DD202245A5 - Verfahren zur herstellung oraler kompositionen - Google Patents
Verfahren zur herstellung oraler kompositionen Download PDFInfo
- Publication number
- DD202245A5 DD202245A5 DD81233993A DD23399381A DD202245A5 DD 202245 A5 DD202245 A5 DD 202245A5 DD 81233993 A DD81233993 A DD 81233993A DD 23399381 A DD23399381 A DD 23399381A DD 202245 A5 DD202245 A5 DD 202245A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- zinc
- hexetidine
- plaque
- oral
- fluoride
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 19
- 238000000034 method Methods 0.000 title claims abstract description 10
- 230000008569 process Effects 0.000 title claims abstract description 6
- DTOUUUZOYKYHEP-UHFFFAOYSA-N 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine Chemical compound CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 DTOUUUZOYKYHEP-UHFFFAOYSA-N 0.000 claims abstract description 63
- 229960004867 hexetidine Drugs 0.000 claims abstract description 63
- 239000002324 mouth wash Substances 0.000 claims abstract description 26
- 230000005764 inhibitory process Effects 0.000 claims abstract description 23
- 230000002195 synergetic effect Effects 0.000 claims abstract description 15
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- 229940051866 mouthwash Drugs 0.000 claims abstract description 14
- 150000003751 zinc Chemical class 0.000 claims abstract description 14
- LJXQPZWIHJMPQQ-UHFFFAOYSA-N pyrimidin-2-amine Chemical compound NC1=NC=CC=N1 LJXQPZWIHJMPQQ-UHFFFAOYSA-N 0.000 claims abstract description 8
- 238000002360 preparation method Methods 0.000 claims abstract description 7
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- BHHYHSUAOQUXJK-UHFFFAOYSA-L zinc fluoride Chemical compound F[Zn]F BHHYHSUAOQUXJK-UHFFFAOYSA-L 0.000 claims description 31
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- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 17
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 16
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- 235000005074 zinc chloride Nutrition 0.000 description 9
- 208000002064 Dental Plaque Diseases 0.000 description 8
- 239000008389 polyethoxylated castor oil Substances 0.000 description 8
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- 238000012360 testing method Methods 0.000 description 8
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- 230000015572 biosynthetic process Effects 0.000 description 7
- 210000000214 mouth Anatomy 0.000 description 7
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- -1 alkylamine salts Chemical class 0.000 description 6
- 229910052757 nitrogen Inorganic materials 0.000 description 6
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- RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 description 5
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- 241000607479 Yersinia pestis Species 0.000 description 4
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 4
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- 238000002474 experimental method Methods 0.000 description 4
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- 125000001453 quaternary ammonium group Chemical group 0.000 description 4
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 4
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- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
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- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 2
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
