BRPI0208535B8 - método para a produção de lipopolissacarídeo que pode gerar 3-o-4’-monofosforil desacilado lipídeo a - Google Patents

método para a produção de lipopolissacarídeo que pode gerar 3-o-4’-monofosforil desacilado lipídeo a

Info

Publication number
BRPI0208535B8
BRPI0208535B8 BRPI0208535A BR0208535A BRPI0208535B8 BR PI0208535 B8 BRPI0208535 B8 BR PI0208535B8 BR PI0208535 A BRPI0208535 A BR PI0208535A BR 0208535 A BR0208535 A BR 0208535A BR PI0208535 B8 BRPI0208535 B8 BR PI0208535B8
Authority
BR
Brazil
Prior art keywords
lps
cells
extracting
culture
producing
Prior art date
Application number
BRPI0208535A
Other languages
English (en)
Portuguese (pt)
Other versions
BR0208535A (pt
BRPI0208535B1 (pt
Inventor
Scott Snyder D
R Myers Kent
Original Assignee
Corixa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corixa Corp filed Critical Corixa Corp
Priority to BR122015016711A priority Critical patent/BR122015016711B8/pt
Publication of BR0208535A publication Critical patent/BR0208535A/pt
Publication of BRPI0208535B1 publication Critical patent/BRPI0208535B1/pt
Publication of BRPI0208535B8 publication Critical patent/BRPI0208535B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
BRPI0208535A 2001-03-30 2002-03-28 método para a produção de lipopolissacarídeo que pode gerar 3-o-4’-monofosforil desacilado lipídeo a BRPI0208535B8 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122015016711A BR122015016711B8 (pt) 2001-03-30 2002-03-28 método para extração de lipopolissacarídeo a partir de cultura de cepa bacteriana, o qual pode gerar 3-o-4'-monofosforil desacilado lipídeo a

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28008901P 2001-03-30 2001-03-30
PCT/US2002/009731 WO2002078637A2 (en) 2001-03-30 2002-03-28 Methods for the production of 3-o-deactivated-4'-monophosphoryl lipid a (3d-mla)

Publications (3)

Publication Number Publication Date
BR0208535A BR0208535A (pt) 2006-02-21
BRPI0208535B1 BRPI0208535B1 (pt) 2016-03-29
BRPI0208535B8 true BRPI0208535B8 (pt) 2021-05-25

Family

ID=23071615

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0208535A BRPI0208535B8 (pt) 2001-03-30 2002-03-28 método para a produção de lipopolissacarídeo que pode gerar 3-o-4’-monofosforil desacilado lipídeo a
BR122015016711A BR122015016711B8 (pt) 2001-03-30 2002-03-28 método para extração de lipopolissacarídeo a partir de cultura de cepa bacteriana, o qual pode gerar 3-o-4'-monofosforil desacilado lipídeo a

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR122015016711A BR122015016711B8 (pt) 2001-03-30 2002-03-28 método para extração de lipopolissacarídeo a partir de cultura de cepa bacteriana, o qual pode gerar 3-o-4'-monofosforil desacilado lipídeo a

Country Status (21)

Country Link
US (3) US20030031684A1 (enExample)
EP (3) EP2465937B1 (enExample)
JP (3) JP4233327B2 (enExample)
KR (2) KR100927099B1 (enExample)
CN (2) CN100577790C (enExample)
AU (1) AU2002306962B2 (enExample)
BR (2) BRPI0208535B8 (enExample)
CA (1) CA2440249C (enExample)
CZ (2) CZ305601B6 (enExample)
DK (2) DK1461418T3 (enExample)
ES (2) ES2517391T3 (enExample)
HU (1) HU228688B1 (enExample)
IL (3) IL157867A0 (enExample)
MX (1) MXPA03008856A (enExample)
NZ (2) NZ528204A (enExample)
PL (2) PL217737B1 (enExample)
PT (2) PT1461418E (enExample)
RU (2) RU2302463C2 (enExample)
SI (2) SI1461418T1 (enExample)
WO (1) WO2002078637A2 (enExample)
ZA (1) ZA200307238B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030031684A1 (en) 2001-03-30 2003-02-13 Corixa Corporation Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA)
FR2848223B1 (fr) * 2002-12-09 2005-02-25 Centre Nat Rech Scient Nouveau procede d'isolement des endotoxines.
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
CA2808919C (en) 2005-12-22 2016-04-19 Glaxosmithkline Biologicals S.A. Streptococcus pneumoniae capsular saccharide vaccine
WO2008134830A1 (en) * 2007-03-22 2008-11-13 Fundação Butantan Method to obtain monophosphoryl lipid a from bordetella pertussis as a by-product of the cellular pertussis vaccine production
UY31101A1 (es) 2007-05-24 2009-01-05 Glaxosmithkline Biologicals Sa Composición antigénica liofilizada
US20130066064A1 (en) * 2010-05-20 2013-03-14 Glaxosmithkline Biologicals S.A, Novel process
AU2012257771C1 (en) 2011-05-17 2015-12-03 Glaxosmithkline Biologicals S.A. Vaccine against Streptococcus pneumoniae
GB201113570D0 (en) 2011-08-05 2011-09-21 Glaxosmithkline Biolog Sa Vaccine
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CN102746414B (zh) * 2012-07-20 2014-04-16 成都生物制品研究所有限责任公司 一种细菌脂多糖的沉降方法
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
US11186652B2 (en) 2015-12-22 2021-11-30 Glaxosmithkline Biologicals Sa LPS extraction process
KR101761348B1 (ko) * 2016-01-06 2017-07-26 한국과학기술연구원 헥사 아실화된 모노포스포릴 지질 a를 생산하는 세균, 및 이를 이용한 헥사 아실화된 모노포스포릴 지질 a 생산 방법
KR102019331B1 (ko) * 2017-07-05 2019-09-09 한국과학기술연구원 모노포스포릴 지질 ａ를 구성적으로 생산하는 세균, 및 이를 이용한 모노포스포릴 지질 ａ 생산 방법
EP3777884A1 (en) 2019-08-15 2021-02-17 GlaxoSmithKline Biologicals S.A. Immunogenic composition
WO2021040414A1 (ko) * 2019-08-29 2021-03-04 주식회사 유바이오로직스 모노포스포릴 지질 ａ를 생산하는 방법
KR102748233B1 (ko) * 2019-08-29 2024-12-31 주식회사 유바이오로직스 모노포스포릴 지질 ａ를 생산하는 방법
EP4077356A1 (en) 2019-12-19 2022-10-26 GlaxoSmithKline Biologicals SA S. aureus antigens and compositions thereof
CN113652455B (zh) * 2021-08-09 2022-04-26 北京华诺泰生物医药科技有限公司 六酰基3d-mla的发酵方法
CN116554361B (zh) * 2023-07-11 2023-11-03 江苏瑞科生物技术股份有限公司 用于提取脂多糖的抽提液和方法

