AU2001275651A1 - Curcumin derivatives with improved water solubility compared to curcumin and medicaments containing the same - Google Patents

Curcumin derivatives with improved water solubility compared to curcumin and medicaments containing the same

Info

Publication number
AU2001275651A1
AU2001275651A1 AU2001275651A AU7565101A AU2001275651A1 AU 2001275651 A1 AU2001275651 A1 AU 2001275651A1 AU 2001275651 A AU2001275651 A AU 2001275651A AU 7565101 A AU7565101 A AU 7565101A AU 2001275651 A1 AU2001275651 A1 AU 2001275651A1
Authority
AU
Australia
Prior art keywords
curcumin
derivatives
water solubility
improved water
medicaments containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001275651A
Inventor
Barbara Bertram
Manfred Hergenhahn
Bernd L. Sorg
Manfred Wiessler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deutsches Krebsforschungszentrum DKFZ
Original Assignee
Deutsches Krebsforschungszentrum DKFZ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforschungszentrum DKFZ filed Critical Deutsches Krebsforschungszentrum DKFZ
Publication of AU2001275651A1 publication Critical patent/AU2001275651A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention relates to curcumin derivatives with improved water solubility compared to curcumin, which are characterized in that the curcumin part is linked to a monosaccharide, oligosaccharide or polysaccharide, and to medicaments containing these derivatives. The curcumin derivatives according to the invention are particularly suitable to prevent and treat cancer, chronic-inflammatory diseases and diseases associated with a retrovirus infection.
AU2001275651A 2000-06-30 2001-06-28 Curcumin derivatives with improved water solubility compared to curcumin and medicaments containing the same Abandoned AU2001275651A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10031955A DE10031955A1 (en) 2000-06-30 2000-06-30 Curcumin derivatives with improved water solubility compared to curcumin and medicaments containing them
DE10031955 2000-06-30
PCT/DE2001/002337 WO2002002582A1 (en) 2000-06-30 2001-06-28 Curcumin derivatives with improved water solubility compared to curcumin and medicaments containing the same

Publications (1)

Publication Number Publication Date
AU2001275651A1 true AU2001275651A1 (en) 2002-01-14

Family

ID=7647388

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001275651A Abandoned AU2001275651A1 (en) 2000-06-30 2001-06-28 Curcumin derivatives with improved water solubility compared to curcumin and medicaments containing the same

Country Status (7)

Country Link
US (1) US20030153512A1 (en)
EP (1) EP1299406B1 (en)
AT (1) ATE307819T1 (en)
AU (1) AU2001275651A1 (en)
CA (1) CA2414605A1 (en)
DE (2) DE10031955A1 (en)
WO (1) WO2002002582A1 (en)