- 229940081974 saccharin Drugs 0.000 description 2
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- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 2
- 239000011746 zinc citrate Substances 0.000 description 2
- 235000006076 zinc citrate Nutrition 0.000 description 2
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- 239000011787 zinc oxide Substances 0.000 description 2
- KXCXYYUMLRUZJH-UHFFFAOYSA-N 1-(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine Chemical compound CCCCC(CC)CN1CNCC(C)(N)C1 KXCXYYUMLRUZJH-UHFFFAOYSA-N 0.000 description 1
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Chemical compound CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 1
- MSJBLPVXRJMJSY-UHFFFAOYSA-N 2,6-bis(2-ethylhexyl)-7a-methyl-1,3,5,7-tetrahydroimidazo[1,5-c]imidazole Chemical compound C1N(CC(CC)CCCC)CC2(C)CN(CC(CC)CCCC)CN21 MSJBLPVXRJMJSY-UHFFFAOYSA-N 0.000 description 1
- VPWNQTHUCYMVMZ-UHFFFAOYSA-N 4,4'-sulfonyldiphenol Chemical class C1=CC(O)=CC=C1S(=O)(=O)C1=CC=C(O)C=C1 VPWNQTHUCYMVMZ-UHFFFAOYSA-N 0.000 description 1
- CNPURSDMOWDNOQ-UHFFFAOYSA-N 4-methoxy-7h-pyrrolo[2,3-d]pyrimidin-2-amine Chemical compound COC1=NC(N)=NC2=C1C=CN2 CNPURSDMOWDNOQ-UHFFFAOYSA-N 0.000 description 1
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- LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical compound CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 description 1
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- 229910052782 aluminium Inorganic materials 0.000 description 1
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- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 230000033558 biomineral tissue development Effects 0.000 description 1
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- 150000001720 carbohydrates Chemical class 0.000 description 1
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- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 229960004830 cetylpyridinium Drugs 0.000 description 1
- NEUSVAOJNUQRTM-UHFFFAOYSA-N cetylpyridinium Chemical class CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 NEUSVAOJNUQRTM-UHFFFAOYSA-N 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
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- 235000019425 dextrin Nutrition 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- SIYLLGKDQZGJHK-UHFFFAOYSA-N dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium Chemical compound C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 SIYLLGKDQZGJHK-UHFFFAOYSA-N 0.000 description 1
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- PIFBJINVDJJYCV-UHFFFAOYSA-J dizinc tetraacetate Chemical compound [Zn+2].[Zn+2].CC([O-])=O.CC([O-])=O.CC([O-])=O.CC([O-])=O PIFBJINVDJJYCV-UHFFFAOYSA-J 0.000 description 1
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- ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 description 1
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- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
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- PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 description 1
- 150000002730 mercury Chemical class 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
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- DXYUWQFEDOQSQY-UHFFFAOYSA-N n'-octadecylpropane-1,3-diamine Chemical compound CCCCCCCCCCCCCCCCCCNCCCN DXYUWQFEDOQSQY-UHFFFAOYSA-N 0.000 description 1
- 230000017066 negative regulation of growth Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
