WO2000045878A3 - Druckluftinhalator zur pulmonalen applikation liposomalen pulver-aerosols sowie dafür geeignete pulver-aerosole - Google Patents

Druckluftinhalator zur pulmonalen applikation liposomalen pulver-aerosols sowie dafür geeignete pulver-aerosole Download PDF

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Publication number
WO2000045878A3
WO2000045878A3 PCT/DE2000/000337 DE0000337W WO0045878A3 WO 2000045878 A3 WO2000045878 A3 WO 2000045878A3 DE 0000337 W DE0000337 W DE 0000337W WO 0045878 A3 WO0045878 A3 WO 0045878A3
Authority
WO
WIPO (PCT)
Prior art keywords
liposomes
compressed air
powder aerosols
receptacle
pulmonary application
Prior art date
Application number
PCT/DE2000/000337
Other languages
English (en)
French (fr)
Other versions
WO2000045878A2 (de
Inventor
Julia Eva Diederichs
Wolfgang Koch
Hubert Loedding
Regina Reszka
Horst Windt
Original Assignee
Max Delbrueck Centrum
Fraunhofer Ges Forschung
Julia Eva Diederichs
Wolfgang Koch
Hubert Loedding
Regina Reszka
Horst Windt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Delbrueck Centrum, Fraunhofer Ges Forschung, Julia Eva Diederichs, Wolfgang Koch, Hubert Loedding, Regina Reszka, Horst Windt filed Critical Max Delbrueck Centrum
Priority to EP00912355A priority Critical patent/EP1148905A2/de
Priority to SK1094-2001A priority patent/SK10942001A3/sk
Priority to KR1020017009854A priority patent/KR20010101991A/ko
Priority to AU34164/00A priority patent/AU3416400A/en
Priority to CA002361807A priority patent/CA2361807A1/en
Priority to PL00349885A priority patent/PL349885A1/xx
Priority to JP2000596997A priority patent/JP2002538855A/ja
Publication of WO2000045878A2 publication Critical patent/WO2000045878A2/de
Publication of WO2000045878A3 publication Critical patent/WO2000045878A3/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/0012—Apparatus for achieving spraying before discharge from the apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02—Spray pistols; Apparatus for discharge
    • B05B7/06—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane
    • B05B7/062—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet
    • B05B7/066—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet with an inner liquid outlet surrounded by at least one annular gas outlet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites

Abstract

Die Erfindung betrifft einen Druckluftinhalator zur pulmonalen Applikation eines wirkstofftragenden oder eines unbeladenen liposomalen Pulver-Aerosols. Die Aufgabe der Erfindung, einen Inhalator zur Verfügung zu stellen, mit dem die pulmonale Applikation von insbesondere wirkstoff-tragenden Liposomen ohne forcierte Atemmanöver ermöglicht wird und mit dem der Wirkstoff in ausreichender Menge an den gewünschten Wirkort gebracht werden kann, ohne daß der Wirkstoff austritt, wird dadurch gelöst, daß der Druckluftinhalator zur pulmonalen Applikation eines liposomalen Pulver-Aerosols, ein Behältnis (20) für eine wäßrige Liposomendispersion, in welchem die wirkstoff-tragenden Liposomen in Wasser dispergiert sind, das über eine Flüssigkeitsdosiereinrichtung (19) mit einer Zerstäuberdüse (1) und mit einer Trocknungseinheit (17) wie Vernebelungskammer zur Sprühtrocknung der Liposomen verbunden ist, an die sich ein Ausgang (18) wie Mundstück anschließt, wobei die Zerstäuberdüse (1) getrennte Zuführungen (14, 16) für die Druckluft und die Liposomendispersion aufweist, umfaßt (Fig. 1). Gegenstand der Erfindung ist ferner ein neuartiges Pulver-Aerosol, bestehend aus Liposomen oder Nanopartikeln.
PCT/DE2000/000337 1999-02-03 2000-02-03 Druckluftinhalator zur pulmonalen applikation liposomalen pulver-aerosols sowie dafür geeignete pulver-aerosole WO2000045878A2 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP00912355A EP1148905A2 (de) 1999-02-03 2000-02-03 Druckluftinhalator zur pulmonalen applikation liposomalen pulver-aerosols sowie dafür geeignete pulver-aerosole
SK1094-2001A SK10942001A3 (sk) 1999-02-03 2000-02-03 Inhalátor na stlačený vzduch na pulmonálnu aplikáciu lipozomálnych práškových aerosólov, ako aj iných práškových aerosólov vhodných na tento účel
KR1020017009854A KR20010101991A (ko) 1999-02-03 2000-02-03 리포좀 분말 에어로졸의 폐적용을 위한 압축 공기 흡입기및 그에 적합한 분말 에어로졸
AU34164/00A AU3416400A (en) 1999-02-03 2000-02-03 Compressed air inhaler for pulmonary application of liposomal powder aerosols and powder aerosols suitable therefor
CA002361807A CA2361807A1 (en) 1999-02-03 2000-02-03 Compressed air inhaler for pulmonary application of liposomal powder aerosols and powder aerosols suitable therefor
PL00349885A PL349885A1 (en) 1999-02-03 2000-02-03 Compressed air inhaler for pulmonary application of liposomal powder aerosols and powder aerosols suitable therefor
JP2000596997A JP2002538855A (ja) 1999-02-03 2000-02-03 リポソーム粉末エアロゾルの肺適用のための圧縮空気吸入器及びそのために適した粉末エアロゾル

