CZ300818B6 - Interleukin-18-vazebné proteiny, príprava a použití - Google Patents
Interleukin-18-vazebné proteiny, príprava a použití Download PDFInfo
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- CZ300818B6 CZ300818B6 CZ20000490A CZ2000490A CZ300818B6 CZ 300818 B6 CZ300818 B6 CZ 300818B6 CZ 20000490 A CZ20000490 A CZ 20000490A CZ 2000490 A CZ2000490 A CZ 2000490A CZ 300818 B6 CZ300818 B6 CZ 300818B6
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| Application Number | Priority Date | Filing Date | Title |
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| IL12155497A IL121554A0 (en) | 1997-08-14 | 1997-08-14 | Interleukin-18 binding proteins their preparation and use |
| IL12163997A IL121639A0 (en) | 1997-08-14 | 1997-08-27 | Interleukin-18 binding proteins their preparation and use |
| IL12186097A IL121860A0 (en) | 1997-08-14 | 1997-09-29 | Interleukin-18 binding proteins their preparation and use |
| IL12213497A IL122134A0 (en) | 1997-08-14 | 1997-11-06 | Interleukin-18 binding proteins their preparation and use |
| IL12546398A IL125463A0 (en) | 1997-08-14 | 1998-07-22 | Interleukin-18 binding proteins their preparation and use |
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| Publication Number | Publication Date |
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| CZ2000490A3 CZ2000490A3 (cs) | 2000-08-16 |
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| CA2276216A1 (en) * | 1998-06-24 | 1999-12-24 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | An artificial peptide capable of neutralizing the biological activity of interleukin-18 |
| EP1110969A4 (en) * | 1998-09-01 | 2002-01-09 | Hayashibara Biochem Lab | INTERLEUKIN 18-BINDING PROTEINS |
| AR022952A1 (es) * | 1999-03-19 | 2002-09-04 | Smithkline Beecham Corp | ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL |
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| EP1101772B1 (en) * | 1999-11-16 | 2009-01-21 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Antibody specific to interleukin 18 precursor |
| KR100951067B1 (ko) | 2000-02-10 | 2010-04-07 | 아보트 러보러터리즈 | 사람 인터류킨-18에 결합하는 항체 및 이를 제조하고사용하는 방법 |
| NZ520122A (en) * | 2000-02-21 | 2005-04-29 | Applied Research Systems | Use of IL-18 inhibitors |
| AU2005211606B2 (en) * | 2000-05-05 | 2007-02-22 | Inserm - Institut National De La Sante Et De La Recherche Medicale | Use of IL-18 inhibitors for the treatment and/or prevention of atherosclerosis |
| JP5122053B2 (ja) * | 2000-05-05 | 2013-01-16 | メルク セロノ ソシエテ アノニム | アテローム性動脈硬化症の治療および／または予防のためのｉｌ−１８阻害剤の用途 |
| AU2002211744B8 (en) * | 2000-10-11 | 2008-03-20 | Viron Therapeutics, Inc. | Nucleic acid molecules and polypeptides for immune modulation |
| US7718368B2 (en) * | 2000-12-04 | 2010-05-18 | Viron Therapeutics Inc. | Immunomodulatory protein and useful embodiments thereof |
| CA2435466C (en) * | 2001-01-29 | 2012-04-03 | Applied Research Systems Ars Holding N.V. | Use of il-18 inhibitors for the treatment and/or prevention of heart disease |
| CN100556450C (zh) * | 2001-05-16 | 2009-11-04 | 耶达研究发展有限公司 | Il-18抑制剂在治疗或预防脓毒症中的应用 |
| CA2445664C (en) * | 2001-05-25 | 2012-03-06 | Ares Trading S.A. | Use of il-18 inhibitors for treating or preventing cns injuries |
| ATE464068T1 (de) | 2001-06-26 | 2010-04-15 | Amgen Fremont Inc | Antikörper gegen opgl |
| UA78516C2 (en) * | 2001-08-10 | 2007-04-10 | Applied Research Systems | Use of inhibitors of il-18 for treatment and/or prevention of hypersensitivity disorders, and in particular of delayed-type hypersensitivity |
