DE10031955A1 - Curcumin-Derivate mit gegenüber Curcumin verbesserter Wasserlöslichkeit und diese enthaltende Arzneimittel - Google Patents

Curcumin-Derivate mit gegenüber Curcumin verbesserter Wasserlöslichkeit und diese enthaltende Arzneimittel

Info

Publication number
DE10031955A1
DE10031955A1 DE10031955A DE10031955A DE10031955A1 DE 10031955 A1 DE10031955 A1 DE 10031955A1 DE 10031955 A DE10031955 A DE 10031955A DE 10031955 A DE10031955 A DE 10031955A DE 10031955 A1 DE10031955 A1 DE 10031955A1
Authority
DE
Germany
Prior art keywords
curcumin
derivatives
derivatives according
curcumin derivatives
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE10031955A
Other languages
German (de)
English (en)
Inventor
Manfred Hergenhahn
Barbara Bertram
Manfred Wiesler
Bernd L Sorg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deutsches Krebsforschungszentrum DKFZ
Original Assignee
Deutsches Krebsforschungszentrum DKFZ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforschungszentrum DKFZ filed Critical Deutsches Krebsforschungszentrum DKFZ
Priority to DE10031955A priority Critical patent/DE10031955A1/de
Priority to DE50107844T priority patent/DE50107844D1/de
Priority to AT01953114T priority patent/ATE307819T1/de
Priority to CA002414605A priority patent/CA2414605A1/en
Priority to EP01953114A priority patent/EP1299406B1/de
Priority to PCT/DE2001/002337 priority patent/WO2002002582A1/de
Priority to US10/312,951 priority patent/US20030153512A1/en
Priority to AU2001275651A priority patent/AU2001275651A1/en
Publication of DE10031955A1 publication Critical patent/DE10031955A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
DE10031955A 2000-06-30 2000-06-30 Curcumin-Derivate mit gegenüber Curcumin verbesserter Wasserlöslichkeit und diese enthaltende Arzneimittel Ceased DE10031955A1 (de)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DE10031955A DE10031955A1 (de) 2000-06-30 2000-06-30 Curcumin-Derivate mit gegenüber Curcumin verbesserter Wasserlöslichkeit und diese enthaltende Arzneimittel
DE50107844T DE50107844D1 (de) 2000-06-30 2001-06-28 Curcumin-derivate mit gegenüber curcumin verbesserter wasserlöslichkeit und diese enthaltende arzneimittel
AT01953114T ATE307819T1 (de) 2000-06-30 2001-06-28 Curcumin-derivate mit gegenüber curcumin verbesserter wasserlöslichkeit und diese enthaltende arzneimittel
CA002414605A CA2414605A1 (en) 2000-06-30 2001-06-28 Curcumin derivatives with improved water solubility compared to curcumin and medicaments containing the same
EP01953114A EP1299406B1 (de) 2000-06-30 2001-06-28 Curcumin-derivate mit gegenüber curcumin verbesserter wasserlöslichkeit und diese enthaltende arzneimittel
PCT/DE2001/002337 WO2002002582A1 (de) 2000-06-30 2001-06-28 Curcumin-derivate mit gegenüber curcumin verbesserter wasserlöslichkeit und diese enthaltende arzneimittel
US10/312,951 US20030153512A1 (en) 2000-06-30 2001-06-28 Curcumin derivatives with improved water solubility compared to curcumin and medicaments containing the same
AU2001275651A AU2001275651A1 (en) 2000-06-30 2001-06-28 Curcumin derivatives with improved water solubility compared to curcumin and medicaments containing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10031955A DE10031955A1 (de) 2000-06-30 2000-06-30 Curcumin-Derivate mit gegenüber Curcumin verbesserter Wasserlöslichkeit und diese enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
DE10031955A1 true DE10031955A1 (de) 2002-01-17

