DD209478A5 - Testsystem und verfahren zur bestimmung von substanzen in fluessigkeiten - Google Patents
Testsystem und verfahren zur bestimmung von substanzen in fluessigkeiten Download PDFInfo
- Publication number
- DD209478A5 DD209478A5 DD83249136A DD24913683A DD209478A5 DD 209478 A5 DD209478 A5 DD 209478A5 DD 83249136 A DD83249136 A DD 83249136A DD 24913683 A DD24913683 A DD 24913683A DD 209478 A5 DD209478 A5 DD 209478A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- test system
- glucose
- enzyme
- determination
- dehydrogenase
- Prior art date
Links
- 238000012360 testing method Methods 0.000 title claims abstract description 28
- 239000000126 substance Substances 0.000 title claims abstract description 21
- 238000000034 method Methods 0.000 title claims abstract description 15
- 239000007788 liquid Substances 0.000 title claims abstract description 8
- 102000004190 Enzymes Human genes 0.000 claims description 44
- 108090000790 Enzymes Proteins 0.000 claims description 44
- 229940088598 enzyme Drugs 0.000 claims description 44
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 claims description 24
- 229950006238 nadide Drugs 0.000 claims description 24
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 19
- 239000008103 glucose Substances 0.000 claims description 19
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 claims description 18
- 108010015776 Glucose oxidase Proteins 0.000 claims description 9
- 239000004366 Glucose oxidase Substances 0.000 claims description 9
- 239000005515 coenzyme Substances 0.000 claims description 9
- 229940116332 glucose oxidase Drugs 0.000 claims description 9
- 235000019420 glucose oxidase Nutrition 0.000 claims description 9
- 238000005259 measurement Methods 0.000 claims description 9
- 102000003992 Peroxidases Human genes 0.000 claims description 6
- 239000007795 chemical reaction product Substances 0.000 claims description 6
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims description 5
- 101710088194 Dehydrogenase Proteins 0.000 claims description 4
- 239000012488 sample solution Substances 0.000 claims description 4
- 241000194107 Bacillus megaterium Species 0.000 claims description 3
- 125000003831 tetrazolyl group Chemical group 0.000 claims description 3
- 241000588624 Acinetobacter calcoaceticus Species 0.000 claims description 2
- 108020005199 Dehydrogenases Proteins 0.000 claims description 2
- 108010046301 glucose peroxidase Proteins 0.000 claims description 2
- 239000000370 acceptor Substances 0.000 claims 2
- XJLXINKUBYWONI-NNYOXOHSSA-N NADP zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-NNYOXOHSSA-N 0.000 claims 1
- 235000001727 glucose Nutrition 0.000 description 19
- 238000006243 chemical reaction Methods 0.000 description 18
- 230000001419 dependent effect Effects 0.000 description 9
- FBWADIKARMIWNM-UHFFFAOYSA-N N-3,5-dichloro-4-hydroxyphenyl-1,4-benzoquinone imine Chemical compound C1=C(Cl)C(O)=C(Cl)C=C1N=C1C=CC(=O)C=C1 FBWADIKARMIWNM-UHFFFAOYSA-N 0.000 description 8
- 230000008878 coupling Effects 0.000 description 8
- 238000010168 coupling process Methods 0.000 description 8
- 238000005859 coupling reaction Methods 0.000 description 8
- 239000011541 reaction mixture Substances 0.000 description 7
- 238000013459 approach Methods 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 230000001575 pathological effect Effects 0.000 description 5
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 238000006911 enzymatic reaction Methods 0.000 description 4
- 108040007629 peroxidase activity proteins Proteins 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 4
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 3
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 3
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 238000007357 dehydrogenase reaction Methods 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 238000011197 physicochemical method Methods 0.000 description 2
