CZ305565B6 - Způsob výroby 3-O-deaktivovaného 4´-monofosforyllipidu A (3D-MLA) - Google Patents
Způsob výroby 3-O-deaktivovaného 4´-monofosforyllipidu A (3D-MLA) Download PDFInfo
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- CZ305565B6 CZ305565B6 CZ2003-2895A CZ20032895A CZ305565B6 CZ 305565 B6 CZ305565 B6 CZ 305565B6 CZ 20032895 A CZ20032895 A CZ 20032895A CZ 305565 B6 CZ305565 B6 CZ 305565B6
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- UVYVLBIGDKGWPX-UHFFFAOYSA-N digitonine Natural products CC1C(C2(CCC3C4(C)CC(O)C(OC5C(C(O)C(OC6C(C(OC7C(C(O)C(O)CO7)O)C(O)C(CO)O6)OC6C(C(OC7C(C(O)C(O)C(CO)O7)O)C(O)C(CO)O6)O)C(CO)O5)O)CC4CCC3C2C2O)C)C2OC11CCC(C)CO1 UVYVLBIGDKGWPX-UHFFFAOYSA-N 0.000 description 1
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- 235000011118 potassium hydroxide Nutrition 0.000 description 1
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- 230000000717 retained effect Effects 0.000 description 1
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- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C07H13/06—Fatty acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28008901P | 2001-03-30 | 2001-03-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CZ20032895A3 CZ20032895A3 (cs) | 2004-02-18 |
| CZ305565B6 true CZ305565B6 (cs) | 2015-12-16 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ2003-2895A CZ305565B6 (cs) | 2001-03-30 | 2002-03-28 | Způsob výroby 3-O-deaktivovaného 4´-monofosforyllipidu A (3D-MLA) |
| CZ2014-776A CZ305601B6 (cs) | 2001-03-30 | 2002-03-28 | Způsob extrakce lipopolysacharidu (LPS) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ2014-776A CZ305601B6 (cs) | 2001-03-30 | 2002-03-28 | Způsob extrakce lipopolysacharidu (LPS) |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US20030031684A1 (enExample) |
| EP (3) | EP1461418B1 (enExample) |
| JP (3) | JP4233327B2 (enExample) |
| KR (2) | KR100884462B1 (enExample) |
| CN (2) | CN1928107B (enExample) |
| AU (1) | AU2002306962B2 (enExample) |
| BR (2) | BR122015016711B8 (enExample) |
| CA (1) | CA2440249C (enExample) |
| CZ (2) | CZ305565B6 (enExample) |
| DK (2) | DK2465937T3 (enExample) |
| ES (2) | ES2415769T3 (enExample) |
| HU (1) | HU228688B1 (enExample) |
| IL (3) | IL157867A0 (enExample) |
| MX (1) | MXPA03008856A (enExample) |
| NZ (2) | NZ548595A (enExample) |
| PL (2) | PL402939A1 (enExample) |
| PT (2) | PT2465937E (enExample) |
| RU (2) | RU2302463C2 (enExample) |
| SI (2) | SI1461418T1 (enExample) |
| WO (1) | WO2002078637A2 (enExample) |
| ZA (1) | ZA200307238B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030031684A1 (en) | 2001-03-30 | 2003-02-13 | Corixa Corporation | Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA) |
| FR2848223B1 (fr) * | 2002-12-09 | 2005-02-25 | Centre Nat Rech Scient | Nouveau procede d'isolement des endotoxines. |
| TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| PL3017827T3 (pl) | 2005-12-22 | 2019-04-30 | Glaxosmithkline Biologicals Sa | Szczepionka z koniugatem polisacharydu pneumokokowego |
| GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
| BRPI0721393B8 (pt) * | 2007-03-22 | 2022-09-06 | Fund Butantan | método para obter lipídeo a monofosforilado da bordetella pertussis como um subproduto da produção de vacina celular contra coqueluche |
| US20090035360A1 (en) | 2007-05-24 | 2009-02-05 | Dominique Ingrid Lemoine | Lyophilised antigen composition |
| US20130066064A1 (en) * | 2010-05-20 | 2013-03-14 | Glaxosmithkline Biologicals S.A, | Novel process |
| BR112013029514A2 (pt) | 2011-05-17 | 2019-09-24 | Glaxosmithkline Biologicals Sa | composição imunogênica, vacina, e, método de tratar ou impedir uma doença |
| GB201113570D0 (en) | 2011-08-05 | 2011-09-21 | Glaxosmithkline Biolog Sa | Vaccine |
| US9241988B2 (en) * | 2012-04-12 | 2016-01-26 | Avanti Polar Lipids, Inc. | Disaccharide synthetic lipid compounds and uses thereof |
