ES8606394A1 - Procedimiento para la obtencion de tetrapeptidos sustituidos - Google Patents

Procedimiento para la obtencion de tetrapeptidos sustituidos

Info

Publication number
ES8606394A1
ES8606394A1 ES527714A ES527714A ES8606394A1 ES 8606394 A1 ES8606394 A1 ES 8606394A1 ES 527714 A ES527714 A ES 527714A ES 527714 A ES527714 A ES 527714A ES 8606394 A1 ES8606394 A1 ES 8606394A1
Authority
ES
Spain
Prior art keywords
free
tetrapeptides
substituted
compounds
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES527714A
Other languages
English (en)
Other versions
ES527714A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8606394A1 publication Critical patent/ES8606394A1/es
Publication of ES527714A0 publication Critical patent/ES527714A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/14—Angiotensins: Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE TETRAPEPTIDOS SUSTITUIDOS. CONSISTE EN CONDENSAR UNA FRACCION DE UN COMPUESTO DE FORMULA (I) DONDE R1 ES H O ACILO, R2 ES ALQUILO O ARALQUILO, R3 ES HIDROXI LIBRE O FUNCIONALMENTE MODIFICADO, R4 ES AMINO LIBRE O SUSTITUIDO O HIDROXI LIBRE O ETERIFICADO, Y -PRO-, -PHE-, ASI COMO -HIS- SON LOS RESTOS DIVALENTES DE LOS AMINOACIDOS PROLINA, FENILALANINA, RESPECTIVAMENTE HISTIDINA, CON UN GRUPO CARBOXI O UN ESTER ACTIVADO DERIVADO DEL MISMO, ANHIDRIDO REACTIVO O AMIDA CICLICA REACTIVA CON UNA FRACCION COMPLEMENTARIA DEL COMPUESTO DE FORMULA (I) CON UN GRUPO AMINO LIBRE, EN PRESENCIA DE UN AGENTE DE CONDENSACION ELEGIDO DEL GRUPO FORMADO POR CARBODIIMIDA, CARBONILDIIMIDAZOL Y OTROS, EN PRESENCIA DE UNA BASE ORGANICA O DE CARBONATOS DE METAL ALCALINO, EN UN DISOLVENTE, Y A TEMPERATURA ENTRE C30JC Y 200JC.
ES527714A 1982-12-03 1983-12-01 Procedimiento para la obtencion de tetrapeptidos sustituidos Expired ES8606394A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH704782 1982-12-03
CH363583 1983-07-01

Publications (2)

Publication Number Publication Date
ES8606394A1 true ES8606394A1 (es) 1986-04-01
ES527714A0 ES527714A0 (es) 1986-04-01

Family

ID=25693492

Family Applications (2)

Application Number Title Priority Date Filing Date
ES527714A Expired ES8606394A1 (es) 1982-12-03 1983-12-01 Procedimiento para la obtencion de tetrapeptidos sustituidos
ES543488A Expired ES8702437A1 (es) 1982-12-03 1985-05-24 Procedimiento para la obtencion de tetrapeptidos sustituidos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES543488A Expired ES8702437A1 (es) 1982-12-03 1985-05-24 Procedimiento para la obtencion de tetrapeptidos sustituidos

Country Status (11)