- 150000004053 quinones Chemical class 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 239000012898 sample dilution Substances 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- WNMXBIHCTDWWGR-BTVCFUMJSA-N 2,3-dihydroxypropyl dihydrogen phosphate (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal Chemical compound OCC(O)COP(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O WNMXBIHCTDWWGR-BTVCFUMJSA-N 0.000 description 1
- QITPSLQLANKSGE-UHFFFAOYSA-N 2-aminoacetic acid;2-hydroxypropanoic acid Chemical compound NCC(O)=O.CC(O)C(O)=O QITPSLQLANKSGE-UHFFFAOYSA-N 0.000 description 1
- 125000006306 4-iodophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1I 0.000 description 1
- VDJKJPMLWJWQIH-UHFFFAOYSA-M 5-ethylphenazin-5-ium;ethyl sulfate Chemical compound CCOS([O-])(=O)=O.C1=CC=C2[N+](CC)=C(C=CC=C3)C3=NC2=C1 VDJKJPMLWJWQIH-UHFFFAOYSA-M 0.000 description 1
- RXGJTUSBYWCRBK-UHFFFAOYSA-M 5-methylphenazinium methyl sulfate Chemical compound COS([O-])(=O)=O.C1=CC=C2[N+](C)=C(C=CC=C3)C3=NC2=C1 RXGJTUSBYWCRBK-UHFFFAOYSA-M 0.000 description 1
- 102100031126 6-phosphogluconolactonase Human genes 0.000 description 1
- 108010029731 6-phosphogluconolactonase Proteins 0.000 description 1
- MBAJNQDWJUHYOF-UHFFFAOYSA-N 7h-purin-6-amine;pyridine-3-carboxamide Chemical compound NC(=O)C1=CC=CN=C1.NC1=NC=NC2=C1NC=N2 MBAJNQDWJUHYOF-UHFFFAOYSA-N 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 101000950981 Bacillus subtilis (strain 168) Catabolic NAD-specific glutamate dehydrogenase RocG Proteins 0.000 description 1
- 102000018832 Cytochromes Human genes 0.000 description 1
- 108010052832 Cytochromes Proteins 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 description 1
- 102000016901 Glutamate dehydrogenase Human genes 0.000 description 1
- 102000057621 Glycerol kinases Human genes 0.000 description 1
- 102000005548 Hexokinase Human genes 0.000 description 1
- 108700040460 Hexokinases Proteins 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 101710163410 Probable glycerol kinase Proteins 0.000 description 1
- 241000589774 Pseudomonas sp. Species 0.000 description 1
- 108010046334 Urease Proteins 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 150000004054 benzoquinones Chemical class 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 150000002211 flavins Chemical class 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 229940020947 fluorescein sodium Drugs 0.000 description 1
- 150000002304 glucoses Chemical class 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- UETZVSHORCDDTH-UHFFFAOYSA-N iron(2+);hexacyanide Chemical compound [Fe+2].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] UETZVSHORCDDTH-UHFFFAOYSA-N 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 1
- 229960000907 methylthioninium chloride Drugs 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 238000006395 oxidase reaction Methods 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/805—Test papers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Emergency Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823211167 DE3211167A1 (de) | 1982-03-26 | 1982-03-26 | Testsystem und verfahren zur bestimmung von substanzen in fluessigkeiten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD209478A5 true DD209478A5 (de) | 1984-05-09 |
Family
ID=6159381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD83249136A DD209478A5 (de) | 1982-03-26 | 1983-03-24 | Testsystem und verfahren zur bestimmung von substanzen in fluessigkeiten |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4490465A (cs) |
| EP (1) | EP0090223B1 (cs) |
| JP (1) | JPS58175498A (cs) |
| CS (1) | CS250227B2 (cs) |
| DD (1) | DD209478A5 (cs) |
| DE (2) | DE3211167A1 (cs) |
| IL (1) | IL68198A (cs) |
| ZA (1) | ZA832105B (cs) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3247894A1 (de) * | 1982-12-24 | 1984-06-28 | Merck Patent Gmbh, 6100 Darmstadt | Testsystem und verfahren zur bestimmung von nad(p)h |
| US4923800A (en) * | 1984-01-10 | 1990-05-08 | Ly Uy Vu | Instrumentless quantitative analysis system |
| US4654310A (en) * | 1984-01-10 | 1987-03-31 | Ly Uy Vu | Instrumentless quantitative analysis system |
| US4746607A (en) * | 1985-02-07 | 1988-05-24 | Eastman Kodak Company | Use of substituted quinone electron transfer agents in analytical determinations |
