DD217807A5 - Verfahren zur herstellung neuer substituierter tetrapeptide - Google Patents

Verfahren zur herstellung neuer substituierter tetrapeptide Download PDF

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Publication number
DD217807A5
DD217807A5 DD83257401A DD25740183A DD217807A5 DD 217807 A5 DD217807 A5 DD 217807A5 DD 83257401 A DD83257401 A DD 83257401A DD 25740183 A DD25740183 A DD 25740183A DD 217807 A5 DD217807 A5 DD 217807A5
Authority
DD
German Democratic Republic
Prior art keywords
compound
salt
pro
sta
phe
Prior art date
Application number
DD83257401A
Other languages
German (de)
English (en)
Inventor
Bernhard Riniker
Peter Buehlmayer
Walter Fuhrer
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DD217807A5 publication Critical patent/DD217807A5/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02Linear peptides containing at least one abnormal peptide link
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/14Angiotensins: Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86Renin inhibitors

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DD83257401A 1982-12-03 1983-12-01 Verfahren zur herstellung neuer substituierter tetrapeptide DD217807A5 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH704782 1982-12-03
CH363583 1983-07-01

Publications (1)

Publication Number Publication Date
DD217807A5 true DD217807A5 (de) 1985-01-23

Family

ID=25693492

Family Applications (1)

Application Number Title Priority Date Filing Date
DD83257401A DD217807A5 (de) 1982-12-03 1983-12-01 Verfahren zur herstellung neuer substituierter tetrapeptide

Country Status (11)

Country Link
US (1) US4595677A (fr)
EP (1) EP0111266A3 (fr)
AU (1) AU2193783A (fr)
DD (1) DD217807A5 (fr)
DK (1) DK555983A (fr)
ES (2) ES8606394A1 (fr)
FI (1) FI834345A (fr)
GR (1) GR79104B (fr)
IL (1) IL70365A0 (fr)
NO (1) NO834441L (fr)
PT (1) PT77761B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751299A (en) * 1983-11-18 1988-06-14 Takeda Chemical Industries, Ltd. Optically active β-lactams and method of their production
DK110285A (da) * 1984-03-12 1985-09-13 Pfizer Polypeptider og polypeptidderivater indeholdende statin eller derivater deraf og farmaceutiske praeparater
US4636491A (en) * 1984-03-27 1987-01-13 Merck & Co., Inc. Renin inhibitory peptides having improved solubility
EP0163237A3 (fr) * 1984-05-29 1988-04-27 Merck & Co. Inc. Inhibiteurs di- et tri-peptidiques de la rénine
US4880781A (en) * 1984-08-06 1989-11-14 The Upjohn Company Renin inhibitory peptides containing an N-alkyl-histidine moiety
EP0181110A3 (fr) * 1984-10-22 1988-05-11 Kissei Pharmaceutical Co. Ltd. Dérivés d'histidine comme inhibiteurs de la rénine
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives
EP0184855A3 (fr) * 1984-12-14 1989-05-03 Abbott Laboratories Composés inhibiteurs de rénine
PT82077B (fr) * 1985-02-26 1987-09-25 Sanofi Sa Procede pour l'obtention des derives aminoalcools peptidiques inhibiteurs de la renine et des proteases acides
FR2585708B1 (fr) * 1985-07-31 1989-07-07 Sanofi Sa Derives aminoalcools peptidiques inhibiteurs de la resine et des proteases acides, leur procede de preparation et leur application en therapeutique
DE3512128A1 (de) * 1985-04-03 1986-10-09 Merck Patent Gmbh, 6100 Darmstadt Peptide
WO1986006379A1 (fr) 1985-04-19 1986-11-06 The Upjohn Company Inhibiteurs de renine a substitution dihalo-statine
US4882420A (en) * 1985-04-19 1989-11-21 The Upjohn Company Dihalo-statine substituted renin inhibitors
DE3514695C2 (de) * 1985-04-24 1994-05-11 Merck Patent Gmbh Mittel und Verfahren zur Bestimmung von Calcium
EP0206807A3 (fr) * 1985-06-28 1988-01-20 Kissei Pharmaceutical Co. Ltd. Dérivés d'amino-acides
CA1290097C (fr) * 1985-07-24 1991-10-01 Merck & Co., Inc. Inhibiteurs d'enzymes de type peptide
US4853463A (en) * 1985-09-04 1989-08-01 Kissei Pharmaceutical Co., Ltd. Amino acid derivatives
JPS6256458A (ja) * 1985-09-04 1987-03-12 Kissei Pharmaceut Co Ltd 新規なアミノ酸誘導体
DE3538749A1 (de) * 1985-10-31 1987-05-07 Merck Patent Gmbh Peptide
US4894437A (en) * 1985-11-15 1990-01-16 The Upjohn Company Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
US4705846A (en) * 1986-03-27 1987-11-10 The Upjohn Company Novel renin inhibiting peptides having a gamma lactam pseudo dipeptide insert
JPS6322081A (ja) * 1986-07-11 1988-01-29 Kissei Pharmaceut Co Ltd 新規なアミノ酸誘導体
EP0321497A1 (fr) * 1986-09-30 1989-06-28 The Upjohn Company Peptides inhibiteurs de la rennine presentant des parties nouvelles a terminaison en c
US4743585A (en) * 1986-11-21 1988-05-10 Warner-Lambert Company Renin inhibitors
US4804743A (en) * 1987-01-29 1989-02-14 Warner-Lambert Copmany Proline-containing renin inhibitors
ATE131066T1 (de) * 1989-02-10 1995-12-15 Wolfgang Schramm Mittel zur hemmung von hiv-proteasen.
CA2359030A1 (fr) * 1999-01-28 2000-08-03 Chugai Seiyaku Kabushiki Kaisha Derives phenethylamine substitues