Country Link
US (1) US4595677A (es)
EP (1) EP0111266A3 (es)
AU (1) AU2193783A (es)
DD (1) DD217807A5 (es)
DK (1) DK555983A (es)
ES (2) ES8606394A1 (es)
FI (1) FI834345A (es)
GR (1) GR79104B (es)
IL (1) IL70365A0 (es)
NO (1) NO834441L (es)
PT (1) PT77761B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751299A (en) * 1983-11-18 1988-06-14 Takeda Chemical Industries, Ltd. Optically active β-lactams and method of their production
CA1254699A (en) * 1984-03-12 1989-05-23 Jasjit S. Bindra Renin inhibitors containing statine or derivatives thereof
US4636491A (en) * 1984-03-27 1987-01-13 Merck & Co., Inc. Renin inhibitory peptides having improved solubility
EP0163237A3 (en) * 1984-05-29 1988-04-27 Merck & Co. Inc. Di- and tri-peptidal renin inhibitors
US4880781A (en) * 1984-08-06 1989-11-14 The Upjohn Company Renin inhibitory peptides containing an N-alkyl-histidine moiety
EP0181110A3 (en) * 1984-10-22 1988-05-11 Kissei Pharmaceutical Co. Ltd. Histidine derivatives as renin inhibitors
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives
EP0184855A3 (en) * 1984-12-14 1989-05-03 Abbott Laboratories Resin inhibiting compounds
PT82077B (fr) * 1985-02-26 1987-09-25 Sanofi Sa Procede pour l'obtention des derives aminoalcools peptidiques inhibiteurs de la renine et des proteases acides
FR2585708B1 (fr) * 1985-07-31 1989-07-07 Sanofi Sa Derives aminoalcools peptidiques inhibiteurs de la resine et des proteases acides, leur procede de preparation et leur application en therapeutique
DE3512128A1 (de) * 1985-04-03 1986-10-09 Merck Patent Gmbh, 6100 Darmstadt Peptide
WO1986006379A1 (en) 1985-04-19 1986-11-06 The Upjohn Company Dihalo-statine substituted renin inhibitors
US4882420A (en) * 1985-04-19 1989-11-21 The Upjohn Company Dihalo-statine substituted renin inhibitors
DE3514695C2 (de) * 1985-04-24 1994-05-11 Merck Patent Gmbh Mittel und Verfahren zur Bestimmung von Calcium
EP0206807A3 (en) * 1985-06-28 1988-01-20 Kissei Pharmaceutical Co. Ltd. Novel amino acid derivatives
CA1290097C (en) * 1985-07-24 1991-10-01 Merck & Co., Inc. Peptide enzyme inhibitors
US4853463A (en) * 1985-09-04 1989-08-01 Kissei Pharmaceutical Co., Ltd. Amino acid derivatives
JPS6256458A (ja) * 1985-09-04 1987-03-12 Kissei Pharmaceut Co Ltd 新規なアミノ酸誘導体
DE3538749A1 (de) * 1985-10-31 1987-05-07 Merck Patent Gmbh Peptide
US4894437A (en) * 1985-11-15 1990-01-16 The Upjohn Company Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties
US4705846A (en) * 1986-03-27 1987-11-10 The Upjohn Company Novel renin inhibiting peptides having a gamma lactam pseudo dipeptide insert
JPS6322081A (ja) * 1986-07-11 1988-01-29 Kissei Pharmaceut Co Ltd 新規なアミノ酸誘導体
WO1988002374A2 (en) * 1986-09-30 1988-04-07 The Upjohn Company Renin inhibitory peptides having novel c-terminal moieties
US4743585A (en) * 1986-11-21 1988-05-10 Warner-Lambert Company Renin inhibitors
US4804743A (en) * 1987-01-29 1989-02-14 Warner-Lambert Copmany Proline-containing renin inhibitors
EP0409962B1 (de) * 1989-02-10 1995-12-06 SCHRAMM, Wolfgang Mittel zur hemmung von hiv-proteasen
US7553969B1 (en) * 1999-01-28 2009-06-30 Chugai Seiyaku Kabushiki Kaisha Substituted phenethylamine derivatives

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH14681A (en) * 1977-11-30 1981-11-10 Pfizer Phenylglycinamides useful in the treatment of ischaemic heart disease
NO812612L (no) * 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
CA1258748A (en) * 1981-10-08 1989-08-22 Daniel F. Veber Renin inhibitory peptides
US4384994A (en) * 1981-10-08 1983-05-24 Merck & Co., Inc. Renin inhibitory peptides
US4478826A (en) * 1981-10-08 1984-10-23 Merck & Co., Inc. Renin inhibitory peptides
US4470971A (en) * 1981-10-19 1984-09-11 Merck & Co., Inc. Renin inhibitory peptides having His13
US4479941A (en) * 1981-12-10 1984-10-30 Merck & Co., Inc. Renin inhibitory peptides having PHE13 delection
CA1245217A (en) * 1981-12-10 1988-11-22 Joshua S. Boger Renin inhibitory peptides having phe su13 xx deletion
FR2531951A1 (fr) * 1982-08-17 1984-02-24 Sanofi Sa Derives peptidiques inhibiteurs de proteases acides, procede pour leur preparation et medicaments qui en contiennent
DE3377497D1 (en) * 1982-09-15 1988-09-01 Haessle Ab Enzyme inhibitors
US4485099A (en) * 1983-06-15 1984-11-27 Merck & Co., Inc. Renin inhibitors containing a C-terminal amide cycle

Also Published As

Publication number Publication date
DK555983A (da) 1984-06-04
FI834345A (fi) 1984-06-04
DD217807A5 (de) 1985-01-23
EP0111266A3 (de) 1987-05-27
GR79104B (es) 1984-10-02
ES8702437A1 (es) 1987-01-01
ES543488A0 (es) 1987-01-01
FI834345A0 (fi) 1983-11-28
NO834441L (no) 1984-06-04
AU2193783A (en) 1984-06-07
ES527714A0 (es) 1986-04-01
US4595677A (en) 1986-06-17
PT77761A (en) 1983-12-01
DK555983D0 (da) 1983-12-02
PT77761B (en) 1986-05-30
EP0111266A2 (de) 1984-06-20
IL70365A0 (en) 1984-03-30

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