Family

ID=7647388

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10031955A Ceased DE10031955A1 (de) 2000-06-30 2000-06-30 Curcumin-Derivate mit gegenüber Curcumin verbesserter Wasserlöslichkeit und diese enthaltende Arzneimittel
DE50107844T Expired - Fee Related DE50107844D1 (de) 2000-06-30 2001-06-28 Curcumin-derivate mit gegenüber curcumin verbesserter wasserlöslichkeit und diese enthaltende arzneimittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE50107844T Expired - Fee Related DE50107844D1 (de) 2000-06-30 2001-06-28 Curcumin-derivate mit gegenüber curcumin verbesserter wasserlöslichkeit und diese enthaltende arzneimittel

Country Status (7)

Country Link
US (1) US20030153512A1 (pt-PT)
EP (1) EP1299406B1 (pt-PT)
AT (1) ATE307819T1 (pt-PT)
AU (1) AU2001275651A1 (pt-PT)
CA (1) CA2414605A1 (pt-PT)
DE (2) DE10031955A1 (pt-PT)
WO (1) WO2002002582A1 (pt-PT)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10245988A1 (de) * 2002-10-01 2004-04-15 Dr. André Rieks, Labor für Enzymtechnologie GmbH Neue Curcumin-Derivate für den Einsatz in Kosmetika, Pharmazeutika und bei der Ernährung
WO2004031122A1 (de) * 2002-10-01 2004-04-15 Dr. André Rieks - Labor Für Enzymtechnologie Gmbh Neue curcumin/tetrahydrocurcumin-derivate für den einsatz in kosmetika, pharmazeutika und bei der ernährung