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH14681A (en) * 1977-11-30 1981-11-10 Pfizer Phenylglycinamides useful in the treatment of ischaemic heart disease
NO812612L (no) * 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
US4478826A (en) * 1981-10-08 1984-10-23 Merck & Co., Inc. Renin inhibitory peptides
US4384994A (en) * 1981-10-08 1983-05-24 Merck & Co., Inc. Renin inhibitory peptides
CA1258748A (fr) * 1981-10-08 1989-08-22 Daniel F. Veber Peptides inhibiteurs de la renine
US4470971A (en) * 1981-10-19 1984-09-11 Merck & Co., Inc. Renin inhibitory peptides having His13
US4479941A (en) * 1981-12-10 1984-10-30 Merck & Co., Inc. Renin inhibitory peptides having PHE13 delection
CA1245217A (fr) * 1981-12-10 1988-11-22 Joshua S. Boger Peptides inhibiteurs de la renine
FR2531951A1 (fr) * 1982-08-17 1984-02-24 Sanofi Sa Derives peptidiques inhibiteurs de proteases acides, procede pour leur preparation et medicaments qui en contiennent
EP0104041B1 (fr) * 1982-09-15 1988-07-27 Aktiebolaget Hässle Inhibiteurs d'enzyme
US4485099A (en) * 1983-06-15 1984-11-27 Merck & Co., Inc. Renin inhibitors containing a C-terminal amide cycle

Also Published As

Publication number Publication date
DK555983A (da) 1984-06-04
ES527714A0 (es) 1986-04-01
IL70365A0 (en) 1984-03-30
FI834345A (fi) 1984-06-04
PT77761B (en) 1986-05-30
GR79104B (fr) 1984-10-02
EP0111266A2 (fr) 1984-06-20
EP0111266A3 (fr) 1987-05-27
ES543488A0 (es) 1987-01-01
DK555983D0 (da) 1983-12-02
US4595677A (en) 1986-06-17
ES8606394A1 (es) 1986-04-01
FI834345A0 (fi) 1983-11-28
ES8702437A1 (es) 1987-01-01
NO834441L (no) 1984-06-04
AU2193783A (en) 1984-06-07
PT77761A (en) 1983-12-01

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