KR830009064A - 황함유 화합물이 시클로덱스트린에 내포된 화합물의 제조방법 - Google Patents

황함유 화합물이 시클로덱스트린에 내포된 화합물의 제조방법 Download PDF

Info

Publication number
KR830009064A
KR830009064A KR1019820000846A KR820000846A KR830009064A KR 830009064 A KR830009064 A KR 830009064A KR 1019820000846 A KR1019820000846 A KR 1019820000846A KR 820000846 A KR820000846 A KR 820000846A KR 830009064 A KR830009064 A KR 830009064A
Authority
KR
South Korea
Prior art keywords
compound
lower alkyl
formula
phenyl
hydrogen
Prior art date
Application number
KR1019820000846A
Other languages
English (en)
Inventor
쥰이찌 이와오
마사유끼 오야
다다시 이소
Original Assignee
미따 쇼오뀨
산뗑세이야꾸고오교가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 미따 쇼오뀨, 산뗑세이야꾸고오교가부시끼가이샤 filed Critical 미따 쇼오뀨
Publication of KR830009064A publication Critical patent/KR830009064A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Materials Engineering (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

황함유 화합물이 시클로덱스트린에 내포된 화합물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 시클로덱스트린을 물 또는 물과 수혼화성 유기 용매의 혼합물 중에서 하기식(I)의 화합물과 반응시킴을 특징으로 하는 하기식(I)의 화합물 또는 그의 염이 시클로덱스트린에 내포된 화합물의 제조방법.
    (상기 식에서,
    A는 직쇄 또는 측쇄 저급 알킬렌이고; R1은 수소, 또는 저급 알킬이고; R2는 수소, 저급 알킬, 페닐, 페닐-저급 알킬, 히드록시페닐-저급 알킬, 히드록시-저급 알킬, 아미노-저급 알킬, 구아니디노-저급 알킬, 이미다졸일-저급 알킬, 인돌일-저급 알킬, 메르캅토-저급 알킬 또는 저급 알킬티오-저급 알킬이고; R1및 R2는 함께 피롤리딘 환 또는 티아졸리딘 환을 만들수도 있으며, 각환은 페닐 또는 피리딜에 의해 치환될 수 있으며, 페닐은 히드록시, 저급 알콕시, 할로겐, 니트로 또는 술파모일에 의해 재치환될 수 있으며; R3는 수소 또는
    상기 저급 알킬 및 저급 알콕시는 1~6의 탄소 원자를 가짐).
  2. 제1항에 있어서, R3가 수소임을 특징으로 하는 화합물의 제조방법.
  3. 제1항에 있어서, R3가임을 특징으로 하는 화합물의 제조방법.
  4. 제1항에 있어서, A가 -CH2CH2-, -CH2CH(CH3)-, -C(CH3)2- 또는 -CH(CH3)-임을 특징으로 하는 화합물의 제조방법.
  5. 제1항에 있어서, 식(I)의 화합물이 (2R,4R)-2-(2-히드록시페닐)-3-(3-메르캅토프로파노일)-4-티아졸리딘카르복실산임을 특징으로 하는 화합물의 제조방법.
  6. 제1항에 있어서, 식(I)의 화합물이 (2S)-1-[(2S)-3-메르캅토-2-메틸프로파노일]-2-피롤리딘카르복실산임을 특징으로하는 화합물의 제조방법.
  7. 제1항에 있어서, 식(I)의 화합물이(4R,4'R)3,3'-[3,3'-디티오비스(프로파노일)]비스[[2-(2-히드록시페닐)-4-티아졸리딘카르복실산]임을 특징으로 하는 화합물의 제조방법.
  8. 제1항에 있어서, 식(I)의 화합물이 N-(2-메르캅토-2-메틸프로파노일)-L-시스테인임을 특징으로 하는 화합물의 제조방법.
  9. 제1항에 있어서, 식(I)의 화합물이 N-(2-메르캅토프로파노일)글리신임을 특징으로 하는 화합물의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019820000846A 1981-02-28 1982-02-26 황함유 화합물이 시클로덱스트린에 내포된 화합물의 제조방법 KR830009064A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56029060A JPS57142962A (en) 1981-02-28 1981-02-28 Cyclodextrin clathrate compound of sulfur-containing compound
JP29060/81 1981-02-28

Publications (1)

Publication Number Publication Date
KR830009064A true KR830009064A (ko) 1983-12-17

