JP2004506025A - プラーク、腫瘍および壊死を造影するための、ｍｒ−イメージングにおける造影剤としてのペルフルオロアルキル含有金属錯体の使用 - Google Patents
プラーク、腫瘍および壊死を造影するための、ｍｒ−イメージングにおける造影剤としてのペルフルオロアルキル含有金属錯体の使用 Download PDFInfo
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- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 4
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- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims description 2
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- WTNMWCJVEAIMLV-UHFFFAOYSA-N 2-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]propanoylamino]acetic acid Chemical compound OC(=O)CNC(=O)C(C)N1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WTNMWCJVEAIMLV-UHFFFAOYSA-N 0.000 description 21
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- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
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- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
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- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
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- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
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- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10040380A DE10040380B4 (de) | 2000-08-11 | 2000-08-11 | Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques |
| PCT/EP2001/008498 WO2002013874A2 (de) | 2000-08-11 | 2001-07-23 | Verwendung von perfluoralkylhaltigen metallkomplexen als kontrastmittel im mr-imaging zur darstellung von plaques, tumoren und nekrosen |
Publications (1)
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|---|---|
| JP2004506025A true JP2004506025A (ja) | 2004-02-26 |
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| JP2002519012A Pending JP2004506025A (ja) | 2000-08-11 | 2001-07-23 | プラーク、腫瘍および壊死を造影するための、ｍｒ−イメージングにおける造影剤としてのペルフルオロアルキル含有金属錯体の使用 |
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| JP (1) | JP2004506025A (ko) |
| KR (1) | KR20030022387A (ko) |
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| AR (1) | AR034139A1 (ko) |
| AU (2) | AU2001277549B2 (ko) |
| BG (1) | BG107542A (ko) |
| BR (1) | BR0113188A (ko) |
| CA (1) | CA2419223A1 (ko) |
| CZ (1) | CZ2003392A3 (ko) |
| DE (1) | DE10066210B4 (ko) |
| EE (1) | EE200300061A (ko) |
| HR (1) | HRP20030173A2 (ko) |
| HU (1) | HUP0300736A3 (ko) |
| IL (1) | IL154385A0 (ko) |
| MX (1) | MXPA03001287A (ko) |
| NO (1) | NO20030604L (ko) |
| NZ (1) | NZ523932A (ko) |
| PL (1) | PL365596A1 (ko) |
| RU (1) | RU2290206C2 (ko) |
| SK (1) | SK1572003A3 (ko) |
| TW (1) | TWI296931B (ko) |
| UA (1) | UA82642C2 (ko) |
| WO (1) | WO2002013874A2 (ko) |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011190183A (ja) * | 2010-03-11 | 2011-09-29 | Noguchi Institute | フルオラス化糖結合型クラウンエーテル誘導体 |
| JPWO2018052037A1 (ja) * | 2016-09-14 | 2019-02-14 | ダイキン工業株式会社 | 分枝含フッ素化合物 |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7344704B2 (en) | 2002-07-10 | 2008-03-18 | Schering Ag | Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi |
| DE10231799B4 (de) * | 2002-07-10 | 2006-10-05 | Schering Ag | Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben |
| DE102005008309A1 (de) * | 2005-02-17 | 2006-08-24 | Schering Ag | Pharmazeutische Mittel enthaltend fluoralkylhaltige Metallkomplexe und Epothilone |
| DE102006021495A1 (de) * | 2006-05-09 | 2007-11-15 | Bayer Schering Pharma Ag | Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel zur Diagnose der Alzheimer Krankheit |
| US7887835B2 (en) * | 2006-09-19 | 2011-02-15 | Fujifilm Corporation | Compound comprising a fluorine-substituted alkyl group and a liposome contrast medium comprising the compound |
| DE102006049821A1 (de) * | 2006-10-18 | 2008-04-24 | Bayer Schering Pharma Aktiengesellschaft | Metallchelate mit perfluoriertem PEG-Rest, Verfahren zu deren Herstellung, sowie deren Verwendung |
| DE102007015598A1 (de) * | 2007-03-29 | 2008-10-02 | Heinrich-Heine-Universität Düsseldorf | Verwendung von fluorhaltigen Verbindungen zu Diagnosezwecken mit Hilfe bildgebender Verfahren |
| US9976072B2 (en) | 2014-03-26 | 2018-05-22 | Chevron U.S.A. Inc. | Multicarboxylate compositions and method of making the same |
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| CN110035996B (zh) | 2016-11-28 | 2022-08-09 | 拜耳医药股份公司 | 用于磁共振成像的新型高弛豫性钆螯合物 |
