DD145059A5 - Verfahren zur herstellung einer antibakteriellen zusammensetzung - Google Patents
Verfahren zur herstellung einer antibakteriellen zusammensetzung Download PDFInfo
- Publication number
- DD145059A5 DD145059A5 DD79214580A DD21458079A DD145059A5 DD 145059 A5 DD145059 A5 DD 145059A5 DD 79214580 A DD79214580 A DD 79214580A DD 21458079 A DD21458079 A DD 21458079A DD 145059 A5 DD145059 A5 DD 145059A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- acid
- item
- thienamycin
- inhibitor
- compound
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 32
- 230000000844 anti-bacterial effect Effects 0.000 title claims description 6
- 238000004519 manufacturing process Methods 0.000 title description 2
- WKDDRNSBRWANNC-ATRFCDNQSA-N Thienamycin Chemical compound C1C(SCCN)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 WKDDRNSBRWANNC-ATRFCDNQSA-N 0.000 claims abstract description 40
- WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 claims abstract description 35
- -1 thienamycin compound Chemical class 0.000 claims description 69
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- 238000002485 combustion reaction Methods 0.000 description 1
- 229940125773 compound 10 Drugs 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000012050 conventional carrier Substances 0.000 description 1
- 239000013058 crude material Substances 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- GOHCTCOGYKAJLZ-UHFFFAOYSA-N ctep Chemical compound CC=1N(C=2C=CC(OC(F)(F)F)=CC=2)C(C)=NC=1C#CC1=CC=NC(Cl)=C1 GOHCTCOGYKAJLZ-UHFFFAOYSA-N 0.000 description 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
- 230000002380 cytological effect Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000001212 derivatisation Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- ZZTURJAZCMUWEP-UHFFFAOYSA-N diaminomethylideneazanium;hydrogen sulfate Chemical compound NC(N)=N.OS(O)(=O)=O ZZTURJAZCMUWEP-UHFFFAOYSA-N 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- POLCUAVZOMRGSN-UHFFFAOYSA-N dipropyl ether Chemical compound CCCOCCC POLCUAVZOMRGSN-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- ZKQFHRVKCYFVCN-UHFFFAOYSA-N ethoxyethane;hexane Chemical compound CCOCC.CCCCCC ZKQFHRVKCYFVCN-UHFFFAOYSA-N 0.000 description 1
- ANEDZEVDORCLPM-UHFFFAOYSA-N ethyl 1,3-dithiane-2-carboxylate Chemical compound CCOC(=O)C1SCCCS1 ANEDZEVDORCLPM-UHFFFAOYSA-N 0.000 description 1
- FQKVLKIRSWZHFS-UHFFFAOYSA-N ethyl 2-oxooctanoate Chemical compound CCCCCCC(=O)C(=O)OCC FQKVLKIRSWZHFS-UHFFFAOYSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 125000004005 formimidoyl group Chemical group [H]\N=C(/[H])* 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000012812 general test Methods 0.000 description 1
- 239000003979 granulating agent Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 1
- 238000012750 in vivo screening Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- SANOUVWGPVYVAV-UHFFFAOYSA-N isovaleramide Chemical compound CC(C)CC(N)=O SANOUVWGPVYVAV-UHFFFAOYSA-N 0.000 description 1
- ZLVXBBHTMQJRSX-VMGNSXQWSA-N jdtic Chemical compound C1([C@]2(C)CCN(C[C@@H]2C)C[C@H](C(C)C)NC(=O)[C@@H]2NCC3=CC(O)=CC=C3C2)=CC=CC(O)=C1 ZLVXBBHTMQJRSX-VMGNSXQWSA-N 0.000 description 1