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19905285 1999-02-03
DE19905285.9 1999-02-03
DE19954107.8 1999-11-02
DE19954107 1999-11-02

Publications (2)

Publication Number Publication Date
WO2000045878A2 WO2000045878A2 (de) 2000-08-10
WO2000045878A3 true WO2000045878A3 (de) 2000-09-28

Family

ID=26051750

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2000/000337 WO2000045878A2 (de) 1999-02-03 2000-02-03 Druckluftinhalator zur pulmonalen applikation liposomalen pulver-aerosols sowie dafür geeignete pulver-aerosole

Country Status (12)

Country Link
EP (1) EP1148905A2 (de)
JP (1) JP2002538855A (de)
KR (1) KR20010101991A (de)
CN (1) CN1338956A (de)
AU (1) AU3416400A (de)
CA (1) CA2361807A1 (de)
DE (1) DE10004860A1 (de)
HU (1) HUP0105445A2 (de)
PL (1) PL349885A1 (de)
RU (1) RU2001124354A (de)
SK (1) SK10942001A3 (de)
WO (1) WO2000045878A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8851069B2 (en) 2004-04-21 2014-10-07 Innovata Biomed Limited Inhaler

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10112167C2 (de) 2001-03-12 2003-02-13 Bionorica Ag Verfahren zur schonenden Gewinnung von Trockenextrakten
US6900317B2 (en) 2002-02-19 2005-05-31 Boehringer Ingelheim Pharma Gmbh & Co. Kg Salts of the CGRP antagonist BIBN4096 and inhalable powdered medicaments containing them
GB0219815D0 (en) * 2002-08-24 2002-10-02 Accentus Plc Preparation of small crystals
US6883517B2 (en) * 2002-09-30 2005-04-26 Asaf Halamish Downdraft nebulizer
US7459146B2 (en) * 2003-05-30 2008-12-02 3M Innovative Properties Company Stabilized aerosol dispersions
KR100682334B1 (ko) * 2006-07-14 2007-02-16 (주)지에프씨 미립상 레시틴 왁스 조성물 제조장치
AU2010218750A1 (en) * 2009-02-26 2010-09-02 Acp Japan Co., Ltd. Gas mist inhaler
BR112013032558B1 (pt) 2011-09-06 2021-01-12 British American Tobacco (Investments) Limited aparelho para aquecer material fumável
WO2013065776A1 (ja) * 2011-11-04 2013-05-10 日本エー・シー・ピー株式会社 ガスミスト吸入器
KR101313993B1 (ko) * 2012-07-24 2013-10-01 한국화학연구원 약물 흡입 장치
KR101373981B1 (ko) * 2012-07-24 2014-03-12 한국화학연구원 약물 흡입 장치
GB201217067D0 (en) 2012-09-25 2012-11-07 British American Tobacco Co Heating smokable material
GB201311620D0 (en) 2013-06-28 2013-08-14 British American Tobacco Co Devices Comprising a Heat Source Material and Activation Chambers for the Same
GB201500582D0 (en) 2015-01-14 2015-02-25 British American Tobacco Co Apparatus for heating or cooling a material contained therein
GB201415381D0 (en) * 2014-08-29 2014-10-15 Algipharma As Inhalable powder formulations of alginate oligomers
US20170055584A1 (en) 2015-08-31 2017-03-02 British American Tobacco (Investments) Limited Article for use with apparatus for heating smokable material