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US20030149113A1 (en) * 2001-10-12 2003-08-07 Caplan Michael J. Conductance of improperly folded proteins through the secretory pathway and related methods for treating disease
US20040115290A1 (en) 2001-06-20 2004-06-17 Tripp Matthew L. Modulation of inflammation by hops fractions and derivatives
US7270835B2 (en) 2001-06-20 2007-09-18 Metaproteomics, Llc Compositions that treat or inhibit pathological conditions associated with inflammatory response
US7718198B2 (en) 2001-06-20 2010-05-18 Metaproteomics, Llc Treatment modalities for autoimmune diseases
US7205151B2 (en) 2001-06-20 2007-04-17 Metaproteomics, Llc Complex mixtures exhibiting selective inhibition of cyclooxygenase-2
US7279185B2 (en) 2001-10-26 2007-10-09 Metaproteonics, Llc Curcuminoid compositions exhibiting synergistic inhibition of the expression and/or activity of cyclooxygenase-2
CA2464334C (en) * 2001-10-26 2012-01-10 Metaproteomics, Llc Curcuminoid compositions exhibiting synergistic inhibition of the expression and/or activity of cyclooxygenase-2
US8158160B2 (en) 2001-11-13 2012-04-17 Eric Hauser Kuhrts Anti-inflammatory cyclooxygenase inhibitors
WO2004005388A1 (en) 2002-07-05 2004-01-15 Exxonmobil Chemical Patents Inc. Functionalized elastomer nanocomposite
US7521481B2 (en) * 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
US7968115B2 (en) 2004-03-05 2011-06-28 Board Of Regents, The University Of Texas System Liposomal curcumin for treatment of cancer
WO2004080396A2 (en) * 2003-03-07 2004-09-23 The University Of Texas Md Anderson Cancer Center Liposomal curcumin for treatment of cancer
JP2005041817A (ja) * 2003-07-23 2005-02-17 Japan Science & Technology Agency クルクミノイド配糖体、及びその製造方法
US7205011B2 (en) * 2003-11-14 2007-04-17 Board Of Regents, Acting For And On Behalf Of, University Of Arizona Anti-inflammatory activity of a specific turmeric extract
US8841326B2 (en) 2004-02-12 2014-09-23 Stc.Unm Therapeutic curcumin derivatives
US7914831B2 (en) * 2004-02-27 2011-03-29 Metaproteomics, Llc Synergistic anti-inflammatory pharmaceutical compositions and related methods using curcuminoids or methylxanthines
US8784881B2 (en) 2004-03-05 2014-07-22 Board Of Regents, The University Of Texas System Liposomal curcumin for treatment of diseases
US20080103213A1 (en) * 2004-03-05 2008-05-01 Board Of Regents, The University Of Texas System Liposomal curcumin for treatment of neurofibromatosis
BRPI0517733A (pt) * 2004-11-17 2008-10-21 Joanne Mclaurin composições compreendendo derivados de scilo-inositol e métodos para tratar transtornos de agregação de proteìna
US20070111970A1 (en) * 2005-10-13 2007-05-17 Antonio Cruz Inositol compounds and uses of same in the treatment of diseases characterized by abnormal protein folding or aggregation or amyloid formation, desposition, accumulation or persistence
US20070197452A1 (en) * 2006-02-17 2007-08-23 Mclaurin Joanne Treatment of amyloid-related diseases
WO2007101353A1 (en) * 2006-03-09 2007-09-13 Waratah Pharmaceuticals Inc. A cyclohexane polyalcohol formulation for treatment of disorders of protein aggregation
WO2007134449A1 (en) * 2006-05-19 2007-11-29 Waratah Pharmaceuticals Inc. Screening methods for amyloid beta modulators
WO2008034244A1 (en) * 2006-09-21 2008-03-27 Waratah Pharmaceuticals Inc. The combination of a cyclohexanehexol and a nsaid for the treatment of neurodegenerative diseases
US20080075671A1 (en) * 2006-09-22 2008-03-27 Di Mauro Thomas M Intranasally administering curcumin to the brain to treat alzheimer's disease
CA2665916C (en) 2006-10-12 2015-12-08 The Research Foundation Of The City University Of New York Novel curcumin and tetrahydrocurcumin derivatives
US20100316631A1 (en) * 2006-10-19 2010-12-16 The Uab Research Foundation Water Soluble Curcumin-Based Compounds
JP2010510254A (ja) * 2006-11-24 2010-04-02 ワラタ ファーマシューティカルズ， インコーポレイテッド アルツハイマー病および関連の神経変性疾患のための併用処置
JP5124712B2 (ja) * 2006-12-28 2013-01-23 マイスターバイオ株式会社 ポリフェノール配糖体の製造方法
FR2913733B1 (fr) 2007-03-14 2009-06-26 Technofan Sa Ventilateur avec moyens de suivi d'usure
CA2683546A1 (en) * 2007-04-12 2008-10-23 Joanne Mclaurin Use of cyclohexanehexol derivatives in the treatment of .alpha.-synucleinopathies
AU2008238577B2 (en) * 2007-04-12 2015-02-19 Waratah Pharmaceuticals Inc. Use of cyclohexanehexol derivatives in the treatment of ocular diseases
WO2008124930A1 (en) * 2007-04-12 2008-10-23 Joanne Mclaurin Use of cyclohexanehexol derivatives for the treatment of polyglutamine diseases
US20100144891A1 (en) * 2007-04-12 2010-06-10 Mclaurin Joanne Use of cyclohexanehexol derivatives in the treatment of amyotrophic lateral sclerosis
US8383865B2 (en) * 2007-04-17 2013-02-26 Codman & Shurtleff, Inc. Curcumin derivatives
ES2562205T3 (es) 2007-04-17 2016-03-03 Codman & Shurtleff, Inc. Hibrídos de curcumina resveratrol
WO2009023357A2 (en) * 2007-05-25 2009-02-19 University Of Rochester Curcumin derivatives and their use as radioprotectors
US7745670B2 (en) * 2008-06-27 2010-06-29 Codman & Shurtleff, Inc. Curcumin-Resveratrol hybrid molecule
US7985776B2 (en) * 2008-06-27 2011-07-26 Codman & Shurtleff, Inc. Iontophoretic delivery of curcumin and curcumin analogs for the treatment of Alzheimer's Disease
US9221877B2 (en) 2008-09-19 2015-12-29 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Curcumin conjugates for treating and preventing cancers
WO2010040232A1 (en) * 2008-10-09 2010-04-15 Waratah Pharmaceuticals Inc. Use of scyllo-inositols for the treatment of macular degeneration-related disorders
US20100286585A1 (en) * 2009-01-26 2010-11-11 Codman & Shurtleff, Inc. Shunt Delivery of Curcumin
US7723515B1 (en) * 2009-01-26 2010-05-25 Codman & Shurtleff, Inc. Methylene blue—curcumin analog for the treatment of alzheimer's disease
KR101157995B1 (ko) * 2009-04-28 2012-06-25 차의과학대학교 산학협력단 신규한 비스-(3-하이드록시-4-메톡시-페닐) 유도체 및 그의 제조방법
US9446145B2 (en) 2009-12-02 2016-09-20 Research Foundation Of The City University Of New York Curcumin-antibody conjugates as anti-cancer agents
CA2786255A1 (en) 2009-12-31 2011-07-07 Organomed Corporation Formulations from natural products, turmeric, and aspirin
WO2011106691A2 (en) 2010-02-26 2011-09-01 Research Foundation Of The City University Of New York Curcumin derivatives
US8796233B2 (en) * 2010-06-17 2014-08-05 California Institute Of Technology Methods and systems for modulating hormones and related methods, agents and compositions
EP2591025B1 (en) 2010-07-05 2016-10-05 Dave, Jagrat Natavar Polymeric composition for ocular devices
US10449193B2 (en) 2011-06-03 2019-10-22 Signpath Pharma Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, lysoPG and lysoPC against drugs that cause channelopathies
US8753674B2 (en) 2011-06-03 2014-06-17 Signpath Pharma Inc. Liposomal mitigation of drug-induced long QT syndrome and potassium delayed-rectifier current
US10349884B2 (en) 2011-06-03 2019-07-16 Sighpath Pharma Inc. Liposomal mitigation of drug-induced inhibition of the cardiac ikr channel
US10117881B2 (en) 2011-06-03 2018-11-06 Signpath Pharma, Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, LYSOPG and LYSOPC against drugs that cause channelopathies
US10238602B2 (en) 2011-06-03 2019-03-26 Signpath Pharma, Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, LysoPG and LysoPC against drugs that cause channelopathies
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CN103396462A (zh) * 2013-08-10 2013-11-20 湖州师范学院 姜黄素类糖苷及其制备方法和在抗帕金森氏病中的应用
JP6224966B2 (ja) * 2013-09-12 2017-11-01 ハウス食品グループ本社株式会社 クルクミノイドのモノ配糖体の製造方法
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US20230016187A1 (en) 2019-11-25 2023-01-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Trem-1 inhibitors for the treatment of vaso-occlusions and tissue injuries in patients suffering from sickle cell disease
WO2022189659A1 (en) 2021-03-12 2022-09-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Trem-1 inhibitors for the treatment of marfan syndrome
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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4026118A1 (de) * 1989-08-17 1991-02-21 Kalamazoo Holdings Inc Curcumin-komplexe