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- 239000006072 paste Substances 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 210000004261 periodontium Anatomy 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
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- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- FNXKBSAUKFCXIK-UHFFFAOYSA-M sodium;hydrogen carbonate;8-hydroxy-7-iodoquinoline-5-sulfonic acid Chemical class [Na+].OC([O-])=O.C1=CN=C2C(O)=C(I)C=C(S(O)(=O)=O)C2=C1 FNXKBSAUKFCXIK-UHFFFAOYSA-M 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
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- 239000003826 tablet Substances 0.000 description 1
- YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical compound [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 description 1
- 230000036367 tooth discoloration Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000001720 vestibular Effects 0.000 description 1
- 150000003752 zinc compounds Chemical class 0.000 description 1
- 229940118827 zinc phenolsulfonate Drugs 0.000 description 1
- LRXTYHSAJDENHV-UHFFFAOYSA-H zinc phosphate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LRXTYHSAJDENHV-UHFFFAOYSA-H 0.000 description 1
- 229910000165 zinc phosphate Inorganic materials 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- BOVNWDGXGNVNQD-UHFFFAOYSA-L zinc;2-hydroxybenzenesulfonate Chemical compound [Zn+2].OC1=CC=CC=C1S([O-])(=O)=O.OC1=CC=CC=C1S([O-])(=O)=O BOVNWDGXGNVNQD-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Inorganic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8032743A GB2084870B (en) | 1980-10-10 | 1980-10-10 | Oral compositions containing pyrimidine amine compounds and zinc salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD202245A5 true DD202245A5 (de) | 1983-09-07 |
Family
ID=10516584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD81233993A DD202245A5 (de) | 1980-10-10 | 1981-10-09 | Verfahren zur herstellung oraler kompositionen |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US4522806A (OSRAM) |
| EP (1) | EP0049830B1 (OSRAM) |
| JP (1) | JPS5793905A (OSRAM) |
| KR (1) | KR830006970A (OSRAM) |
| AR (1) | AR227068A1 (OSRAM) |
| AT (1) | ATE15328T1 (OSRAM) |
| AU (1) | AU545501B2 (OSRAM) |
| BR (1) | BR8106557A (OSRAM) |
| CA (1) | CA1168159A (OSRAM) |
| CU (1) | CU35541A (OSRAM) |
| DD (1) | DD202245A5 (OSRAM) |
| DE (1) | DE3172144D1 (OSRAM) |
| DK (1) | DK449381A (OSRAM) |
| ES (1) | ES8205554A1 (OSRAM) |
| FI (1) | FI75269C (OSRAM) |
| GB (1) | GB2084870B (OSRAM) |
| GR (1) | GR75374B (OSRAM) |
| IL (1) | IL63877A0 (OSRAM) |
| IN (1) | IN155108B (OSRAM) |
| IT (1) | IT1140455B (OSRAM) |
| MA (1) | MA19299A1 (OSRAM) |
| MC (1) | MC1416A1 (OSRAM) |
| NO (1) | NO155955C (OSRAM) |
| NZ (1) | NZ198348A (OSRAM) |
| PH (1) | PH17278A (OSRAM) |
| PL (1) | PL233353A1 (OSRAM) |
| PT (1) | PT73749B (OSRAM) |
| ZA (1) | ZA816678B (OSRAM) |
| ZW (1) | ZW23581A1 (OSRAM) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2084870B (en) * | 1980-10-10 | 1985-05-09 | Muhlemann R Hans | Oral compositions containing pyrimidine amine compounds and zinc salts |
| US4485089A (en) * | 1983-10-17 | 1984-11-27 | Hercules Incorporated | Gel toothpastes |
| EP0152836B1 (de) * | 1984-02-20 | 1990-06-20 | Blendax GmbH | Mittel zur oralen Hygiene |
| DE3406005C1 (de) * | 1984-02-20 | 1985-09-26 | Blendax-Werke R. Schneider Gmbh & Co, 6500 Mainz | Mittel zur oralen Hygiene |