- 150000003951 lactams Chemical class 0.000 description 1
- RYZCLUQMCYZBJQ-UHFFFAOYSA-H lead(2+);dicarbonate;dihydroxide Chemical compound [OH-].[OH-].[Pb+2].[Pb+2].[Pb+2].[O-]C([O-])=O.[O-]C([O-])=O RYZCLUQMCYZBJQ-UHFFFAOYSA-H 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 239000006194 liquid suspension Substances 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- HHQJWDKIRXRTLS-UHFFFAOYSA-N n'-bromobutanediamide Chemical compound NC(=O)CCC(=O)NBr HHQJWDKIRXRTLS-UHFFFAOYSA-N 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 150000003009 phosphonic acids Chemical group 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000012746 preparative thin layer chromatography Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 229960000948 quinine Drugs 0.000 description 1
- 229960001811 quinine hydrochloride Drugs 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- ILYPJQIFUVDUAO-UHFFFAOYSA-N tert-butyl 2-[(2,2-dimethylcyclopropanecarbonyl)amino]hex-2-enoate Chemical compound CCCC=C(C(=O)OC(C)(C)C)NC(=O)C1CC1(C)C ILYPJQIFUVDUAO-UHFFFAOYSA-N 0.000 description 1
- QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical class C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 description 1
- 239000002132 β-lactam antibiotic Substances 0.000 description 1
- 229940124586 β-lactam antibiotics Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92721378A | 1978-07-24 | 1978-07-24 | |
| US5023279A | 1979-06-22 | 1979-06-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD145059A5 true DD145059A5 (de) | 1980-11-19 |
Family
ID=26728043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD79214580A DD145059A5 (de) | 1978-07-24 | 1979-07-24 | Verfahren zur herstellung einer antibakteriellen zusammensetzung |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0007614B1 (xx) |
| AR (1) | AR244550A1 (xx) |
| AU (1) | AU529315B2 (xx) |
| CA (1) | CA1136549A (xx) |
| CZ (1) | CZ280583B6 (xx) |
| DD (1) | DD145059A5 (xx) |
| DE (1) | DE2964609D1 (xx) |
| EG (1) | EG14367A (xx) |
| ES (1) | ES482774A1 (xx) |
| FI (1) | FI792282A (xx) |
| GR (1) | GR69997B (xx) |
| HK (1) | HK23286A (xx) |
| HU (1) | HU182973B (xx) |
| IE (1) | IE51691B1 (xx) |
| IL (1) | IL57798A (xx) |
| NZ (1) | NZ190993A (xx) |
| PH (1) | PH16620A (xx) |
| PT (1) | PT69955B (xx) |
| SK (1) | SK513779A3 (xx) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5071843A (en) * | 1978-07-24 | 1991-12-10 | Merck & Co., Inc. | Combination of 2-substituted carbapenems with dipeptidase inhibitors |
| US4880793A (en) * | 1978-07-24 | 1989-11-14 | Merck & Co., Inc. | Combination of thienamycin-type antibiotics with dipeptidase inhibitors |
| IE50333B1 (en) * | 1979-11-02 | 1986-04-02 | Merck & Co Inc | Antibacterial compositions comprising a beta-lactam-type compound and a 3-substituted propenoate |
| EP0048025B1 (en) * | 1980-09-17 | 1986-01-15 | Merck & Co. Inc. | Antibacterial composition of thienamycin type compound and a dipeptidase inhibitor |
| PT73640B (en) * | 1980-09-17 | 1983-10-19 | Merck & Co Inc | Process for preparing chemical compounds selectively inhibit the metabolism of dipeptidase |