Family Cites Families (2)

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IL112205A0 (en) * 1994-01-06 1995-03-15 Res Dev Foundation Curcumin, analogues of curcumin and novel uses thereof
US6673843B2 (en) * 1999-06-30 2004-01-06 Emory University Curcumin and curcuminoid inhibition of angiogenesis

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
DE4026118A1 (de) * 1989-08-17 1991-02-21 Kalamazoo Holdings Inc Curcumin-komplexe

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10245988A1 (de) * 2002-10-01 2004-04-15 Dr. André Rieks, Labor für Enzymtechnologie GmbH Neue Curcumin-Derivate für den Einsatz in Kosmetika, Pharmazeutika und bei der Ernährung
WO2004031122A1 (de) * 2002-10-01 2004-04-15 Dr. André Rieks - Labor Für Enzymtechnologie Gmbh Neue curcumin/tetrahydrocurcumin-derivate für den einsatz in kosmetika, pharmazeutika und bei der ernährung
DE10245988B4 (de) * 2002-10-01 2005-01-27 Dr. André Rieks, Labor für Enzymtechnologie GmbH Neue Curcumin-Derivate für den Einsatz in Kosmetika, Pharmazeutika und bei der Ernährung

Also Published As

Publication number Publication date
AU2001275651A1 (en) 2002-01-14
ATE307819T1 (de) 2005-11-15
EP1299406B1 (de) 2005-10-26
WO2002002582A1 (de) 2002-01-10
DE50107844D1 (de) 2005-12-01
US20030153512A1 (en) 2003-08-14
CA2414605A1 (en) 2002-12-30
EP1299406A1 (de) 2003-04-09

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