| GB8411731D0 (en) * | 1984-05-09 | 1984-06-13 | Unilever Plc | Oral compositions |
| US4664906A (en) * | 1984-08-30 | 1987-05-12 | Johnson & Johnson Products Inc. | Oral compositions |
| US4647452A (en) * | 1985-11-08 | 1987-03-03 | Lever Brothers Company | Oral compositions of salicylamides and zinc salts for the synergistic inhibition of dental plaque |
| DE3600165A1 (de) * | 1986-01-07 | 1987-07-09 | Blendax Werke Schneider Co | Mittel zur oralen hygiene |
| US4666517A (en) * | 1986-06-04 | 1987-05-19 | Colgate-Palmolive Co. | Antiplaque oral composition |
| US4770634A (en) * | 1986-06-11 | 1988-09-13 | Pellico Michael A | Method for treating teeth with foamable fluoride compositions |
| JPH0747531B2 (ja) * | 1986-06-27 | 1995-05-24 | ライオン株式会社 | 口腔用組成物 |
| US4774078A (en) * | 1986-10-06 | 1988-09-27 | Colgate-Palmolive Company | Stable antiplaque dentifrice based on hexetidine, zinc ion and fluoride |
| IN168400B (OSRAM) * | 1987-01-30 | 1991-03-23 | Colgate Palmolive Co | |
| JPH01139524A (ja) * | 1987-11-25 | 1989-06-01 | Shiseido Co Ltd | 口腔用組成物 |
| US5174989A (en) * | 1987-11-25 | 1992-12-29 | Shiseido Company Ltd. | Oral composition |
| US4961923A (en) * | 1988-02-19 | 1990-10-09 | Dentsply Management Corp. | Irrigants for use in scaling and/or lavage apparatus |
| US6190642B1 (en) | 1988-02-19 | 2001-02-20 | Dentsply Research & Development Corp. | Irrigating and lavage compositions |
| FR2631823B1 (fr) * | 1988-05-30 | 1992-05-29 | Dana Dominique | Nouvelle composition de dentifrice |
| US4992276A (en) * | 1988-12-14 | 1991-02-12 | Warner-Lambert Company | Antiseptic compositions containing hexahydro-5-pyrimidinamine compounds and thymol and methods for preparing same |
| EP0408174A1 (en) * | 1989-07-12 | 1991-01-16 | Warner-Lambert Company | Antiseptic composition containing hexahydro-5-pyrimidinamine compounds |
| GB8920796D0 (en) * | 1989-09-14 | 1989-11-01 | Rolla Gunnar | Dentifrice compositions |
| US5174990A (en) * | 1990-02-07 | 1992-12-29 | 7-L Corporation | Mouthrinse and method of preparation |
| US5104644A (en) * | 1990-02-07 | 1992-04-14 | 7-L Corporation | Mouthrinse composition |
| US5310546A (en) * | 1990-02-07 | 1994-05-10 | 7-L Corporation | Mouthrinse and method of preparation |
| US5985249A (en) * | 1990-03-22 | 1999-11-16 | Ultradent Products, Inc. | Sticky dental compositions for adhering a passive-type dental tray over a person's teeth |
| US5851512A (en) * | 1990-03-22 | 1998-12-22 | Ultradent Products, Inc. | Dental compositions having a sticky matrix material for treating sensitive teeth |
| US5855870A (en) * | 1990-03-22 | 1999-01-05 | Ultradent Products, Inc. | Method for treating sensitive teeth |
| US6036943A (en) * | 1990-03-22 | 2000-03-14 | Ultradent Products, Inc. | Methods for treating a person's teeth using sticky dental compositions in combination with passive-type dental trays |
| US5328690A (en) * | 1991-02-21 | 1994-07-12 | University Of South Alabama | Polyamino acid dispersants |
| GB9117140D0 (en) * | 1991-08-08 | 1991-09-25 | Unilever Plc | Treatment of periodontitis |
| US5281410A (en) * | 1991-10-23 | 1994-01-25 | The Proctor & Gamble Company | Methods of reducing plaque and gingivitis with reduced staining |
| US5145666A (en) * | 1991-10-23 | 1992-09-08 | The Proctor & Gamble Co. | Methods of reducing plaque and gingivitis with reduced staining |
| US5213790A (en) * | 1991-10-23 | 1993-05-25 | The Procter & Gamble Co. | Methods of reducing plaque and gingivitis with reduced staining |