Family

ID=12265815

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019820000846A KR830009064A (ko) 1981-02-28 1982-02-26 황함유 화합물이 시클로덱스트린에 내포된 화합물의 제조방법

Country Status (10)

Country Link
US (1) US4482709A (ko)
EP (1) EP0072868B1 (ko)
JP (1) JPS57142962A (ko)
KR (1) KR830009064A (ko)
DE (1) DE3233697T1 (ko)
ES (1) ES8302783A1 (ko)
GB (1) GB2106917A (ko)
IT (1) IT1150200B (ko)
NL (1) NL8220038A (ko)
WO (1) WO1982002890A1 (ko)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1140394B (it) * 1981-12-23 1986-09-24 Maggioni Farma Dipeptidi contenenti un residuo di metionina ad attivita' epatoprotettrice
GB2138813B (en) * 1983-04-25 1987-02-04 Squibb & Sons Inc Proline derivatives
JPS6025967A (ja) * 1983-07-21 1985-02-08 Eisai Co Ltd トリパミド包接化合物
JPS6081166A (ja) * 1983-10-11 1985-05-09 Fujisawa Pharmaceut Co Ltd ２−ニトロオキシメチル−６−クロロピリジンのβ−シクロデキストリン包接化合物およびその製造法
JPS60152535A (ja) * 1984-01-20 1985-08-10 Ichiro Shibauchi 架橋剤及びその製造方法
HU193933B (en) * 1984-06-08 1987-12-28 Nitrokemia Ipartelepek Herbicide or plant growth stimulating agent comprising beta-cyclodextrin complex of benzolsulphonylurea derivative and process for preparing the active substances
US4883785A (en) * 1984-07-27 1989-11-28 Chow Wing Sun Complex of anti-fungal agent and cyclodextrin and method
US4636522A (en) * 1985-03-22 1987-01-13 E. R. Squibb & Sons, Inc. Acylaminoalkanoyl urethanes or thiourethanes
KR870007114A (ko) * 1986-01-21 1987-08-14 우에노 기미오 티올 에스테르 유도체의 안정된 고형제
EP0318859A3 (en) * 1987-12-03 1990-08-16 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
US5210266A (en) * 1987-12-03 1993-05-11 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
US5179125A (en) * 1987-12-03 1993-01-12 Dainippon Pharmaceutical Co., Ltd. N-substituted mercaptopropanamide derivatives
FR2651229B1 (fr) * 1989-08-24 1991-12-13 Inst Nat Sante Rech Med Nouveaux derives d'amino-acides, leur procede de preparation et leur application therapeutique.
US4948395A (en) * 1989-09-12 1990-08-14 Advanced Separations Technologies Inc. Chiral separation media
US5064944A (en) * 1989-09-12 1991-11-12 Advanced Separation Technologies Inc. Chiral separation media
US5154738A (en) * 1989-09-12 1992-10-13 Advanced Separation Technologies, Inc. Chiral separation media
US6025393A (en) * 1995-09-25 2000-02-15 Santen Pharmaceutical Co., Ltd. Method for treatment of inflammatory intestinal diseases
ES2118673T3 (es) * 1996-10-29 2001-04-16 Staroil Ltd Composiciones solubles en la boca que contienen n-acetilcisteina y ciclodextrina.
FR2912061A1 (fr) * 2007-02-01 2008-08-08 Aliscience Soc Par Actions Sim Complexes d'inclusion de cysteine, leur presparation et les compositions les contenant
CN113088699B (zh) * 2021-03-31 2022-04-05 南昌航空大学 一种废弃线路板酸浸液中金的吸附还原回收和强酸回用的方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US435618A (en) * 1890-09-02 Gustavus a
CH451186A (de) * 1961-11-02 1968-05-15 Santen Phamarceutical Co Ltd Verfahren zur Herstellung von N-Mercaptopropionylglycin und dessen Derivaten
JPS5089516A (ko) * 1973-12-14 1975-07-18
JPS5094108A (ko) * 1973-12-20 1975-07-26
JPS5835968B2 (ja) * 1974-02-25 1983-08-05 帝人株式会社 サイクロデキストリン包接化合物の製造法
US4046889A (en) * 1976-02-13 1977-09-06 E. R. Squibb & Sons, Inc. Azetidine-2-carboxylic acid derivatives
JPS535112A (en) * 1976-03-08 1978-01-18 Santen Pharmaceutical Co Ltd New cysteine derivatives
US4053651A (en) * 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
JPS545916A (en) * 1977-06-17 1979-01-17 Santen Pharmaceutical Co Ltd Novel cystein derivative
AU528115B2 (en) * 1978-04-08 1983-04-14 Santen Pharmaceutical Co. Ltd. Antihypertensive 4-thiazolidine/carboxylic acids
JPS584711B2 (ja) * 1978-08-02 1983-01-27 参天製薬株式会社 ピロリジン誘導体
JPS6011888B2 (ja) * 1978-10-11 1985-03-28 参天製薬株式会社 リウマチ疾患治療薬
US4347371A (en) * 1978-12-30 1982-08-31 Santen Pharmaceutical Co., Ltd. Disulfide compounds
US4256761A (en) * 1979-07-13 1981-03-17 Usv Pharmaceutical Corporation Antihypertensive amides
ZA811340B (en) * 1980-06-09 1982-03-31 Morton Norwich Products Inc N-(cycloalkyl)amino acid compounds
JPS5732260A (en) * 1980-08-07 1982-02-20 Meito Sangyo Kk Mercaptofatty acid derivative and its preparation

