DE10004860A1 - Druckluftinhalator zur pulmonalen Applikation liposomalen Pulver-Aerosols sowie dafür geeignete Pulver-Aerosole - Google Patents

Druckluftinhalator zur pulmonalen Applikation liposomalen Pulver-Aerosols sowie dafür geeignete Pulver-Aerosole

Info

Publication number
DE10004860A1
DE10004860A1 DE10004860A DE10004860A DE10004860A1 DE 10004860 A1 DE10004860 A1 DE 10004860A1 DE 10004860 A DE10004860 A DE 10004860A DE 10004860 A DE10004860 A DE 10004860A DE 10004860 A1 DE10004860 A1 DE 10004860A1
Authority
DE
Germany
Prior art keywords
powder aerosol
liposomes
compressed air
liposomal
cholesterol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10004860A
Other languages
German (de)
English (en)
Inventor
Julia Eva Diederichs
Wolfgang Koch
Hubert Loedding
Regina Reszka
Horst Windt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV
Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft
Original Assignee
Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV
Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV, Max Delbrueck Centrum fuer Molekulare in der Helmholtz Gemeinschaft filed Critical Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV
Priority to DE10004860A priority Critical patent/DE10004860A1/de
Publication of DE10004860A1 publication Critical patent/DE10004860A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/0012—Apparatus for achieving spraying before discharge from the apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/06—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane
    • B05B7/062—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet
    • B05B7/066—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet with an inner liquid outlet surrounded by at least one annular gas outlet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
DE10004860A 1999-02-03 2000-02-03 Druckluftinhalator zur pulmonalen Applikation liposomalen Pulver-Aerosols sowie dafür geeignete Pulver-Aerosole Withdrawn DE10004860A1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE10004860A DE10004860A1 (de) 1999-02-03 2000-02-03 Druckluftinhalator zur pulmonalen Applikation liposomalen Pulver-Aerosols sowie dafür geeignete Pulver-Aerosole

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19905285 1999-02-03
DE19954107 1999-11-02
DE10004860A DE10004860A1 (de) 1999-02-03 2000-02-03 Druckluftinhalator zur pulmonalen Applikation liposomalen Pulver-Aerosols sowie dafür geeignete Pulver-Aerosole

Publications (1)

Publication Number Publication Date
DE10004860A1 true DE10004860A1 (de) 2000-10-05

Family

ID=26051750

Family Applications (1)

Application Number Title Priority Date Filing Date
DE10004860A Withdrawn DE10004860A1 (de) 1999-02-03 2000-02-03 Druckluftinhalator zur pulmonalen Applikation liposomalen Pulver-Aerosols sowie dafür geeignete Pulver-Aerosole

Country Status (12)

Country Link
EP (1) EP1148905A2 (sk)
JP (1) JP2002538855A (sk)
KR (1) KR20010101991A (sk)
CN (1) CN1338956A (sk)
AU (1) AU3416400A (sk)
CA (1) CA2361807A1 (sk)
DE (1) DE10004860A1 (sk)
HU (1) HUP0105445A2 (sk)
PL (1) PL349885A1 (sk)
RU (1) RU2001124354A (sk)
SK (1) SK10942001A3 (sk)
WO (1) WO2000045878A2 (sk)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10112167A1 (de) * 2001-03-12 2002-10-02 Bionorica Ag Verfahren zur schonenden Gewinnung von Trockenextrakten
WO2003092851A1 (en) * 2002-05-02 2003-11-13 Accentus Plc Preparation of small crystals