| US5292527A (en) * | 1992-07-02 | 1994-03-08 | Bausch & Lomb Incorporated | Non-alcoholic aqueous mouthwash |
| US5281411A (en) * | 1992-07-31 | 1994-01-25 | The Procter & Gamble Company | Oral compositions |
| US5514366A (en) * | 1993-04-07 | 1996-05-07 | Diamond; Jeffrey H. | Dental and oral preparation for smokers for solubilizing and removing tobacco tars as well as onion and garlic essential oils |
| US5330748A (en) * | 1993-05-19 | 1994-07-19 | Church & Dwight Co., Inc. | Dentifrices containing zinc oxide particles |
| US5385727A (en) * | 1993-05-19 | 1995-01-31 | Church & Dwight Co., Inc. | Dentifrices containing zinc oxide particles and sodium bicarbonate |
| US6086856A (en) * | 1994-03-28 | 2000-07-11 | Oralcare Systems, Inc. | System for delivering foamed oral hygiene compositions |
| US5587147A (en) * | 1994-06-30 | 1996-12-24 | Church & Dwight Co., Inc. | Aqueous zinc-polyamide complex solution |
| US5665333A (en) * | 1995-01-17 | 1997-09-09 | Homola; Andrew M. | Methods, compositions, and dental delivery systems for the protection of the surfaces of teeth |
| US5714447A (en) * | 1996-01-24 | 1998-02-03 | Church & Dwight Co., Inc. | Deodorant soap or detergent composition containing a zinc compound and a polyamine |
| US5824289A (en) * | 1996-03-05 | 1998-10-20 | Sultan Dental Products | Dental fluoride foam |
| US6251369B1 (en) | 1996-03-05 | 2001-06-26 | Sultan Dental Products | Dental fluoride foam |
| US5961958A (en) * | 1996-07-16 | 1999-10-05 | Four Star Partners | Methods, compositions, and dental delivery systems for the protection of the surfaces of teeth |
| US6030212A (en) * | 1996-09-27 | 2000-02-29 | Dentsply Research & Development Corp. | Stacking reservoir and scaler system |
| US6306370B1 (en) | 1997-05-30 | 2001-10-23 | Ultradent Products, Inc. | Compositions and methods for whitening and desensitizing teeth |
| US6086372A (en) * | 1997-06-04 | 2000-07-11 | Block Drug Company, Inc. | Dental and oral preparation |
| US6096328A (en) | 1997-06-06 | 2000-08-01 | The Procter & Gamble Company | Delivery system for an oral care substance using a strip of material having low flexural stiffness |
| US20020018754A1 (en) * | 1999-03-15 | 2002-02-14 | Paul Albert Sagel | Shapes for tooth whitening strips |
| US6582708B1 (en) | 2000-06-28 | 2003-06-24 | The Procter & Gamble Company | Tooth whitening substance |
| US5948390A (en) * | 1997-08-25 | 1999-09-07 | Pfizer Inc. | Stable zinc/citrate/CPC oral rinse formulations |
| JP3719874B2 (ja) | 1998-04-24 | 2005-11-24 | サンスター株式会社 | 口腔用組成物 |
| US8936778B2 (en) * | 1998-11-12 | 2015-01-20 | Ultradent Products, Inc. | Methods for bleaching and desensitizing teeth |
| US6309625B1 (en) | 1998-11-12 | 2001-10-30 | Ultradent Products, Inc. | One-part dental compositions and methods for bleaching and desensitizing teeth |
| NO990975A (no) | 1999-03-01 | 2000-02-21 | Orix As | Oralt preparat som er effektivt mot halitose |
| ATE238766T1 (de) | 1999-07-02 | 2003-05-15 | Procter & Gamble | Zusammensetzungen zur freisetzung von mundpflegewirkstoffen enthaltend organosiloxan harze durch verwendung eines wiederablösbaren trägerstreifens |
| US6306372B1 (en) * | 2000-06-21 | 2001-10-23 | Noville Inc. | Oral hygiene compositions which mask the burn sensation and the astringency of eucalyptol and zinc |
| JP2004501173A (ja) * | 2000-06-28 | 2004-01-15 | ザ、プロクター、エンド、ギャンブル、カンパニー | ペルオキシド活性物質の安定性を高める構造体及び組成物 |
| JP2005523315A (ja) * | 2002-04-16 | 2005-08-04 | コスメティカ， インコーポレイテッド | パーソナルケア製品のためのポリマー性臭気吸収成分 |
