ES517545A0 - Procedimiento para la obtencion de nuevos derivados de cis-biciclo 3.3.0 octano. - Google Patents
Procedimiento para la obtencion de nuevos derivados de cis-biciclo 3.3.0 octano.Info
- Publication number
- ES517545A0 ES517545A0 ES517545A ES517545A ES517545A0 ES 517545 A0 ES517545 A0 ES 517545A0 ES 517545 A ES517545 A ES 517545A ES 517545 A ES517545 A ES 517545A ES 517545 A0 ES517545 A0 ES 517545A0
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- cis
- group
- octano
- bicycle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- AEBWATHAIVJLTA-UHFFFAOYSA-N 1,2,3,3a,4,5,6,6a-octahydropentalene Chemical class C1CCC2CCCC21 AEBWATHAIVJLTA-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4018—Esters of cycloaliphatic acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fats And Perfumes (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3146278A DE3146278C2 (de) | 1981-11-21 | 1981-11-21 | cis-Bicyclo[3.3.0]octanderivate, diese enthaltende Arzneimittel und Verfahren zur Herstellung dieser Verbindungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES517545A0 true ES517545A0 (es) | 1983-08-16 |
| ES8308299A1 ES8308299A1 (es) | 1983-08-16 |
Family
ID=6146953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES517545A Expired ES8308299A1 (es) | 1981-11-21 | 1982-11-20 | Procedimiento para la obtencion de nuevos derivados de cis-biciclo 3.3.0 octano. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4510323A (es) |
| EP (1) | EP0080061B1 (es) |
| JP (1) | JPS5892637A (es) |
| AT (1) | ATE11668T1 (es) |
| AU (1) | AU556560B2 (es) |
| CA (1) | CA1202968A (es) |
| DD (1) | DD207196A5 (es) |
| DE (2) | DE3146278C2 (es) |
| DK (1) | DK155934C (es) |
| ES (1) | ES8308299A1 (es) |
| GR (1) | GR77643B (es) |
| HK (1) | HK40488A (es) |
| HU (1) | HU187814B (es) |
| IE (1) | IE53785B1 (es) |
| MY (1) | MY8700890A (es) |
| PL (1) | PL137185B1 (es) |
| PT (1) | PT75694B (es) |
| SG (1) | SG5788G (es) |
| SU (1) | SU1225482A3 (es) |
| YU (1) | YU42604B (es) |
| ZA (1) | ZA826928B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3408699A1 (de) * | 1984-03-08 | 1985-09-12 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE3914735A1 (de) * | 1989-05-05 | 1990-11-08 | Gruenenthal Gmbh | Pharmakologisch wirksame ester, diese enthaltende arzneimittel und die herstellung dieser ester und arzneimittel |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201699A (en) * | 1922-06-02 | 1923-08-09 | Joseph Gardner | Improvements in mechanical lubricators |
| DE2912409A1 (de) * | 1978-03-31 | 1979-10-11 | Ono Pharmaceutical Co | 6,9-methano-pgi tief 2 -analoge |
| CA1201712A (en) * | 1980-02-28 | 1986-03-11 | Paul A. Aristoff | Carbacyclin analogs |
| JPS56145239A (en) * | 1980-04-11 | 1981-11-11 | Sumitomo Chem Co Ltd | Novel bicyclooctane derivative and its preparation |
-
1981
- 1981-11-21 DE DE3146278A patent/DE3146278C2/de not_active Expired
-
1982
- 1982-09-15 IE IE2252/82A patent/IE53785B1/en not_active IP Right Cessation
- 1982-09-20 GR GR69316A patent/GR77643B/el unknown
- 1982-09-21 CA CA000411873A patent/CA1202968A/en not_active Expired
- 1982-09-21 ZA ZA826928A patent/ZA826928B/xx unknown
- 1982-09-28 AU AU88813/82A patent/AU556560B2/en not_active Ceased
- 1982-10-18 AT AT82109592T patent/ATE11668T1/de not_active IP Right Cessation
- 1982-10-18 EP EP82109592A patent/EP0080061B1/de not_active Expired
- 1982-10-18 PT PT75694A patent/PT75694B/pt not_active IP Right Cessation
- 1982-10-18 DE DE8282109592T patent/DE3262233D1/de not_active Expired
- 1982-10-28 SU SU823505874A patent/SU1225482A3/ru active
- 1982-11-17 HU HU823681A patent/HU187814B/hu not_active IP Right Cessation
- 1982-11-17 US US06/442,240 patent/US4510323A/en not_active Expired - Fee Related
- 1982-11-18 DD DD82245014A patent/DD207196A5/de not_active IP Right Cessation
- 1982-11-18 YU YU2578/82A patent/YU42604B/xx unknown
- 1982-11-18 PL PL1982239099A patent/PL137185B1/pl unknown
- 1982-11-18 DK DK513982A patent/DK155934C/da not_active IP Right Cessation
- 1982-11-20 JP JP57202906A patent/JPS5892637A/ja active Granted
- 1982-11-20 ES ES517545A patent/ES8308299A1/es not_active Expired
-
1987
- 1987-12-30 MY MY890/87A patent/MY8700890A/xx unknown
-
1988
- 1988-01-25 SG SG57/88A patent/SG5788G/en unknown
- 1988-06-02 HK HK404/88A patent/HK40488A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU187814B (en) | 1986-02-28 |
| YU42604B (en) | 1988-10-31 |
| DE3146278A1 (de) | 1983-06-01 |
| YU257882A (en) | 1985-03-20 |
| HK40488A (en) | 1988-06-10 |
| PT75694A (de) | 1982-11-01 |
| IE53785B1 (en) | 1989-02-15 |
| JPS5892637A (ja) | 1983-06-02 |
| PL239099A1 (en) | 1983-05-23 |
| DE3146278C2 (de) | 1984-10-31 |
| EP0080061A1 (de) | 1983-06-01 |
| DK155934C (da) | 1989-10-09 |
| AU556560B2 (en) | 1986-11-06 |
| JPH0336821B2 (es) | 1991-06-03 |
| ATE11668T1 (de) | 1985-02-15 |
| EP0080061B1 (de) | 1985-02-06 |
| IE822252L (en) | 1983-04-21 |
| CA1202968A (en) | 1986-04-08 |
| DK155934B (da) | 1989-06-05 |
| DE3262233D1 (en) | 1985-03-21 |
| SG5788G (en) | 1989-06-02 |
| SU1225482A3 (ru) | 1986-04-15 |
| DK513982A (da) | 1983-05-22 |
| GR77643B (es) | 1984-09-25 |
| AU8881382A (en) | 1983-05-26 |
| ES8308299A1 (es) | 1983-08-16 |
| PL137185B1 (en) | 1986-05-31 |
| ZA826928B (en) | 1983-11-30 |
| US4510323A (en) | 1985-04-09 |
| MY8700890A (en) | 1987-12-31 |
| PT75694B (de) | 1985-01-10 |
| DD207196A5 (de) | 1984-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970519 |