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US7718198B2 (en) 2001-06-20 2010-05-18 Metaproteomics, Llc Treatment modalities for autoimmune diseases
US7279185B2 (en) 2001-10-26 2007-10-09 Metaproteonics, Llc Curcuminoid compositions exhibiting synergistic inhibition of the expression and/or activity of cyclooxygenase-2
ATE482696T1 (en) * 2001-10-26 2010-10-15 Metaproteomics Llc CUCUMINOID COMPOSITIONS WITH SYNERGISTIC INHIBITION OF THE EXPRESSION AND/OR ACTION OF CYCLOOXYGENASE-2
US8158160B2 (en) 2001-11-13 2012-04-17 Eric Hauser Kuhrts Anti-inflammatory cyclooxygenase inhibitors
EP1527127B1 (en) 2002-07-05 2009-02-11 Exxonmobil Chemical Patents Inc. Functionalized elastomer nanocomposite
DE10245988B4 (en) * 2002-10-01 2005-01-27 Dr. André Rieks, Labor für Enzymtechnologie GmbH New curcumin derivatives for use in cosmetics, pharmaceuticals and nutrition
AU2003270283A1 (en) * 2002-10-01 2004-04-23 Dr. Andre Rieks - Labor Fur Enzymtechnologie Gmbh Novel curcumin/tetrahydrocurcumin derivatives for using in cosmetics, pharmaceuticals and for nutrition
US7521481B2 (en) 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
WO2004080396A2 (en) * 2003-03-07 2004-09-23 The University Of Texas Md Anderson Cancer Center Liposomal curcumin for treatment of cancer
US7968115B2 (en) 2004-03-05 2011-06-28 Board Of Regents, The University Of Texas System Liposomal curcumin for treatment of cancer
JP2005041817A (en) * 2003-07-23 2005-02-17 Japan Science & Technology Agency Curcuminoid glycoside and method for producing the same
US7205011B2 (en) * 2003-11-14 2007-04-17 Board Of Regents, Acting For And On Behalf Of, University Of Arizona Anti-inflammatory activity of a specific turmeric extract
US8841326B2 (en) 2004-02-12 2014-09-23 Stc.Unm Therapeutic curcumin derivatives
US7914831B2 (en) * 2004-02-27 2011-03-29 Metaproteomics, Llc Synergistic anti-inflammatory pharmaceutical compositions and related methods using curcuminoids or methylxanthines
US8784881B2 (en) * 2004-03-05 2014-07-22 Board Of Regents, The University Of Texas System Liposomal curcumin for treatment of diseases
US20080103213A1 (en) * 2004-03-05 2008-05-01 Board Of Regents, The University Of Texas System Liposomal curcumin for treatment of neurofibromatosis
EP1824496A4 (en) * 2004-11-17 2008-07-16 Joanne Mclaurin Compositions comprising scyllo-inositol derivatives and methods to treat disorders of protein aggregation
WO2007119108A2 (en) * 2005-10-13 2007-10-25 Waratah Pharmaceuticals Inc. Inositol derivatives and their uses in the treatment of diseases characterized by abnormal protein folding or aggregation or amyloid formation, deposition, accumulation or persistence
US20070197452A1 (en) * 2006-02-17 2007-08-23 Mclaurin Joanne Treatment of amyloid-related diseases
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US20110028719A1 (en) * 2006-05-19 2011-02-03 Jacek Slon-Usakiewicz Screening methods for amyloid beta modulators
WO2008034244A1 (en) * 2006-09-21 2008-03-27 Waratah Pharmaceuticals Inc. The combination of a cyclohexanehexol and a nsaid for the treatment of neurodegenerative diseases
US20080075671A1 (en) * 2006-09-22 2008-03-27 Di Mauro Thomas M Intranasally administering curcumin to the brain to treat alzheimer's disease
JP2010506836A (en) * 2006-10-12 2010-03-04 リサーチ ファウンデイション オブ ザ シティー ユニヴァーシティ オブ ニューヨーク Novel curcumin and tetrahydrocurcumin derivatives
WO2008051474A1 (en) * 2006-10-19 2008-05-02 The Uab Research Foundation Water soluble curcumin-based compounds
JP2010510254A (en) * 2006-11-24 2010-04-02 ワラタ ファーマシューティカルズ， インコーポレイテッド Combination treatment for Alzheimer's disease and related neurodegenerative diseases
JP5124712B2 (en) * 2006-12-28 2013-01-23 マイスターバイオ株式会社 Method for producing polyphenol glycoside
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ES2425264T3 (en) * 2007-04-12 2013-10-14 Waratah Pharmaceuticals, Inc. Use of cyclohexanehexol derivatives in the treatment of eye diseases
WO2008124931A1 (en) * 2007-04-12 2008-10-23 Joanne Mclaurin Use of cyclohexanehexol derivatives in the treatment of amyotrophic lateral sclerosis
WO2008124930A1 (en) * 2007-04-12 2008-10-23 Joanne Mclaurin Use of cyclohexanehexol derivatives for the treatment of polyglutamine diseases
WO2008124929A1 (en) * 2007-04-12 2008-10-23 Joanne Mclaurin USE OF CYCLOHEXANEHEXOL DERIVATIVES IN THE TREATMENT OF α-SYNUCLEINOPATHIES
US8383865B2 (en) * 2007-04-17 2013-02-26 Codman & Shurtleff, Inc. Curcumin derivatives
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WO2009023357A2 (en) * 2007-05-25 2009-02-19 University Of Rochester Curcumin derivatives and their use as radioprotectors
US7745670B2 (en) * 2008-06-27 2010-06-29 Codman & Shurtleff, Inc. Curcumin-Resveratrol hybrid molecule
US7985776B2 (en) 2008-06-27 2011-07-26 Codman & Shurtleff, Inc. Iontophoretic delivery of curcumin and curcumin analogs for the treatment of Alzheimer's Disease
WO2010033580A2 (en) 2008-09-19 2010-03-25 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Curcumin conjugates for treating and preventing cancers
JP2012505162A (en) * 2008-10-09 2012-03-01 ワラタ ファーマシューティカルズ， インコーポレイテッド Use of scyllo-inositol for treating macular degeneration related disorders
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US7723515B1 (en) * 2009-01-26 2010-05-25 Codman & Shurtleff, Inc. Methylene blue—curcumin analog for the treatment of alzheimer's disease
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Also Published As

Publication number Publication date
EP1299406B1 (en) 2005-10-26
WO2002002582A1 (en) 2002-01-10
US20030153512A1 (en) 2003-08-14
ATE307819T1 (en) 2005-11-15
DE10031955A1 (en) 2002-01-17
CA2414605A1 (en) 2002-12-30
DE50107844D1 (en) 2005-12-01
EP1299406A1 (en) 2003-04-09

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