BR122015016711B8 - método para extração de lipopolissacarídeo a partir de cultura de cepa bacteriana, o qual pode gerar 3-o-4'-monofosforil desacilado lipídeo a - Google Patents

método para extração de lipopolissacarídeo a partir de cultura de cepa bacteriana, o qual pode gerar 3-o-4'-monofosforil desacilado lipídeo a

Info

Publication number
BR122015016711B8
BR122015016711B8 BR122015016711A BR122015016711A BR122015016711B8 BR 122015016711 B8 BR122015016711 B8 BR 122015016711B8 BR 122015016711 A BR122015016711 A BR 122015016711A BR 122015016711 A BR122015016711 A BR 122015016711A BR 122015016711 B8 BR122015016711 B8 BR 122015016711B8
Authority
BR
Brazil
Prior art keywords
extracting
monophosphoryl lipid
lps
bacterial strain
lipopolysaccharide
Prior art date
Application number
BR122015016711A
Other languages
English (en)
Portuguese (pt)
Other versions
BR122015016711B1 (pt
Inventor
Scott Snyder D
R Myers Kent
Original Assignee
Corixa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corixa Corp filed Critical Corixa Corp
Publication of BR122015016711B1 publication Critical patent/BR122015016711B1/pt
Publication of BR122015016711B8 publication Critical patent/BR122015016711B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
BR122015016711A 2001-03-30 2002-03-28 método para extração de lipopolissacarídeo a partir de cultura de cepa bacteriana, o qual pode gerar 3-o-4'-monofosforil desacilado lipídeo a BR122015016711B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28008901P 2001-03-30 2001-03-30
BRPI0208535A BRPI0208535B8 (pt) 2001-03-30 2002-03-28 método para a produção de lipopolissacarídeo que pode gerar 3-o-4’-monofosforil desacilado lipídeo a
PCT/US2002/009731 WO2002078637A2 (en) 2001-03-30 2002-03-28 Methods for the production of 3-o-deactivated-4'-monophosphoryl lipid a (3d-mla)

Publications (2)

Publication Number Publication Date
BR122015016711B1 BR122015016711B1 (pt) 2016-08-02
BR122015016711B8 true BR122015016711B8 (pt) 2021-07-27

Family

ID=23071615

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0208535A BRPI0208535B8 (pt) 2001-03-30 2002-03-28 método para a produção de lipopolissacarídeo que pode gerar 3-o-4’-monofosforil desacilado lipídeo a
BR122015016711A BR122015016711B8 (pt) 2001-03-30 2002-03-28 método para extração de lipopolissacarídeo a partir de cultura de cepa bacteriana, o qual pode gerar 3-o-4'-monofosforil desacilado lipídeo a

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0208535A BRPI0208535B8 (pt) 2001-03-30 2002-03-28 método para a produção de lipopolissacarídeo que pode gerar 3-o-4’-monofosforil desacilado lipídeo a

Country Status (21)

Country Link
US (3) US20030031684A1 (enExample)
EP (3) EP1461418B1 (enExample)
JP (3) JP4233327B2 (enExample)
KR (2) KR100884462B1 (enExample)
CN (2) CN100577790C (enExample)
AU (1) AU2002306962B2 (enExample)
BR (2) BRPI0208535B8 (enExample)
CA (1) CA2440249C (enExample)
CZ (2) CZ305565B6 (enExample)
DK (2) DK1461418T3 (enExample)
ES (2) ES2517391T3 (enExample)
HU (1) HU228688B1 (enExample)
IL (3) IL157867A0 (enExample)
MX (1) MXPA03008856A (enExample)
NZ (2) NZ528204A (enExample)
PL (2) PL402939A1 (enExample)
PT (2) PT1461418E (enExample)
RU (2) RU2302463C2 (enExample)
SI (2) SI1461418T1 (enExample)
WO (1) WO2002078637A2 (enExample)
ZA (1) ZA200307238B (enExample)

