10199054 C DE 10199054C DE 10199054 I1 DE10199054 I1 DE 10199054I1
- Authority
- DE
- Germany
- Prior art keywords
- hypoglycemic agent
- hypoglycemic
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6227685 | 1985-03-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE10199054I1 true DE10199054I1 (de) | 2002-01-10 |
DE10199054I2 DE10199054I2 (de) | 2006-04-27 |
Family
ID=13195452
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8686302217T Expired - Lifetime DE3683662D1 (de) | 1985-03-27 | 1986-03-26 | Hypoglycemisches agens. |
DE2001199054 Active DE10199054I2 (de) | 1985-03-27 | 1986-03-26 | Hypoglycenisches Agens |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8686302217T Expired - Lifetime DE3683662D1 (de) | 1985-03-27 | 1986-03-26 | Hypoglycemisches agens. |
Country Status (4)
Country | Link |
---|---|
US (2) | US4816484A (de) |
EP (1) | EP0196222B1 (de) |
JP (1) | JPS6354321A (de) |
DE (2) | DE3683662D1 (de) |
Families Citing this family (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2501432Y2 (ja) * | 1990-01-23 | 1996-06-19 | ヤンマー農機株式会社 | 移植機における苗植え間隔検出装置 |
FR2676056B1 (fr) * | 1991-05-03 | 1993-07-16 | Adir | Nouveaux derives du benzopyranne leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
ES2100291T3 (es) * | 1991-07-30 | 1997-06-16 | Ajinomoto Kk | Cristales de n-(trans-4-isopropilciclohexilcarbonil)-d-fenilalanina y metodos para prepararlos. |
US5463116A (en) * | 1991-07-30 | 1995-10-31 | Ajinomoto Co., Inc. | Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them |
US5466864A (en) * | 1993-02-25 | 1995-11-14 | Ajinomoto Co., Inc. | Method for recovering L-phenylalanine |
US5831118A (en) * | 1996-06-18 | 1998-11-03 | Katayama Seiyakusyo Co., Ltd. | Epimerization of 2- or 4- substituted cyclohexanecarboxylic acids |
WO1998022105A1 (fr) | 1996-11-15 | 1998-05-28 | Ajinomoto Co., Inc. | Preparation en comprimes |
US20040176457A1 (en) * | 2003-02-27 | 2004-09-09 | Hemmingsen Lisbeth Tofte | Novel NIDDM regimen |
DE69818049T2 (de) | 1997-06-23 | 2004-07-15 | Tanabe Seiyaku Co., Ltd. | Inhibitoren der alpha4-beta1 vermittelten zelladhäsion |
US6685617B1 (en) | 1998-06-23 | 2004-02-03 | Pharmacia & Upjohn Company | Inhibitors of α4β1 mediated cell adhesion |
US6878749B2 (en) * | 1999-09-17 | 2005-04-12 | Novartis Ag | Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes |
AU2005200818B2 (en) * | 1999-09-17 | 2008-07-17 | Novartis Ag | Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes |
CO5200844A1 (es) * | 1999-09-17 | 2002-09-27 | Novartis Ag | Una combinacion que comprende nateglinida y cuando por menos otro compuesto antidiabetico usada para el tratamiento de desordenes metabolicos, especialmente diabetes, o de una enfermedad o condicion asociada con dibetes |
US6559188B1 (en) | 1999-09-17 | 2003-05-06 | Novartis Ag | Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes |
DK1741445T3 (da) | 2000-01-21 | 2013-11-04 | Novartis Ag | Kombinationer omfattende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler |
WO2001068136A1 (fr) * | 2000-03-17 | 2001-09-20 | Ajinomoto Co., Inc. | Medicaments permettant de traiter les complications du diabete et des neuropathies et utilisation de ces medicaments |
AR033390A1 (es) | 2000-08-22 | 2003-12-17 | Novartis Ag | Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes |
PT1334963E (pt) | 2000-10-18 | 2007-09-20 | Ajinomoto Kk | Processo para a produção de cristais de nateglinida |
DK1334962T3 (da) * | 2000-10-18 | 2007-12-10 | Ajinomoto Kk | Fremgangsmåder til fremstilling af acylphenylalanin |
ES2288997T3 (es) | 2000-10-24 | 2008-02-01 | Ajinomoto Co., Inc. | Procedimiento para producir cristales de nateglinida de tipo b. |
CA2426764C (en) * | 2000-10-24 | 2010-04-20 | Ajinomoto Co., Inc. | Nateglinide-containing hydrophilic pharmaceutical preparation |
US6740776B2 (en) | 2001-07-16 | 2004-05-25 | Novartis Ag | Air oxidation of an aromatic aldehyde to an aromatic acid |
CN1335182A (zh) * | 2001-08-08 | 2002-02-13 | 华中科技大学 | 胰岛素口腔喷剂及其制备工艺 |
US20050101638A1 (en) * | 2002-11-08 | 2005-05-12 | Webb Randy L. | Combination of organic compounds |
TW200304813A (en) * | 2002-03-11 | 2003-10-16 | Novartis Ag | Salts of organic acid |
EP1496048A4 (de) * | 2002-04-15 | 2006-08-02 | Ajinomoto Kk | Neuer nateglinidkristall |
JP4615866B2 (ja) * | 2002-04-15 | 2011-01-19 | ノバルティス アーゲー | N−(トランス−4−イソプロピルシクロヘキシルカルボニル)−d−フェニルアラニンの結晶形 |
US7411089B2 (en) | 2002-04-15 | 2008-08-12 | Ajinomoto Co., Inc. | Nateglinide crystals |
CN100363332C (zh) * | 2002-04-26 | 2008-01-23 | 中国人民解放军军事医学科学院毒物药物研究所 | 芳香性氨基酸衍生物,其制备方法及其医药用途 |
MXNL04000084A (es) | 2002-04-29 | 2006-02-28 | Biocon Ltd | Forma novedosa de n-(trans-4-isopropilciclohexilcarbonil)-d-fenilalanina. |
KR100983990B1 (ko) * | 2002-05-28 | 2010-09-30 | 아지노모토 가부시키가이샤 | Atp 시트르산 리아제의 발현 억제용 의약 조성물 |
US20050096367A1 (en) * | 2002-05-28 | 2005-05-05 | Yoshiro Kitahara | Pharmaceutical composition for suppression of the expression of ATP citrate lyase and use thereof |
US6861553B2 (en) * | 2002-07-03 | 2005-03-01 | Teva Pharmaceuticals Industries Ltd. | Process for preparing nateglinide and intermediates thereof |
CN100384813C (zh) * | 2002-07-03 | 2008-04-30 | 特瓦制药工业有限公司 | 制备那格列奈及其中间体的方法 |
US20050075400A1 (en) * | 2002-07-18 | 2005-04-07 | Ronit Yahalomi | Polymorphic forms of nateglinide |
US7420084B2 (en) * | 2002-07-18 | 2008-09-02 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of nateglinide |
JP2006511614A (ja) * | 2002-07-18 | 2006-04-06 | テバ ファーマシューティカル インダストリーズ リミティド | ナテグリニドの多形性形状 |
US7148376B2 (en) * | 2002-07-18 | 2006-12-12 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of nateglinide |
US7358390B2 (en) * | 2002-07-18 | 2008-04-15 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of nateglinide |