| EP0048301A1 (en) * | 1980-09-24 | 1982-03-31 | Merck & Co. Inc. | 2-(Cyclopropane-carboxamido)-2-alkenoic acids, their esters and salts, and antibacterial compositions comprising the same and a thienamycin-type compound |
| NZ201471A (en) * | 1981-08-10 | 1985-09-13 | Merck & Co Inc | Antibacterial compositions containing penems and dipeptidase inhibitors |
| JPS6025952A (ja) * | 1983-07-20 | 1985-02-08 | Sumitomo Chem Co Ltd | 光学活性２，２−ジメチルシクロプロパン−１−カルボン酸誘導体の製造法 |
| CA1246450A (en) * | 1984-04-30 | 1988-12-13 | Merck & Co., Inc. | Combination of 2-substituted carbapenems with cipeptide inhibitors |
| IE851586L (en) * | 1984-07-02 | 1986-01-02 | Interchem Internat S A | I methylcarbapenems having a 2-quaternary¹heteroarylalkylthio substituent |
| CA1273012A (en) * | 1984-07-02 | 1990-08-21 | Burton G. Christensen | 1-methylcarbapenems having an externally alkylated mono- of bicyclic 2-quarternary heteroarylalkylthio substituent |
| CA1273011A (en) * | 1984-07-02 | 1990-08-21 | Susan M. Schmitt | Carbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkylthio substituent |
| NO172099C (no) * | 1984-10-15 | 1993-06-09 | Sankyo Co | Fremgangsmaate til fremstilling av et preparat som inneholder et penem -eller karbapenemantibiotikum og en n-acetylert aminosyre |
| US4680292A (en) * | 1984-12-13 | 1987-07-14 | Merck & Co., Inc. | Carbapenems and 1-methylcarbapenems having a 2-heteroaryliumaliphatic substituent |
| US4739113A (en) * | 1986-05-30 | 1988-04-19 | Merck & Co., Inc. | Bis(cyclopropanecarboxamido)alkadienedioic acids as renal dipeptidase inhibitors |
| EP0464900A3 (en) | 1990-06-26 | 1992-07-22 | Merck & Co. Inc. | 2-biphenyl-carbapenems |
| CA2052730A1 (en) | 1990-10-11 | 1992-04-12 | Frank P. Dininno | 2-(substituted-dibenzofuranyl and dibenzothienyl) carbapenem antibacterial agents |
| EP0497353B1 (en) * | 1991-02-01 | 2002-05-08 | Suntory Limited | Use of cilastatin, glutathione or N-acetyl-L-cysteine for the preparation of a medicament for the improvement of gastrointestinal absorption of penem or carbapenem antibiotics |
| US6297231B1 (en) | 1996-10-28 | 2001-10-02 | Merck & Co., Inc. | Stabilized carbapenem antibiotic compositions and method of making |
| US6255300B1 (en) | 1997-09-09 | 2001-07-03 | Merck & Co., Inc. | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment |
| US6277843B1 (en) | 1997-09-17 | 2001-08-21 | Merck & Co., Inc. | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment |
| US6271222B1 (en) | 1998-05-28 | 2001-08-07 | Merck & Co., Inc. | Penem antibacterial compounds, compositions and methods of treatment |
| US6288054B1 (en) | 1998-06-02 | 2001-09-11 | Merck & Co., Inc. | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment |
| US6310055B2 (en) | 1998-06-02 | 2001-10-30 | Merck & Co., Inc. | Halophenoxy substituted carbapenem antibacterial compounds |
| US6284753B2 (en) | 1998-06-02 | 2001-09-04 | Merck & Co., Inc. | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment |
| JP2002518498A (ja) | 1998-06-25 | 2002-06-25 | メルク エンド カムパニー インコーポレーテッド | ナフト［１，８−ｄｅ］チアジン−２−イルメチルカルバペネム抗菌物質 |
| EP1089999A4 (en) | 1998-06-25 | 2002-12-04 | Merck & Co Inc | CARBAPENEM ANTIBACTERIALS (HETEROCYCLIC) SUBSTITUTED BY METHYL |