| CN102746414B (zh) * | 2012-07-20 | 2014-04-16 | 成都生物制品研究所有限责任公司 | 一种细菌脂多糖的沉降方法 |
| GB201518684D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Vaccine |
| US11186652B2 (en) | 2015-12-22 | 2021-11-30 | Glaxosmithkline Biologicals Sa | LPS extraction process |
| KR101761348B1 (ko) * | 2016-01-06 | 2017-07-26 | 한국과학기술연구원 | 헥사 아실화된 모노포스포릴 지질 a를 생산하는 세균, 및 이를 이용한 헥사 아실화된 모노포스포릴 지질 a 생산 방법 |
| KR102019331B1 (ko) * | 2017-07-05 | 2019-09-09 | 한국과학기술연구원 | 모노포스포릴 지질 ａ를 구성적으로 생산하는 세균, 및 이를 이용한 모노포스포릴 지질 ａ 생산 방법 |
| EP3777884A1 (en) | 2019-08-15 | 2021-02-17 | GlaxoSmithKline Biologicals S.A. | Immunogenic composition |
| KR102748233B1 (ko) * | 2019-08-29 | 2024-12-31 | 주식회사 유바이오로직스 | 모노포스포릴 지질 ａ를 생산하는 방법 |
| WO2021040414A1 (ko) * | 2019-08-29 | 2021-03-04 | 주식회사 유바이오로직스 | 모노포스포릴 지질 ａ를 생산하는 방법 |
| WO2021122551A1 (en) | 2019-12-19 | 2021-06-24 | Glaxosmithkline Biologicals Sa | S. aureus antigens and compositions thereof |
| CN113652455B (zh) * | 2021-08-09 | 2022-04-26 | 北京华诺泰生物医药科技有限公司 | 六酰基3d-mla的发酵方法 |
| CN116554361B (zh) * | 2023-07-11 | 2023-11-03 | 江苏瑞科生物技术股份有限公司 | 用于提取脂多糖的抽提液和方法 |
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| US4912094A (en) * | 1988-06-29 | 1990-03-27 | Ribi Immunochem Research, Inc. | Modified lipopolysaccharides and process of preparation |
| US5057598A (en) * | 1983-05-06 | 1991-10-15 | Centocor, Inc. | Monoclonal antibodies reactive with endotoxin core |
| WO1999056776A2 (en) * | 1998-05-07 | 1999-11-11 | Corixa Corporation | Adjuvant composition and methods for its use |
| WO2000078353A2 (en) * | 1999-06-22 | 2000-12-28 | Corixa Corporation | Aqueous immunologic adjuvant compositions of monophosphoryl lipid a |
| WO2001070756A2 (de) * | 2000-03-20 | 2001-09-27 | Pharma-Zentrale Gmbh | Lipopolysaccharide aus escherichia coli |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5A (en) * | 1836-08-10 | Thomas Blanchard | Machine for mortising solid wooden shells of ships' tackle-blocks | |
| JPS5758889A (en) * | 1980-08-19 | 1982-04-08 | Shell Int Research | Preparation of microbiological polysaccharide |
| US4436727A (en) | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| US4436728A (en) * | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| US4612304A (en) * | 1985-06-11 | 1986-09-16 | Ss Pharmaceutical Co., Ltd. | Antitumor formulation containing lipopolysaccharide with trehalose derivatives |
| US5554372A (en) * | 1986-09-22 | 1996-09-10 | Emory University | Methods and vaccines comprising surface-active copolymers |
| US5068191A (en) * | 1989-08-31 | 1991-11-26 | The Biomembrane Institute | Purified histo-blood group a glycosyltransferase and antibodies thereto |
| US5552141A (en) * | 1991-10-30 | 1996-09-03 | Ribi; Hans O. | Polymeric immunological adjuvants |
| EP0761231B1 (en) | 1992-06-25 | 2000-01-12 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Vaccine composition containing adjuvants |
| RU2051969C1 (ru) * | 1992-07-31 | 1996-01-10 | Иркутский научно-исследовательский противочумный институт Сибири и Дальнего Востока | Способ получения бактериальных липополисахаридов |
| ES2162139T5 (es) | 1993-03-23 | 2008-05-16 | Smithkline Beecham Biologicals S.A. | Composiciones de vacuna que contienen monofosforil-lipido a 3-o-desacilado. |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| US5648343A (en) * | 1994-02-28 | 1997-07-15 | The University Of Georgia Research Foundation | Method for treating LPS-mediated disorders |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| US5762943A (en) * | 1996-05-14 | 1998-06-09 | Ribi Immunochem Research, Inc. | Methods of treating type I hypersensitivity using monophosphoryl lipid A |
| US5855913A (en) * | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US5985309A (en) * | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US5846789A (en) * | 1996-12-10 | 1998-12-08 | Council Of Scientific And Industrial Research | Process for preparing nontoxic lipopolysaccharides from acidiphilium species |