| US4649121A (en) * | 1985-02-26 | 1987-03-10 | Miles Laboratories, Inc. | Viability test device |
| US4772550A (en) * | 1986-02-10 | 1988-09-20 | Miles Inc. | Heterogeneous specific binding assay employing an aggregatable binding reagent |
| US5220035A (en) * | 1986-04-04 | 1993-06-15 | Miles Inc. | Dithiol-(2-nitrobenzoate) indicators |
| CA1295216C (en) * | 1986-04-04 | 1992-02-04 | James P. Albarella | Rainbow test device |
| US4898813A (en) * | 1986-04-04 | 1990-02-06 | Albarella James P | Catalytic test composition intended to produce a range of colors |
| US4975367A (en) * | 1986-04-04 | 1990-12-04 | Miles Inc. | Catalytic test composition intended to produce a range of colors |
| US4812400A (en) * | 1986-07-14 | 1989-03-14 | Steinman Gary D | Process for measuring sodium levels in biological fluids |
| US4814142A (en) * | 1987-05-22 | 1989-03-21 | Polymer Technology International Corp. | Test strip having a non-particulate dialyzed polymer layer |
| US5037738A (en) * | 1987-06-03 | 1991-08-06 | Abbott Laboratories | Simultaneous assay for glucose and urea |
| US4855228A (en) * | 1987-09-11 | 1989-08-08 | Miles Inc. | Multiple oxidative indicator system for visual determination of hydrogen peroxide |
| US5200325A (en) * | 1988-02-10 | 1993-04-06 | Miles Inc. | Self-indicating analysis employing stoichiometric chemical subtraction |
| JP2811319B2 (ja) * | 1989-04-18 | 1998-10-15 | 旭化成工業株式会社 | 胆汁酸の高感度測定法および測定用組成物 |
| US5334507A (en) * | 1991-09-20 | 1994-08-02 | Toyo Boseki Kabushiki Kaisha | Composition for measurement of potassium ion concentration and composition for elimination of ammonium ions |
| DE4215275A1 (de) * | 1992-05-09 | 1993-11-11 | Merck Patent Gmbh | Mittel und Verfahren zur Behandlung von Körperflüssigkeiten bei der Bestimmung von Neopterin |
| JPH06153991A (ja) * | 1992-11-18 | 1994-06-03 | Unitika Ltd | ホスファターゼ測定試薬 |
| US5416004A (en) * | 1993-01-19 | 1995-05-16 | Detwiler; Richard L. | Multilayer analytical element containing primary amine buffer and method for the determination of ethanol |
| EP1579814A3 (en) | 1996-05-17 | 2006-06-14 | Roche Diagnostics Operations, Inc. | Methods and apparatus for sampling and analyzing body fluid |
| US20020010406A1 (en) | 1996-05-17 | 2002-01-24 | Douglas Joel S. | Methods and apparatus for expressing body fluid from an incision |
| US5824491A (en) * | 1996-05-17 | 1998-10-20 | Mercury Diagnostics, Inc. | Dry reagent test strip comprising benzidine dye precursor and antipyrine compound |
| WO2002100278A1 (en) * | 2001-06-08 | 2002-12-19 | Roche Diagnostics Gmbh | Sampling devices and methods utilizing a horizontal capillary test strip |
| WO2002100274A1 (en) | 2001-06-08 | 2002-12-19 | Hoffmann-La Roche Ag | Bodily fluid sampling device and test media cassette to be used with such a device |
| US7731900B2 (en) | 2002-11-26 | 2010-06-08 | Roche Diagnostics Operations, Inc. | Body fluid testing device |
| US7244264B2 (en) | 2002-12-03 | 2007-07-17 | Roche Diagnostics Operations, Inc. | Dual blade lancing test strip |
| WO2004056269A1 (en) | 2002-12-23 | 2004-07-08 | Roche Diagnostics Gmbh | Body fluid testing device |
| US7582258B2 (en) | 2002-12-23 | 2009-09-01 | Roche Diagnostics Operations, Inc. | Body fluid testing device |
| US20040127818A1 (en) * | 2002-12-27 | 2004-07-01 | Roe Steven N. | Precision depth control lancing tip |
| DE60329712D1 (de) | 2002-12-30 | 2009-11-26 | Hoffmann La Roche | Blutaquisitionssuspensionssystem |
| US7214200B2 (en) | 2002-12-30 | 2007-05-08 | Roche Diagnostics Operations, Inc. | Integrated analytical test element |
| EP1581114B1 (en) | 2002-12-30 | 2014-04-30 | Roche Diagnostics GmbH | Flexible test strip lancet device |
| ATE537752T1 (de) * | 2003-01-29 | 2012-01-15 | Hoffmann La Roche | Integrierter lanzetten-teststreifen |
| US7909776B2 (en) | 2004-04-30 | 2011-03-22 | Roche Diagnostics Operations, Inc. | Lancets for bodily fluid sampling supplied on a tape |
| US7322942B2 (en) | 2004-05-07 | 2008-01-29 | Roche Diagnostics Operations, Inc. | Integrated disposable for automatic or manual blood dosing |