| US6949240B2 (en) * | 2002-05-23 | 2005-09-27 | The Procter & Gamble Company | Tooth whitening products |
| US6924325B2 (en) * | 2002-06-21 | 2005-08-02 | Kerr Corporation | Silver-containing dental composition |
| US8524200B2 (en) | 2002-09-11 | 2013-09-03 | The Procter & Gamble Company | Tooth whitening products |
| US7563451B2 (en) | 2003-07-22 | 2009-07-21 | Iowa State University Research Foundation, Inc. | Capped mesoporous silicates |
| US20060018966A1 (en) * | 2003-07-22 | 2006-01-26 | Lin Victor S | Antimicrobial mesoporous silica nanoparticles |
| US20060254988A1 (en) * | 2005-05-10 | 2006-11-16 | Confirm Monitoring Systems, Inc. | Methods and compositions for the treatment of water |
| ES2507070T3 (es) | 2006-02-03 | 2014-10-14 | Omp, Inc. | Tratamiento antienvejecimiento utilizando composiciones de cobre y zinc |
| US7687650B2 (en) | 2006-02-03 | 2010-03-30 | Jr Chem, Llc | Chemical compositions and methods of making them |
| US7897800B2 (en) | 2006-02-03 | 2011-03-01 | Jr Chem, Llc | Chemical compositions and methods of making them |
| ATE431128T1 (de) * | 2006-03-22 | 2009-05-15 | Procter & Gamble | Zink enthaltende mundzusammensetzungen |
| US8647644B1 (en) | 2006-04-19 | 2014-02-11 | Iowa State University Research Foundation, Inc. | Methods of using capped mesoporous silicates |
| WO2008036855A2 (en) * | 2006-09-21 | 2008-03-27 | Alcon Research, Ltd. | Self-preserved aqueous pharmaceutical compositions |
| TWI394564B (zh) * | 2006-09-21 | 2013-05-01 | Alcon Res Ltd | 自行保存型水性藥學組成物 |
| US7867522B2 (en) | 2006-09-28 | 2011-01-11 | Jr Chem, Llc | Method of wound/burn healing using copper-zinc compositions |
| MX2009003042A (es) * | 2006-09-28 | 2009-04-02 | Alcon Res Ltd | Composiciones farmaceuticas acuosas auto-preservadas. |
| DE102006060911A1 (de) | 2006-12-20 | 2008-07-03 | Henkel Kgaa | Mund- und Zahnpflege- und -reinigungsmittel zur Bekämpfung von Halitosis |
| US8273791B2 (en) | 2008-01-04 | 2012-09-25 | Jr Chem, Llc | Compositions, kits and regimens for the treatment of skin, especially décolletage |
| TWI544927B (zh) | 2008-03-17 | 2016-08-11 | 愛爾康研究有限公司 | 具有低濃度的表面活性劑以促進治療劑之生物可利用性的藥學組成物 |
| DE202009019116U1 (de) * | 2008-03-17 | 2016-08-01 | Alcon Research, Ltd. | Wässrige pharmazeutische Zusammensetzungen, die Borat-Polyol-Komplexe enthalten |
| WO2010085753A1 (en) | 2009-01-23 | 2010-07-29 | Jr Chem, Llc | Rosacea treatments and kits for performing them |
| TWI489997B (zh) * | 2009-06-19 | 2015-07-01 | Alcon Res Ltd | 含有硼酸－多元醇錯合物之水性藥學組成物 |
| US8952057B2 (en) | 2011-01-11 | 2015-02-10 | Jr Chem, Llc | Compositions for anorectal use and methods for treating anorectal disorders |
| AU2013331240B8 (en) | 2012-10-17 | 2016-11-24 | The Procter & Gamble Company | Strip for the delivery of an oral care active and methods for applying oral care actives |
| CN111527399A (zh) | 2017-12-18 | 2020-08-11 | 高露洁-棕榄公司 | 分析方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB771768A (en) * | 1953-11-19 | 1957-04-03 | Warner Lambert Pharmaceutical | Improved dental therapeutic compositions |
| BE540230A (OSRAM) * | 1954-08-02 | |||
| US3095356A (en) * | 1956-02-20 | 1963-06-25 | Monsanto Chemicals | Dentifrice comprising insoluble sodium metaphosphate and a cadmium, tin, zinc, manganese or iron compound to inhibit calcium ion sequestering |
| SE409413B (sv) * | 1968-08-05 | 1979-08-20 | Colgate Palmolive Co | Agglomererat material for anvendning som en bestandsdel i en tandkrem |
| US3622662A (en) * | 1969-04-21 | 1971-11-23 | Colgate Palmolive Co | Stable dental cream |
