AR034139A1 - Uso de complejos metalicos que contienen perfluoralquilo como medios de contraste para representar placas, tumores y necrosis en imagenes por resonancia magnetica - Google Patents

Uso de complejos metalicos que contienen perfluoralquilo como medios de contraste para representar placas, tumores y necrosis en imagenes por resonancia magnetica

Info

Publication number
AR034139A1
AR034139A1 ARP010103833A ARP010103833A AR034139A1 AR 034139 A1 AR034139 A1 AR 034139A1 AR P010103833 A ARP010103833 A AR P010103833A AR P010103833 A ARP010103833 A AR P010103833A AR 034139 A1 AR034139 A1 AR 034139A1
Authority
AR
Argentina
Prior art keywords
magnetic resonance
metal complexes
perfluoralquilo
necrosis
tumors
Prior art date
Application number
ARP010103833A
Other languages
English (en)
Inventor
Platzek Johannes Dr
Mareski Peter Dr
Niedballa Ulrich Dr
Raduchel Bernd Dr
Weinmann Hanns-Joachim Dr
Misselwitz Bernd Dr
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10040380A external-priority patent/DE10040380B4/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of AR034139A1 publication Critical patent/AR034139A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Uso de complejos metálicos con contenido de perfluoroalquilo, que presentan una concentración crítica de micelas 1 nm y una relajación de protones en plasma (R1) > 10 l/mmol.s, como medio de contraste en imágenes de resonancia magnética, tanto para la representación de placas arterioescleróticas, ganglios linfáticos, tejido infartado y necrótico, y como también para la representación independiente de tejido necrótico y tejido tumoral.
ARP010103833A 2000-08-11 2001-08-10 Uso de complejos metalicos que contienen perfluoralquilo como medios de contraste para representar placas, tumores y necrosis en imagenes por resonancia magnetica AR034139A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10040380A DE10040380B4 (de) 2000-08-11 2000-08-11 Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques

Publications (1)

Publication Number Publication Date
AR034139A1 true AR034139A1 (es) 2004-02-04

Family

ID=7652860

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010103833A AR034139A1 (es) 2000-08-11 2001-08-10 Uso de complejos metalicos que contienen perfluoralquilo como medios de contraste para representar placas, tumores y necrosis en imagenes por resonancia magnetica

Country Status (26)

Country Link
EP (1) EP1307236A2 (es)
JP (1) JP2004506025A (es)
KR (1) KR20030022387A (es)
CN (1) CN1469757A (es)
AR (1) AR034139A1 (es)
AU (2) AU2001277549B2 (es)
BG (1) BG107542A (es)
BR (1) BR0113188A (es)
CA (1) CA2419223A1 (es)
CZ (1) CZ2003392A3 (es)
DE (1) DE10066210B4 (es)
EE (1) EE200300061A (es)
HR (1) HRP20030173A2 (es)
HU (1) HUP0300736A3 (es)
IL (1) IL154385A0 (es)
MX (1) MXPA03001287A (es)
NO (1) NO20030604L (es)
NZ (1) NZ523932A (es)
PL (1) PL365596A1 (es)
RU (1) RU2290206C2 (es)
SK (1) SK1572003A3 (es)
TW (1) TWI296931B (es)
UA (1) UA82642C2 (es)
WO (1) WO2002013874A2 (es)
YU (1) YU10603A (es)
ZA (1) ZA200301949B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10231799B4 (de) * 2002-07-10 2006-10-05 Schering Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben
US7344704B2 (en) 2002-07-10 2008-03-18 Schering Ag Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi
DE102005008309A1 (de) * 2005-02-17 2006-08-24 Schering Ag Pharmazeutische Mittel enthaltend fluoralkylhaltige Metallkomplexe und Epothilone
DE102006021495A1 (de) * 2006-05-09 2007-11-15 Bayer Schering Pharma Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel zur Diagnose der Alzheimer Krankheit
US7887835B2 (en) * 2006-09-19 2011-02-15 Fujifilm Corporation Compound comprising a fluorine-substituted alkyl group and a liposome contrast medium comprising the compound
DE102006049821A1 (de) * 2006-10-18 2008-04-24 Bayer Schering Pharma Aktiengesellschaft Metallchelate mit perfluoriertem PEG-Rest, Verfahren zu deren Herstellung, sowie deren Verwendung
DE102007015598A1 (de) * 2007-03-29 2008-10-02 Heinrich-Heine-Universität Düsseldorf Verwendung von fluorhaltigen Verbindungen zu Diagnosezwecken mit Hilfe bildgebender Verfahren
JP2011190183A (ja) * 2010-03-11 2011-09-29 Noguchi Institute フルオラス化糖結合型クラウンエーテル誘導体
US9976072B2 (en) * 2014-03-26 2018-05-22 Chevron U.S.A. Inc. Multicarboxylate compositions and method of making the same
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
EP3514137A4 (en) * 2016-09-14 2020-10-07 Daikin Industries, Ltd. COMPOUND CONTAINING BRANCHED FLUORINE
KR102464647B1 (ko) 2016-11-28 2022-11-08 바이엘 파마 악티엔게젤샤프트 자기 공명 영상화에 사용하기 위한 높은 이완도 가돌리늄 킬레이트 화합물
AU2019382881A1 (en) 2018-11-23 2021-05-20 Bayer Aktiengesellschaft Formulation of contrast media and process of preparation thereof
CN109867635A (zh) * 2019-02-14 2019-06-11 华东师范大学 一种t1型胶束磁共振成像造影剂及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19603033A1 (de) * 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
JPH10112939A (ja) * 1996-10-07 1998-04-28 Nec Corp 電源切替回路
DE19729013A1 (de) * 1997-07-03 1999-02-04 Schering Ag Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis

Also Published As

Publication number Publication date
DE10066210B4 (de) 2008-02-28
CA2419223A1 (en) 2003-02-11
AU2001277549B2 (en) 2007-02-08
NO20030604L (no) 2003-04-11
HUP0300736A3 (en) 2010-01-28
HUP0300736A2 (hu) 2003-09-29
AU7754901A (en) 2002-02-25
JP2004506025A (ja) 2004-02-26
RU2290206C2 (ru) 2006-12-27
NZ523932A (en) 2007-07-27
CZ2003392A3 (cs) 2003-09-17
HRP20030173A2 (en) 2005-04-30
KR20030022387A (ko) 2003-03-15
SK1572003A3 (en) 2003-10-07
EE200300061A (et) 2004-12-15
PL365596A1 (en) 2005-01-10
TWI296931B (en) 2008-05-21
CN1469757A (zh) 2004-01-21
EP1307236A2 (de) 2003-05-07
WO2002013874A2 (de) 2002-02-21
BG107542A (bg) 2003-09-30
ZA200301949B (en) 2004-12-14
BR0113188A (pt) 2003-06-24
UA82642C2 (uk) 2008-05-12
IL154385A0 (en) 2003-09-17
WO2002013874A8 (de) 2002-06-13
YU10603A (sh) 2006-05-25
NO20030604D0 (no) 2003-02-07
MXPA03001287A (es) 2003-10-06

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