DD207196A5 - Verfahren zur herstellung von neuen cis- bicyclo (3.3.0) octanderivaten - Google Patents

Verfahren zur herstellung von neuen cis- bicyclo (3.3.0) octanderivaten Download PDF

Info

Publication number
DD207196A5
DD207196A5 DD82245014A DD24501482A DD207196A5 DD 207196 A5 DD207196 A5 DD 207196A5 DD 82245014 A DD82245014 A DD 82245014A DD 24501482 A DD24501482 A DD 24501482A DD 207196 A5 DD207196 A5 DD 207196A5
Authority
DD
German Democratic Republic
Prior art keywords
radical
formula
compounds
compound
bicyclo
Prior art date
Application number
DD82245014A
Other languages
German (de)
English (en)
Inventor
Boehlke
Loschen
Michel
Mueller
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of DD207196A5 publication Critical patent/DD207196A5/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4018Esters of cycloaliphatic acids
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fats And Perfumes (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DD82245014A 1981-11-21 1982-11-18 Verfahren zur herstellung von neuen cis- bicyclo (3.3.0) octanderivaten DD207196A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3146278A DE3146278C2 (de) 1981-11-21 1981-11-21 cis-Bicyclo[3.3.0]octanderivate, diese enthaltende Arzneimittel und Verfahren zur Herstellung dieser Verbindungen

Publications (1)

Publication Number Publication Date
DD207196A5 true DD207196A5 (de) 1984-02-22

Family

ID=6146953

Family Applications (1)

Application Number Title Priority Date Filing Date
DD82245014A DD207196A5 (de) 1981-11-21 1982-11-18 Verfahren zur herstellung von neuen cis- bicyclo (3.3.0) octanderivaten

Country Status (21)

Country Link
US (1) US4510323A (fr)
EP (1) EP0080061B1 (fr)
JP (1) JPS5892637A (fr)
AT (1) ATE11668T1 (fr)
AU (1) AU556560B2 (fr)
CA (1) CA1202968A (fr)
DD (1) DD207196A5 (fr)
DE (2) DE3146278C2 (fr)
DK (1) DK155934C (fr)
ES (1) ES8308299A1 (fr)
GR (1) GR77643B (fr)
HK (1) HK40488A (fr)
HU (1) HU187814B (fr)
IE (1) IE53785B1 (fr)
MY (1) MY8700890A (fr)
PL (1) PL137185B1 (fr)
PT (1) PT75694B (fr)
SG (1) SG5788G (fr)
SU (1) SU1225482A3 (fr)
YU (1) YU42604B (fr)
ZA (1) ZA826928B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3408699A1 (de) * 1984-03-08 1985-09-12 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3914735A1 (de) * 1989-05-05 1990-11-08 Gruenenthal Gmbh Pharmakologisch wirksame ester, diese enthaltende arzneimittel und die herstellung dieser ester und arzneimittel

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201699A (en) * 1922-06-02 1923-08-09 Joseph Gardner Improvements in mechanical lubricators
IT1113341B (it) * 1978-03-31 1986-01-20 Ono Pharmaceutical Co Analoghi della 6,9-metano-pgi2
CA1201712A (fr) * 1980-02-28 1986-03-11 Paul A. Aristoff Analogues de la carbacycline
JPS56145239A (en) * 1980-04-11 1981-11-11 Sumitomo Chem Co Ltd Novel bicyclooctane derivative and its preparation

Also Published As

Publication number Publication date
ATE11668T1 (de) 1985-02-15
JPS5892637A (ja) 1983-06-02
PL137185B1 (en) 1986-05-31
DK155934B (da) 1989-06-05
ES517545A0 (es) 1983-08-16
ES8308299A1 (es) 1983-08-16
IE822252L (en) 1983-04-21
ZA826928B (en) 1983-11-30
DE3262233D1 (en) 1985-03-21
DE3146278A1 (de) 1983-06-01
SU1225482A3 (ru) 1986-04-15
DK513982A (da) 1983-05-22
MY8700890A (en) 1987-12-31
YU257882A (en) 1985-03-20
SG5788G (en) 1989-06-02
EP0080061B1 (fr) 1985-02-06
GR77643B (fr) 1984-09-25
AU8881382A (en) 1983-05-26
PT75694B (de) 1985-01-10
DE3146278C2 (de) 1984-10-31
PL239099A1 (en) 1983-05-23
IE53785B1 (en) 1989-02-15
HK40488A (en) 1988-06-10
PT75694A (de) 1982-11-01
DK155934C (da) 1989-10-09
EP0080061A1 (fr) 1983-06-01
CA1202968A (fr) 1986-04-08
JPH0336821B2 (fr) 1991-06-03
HU187814B (en) 1986-02-28
AU556560B2 (en) 1986-11-06
YU42604B (en) 1988-10-31
US4510323A (en) 1985-04-09

Similar Documents

Publication Publication Date Title
EP0055208B1 (fr) Carbacyclines, procédé pour les préparer et leur utilisation comme médicaments
CH647222A5 (de) 9-desoxy-9a-methylen-isostere von pgi-2 und verfahren zu deren herstellung.
CH636354A5 (de) Neue prostaglandin-i(2)-derivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel.
EP0119949B1 (fr) Carbacyclines, leur procédé de préparation, et leur utilisation comme médicaments
EP0099538A1 (fr) Carbacyclines, procédé pour leur préparation et leur utilisation comme médicaments
DE2627671A1 (de) Arzneimittel, enthaltend ein lacton eines prostaglandins oder prostaglandinanalogen
EP0069692A1 (fr) Carbacyclines, leur préparation et application pharmaceutique
EP0057660B1 (fr) Dérivés de prostacycline, leurs préparations et applications comme médicaments
EP0105288B1 (fr) Carbacycline, preparation et utilisation
DD207196A5 (de) Verfahren zur herstellung von neuen cis- bicyclo (3.3.0) octanderivaten
DE2517773A1 (de) Neue 11-oxo-prostaglandin-derivate und verfahren zu ihrer herstellung
EP0086404B1 (fr) Carbacyclines, procédé pour leur préparation et leur application comme médicaments
EP0098794B1 (fr) Carbacyclines, procédé pour leur préparation et leur utilisation comme médicaments
EP0113311B1 (fr) 5-Fluorocarbacyclines, procédé pour leur préparation et leur utilisation comme médicaments
DE3006708A1 (de) Thromboxananaloge und thromboxanzwischenprodukte
EP0051557A1 (fr) Dérivés 5-cyano-prostacyclines, leur procédé de préparation et leur utilisation dans des médicaments
EP0224275A1 (fr) Carbacyclines, leur procédé de préparation et leur utilisation comme médicaments
WO1989000990A1 (fr) Nouveaux derives de carbacycline substitues en 9, leur procede de fabrication et leur emploi a titre de medicaments
DD234414A5 (de) Verfahren zur herstellung neuer carbacycline
DE3306125A1 (de) Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3308561A1 (de) 19,20-methylenprostacyclinderivate und verfahren zu ihrer herstellung
DD202010A5 (de) Verfahren zur herstellung neuer carbacycline
DD202287A5 (de) Verfahren zur herstellung von (13e)-(8r,11r,12r)-11,15-dihydroxy-16,19-dimethyl-9 oxo-13,18-prostadiensaeuren sowie deren salze

Legal Events

Date Code Title Description
ENJ Ceased due to non-payment of renewal fee