CZ2003392A3 - Kontrastní prostředek pro zobrazení plaků, nádorů a nekróz pomocí magnetické resonance - Google Patents

Kontrastní prostředek pro zobrazení plaků, nádorů a nekróz pomocí magnetické resonance Download PDF

Info

Publication number
CZ2003392A3
CZ2003392A3 CZ2003392A CZ2003392A CZ2003392A3 CZ 2003392 A3 CZ2003392 A3 CZ 2003392A3 CZ 2003392 A CZ2003392 A CZ 2003392A CZ 2003392 A CZ2003392 A CZ 2003392A CZ 2003392 A3 CZ2003392 A3 CZ 2003392A3
Authority
CZ
Czechia
Prior art keywords
formula
groups
mmol
complex
group
Prior art date
Application number
CZ2003392A
Other languages
Czech (cs)
English (en)
Inventor
Johannes Platzek
Peter Mareski
Ulrich Niedballa
Bernd Radüchel
Hanns-Joachim Weinmann
Bernd Misselwitz
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10040380A external-priority patent/DE10040380B4/de
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of CZ2003392A3 publication Critical patent/CZ2003392A3/cs

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CZ2003392A 2000-08-11 2001-07-23 Kontrastní prostředek pro zobrazení plaků, nádorů a nekróz pomocí magnetické resonance CZ2003392A3 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10040380A DE10040380B4 (de) 2000-08-11 2000-08-11 Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques

Publications (1)

Publication Number Publication Date
CZ2003392A3 true CZ2003392A3 (cs) 2003-09-17

Family

ID=7652860

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ2003392A CZ2003392A3 (cs) 2000-08-11 2001-07-23 Kontrastní prostředek pro zobrazení plaků, nádorů a nekróz pomocí magnetické resonance

Country Status (26)

Country Link
EP (1) EP1307236A2 (ko)
JP (1) JP2004506025A (ko)
KR (1) KR20030022387A (ko)
CN (1) CN1469757A (ko)
AR (1) AR034139A1 (ko)
AU (2) AU2001277549B2 (ko)
BG (1) BG107542A (ko)
BR (1) BR0113188A (ko)
CA (1) CA2419223A1 (ko)
CZ (1) CZ2003392A3 (ko)
DE (1) DE10066210B4 (ko)
EE (1) EE200300061A (ko)
HR (1) HRP20030173A2 (ko)
HU (1) HUP0300736A3 (ko)
IL (1) IL154385A0 (ko)
MX (1) MXPA03001287A (ko)
NO (1) NO20030604L (ko)
NZ (1) NZ523932A (ko)
PL (1) PL365596A1 (ko)
RU (1) RU2290206C2 (ko)
SK (1) SK1572003A3 (ko)
TW (1) TWI296931B (ko)
UA (1) UA82642C2 (ko)
WO (1) WO2002013874A2 (ko)
YU (1) YU10603A (ko)
ZA (1) ZA200301949B (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7344704B2 (en) 2002-07-10 2008-03-18 Schering Ag Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi
DE10231799B4 (de) * 2002-07-10 2006-10-05 Schering Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben
DE102005008309A1 (de) * 2005-02-17 2006-08-24 Schering Ag Pharmazeutische Mittel enthaltend fluoralkylhaltige Metallkomplexe und Epothilone
DE102006021495A1 (de) * 2006-05-09 2007-11-15 Bayer Schering Pharma Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel zur Diagnose der Alzheimer Krankheit
US7887835B2 (en) * 2006-09-19 2011-02-15 Fujifilm Corporation Compound comprising a fluorine-substituted alkyl group and a liposome contrast medium comprising the compound
DE102006049821A1 (de) * 2006-10-18 2008-04-24 Bayer Schering Pharma Aktiengesellschaft Metallchelate mit perfluoriertem PEG-Rest, Verfahren zu deren Herstellung, sowie deren Verwendung
DE102007015598A1 (de) * 2007-03-29 2008-10-02 Heinrich-Heine-Universität Düsseldorf Verwendung von fluorhaltigen Verbindungen zu Diagnosezwecken mit Hilfe bildgebender Verfahren
JP2011190183A (ja) * 2010-03-11 2011-09-29 Noguchi Institute フルオラス化糖結合型クラウンエーテル誘導体
US9976072B2 (en) 2014-03-26 2018-05-22 Chevron U.S.A. Inc. Multicarboxylate compositions and method of making the same
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
CN109715597A (zh) * 2016-09-14 2019-05-03 大金工业株式会社 含支链含氟化合物
CN110035996B (zh) 2016-11-28 2022-08-09 拜耳医药股份公司 用于磁共振成像的新型高弛豫性钆螯合物
PE20211471A1 (es) 2018-11-23 2021-08-05 Bayer Ag Formulacion de medios de contraste y proceso para prepararlos
CN109867635A (zh) * 2019-02-14 2019-06-11 华东师范大学 一种t1型胶束磁共振成像造影剂及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19603033A1 (de) * 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
JPH10112939A (ja) * 1996-10-07 1998-04-28 Nec Corp 電源切替回路
DE19729013A1 (de) * 1997-07-03 1999-02-04 Schering Ag Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis

Also Published As

Publication number Publication date
DE10066210B4 (de) 2008-02-28
RU2290206C2 (ru) 2006-12-27
EE200300061A (et) 2004-12-15
HRP20030173A2 (en) 2005-04-30
NO20030604D0 (no) 2003-02-07
SK1572003A3 (en) 2003-10-07
EP1307236A2 (de) 2003-05-07
WO2002013874A8 (de) 2002-06-13
BR0113188A (pt) 2003-06-24
PL365596A1 (en) 2005-01-10
NO20030604L (no) 2003-04-11
AU7754901A (en) 2002-02-25
IL154385A0 (en) 2003-09-17
KR20030022387A (ko) 2003-03-15
JP2004506025A (ja) 2004-02-26
CN1469757A (zh) 2004-01-21
HUP0300736A3 (en) 2010-01-28
BG107542A (bg) 2003-09-30
MXPA03001287A (es) 2003-10-06
ZA200301949B (en) 2004-12-14
HUP0300736A2 (hu) 2003-09-29
CA2419223A1 (en) 2003-02-11
YU10603A (sh) 2006-05-25
AR034139A1 (es) 2004-02-04
WO2002013874A2 (de) 2002-02-21
AU2001277549B2 (en) 2007-02-08
UA82642C2 (uk) 2008-05-12
NZ523932A (en) 2007-07-27
TWI296931B (en) 2008-05-21

Similar Documents

Publication Publication Date Title
JP4163381B2 (ja) 生理学的薬剤の検出のための磁気共鳴造影剤
CZ2003392A3 (cs) Kontrastní prostředek pro zobrazení plaků, nádorů a nekróz pomocí magnetické resonance
US6818203B2 (en) Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of plaque, tumors and necroses
KR100820387B1 (ko) 당 잔기를 포함하는 퍼플루오로알킬 함유 착물, 이의 제조방법 및 용도
JP2001518471A (ja) 梗塞および壊死の造影のための造影剤
US7618957B2 (en) Perfluoroalkyl-containing complexes, process for their production as well as their use
JP2009501174A (ja) ペルフルオロアルキル含有錯体、製造方法およびその使用
US6641797B2 (en) Perfluoroalkyl-containing complexes with sugar radicals, process for their production and their use
CZ2003341A3 (cs) Perfluoralkylované komplexy s polárními zbytky, způsob jejich přípravy a jejich použití
JP5475454B2 (ja) 過弗素化されたｐｅｇ基を有する金属キレート類、それらの製剤方法、及びそれらの使用
DE10040380A1 (de) Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques, Tumoren und Nekrosen