| JP3595966B2 (ja) * | 1996-12-25 | 2004-12-02 | カウンシィル オブ サイアンティフィック アンド インダストリアル リサーチ | 内毒血症または敗血症の予防に有効な新規の効力のある非毒性リポ多糖体の調製方法 |
| CA2284586C (en) | 1997-04-01 | 2011-02-08 | Ribi Immunochem Research, Inc. | Aqueous immunologic adjuvant compositions of monophosphoryl lipid a |
| US20030031684A1 (en) * | 2001-03-30 | 2003-02-13 | Corixa Corporation | Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA) |
-
2002
- 2002-03-14 US US10/099,313 patent/US20030031684A1/en not_active Abandoned
- 2002-03-28 SI SI200231029T patent/SI1461418T1/sl unknown
- 2002-03-28 RU RU2003131677/13A patent/RU2302463C2/ru active
- 2002-03-28 ES ES02757857T patent/ES2415769T3/es not_active Expired - Lifetime
- 2002-03-28 BR BR122015016711A patent/BR122015016711B8/pt not_active IP Right Cessation
- 2002-03-28 MX MXPA03008856A patent/MXPA03008856A/es active IP Right Grant
- 2002-03-28 EP EP02757857.4A patent/EP1461418B1/en not_active Expired - Lifetime
- 2002-03-28 JP JP2002576905A patent/JP4233327B2/ja not_active Expired - Lifetime
- 2002-03-28 EP EP11176339A patent/EP2479280A1/en not_active Withdrawn
- 2002-03-28 NZ NZ548595A patent/NZ548595A/en not_active IP Right Cessation
- 2002-03-28 AU AU2002306962A patent/AU2002306962B2/en not_active Expired
- 2002-03-28 PT PT111763405T patent/PT2465937E/pt unknown
- 2002-03-28 CZ CZ2003-2895A patent/CZ305565B6/cs not_active IP Right Cessation
- 2002-03-28 KR KR1020037012849A patent/KR100884462B1/ko not_active Expired - Lifetime
- 2002-03-28 NZ NZ528204A patent/NZ528204A/en not_active IP Right Cessation
- 2002-03-28 KR KR1020087022154A patent/KR100927099B1/ko not_active Expired - Lifetime
- 2002-03-28 IL IL15786702A patent/IL157867A0/xx unknown
- 2002-03-28 CN CN2006101536435A patent/CN1928107B/zh not_active Expired - Lifetime
- 2002-03-28 PL PL402939A patent/PL402939A1/pl not_active Application Discontinuation
- 2002-03-28 ES ES11176340.5T patent/ES2517391T3/es not_active Expired - Lifetime
- 2002-03-28 PT PT2757857T patent/PT1461418E/pt unknown
- 2002-03-28 SI SI200231048T patent/SI2465937T1/sl unknown
- 2002-03-28 WO PCT/US2002/009731 patent/WO2002078637A2/en not_active Ceased
- 2002-03-28 HU HU0304091A patent/HU228688B1/hu unknown
- 2002-03-28 EP EP11176340.5A patent/EP2465937B1/en not_active Expired - Lifetime
- 2002-03-28 CZ CZ2014-776A patent/CZ305601B6/cs not_active IP Right Cessation
- 2002-03-28 BR BRPI0208535A patent/BRPI0208535B8/pt not_active IP Right Cessation
- 2002-03-28 PL PL373657A patent/PL217737B1/pl not_active IP Right Cessation
- 2002-03-28 CN CN02807697A patent/CN100577790C/zh not_active Expired - Lifetime
- 2002-03-28 DK DK11176340.5T patent/DK2465937T3/da active
- 2002-03-28 CA CA2440249A patent/CA2440249C/en not_active Expired - Lifetime
- 2002-03-28 DK DK02757857.4T patent/DK1461418T3/da active
-
2003
- 2003-09-11 IL IL157867A patent/IL157867A/en active IP Right Grant
- 2003-09-16 ZA ZA2003/07238A patent/ZA200307238B/en unknown
-
2006
- 2006-11-16 RU RU2006140606/15A patent/RU2427378C2/ru active
-
2007
- 2007-01-09 US US11/621,306 patent/US20070212758A1/en not_active Abandoned
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2008
- 2008-02-21 IL IL189651A patent/IL189651A/en active IP Right Grant
- 2008-02-29 JP JP2008049418A patent/JP2008255335A/ja not_active Withdrawn
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2011
- 2011-11-22 JP JP2011254760A patent/JP5730178B2/ja not_active Expired - Lifetime
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2014
- 2014-05-06 US US14/271,431 patent/US9512159B2/en not_active Expired - Fee Related
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| Date | Code | Title | Description |
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| MK4A | Patent expired |
Effective date: 20220328 |