US7534913B2 (en) * | 2002-07-18 | 2009-05-19 | Teva Pharmaceutica Industries Ltd. | Crystalline form of nateglinide |
WO2004067495A1 (fr) * | 2003-01-28 | 2004-08-12 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Composes d'alanine, leur procede de preparation et leur utilisation |
EP1616886A4 (de) * | 2003-02-18 | 2006-06-14 | Konishi Co Ltd | Kuratives harz, herstellungsverfahren und kurative harzzusammensetzung |
HU227073B1 (hu) * | 2003-07-10 | 2010-06-28 | Richter Gedeon Nyrt | Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata |
US8173840B2 (en) * | 2003-07-29 | 2012-05-08 | Signature R&D Holdings, Llc | Compounds with high therapeutic index |
US7589233B2 (en) * | 2003-07-29 | 2009-09-15 | Signature R&D Holdings, Llc | L-Threonine derivatives of high therapeutic index |
EP1663950A1 (de) * | 2003-09-11 | 2006-06-07 | Solvay Fluor GmbH | Herstellung von n-acylverbindungen |
JP5395327B2 (ja) | 2003-09-17 | 2014-01-22 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 機構ベースの標的化した膵臓β細胞画像化および治療 |
EP1656339A1 (de) * | 2004-05-07 | 2006-05-17 | Teva Pharmaceutical Industries Ltd | Polymorphe form von nateglinid |
GB0413084D0 (en) * | 2004-06-11 | 2004-07-14 | Cipla Ltd | Process |
US7425648B2 (en) | 2005-01-03 | 2008-09-16 | A.M.S.A. Anonima Materie Sintetiche E. Affini S.P.A. | Process for the preparation of nateglinide, preferably in B-form |
KR20070102694A (ko) * | 2005-01-31 | 2007-10-19 | 아지노모토 가부시키가이샤 | 혈당 강하제를 함유하는, 내당능 이상, 경계형 당뇨병,인슐린 저항성 및 고인슐린혈증 개선 또는 치료용 의약조성물 |
GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
KR101352588B1 (ko) | 2005-09-14 | 2014-01-17 | 다케다 야쿠힌 고교 가부시키가이샤 | 당뇨병 치료용 디펩티딜 펩티다아제 억제제 |
KR20080086442A (ko) * | 2005-11-07 | 2008-09-25 | 일릭서 파마슈티컬즈, 인크. | 메트포민 및 메글리티나이드의 화합물 |
US7615649B2 (en) | 2006-01-26 | 2009-11-10 | Iowa State University Research Foundation, Inc, | Synthesis of polycyclic procyanidins |
CN101415668B (zh) * | 2006-03-31 | 2013-06-19 | 味之素株式会社 | 羧酸酰氯化合物的制造方法 |
WO2007113650A2 (en) * | 2006-04-05 | 2007-10-11 | Cadila Pharmaceuticals Limited | A novel and improved process fro the preparation of nateglinide and its polymorph form-h |
CN100383114C (zh) * | 2006-07-21 | 2008-04-23 | 杭州保灵有限公司 | 一种那格列奈的制备工艺 |
WO2009137082A1 (en) * | 2008-05-08 | 2009-11-12 | Concert Pharmaceuticals, Inc. | 4-isopropylcyclohexylcarbonyl amino acid derivatives |
JP5659224B2 (ja) | 2009-05-15 | 2015-01-28 | ノバルティス アーゲー | アルドステロンシンターゼ阻害剤としてのアリールピリジン |
SG176010A1 (en) | 2009-05-28 | 2011-12-29 | Novartis Ag | Substituted aminobutyric derivatives as neprilysin inhibitors |
AU2010251967B9 (en) | 2009-05-28 | 2014-04-03 | Novartis Ag | Substituted aminopropionic derivatives as neprilysin inhibitors |
WO2011041293A1 (en) | 2009-09-30 | 2011-04-07 | Takeda Pharmaceutical Company Limited | Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors |
ES2663351T3 (es) | 2009-11-17 | 2018-04-12 | Novartis Ag | Derivados de aril-piridina como inhibidores de la aldosterona sintasa |
JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
JP5575913B2 (ja) | 2009-11-30 | 2014-08-20 | ノバルティス アーゲー | アルドステロン合成酵素阻害剤としてのイミダゾール誘導体 |
PL2531501T3 (pl) | 2010-02-03 | 2014-05-30 | Takeda Pharmaceuticals Co | Inhibitory kinazy 1 regulującej sygnał apoptotyczny |
KR20130087485A (ko) * | 2010-06-14 | 2013-08-06 | 씨아이피엘에이 엘티디. | 나테글리니드의 제조 방법 |
US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
WO2012095548A2 (es) | 2011-01-13 | 2012-07-19 | Centro De Investigación Biomédica En Red De Enfermedades Neurodegenerativas (Ciberned) | Compuestos para el tratamiento de enfermedades neurodegenerativas |
WO2013066277A1 (en) | 2011-11-03 | 2013-05-10 | Mahmut Bilgic | Synergic compositions |
WO2013077819A1 (en) | 2011-11-23 | 2013-05-30 | Mahmut Bilgic | Pharmaceutical formulations comprising nateglinide |
UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
JP6295277B2 (ja) | 2013-02-14 | 2018-03-14 | ノバルティス アーゲー | Nep(中性エンドペプチダーゼ)阻害剤としての置換ビスフェニルブタン酸ホスホン酸誘導体 |
AU2014293387B2 (en) | 2013-07-25 | 2017-04-20 | Novartis Ag | Bioconjugates of synthetic apelin polypeptides |
KR20160031551A (ko) | 2013-07-25 | 2016-03-22 | 노파르티스 아게 | 심부전의 치료를 위한 시클릭 폴리펩티드 |
EA201791668A1 (ru) | 2015-01-23 | 2017-11-30 | Новартис Аг | Синтетические конъюгаты апелина с жирной кислотой с улучшенным периодом полураспада |
EP3096122B1 (de) | 2015-05-20 | 2017-05-31 | CORGHI S.p.A. | Auswuchtmaschine |
JP6720512B2 (ja) * | 2015-11-27 | 2020-07-08 | 住友化学株式会社 | トランス−シクロヘキサンカルボン酸の製造方法 |
CN108602758B (zh) | 2016-02-05 | 2021-01-26 | 斯福瑞股份公司 | 制备反式-4-氨基-1-环己烷基羧酸及其衍生物的方法 |
UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT377496B (de) * | 1981-06-19 | 1985-03-25 | Voith Gmbh J M | Vorrichtung zum anwickeln einer warenbahn auf eine neu eingelegte wickelhuelse in einer doppeltragwalzen-wickelmaschine |
JPS58189121A (ja) * | 1982-04-30 | 1983-11-04 | Ajinomoto Co Inc | インシユリン投与賦活剤 |
DE3382112D1 (de) * | 1982-04-30 | 1991-02-21 | Ajinomoto Kk | Pharmazeutische zusammensetzung. |
-
1986
- 1986-03-19 JP JP61061833A patent/JPS6354321A/ja active Granted
- 1986-03-26 EP EP86302217A patent/EP0196222B1/de not_active Expired - Lifetime
- 1986-03-26 DE DE8686302217T patent/DE3683662D1/de not_active Expired - Lifetime
- 1986-03-26 DE DE2001199054 patent/DE10199054I2/de active Active
-
1988
- 1988-01-21 US US07/146,719 patent/US4816484A/en not_active Ceased
-
1993
- 1993-11-23 US US08/157,564 patent/USRE34878E/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPS6354321A (ja) | 1988-03-08 |
EP0196222B1 (de) | 1992-01-29 |
EP0196222A2 (de) | 1986-10-01 |
EP0196222A3 (en) | 1988-02-24 |
JPH0415221B2 (de) | 1992-03-17 |
USRE34878E (en) | 1995-03-14 |
DE3683662D1 (de) | 1992-03-12 |
DE10199054I2 (de) | 2006-04-27 |
US4816484A (en) | 1989-03-28 |
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