| HRP20040758B1 (hr) * | 2002-03-22 | 2012-10-31 | Institut National de la Santé et de la Recherche Médicale | Uporaba il-18 inhibitora za lijeäśenje i/ili prevenciju perifernih krvožilnih bolesti |
| WO2004019866A2 (en) | 2002-08-28 | 2004-03-11 | Immunex Corporation | Compositions and methods for treating cardiovascular disease |
| WO2004032837A2 (en) * | 2002-10-08 | 2004-04-22 | Ares Trading S.A. | The use of cytokine able to bind il-18bp and of inhibiting the activity of a second cytokine |
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| US7491803B2 (en) | 2003-04-30 | 2009-02-17 | Japan Science & Technology Agency | Human anti-human interleukin-18 antibody, fragment thereof and method for using same |
| ES2384241T3 (es) | 2003-05-13 | 2012-07-02 | Merck Serono Sa | Variantes activas de la proteína que fija IL-18 y usos médicos de las mismas |
| HRP20070196T3 (hr) | 2003-11-05 | 2007-06-30 | Ares Trading S.A. | Postupak za pročišćavanje il-18 vezivnog proteina |
| CN101018808B (zh) * | 2003-11-12 | 2014-07-23 | 科罗拉多州大学评议会 | 调节肿瘤坏死因子α的组合物和方法 |
| US20050100965A1 (en) * | 2003-11-12 | 2005-05-12 | Tariq Ghayur | IL-18 binding proteins |
| US7968684B2 (en) * | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| IL159670A0 (en) * | 2003-12-31 | 2004-06-01 | Yeda Res & Dev | Use of il-18 binding protein in inflammations |
| RS50531B (sr) * | 2004-03-01 | 2010-05-07 | Ares Trading S.A. | Upotreba podloge za ćelijsku kulturu bez sadržaja seruma za produkciju il-18bp u ćelijama sisara |
| WO2005097998A2 (en) * | 2004-03-31 | 2005-10-20 | Regeneron Pharmaceuticals, Inc. | Il-18 specific polypeptides and therapeutic uses thereof |
| EP1761552B1 (en) * | 2004-06-29 | 2008-09-17 | Ares Trading S.A. | Process for the purification of il-18 binding protein |
| ATE517917T1 (de) * | 2005-06-03 | 2011-08-15 | Ares Trading Sa | Herstellung eines rekombinanten il-18-bindenden proteins |
| CA2610691C (en) * | 2005-06-03 | 2015-12-01 | Laboratoires Serono S.A. | Use of il-18bp isoforms for the treatment and/or prevention of neurological inflammatory diseases |
| EP1891088B1 (en) * | 2005-06-10 | 2011-10-19 | Ares Trading S.A. | Process for the purification of il-18 binding protein |
| CN101003812B (zh) * | 2006-01-17 | 2011-01-05 | 温州医学院 | 一种用于制备重组人egf-il18融合蛋白的方法 |
| TWI422387B (zh) | 2006-05-25 | 2014-01-11 | Glaxo Group Ltd | 免疫球蛋白 |
| WO2010040736A2 (en) * | 2008-10-07 | 2010-04-15 | Ablynx Nv | Amino acid sequences directed against il18 and/or the il-18 receptor and polypeptides comprising the same for the treatment of diseases and/or disorders associated with il-18 mediated signaling |
| CA2897067A1 (en) * | 2013-01-02 | 2014-07-10 | Wilsa, Inc. | Method and apparatus for conditioning fluids |
| PH12016500425B1 (en) * | 2013-09-05 | 2022-07-29 | Ab2 Bio Sa | Il-18 binding protein (il-18bp) in inflammatory diseases |
| JP7274259B2 (ja) | 2015-03-05 | 2023-05-16 | エイビー２ バイオ ソシエテアノニム | 炎症性疾患におけるｉｌ－１８結合タンパク質（ｉｌ－１８ｂｐ）および抗体 |
| EP3943097A1 (en) | 2020-07-24 | 2022-01-26 | AB2 Bio SA | Car-t cell therapy |
| WO2023143535A1 (zh) * | 2022-01-28 | 2023-08-03 | 和径医药科技（上海）有限公司 | 一种靶向il-18bp的抗体及其应用 |
| WO2023178192A1 (en) * | 2022-03-15 | 2023-09-21 | Compugen Ltd. | Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer |
| CN114605521A (zh) * | 2022-04-06 | 2022-06-10 | 内蒙古农业大学 | 一种细胞免疫调节蛋白及其应用 |
| CN114891125B (zh) * | 2022-06-16 | 2023-04-11 | 广东医科大学 | 一种长效重组白细胞介素-18结合蛋白及其生产方法与应用 |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1003781A1 (en) * | 1997-08-14 | 2000-05-31 | Yeda Research & Development Company, Ltd. | Interleukin-18 binding proteins, their preparation and use |
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