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US20030031684A1 (en) * 2001-03-30 2003-02-13 Corixa Corporation Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA)
FR2848223B1 (fr) * 2002-12-09 2005-02-25 Centre Nat Rech Scient Nouveau procede d'isolement des endotoxines.
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DK2384765T3 (en) 2005-12-22 2017-01-09 Glaxosmithkline Biologicals Sa Vaccine against Streptococcus pneumoniae.
WO2008134830A1 (en) * 2007-03-22 2008-11-13 Fundação Butantan Method to obtain monophosphoryl lipid a from bordetella pertussis as a by-product of the cellular pertussis vaccine production
MX2009012381A (es) 2007-05-24 2009-12-01 Glaxosmithkline Biolog Sa Composicion antigenica liofilizada.
US20130066064A1 (en) * 2010-05-20 2013-03-14 Glaxosmithkline Biologicals S.A, Novel process
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GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
BR112018012791B1 (pt) * 2015-12-22 2022-03-29 Glaxosmithkline Biologicals S.A. Solução de extração de lipopolissacarídeo (lps), e, método de extração de lps
KR101761348B1 (ko) * 2016-01-06 2017-07-26 한국과학기술연구원 헥사 아실화된 모노포스포릴 지질 a를 생산하는 세균, 및 이를 이용한 헥사 아실화된 모노포스포릴 지질 a 생산 방법
KR102019331B1 (ko) * 2017-07-05 2019-09-09 한국과학기술연구원 모노포스포릴 지질 ａ를 구성적으로 생산하는 세균, 및 이를 이용한 모노포스포릴 지질 ａ 생산 방법
EP3777884A1 (en) 2019-08-15 2021-02-17 GlaxoSmithKline Biologicals S.A. Immunogenic composition
KR102748233B1 (ko) * 2019-08-29 2024-12-31 주식회사 유바이오로직스 모노포스포릴 지질 ａ를 생산하는 방법
US12173342B2 (en) 2019-08-29 2024-12-24 Eubiologics Co., Ltd. Method for producing monophosphoryl lipid A
US20230045642A1 (en) 2019-12-19 2023-02-09 Glaxosmithkline Biologicals Sa S. aureus antigens and compositions thereof
CN113652455B (zh) * 2021-08-09 2022-04-26 北京华诺泰生物医药科技有限公司 六酰基3d-mla的发酵方法
CN116554361B (zh) * 2023-07-11 2023-11-03 江苏瑞科生物技术股份有限公司 用于提取脂多糖的抽提液和方法

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Also Published As

Publication number Publication date
EP1461418A4 (en) 2006-05-17
JP5730178B2 (ja) 2015-06-03
PL402939A1 (pl) 2013-08-19
BRPI0208535B8 (pt) 2021-05-25
JP2004535477A (ja) 2004-11-25
HUP0304091A3 (en) 2011-04-28
KR100927099B1 (ko) 2009-11-13
CZ305565B6 (cs) 2015-12-16
HK1165494A1 (en) 2012-10-05
US20140243513A1 (en) 2014-08-28
RU2302463C2 (ru) 2007-07-10
KR20080088666A (ko) 2008-10-02
KR100884462B1 (ko) 2009-02-20
PL373657A1 (en) 2005-09-05
SI2465937T1 (sl) 2014-11-28
CN1928107A (zh) 2007-03-14
CN1608127A (zh) 2005-04-20
EP1461418B1 (en) 2013-04-24
NZ528204A (en) 2006-12-22
JP2008255335A (ja) 2008-10-23
WO2002078637A3 (en) 2004-07-22
CA2440249A1 (en) 2002-10-10
DK2465937T3 (da) 2014-11-10
IL189651A (en) 2011-02-28
ES2517391T3 (es) 2014-11-03
DK1461418T3 (da) 2013-07-08
BRPI0208535B1 (pt) 2016-03-29
BR0208535A (pt) 2006-02-21
AU2002306962A2 (en) 2002-10-15
HK1075913A1 (zh) 2005-12-30
HK1104319A1 (en) 2008-01-11
SI1461418T1 (sl) 2013-08-30
PT2465937E (pt) 2014-11-03
RU2006140606A (ru) 2008-05-27
US20070212758A1 (en) 2007-09-13
BR122015016711B1 (pt) 2016-08-02
EP1461418A2 (en) 2004-09-29
IL157867A (en) 2011-07-31
CN100577790C (zh) 2010-01-06
CN1928107B (zh) 2010-12-22
US20030031684A1 (en) 2003-02-13
US9512159B2 (en) 2016-12-06
KR20060015704A (ko) 2006-02-20
MXPA03008856A (es) 2003-12-04
IL157867A0 (en) 2004-03-28
EP2479280A1 (en) 2012-07-25
RU2427378C2 (ru) 2011-08-27
WO2002078637A2 (en) 2002-10-10
HU228688B1 (en) 2013-05-28
AU2002306962B2 (en) 2008-04-24
ES2415769T3 (es) 2013-07-26
EP2465937A1 (en) 2012-06-20
ZA200307238B (en) 2005-08-31
PT1461418E (pt) 2013-07-09
WO2002078637A9 (en) 2004-01-15
EP2465937B1 (en) 2014-08-13
PL217737B1 (pl) 2014-08-29
RU2003131677A (ru) 2005-04-20
CA2440249C (en) 2013-07-09
IL189651A0 (en) 2008-06-05
NZ548595A (en) 2008-04-30
JP2012057170A (ja) 2012-03-22
JP4233327B2 (ja) 2009-03-04
CZ20032895A3 (cs) 2004-02-18
HUP0304091A2 (hu) 2004-03-29
CZ305601B6 (cs) 2015-12-30

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