| US7488298B2 (en) | 2004-10-08 | 2009-02-10 | Roche Diagnostics Operations, Inc. | Integrated lancing test strip with capillary transfer sheet |
| EP1870046A1 (de) * | 2006-06-22 | 2007-12-26 | Roche Diagnostics GmbH | Biegeweiche Vorrichtung zum Einbringen einer medizinischen Vorrichtung in den Körper |
| ATE534328T1 (de) * | 2007-05-29 | 2011-12-15 | Hoffmann La Roche | Flexible lanzette in einem lanzettensystem |
| WO2012028697A1 (en) | 2010-09-01 | 2012-03-08 | Eth Zürich, Institute Of Molecular Biology And Biophysics | Affinity purification system based on donor strand complementation |
| US9845474B2 (en) | 2012-10-24 | 2017-12-19 | Calysta, Inc. | Engineering of multi-carbon substrate utilization pathways in methanotrophic bacteria |
| WO2021167011A1 (ja) * | 2020-02-21 | 2021-08-26 | キッコーマン株式会社 | 検体の状態を評価するためのデバイス、それを含むシステム、検体の状態を評価する方法及びそれに用いる乳酸デヒドロゲナーゼ |
| US20230365959A1 (en) * | 2020-09-29 | 2023-11-16 | Kikkoman Corporation | Method for improving the stability of a composition comprising a flavin-dependent lactate dehydrogenase |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE142973C (cs) * | ||||
| DE143180C (cs) * | ||||
| SE173761C1 (cs) * | 1956-11-07 | 1960-12-20 | ||
| JPS4940192A (cs) * | 1972-08-17 | 1974-04-15 | ||
| CA1056746A (en) * | 1974-09-06 | 1979-06-19 | Chung J. Lai | Biologically active membrane material |
| US4056442A (en) * | 1976-06-01 | 1977-11-01 | The Dow Chemical Company | Lipase composition for glycerol ester determination |
| US4120755A (en) * | 1977-04-28 | 1978-10-17 | Beckman Instruments, Inc. | Kinetic method for determination of glucose concentrations with glucose dehydrogenase |
| SU905787A1 (ru) * | 1978-07-31 | 1982-02-15 | Иркутский Государственный Медицинский Институт | Способ определени аденозинтрифосфорной кислоты в крови |
| DE2905708A1 (de) * | 1979-02-15 | 1980-08-28 | Vitatron Scientific Bv | Verfahren zur photometrischen bestimmung von zwei oder mehr bestandteilen einer fluessigkeitsprobe sowie reagenzsatz zur durchfuehrung dieser photometrischen bestimmung |
| US4259440A (en) * | 1979-05-21 | 1981-03-31 | Miles Laboratories, Inc. | Hydrolysis and assay of triglycerides |
| SU857874A1 (ru) * | 1979-07-23 | 1981-08-23 | Ордена Ленина Институт Химической Физики Ан Ссср | Способ количественного определени глюкозы |
| DE2950381A1 (de) * | 1979-12-14 | 1981-06-19 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und reagens zur bestimmulng von triglyceriden |
| US4309502A (en) * | 1980-06-30 | 1982-01-05 | Beckman Instruments, Inc. | Enzymatic assay for glycerol and triglycerides and a reagent for use therein |
| US4340669A (en) * | 1981-02-12 | 1982-07-20 | Miles Laboratories, Inc. | System for the determination of glucose in fluids |
| DE3210095A1 (de) * | 1982-03-19 | 1983-09-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und reagenz zur bestimmung von glycerin |
-
1982
- 1982-03-26 DE DE19823211167 patent/DE3211167A1/de not_active Withdrawn
-
1983
- 1983-03-11 DE DE8383102388T patent/DE3373314D1/de not_active Expired
- 1983-03-11 EP EP83102388A patent/EP0090223B1/de not_active Expired
- 1983-03-22 IL IL68198A patent/IL68198A/xx unknown
- 1983-03-23 CS CS831987A patent/CS250227B2/cs unknown
- 1983-03-24 ZA ZA832105A patent/ZA832105B/xx unknown
- 1983-03-24 DD DD83249136A patent/DD209478A5/de not_active IP Right Cessation
- 1983-03-25 US US06/478,765 patent/US4490465A/en not_active Expired - Fee Related
- 1983-03-25 JP JP58049099A patent/JPS58175498A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE3211167A1 (de) | 1983-09-29 |
| ZA832105B (en) | 1983-12-28 |
| IL68198A (en) | 1986-09-30 |
| JPS58175498A (ja) | 1983-10-14 |
| CS250227B2 (en) | 1987-04-16 |
| EP0090223A3 (en) | 1985-08-14 |
| IL68198A0 (en) | 1983-06-15 |
| DE3373314D1 (en) | 1987-10-08 |
| US4490465A (en) | 1984-12-25 |
| EP0090223B1 (de) | 1987-09-02 |
| EP0090223A2 (de) | 1983-10-05 |
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| Date | Code | Title | Description |
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| ENJ | Ceased due to non-payment of renewal fee |