US11924930B2 (en) 2015-08-31 2024-03-05 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US20170055575A1 (en) 2015-08-31 2017-03-02 British American Tobacco (Investments) Limited Material for use with apparatus for heating smokable material
US20170119046A1 (en) 2015-10-30 2017-05-04 British American Tobacco (Investments) Limited Apparatus for Heating Smokable Material
US20170119047A1 (en) 2015-10-30 2017-05-04 British American Tobacco (Investments) Limited Article for Use with Apparatus for Heating Smokable Material
JP6743280B2 (ja) * 2016-04-15 2020-08-19 ケーエーイーアール バイオセラピューティックス コーポレーション エアロゾル化ノズル及びエアロゾル化ノズルの操作方法
GB201817868D0 (en) * 2018-11-01 2018-12-19 Nicoventures Trading Ltd Aerosolised formulation
CN111514418B (zh) * 2019-06-12 2022-01-14 中南大学湘雅二医院 一种自吸式经鼻粉末材料给送装置

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0166476A2 (de) * 1984-05-28 1986-01-02 MALLINCKRODT, INC.(a Missouri corporation) Inhaliergerät mit einem Aerosolgenerator
EP0223831B1 (de) * 1985-05-22 1992-07-15 Liposome Technology, Inc. Verfahren und system zum einatmen von liposomen
US5209821A (en) * 1985-05-09 1993-05-11 Purdue Research Foundation Apparatus for removing volatiles from, or dehydrating, liquid products
GB2294401A (en) * 1994-10-26 1996-05-01 Ritzau Pari Werk Gmbh Paul Apparatus for generating an exact dose of aerosol
EP0855224A2 (de) * 1997-01-27 1998-07-29 Medic-Aid Limited Zerstäuber

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0166476A2 (de) * 1984-05-28 1986-01-02 MALLINCKRODT, INC.(a Missouri corporation) Inhaliergerät mit einem Aerosolgenerator
US5209821A (en) * 1985-05-09 1993-05-11 Purdue Research Foundation Apparatus for removing volatiles from, or dehydrating, liquid products
EP0223831B1 (de) * 1985-05-22 1992-07-15 Liposome Technology, Inc. Verfahren und system zum einatmen von liposomen
GB2294401A (en) * 1994-10-26 1996-05-01 Ritzau Pari Werk Gmbh Paul Apparatus for generating an exact dose of aerosol
EP0855224A2 (de) * 1997-01-27 1998-07-29 Medic-Aid Limited Zerstäuber

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8851069B2 (en) 2004-04-21 2014-10-07 Innovata Biomed Limited Inhaler

Also Published As

Publication number Publication date
KR20010101991A (ko) 2001-11-15
SK10942001A3 (sk) 2002-05-09
CN1338956A (zh) 2002-03-06
DE10004860A1 (de) 2000-10-05
HUP0105445A2 (en) 2002-06-29
CA2361807A1 (en) 2000-08-10
WO2000045878A2 (de) 2000-08-10
AU3416400A (en) 2000-08-25
PL349885A1 (en) 2002-09-23
JP2002538855A (ja) 2002-11-19
EP1148905A2 (de) 2001-10-31
RU2001124354A (ru) 2003-06-20

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