| NO130143B (OSRAM) * | 1969-04-21 | 1974-07-15 | Colgate Palmolive Co | |
| GB1310374A (en) * | 1970-11-06 | 1973-03-21 | Unilever Ltd | Toothpaste composition |
| US3985537A (en) * | 1971-06-05 | 1976-10-12 | Kali-Chemie Aktiengesellschaft | Process for making calcined alkali phosphates of high citrate solubility for use as fertilizers |
| US4100269A (en) * | 1973-06-28 | 1978-07-11 | Lever Brothers Company | Anticalculus dentifrice |
| US4022880A (en) * | 1973-09-26 | 1977-05-10 | Lever Brothers Company | Anticalculus composition |
| GB1461896A (en) * | 1974-02-07 | 1977-01-19 | Colgate Lmolive Co | Dentifrices |
| US4170634A (en) * | 1975-01-28 | 1979-10-09 | Colgate Palmolive Company | Modified abrasive system for dentifrices |
| US4187288A (en) * | 1975-01-28 | 1980-02-05 | Colgate Palmolive Company | Modified abrasive system for dentifrices |
| US3989814A (en) * | 1975-01-28 | 1976-11-02 | Colgate-Palmolive Company | Calcium pyrophosphate abrasive system for dentifrice |
| DE2626935A1 (de) * | 1976-06-16 | 1977-12-29 | Dolorgiet Arzneimittelfabrik | Desinfizierende mittel |
| US4142050A (en) * | 1975-11-06 | 1979-02-27 | Doll Gmbh | Salts of 1,3-bis(β-ethylhexyl)-5-amino-5-methyl-hexahydropyrimidine |
| US4138477A (en) * | 1976-05-28 | 1979-02-06 | Colgate Palmolive Company | Composition to control mouth odor |
| GB2001526A (en) * | 1977-07-26 | 1979-02-07 | Warner & Co Ltd W | Dentifrice containing hexetidine and fluorides |
| GB2084870B (en) * | 1980-10-10 | 1985-05-09 | Muhlemann R Hans | Oral compositions containing pyrimidine amine compounds and zinc salts |
-
1980
- 1980-10-10 GB GB8032743A patent/GB2084870B/en not_active Expired
-
1981
- 1981-09-14 NZ NZ198348A patent/NZ198348A/en unknown
- 1981-09-18 IL IL63877A patent/IL63877A0/xx unknown
- 1981-09-18 ZW ZW235/81A patent/ZW23581A1/xx unknown
- 1981-09-24 ES ES505746A patent/ES8205554A1/es not_active Expired
- 1981-09-25 MC MC811545A patent/MC1416A1/xx unknown
- 1981-09-25 ZA ZA816678A patent/ZA816678B/xx unknown
- 1981-09-25 IN IN1079/CAL/81A patent/IN155108B/en unknown
- 1981-09-29 AU AU75756/81A patent/AU545501B2/en not_active Ceased
- 1981-09-30 AR AR286944A patent/AR227068A1/es active
- 1981-09-30 PT PT73749A patent/PT73749B/pt unknown
- 1981-10-02 DE DE8181107848T patent/DE3172144D1/de not_active Expired
- 1981-10-02 EP EP81107848A patent/EP0049830B1/en not_active Expired
- 1981-10-02 AT AT81107848T patent/ATE15328T1/de not_active IP Right Cessation
- 1981-10-07 GR GR66221A patent/GR75374B/el unknown
- 1981-10-08 PL PL23335381A patent/PL233353A1/xx unknown
- 1981-10-08 MA MA19500A patent/MA19299A1/fr unknown
- 1981-10-09 BR BR8106557A patent/BR8106557A/pt unknown
- 1981-10-09 CU CU8135541A patent/CU35541A/es unknown
- 1981-10-09 FI FI813136A patent/FI75269C/fi not_active IP Right Cessation
- 1981-10-09 DK DK449381A patent/DK449381A/da not_active Application Discontinuation
- 1981-10-09 IT IT24436/81A patent/IT1140455B/it active
- 1981-10-09 NO NO813412A patent/NO155955C/no unknown
- 1981-10-09 JP JP56160371A patent/JPS5793905A/ja active Granted
- 1981-10-09 DD DD81233993A patent/DD202245A5/de unknown
- 1981-10-09 CA CA000387691A patent/CA1168159A/en not_active Expired
- 1981-10-09 PH PH26335A patent/PH17278A/en unknown
- 1981-10-10 KR KR1019810003819A patent/KR830006970A/ko not_active Withdrawn
-
1983
- 1983-12-19 US US06/563,011 patent/US4522806A/en not_active Expired - Fee Related
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