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6900317B2 (en) 2002-02-19 2005-05-31 Boehringer Ingelheim Pharma Gmbh & Co. Kg Salts of the CGRP antagonist BIBN4096 and inhalable powdered medicaments containing them
US6883517B2 (en) * 2002-09-30 2005-04-26 Asaf Halamish Downdraft nebulizer
US7459146B2 (en) * 2003-05-30 2008-12-02 3M Innovative Properties Company Stabilized aerosol dispersions
JP2007533387A (ja) 2004-04-21 2007-11-22 イノベータ バイオメド リミテッド 吸入器
KR100682334B1 (ko) * 2006-07-14 2007-02-16 (주)지에프씨 미립상 레시틴 왁스 조성물 제조장치
US8875698B2 (en) * 2009-02-26 2014-11-04 Acp Japan Gas mist inhaler
JP5808490B2 (ja) 2011-09-06 2015-11-10 ブリティッシュ アメリカン タバコ （インヴェストメンツ） リミテッドＢｒｉｔｉｓｈ Ａｍｅｒｉｃａｎｔｏｂａｃｃｏ （Ｉｎｖｅｓｔｍｅｎｔｓ） Ｌｉｍｉｔｅｄ 喫煙材の加熱
US20140053839A1 (en) * 2011-11-04 2014-02-27 Acp Japan Co., Ltd. Gas mist inhaler
KR101373981B1 (ko) * 2012-07-24 2014-03-12 한국화학연구원 약물 흡입 장치
KR101313993B1 (ko) * 2012-07-24 2013-10-01 한국화학연구원 약물 흡입 장치
GB201217067D0 (en) 2012-09-25 2012-11-07 British American Tobacco Co Heating smokable material
GB201311620D0 (en) 2013-06-28 2013-08-14 British American Tobacco Co Devices Comprising a Heat Source Material and Activation Chambers for the Same
GB201500582D0 (en) 2015-01-14 2015-02-25 British American Tobacco Co Apparatus for heating or cooling a material contained therein
GB201415381D0 (en) * 2014-08-29 2014-10-15 Algipharma As Inhalable powder formulations of alginate oligomers
US11924930B2 (en) 2015-08-31 2024-03-05 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US20170055584A1 (en) 2015-08-31 2017-03-02 British American Tobacco (Investments) Limited Article for use with apparatus for heating smokable material
US20170055575A1 (en) 2015-08-31 2017-03-02 British American Tobacco (Investments) Limited Material for use with apparatus for heating smokable material
US20170119047A1 (en) 2015-10-30 2017-05-04 British American Tobacco (Investments) Limited Article for Use with Apparatus for Heating Smokable Material
US20170119046A1 (en) 2015-10-30 2017-05-04 British American Tobacco (Investments) Limited Apparatus for Heating Smokable Material
BR112018071191A2 (pt) * 2016-04-15 2019-02-12 Kaer Biotherapeutics Corporation injetor para a geração a partir de um fluido e um gás e método para a geração de um aerossol a partir de um fluido e um gás por meio da operação de um injetor
GB201817868D0 (en) * 2018-11-01 2018-12-19 Nicoventures Trading Ltd Aerosolised formulation
CN111514418B (zh) * 2019-06-12 2022-01-14 中南大学湘雅二医院 一种自吸式经鼻粉末材料给送装置

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3569880D1 (de) * 1984-05-28 1989-06-08 Mallinckrodt Inc Aerosol generator-inhalator
US5209821A (en) * 1985-05-09 1993-05-11 Purdue Research Foundation Apparatus for removing volatiles from, or dehydrating, liquid products
EP0223831B1 (en) * 1985-05-22 1992-07-15 Liposome Technology, Inc. Liposome inhalation method and system
DE4438292C2 (de) * 1994-10-26 1999-07-22 Pari Gmbh Dosisgenaue Aerosolerzeugung für die Inhalationstherapie
GB2321419B (en) * 1997-01-27 2001-02-07 Medic Aid Ltd Atomizer

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10112167A1 (de) * 2001-03-12 2002-10-02 Bionorica Ag Verfahren zur schonenden Gewinnung von Trockenextrakten
DE10112167C2 (de) * 2001-03-12 2003-02-13 Bionorica Ag Verfahren zur schonenden Gewinnung von Trockenextrakten
US6996919B2 (en) 2001-03-12 2006-02-14 Bionorica Ag Process for obtaining dry extracts under mild conditions
WO2003092851A1 (en) * 2002-05-02 2003-11-13 Accentus Plc Preparation of small crystals
US7326294B2 (en) 2002-05-02 2008-02-05 Accentus Plc Preparation of small crystals

Also Published As

Publication number Publication date
WO2000045878A2 (de) 2000-08-10
RU2001124354A (ru) 2003-06-20
KR20010101991A (ko) 2001-11-15
HUP0105445A2 (en) 2002-06-29
SK10942001A3 (sk) 2002-05-09
JP2002538855A (ja) 2002-11-19
PL349885A1 (en) 2002-09-23
EP1148905A2 (de) 2001-10-31
WO2000045878A3 (de) 2000-09-28
CA2361807A1 (en) 2000-08-10
AU3416400A (en) 2000-08-25
CN1338956A (zh) 2002-03-06

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Legal Events

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OP8 Request for examination as to paragraph 44 patent law
8139 Disposal/non-payment of the annual fee