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Also Published As

Publication number Publication date
IL157867A (en) 2011-07-31
BR0208535A (pt) 2006-02-21
KR20060015704A (ko) 2006-02-20
MXPA03008856A (es) 2003-12-04
WO2002078637A9 (en) 2004-01-15
US9512159B2 (en) 2016-12-06
RU2427378C2 (ru) 2011-08-27
CA2440249A1 (en) 2002-10-10
CZ20032895A3 (cs) 2004-02-18
CN1928107A (zh) 2007-03-14
PL402939A1 (pl) 2013-08-19
EP2465937B1 (en) 2014-08-13
US20070212758A1 (en) 2007-09-13
ES2415769T3 (es) 2013-07-26
PL373657A1 (en) 2005-09-05
NZ528204A (en) 2006-12-22
JP2012057170A (ja) 2012-03-22
CN100577790C (zh) 2010-01-06
JP2004535477A (ja) 2004-11-25
KR100884462B1 (ko) 2009-02-20
WO2002078637A2 (en) 2002-10-10
EP1461418B1 (en) 2013-04-24
JP5730178B2 (ja) 2015-06-03
HK1165494A1 (en) 2012-10-05
AU2002306962B2 (en) 2008-04-24
PT1461418E (pt) 2013-07-09
CZ305565B6 (cs) 2015-12-16
BRPI0208535B1 (pt) 2016-03-29
RU2302463C2 (ru) 2007-07-10
NZ548595A (en) 2008-04-30
ES2517391T3 (es) 2014-11-03
EP2465937A1 (en) 2012-06-20
CN1608127A (zh) 2005-04-20
SI1461418T1 (sl) 2013-08-30
BR122015016711B8 (pt) 2021-07-27
BR122015016711B1 (pt) 2016-08-02
CN1928107B (zh) 2010-12-22
AU2002306962A2 (en) 2002-10-15
PL217737B1 (pl) 2014-08-29
RU2003131677A (ru) 2005-04-20
RU2006140606A (ru) 2008-05-27
EP1461418A2 (en) 2004-09-29
DK1461418T3 (da) 2013-07-08
JP4233327B2 (ja) 2009-03-04
KR20080088666A (ko) 2008-10-02
ZA200307238B (en) 2005-08-31
HK1075913A1 (zh) 2005-12-30
US20030031684A1 (en) 2003-02-13
WO2002078637A3 (en) 2004-07-22
JP2008255335A (ja) 2008-10-23
HUP0304091A2 (hu) 2004-03-29
HU228688B1 (en) 2013-05-28
CZ305601B6 (cs) 2015-12-30
EP2479280A1 (en) 2012-07-25
CA2440249C (en) 2013-07-09
IL189651A (en) 2011-02-28
PT2465937E (pt) 2014-11-03
IL157867A0 (en) 2004-03-28
HK1104319A1 (en) 2008-01-11
US20140243513A1 (en) 2014-08-28
DK2465937T3 (da) 2014-11-10
IL189651A0 (en) 2008-06-05
EP1461418A4 (en) 2006-05-17
KR100927099B1 (ko) 2009-11-13
HUP0304091A3 (en) 2011-04-28
SI2465937T1 (sl) 2014-11-28

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