Also Published As

Publication number Publication date
EP0072868A4 (en) 1983-07-04
IT8219838A0 (it) 1982-02-24
EP0072868B1 (en) 1985-07-24
JPS57142962A (en) 1982-09-03
DE3233697C2 (ko) 1989-01-19
ES509911A0 (es) 1983-01-16
GB2106917A (en) 1983-04-20
NL8220038A (nl) 1983-01-03
US4482709A (en) 1984-11-13
EP0072868A1 (en) 1983-03-02
JPS6217994B2 (ko) 1987-04-21
ES8302783A1 (es) 1983-01-16
DE3233697T1 (de) 1983-03-24
IT1150200B (it) 1986-12-10
WO1982002890A1 (en) 1982-09-02

Similar Documents

Publication Publication Date Title
KR830009064A (ko) 황함유 화합물이 시클로덱스트린에 내포된 화합물의 제조방법
SE8205698L (sv) N-(4-(3-aminopropyl)aminobutyl-2-(omega-guanidinofettsyra-amido)-2-substituerad-etanamid, salt derav och forfarande for framstellning derav
KR960007592A (ko) 신규한 피롤로카바졸
UA7051A1 (uk) N-[6-метоксі-5-(перфторалкін)-1-нафтоіл]-n-метілгліцин чи його тіонафтоільні аналоги як інгібітори албдозоредуктази
IT1206130B (it) Composti per abbassare i livelli dei lipidi.
KR930702285A (ko) 옥시술포닐 카르바메이트
KR900701262A (ko) 췌장염 등에 대한 치료제
ES521376A0 (es) Procedimiento para preparar n-(1,3-ditiolan-2-ilideno)anilinas.
KR910006292A (ko) 방향족 산의 n-아자비시클로 [3.3.0] 옥탄 아미드
KR880007481A (ko) 아졸 유도체
KR850000390A (ko) 치환된 알칸티오카복실산 유도체의 제조방법
AU552716B2 (en) N-(p-sulfophenyl)-cinnamamide
ES517545A0 (es) Procedimiento para la obtencion de nuevos derivados de cis-biciclo 3.3.0 octano.
ES533854A0 (es) Procedimiento para preparar 4-(sustituida alquil)-n-(1,3-ditiolan-2-ilideno)anilina
KR830000198A (ko) [1-옥소-2-아릴 또는 티에닐-2-치환-5-인다닐옥시(또는 티오)]알카노익 애시드의 제법
KR900016173A (ko) 항과 혈당증제로서 유용한 나프탈레닐-3h-1,2,3,5-옥사티아디아졸 2-옥사이드
KR890014568A (ko) 유기 화합물 및 이의 약제학적 용도
KR890003690A (ko) 우레아 유도체
KR840004062A (ko) 4-아미노부티르산 유도체의 제조방법
KR930000528A (ko) 아미노피롤리딘 백금화합물 및 그 제조방법
KR910000598A (ko) 아미노메틸페놀 및 이들 화합물을 함유하는 살균제
KR880006186A (ko) 4-하이드록시-4-(치환된 알케닐)사이클로헥산 카복실산
DE3364034D1 (en) Vinylogous carboxamides, process for preparing them and medicines containing these compounds
ES380890A1 (es) Procedimiento para la preparacion de colorantes azoicos.
KR890002133A (ko) 프리스티나마이신 iib 유도체의 제조 방법