| US6265395B1 (en) | 1998-06-25 | 2001-07-24 | Merck & Co., Inc. | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment |
| US6294528B1 (en) | 1998-06-25 | 2001-09-25 | Merck & Co., Inc. | Carbapenem antibacterial compounds, compositions containing such compounds and method of treatment |
| US6346525B1 (en) | 1998-06-25 | 2002-02-12 | Merck & Co., Inc. | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment |
| US6316488B1 (en) | 1999-06-17 | 2001-11-13 | Merck & Co., Inc. | Antibiotic compound |
| US6221859B1 (en) | 1999-08-27 | 2001-04-24 | Merck & Co., Inc. | Carbapenem antibacterial compositions and methods of the treatment |
| WO2012104793A1 (en) * | 2011-02-02 | 2012-08-09 | Indian Council Of Medical Research | An antibacterial and antiviral compound |
| AU2012275499A1 (en) | 2011-06-27 | 2013-12-19 | Kyorin Pharmaceutical Co., Ltd. | Bridged bicyclic compounds for the treatment of bacterial infections |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2272684A1 (en) * | 1975-01-07 | 1975-12-26 | Ito Shojiro | Antibiotic-unsaturated acid compsns. - having a synergistic effect against gram positive and negative bacteria |
-
1979
- 1979-07-04 AR AR79277427A patent/AR244550A1/es active
- 1979-07-12 PH PH22771A patent/PH16620A/en unknown
- 1979-07-12 NZ NZ190993A patent/NZ190993A/xx unknown
- 1979-07-13 IL IL57798A patent/IL57798A/xx unknown
- 1979-07-16 AU AU48932/79A patent/AU529315B2/en not_active Expired
- 1979-07-20 GR GR59656A patent/GR69997B/el unknown
- 1979-07-20 CA CA000332316A patent/CA1136549A/en not_active Expired
- 1979-07-20 PT PT69955A patent/PT69955B/pt unknown
- 1979-07-20 FI FI792282A patent/FI792282A/fi not_active Application Discontinuation
- 1979-07-20 HU HU79ME2286A patent/HU182973B/hu unknown
- 1979-07-23 ES ES482774A patent/ES482774A1/es not_active Expired
- 1979-07-23 CZ CS795137A patent/CZ280583B6/cs unknown
- 1979-07-23 SK SK5137-79A patent/SK513779A3/sk unknown
- 1979-07-24 EG EG443/79A patent/EG14367A/xx active
- 1979-07-24 DD DD79214580A patent/DD145059A5/de unknown
- 1979-07-24 DE DE7979102615T patent/DE2964609D1/de not_active Expired
- 1979-07-24 EP EP79102615A patent/EP0007614B1/en not_active Expired
- 1979-08-08 IE IE1388/79A patent/IE51691B1/en not_active IP Right Cessation
-
1986
- 1986-04-03 HK HK232/86A patent/HK23286A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL57798A (en) | 1986-11-30 |
| AR244550A1 (es) | 1993-11-30 |
| EP0007614B1 (en) | 1983-01-26 |
| CZ513779A3 (en) | 1995-10-18 |
| PT69955A (en) | 1979-08-01 |
| SK278357B6 (en) | 1997-01-08 |
| NZ190993A (en) | 1981-10-19 |
| HU182973B (en) | 1984-03-28 |
| EG14367A (en) | 1984-09-30 |
| AU529315B2 (en) | 1983-06-02 |
| AU4893279A (en) | 1980-01-31 |
| PT69955B (pt) | 1981-06-11 |
| IL57798A0 (en) | 1979-11-30 |
| HK23286A (en) | 1986-04-11 |
| CZ280583B6 (cs) | 1996-02-14 |
| CA1136549A (en) | 1982-11-30 |
| DE2964609D1 (en) | 1983-03-03 |
| SK513779A3 (en) | 1997-01-08 |
| FI792282A (fi) | 1980-01-25 |
| GR69997B (xx) | 1982-07-23 |
| PH16620A (en) | 1983-11-28 |
| IE51691B1 (en) | 1987-02-18 |
| ES482774A1 (es) | 1980-09-01 |
| IE791388L (en) | 1980-01-24 |
| EP0007614A1 (en) | 1980-02-06 |
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