| PE20211471A1 (es) | 2018-11-23 | 2021-08-05 | Bayer Ag | Formulacion de medios de contraste y proceso para prepararlos |
| CN109867635A (zh) * | 2019-02-14 | 2019-06-11 | 华东师范大学 | 一种t1型胶束磁共振成像造影剂及其制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19603033A1 (de) * | 1996-01-19 | 1997-07-24 | Schering Ag | Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik |
| JPH10112939A (ja) * | 1996-10-07 | 1998-04-28 | Nec Corp | 電源切替回路 |
| DE19729013A1 (de) * | 1997-07-03 | 1999-02-04 | Schering Ag | Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik |
| US6019959A (en) * | 1997-07-31 | 2000-02-01 | Schering Aktiengesellschaft | Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis |
-
2000
- 2000-08-11 DE DE10066210A patent/DE10066210B4/de not_active Expired - Fee Related
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2001
- 2001-07-23 KR KR10-2003-7002023A patent/KR20030022387A/ko not_active IP Right Cessation
- 2001-07-23 AU AU2001277549A patent/AU2001277549B2/en not_active Ceased
- 2001-07-23 EP EP01955366A patent/EP1307236A2/de not_active Withdrawn
- 2001-07-23 CA CA002419223A patent/CA2419223A1/en not_active Abandoned
- 2001-07-23 PL PL01365596A patent/PL365596A1/xx not_active Application Discontinuation
- 2001-07-23 BR BR0113188-5A patent/BR0113188A/pt not_active IP Right Cessation
- 2001-07-23 HU HU0300736A patent/HUP0300736A3/hu unknown
- 2001-07-23 EE EEP200300061A patent/EE200300061A/xx unknown
- 2001-07-23 SK SK157-2003A patent/SK1572003A3/sk not_active Application Discontinuation
- 2001-07-23 JP JP2002519012A patent/JP2004506025A/ja active Pending
- 2001-07-23 CZ CZ2003392A patent/CZ2003392A3/cs unknown
- 2001-07-23 MX MXPA03001287A patent/MXPA03001287A/es active IP Right Grant
- 2001-07-23 CN CNA018172717A patent/CN1469757A/zh active Pending
- 2001-07-23 WO PCT/EP2001/008498 patent/WO2002013874A2/de not_active Application Discontinuation
- 2001-07-23 RU RU2003105810/15A patent/RU2290206C2/ru not_active IP Right Cessation
- 2001-07-23 AU AU7754901A patent/AU7754901A/xx active Pending
- 2001-07-23 UA UA2003032067A patent/UA82642C2/uk unknown
- 2001-07-23 YU YU10603A patent/YU10603A/sh unknown
- 2001-07-23 IL IL15438501A patent/IL154385A0/xx unknown
- 2001-07-23 NZ NZ523932A patent/NZ523932A/en unknown
- 2001-08-10 TW TW090119643A patent/TWI296931B/zh active
- 2001-08-10 AR ARP010103833A patent/AR034139A1/es unknown
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2003
- 2003-02-07 NO NO20030604A patent/NO20030604L/no not_active Application Discontinuation
- 2003-02-07 BG BG107542A patent/BG107542A/bg unknown
- 2003-03-10 ZA ZA200301949A patent/ZA200301949B/en unknown
- 2003-03-10 HR HR20030173A patent/HRP20030173A2/hr not_active Application Discontinuation
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011190183A (ja) * | 2010-03-11 | 2011-09-29 | Noguchi Institute | フルオラス化糖結合型クラウンエーテル誘導体 |
| JPWO2018052037A1 (ja) * | 2016-09-14 | 2019-02-14 | ダイキン工業株式会社 | 分枝含フッ素化合物 |
| US11104639B2 (en) | 2016-09-14 | 2021-08-31 | Daikin Industries, Ltd. | Branched fluorine-containing compound |
| JP7037069B2 (ja) | 2016-09-14 | 2022-03-16 | ダイキン工業株式会社 | 分枝含フッ素化合物 |
| US11680037B2 (en) | 2016-09-14 | 2023-06-20 | Daikin Industries, Ltd. | Branched fluorine-containing compound |
Also Published As
| Publication number | Publication date |
|---|---|
| DE10066210B4 (de) | 2008-02-28 |
| RU2290206C2 (ru) | 2006-12-27 |
| EE200300061A (et) | 2004-12-15 |
| HRP20030173A2 (en) | 2005-04-30 |
| NO20030604D0 (no) | 2003-02-07 |
| SK1572003A3 (en) | 2003-10-07 |
| EP1307236A2 (de) | 2003-05-07 |
| WO2002013874A8 (de) | 2002-06-13 |
| BR0113188A (pt) | 2003-06-24 |
| PL365596A1 (en) | 2005-01-10 |
| NO20030604L (no) | 2003-04-11 |
| AU7754901A (en) | 2002-02-25 |
| IL154385A0 (en) | 2003-09-17 |
| KR20030022387A (ko) | 2003-03-15 |
| CN1469757A (zh) | 2004-01-21 |
| HUP0300736A3 (en) | 2010-01-28 |
| BG107542A (bg) | 2003-09-30 |
| MXPA03001287A (es) | 2003-10-06 |
| ZA200301949B (en) | 2004-12-14 |
| HUP0300736A2 (hu) | 2003-09-29 |
| CA2419223A1 (en) | 2003-02-11 |
| YU10603A (sh) | 2006-05-25 |
| AR034139A1 (es) | 2004-02-04 |
| WO2002013874A2 (de) | 2002-02-21 |
| AU2001277549B2 (en) | 2007-02-08 |
| UA82642C2 (uk) | 2008-05-12 |
| CZ2003392A3 (cs) | 2003-09-17 |
| NZ523932A (en) | 2007-07-27 |
| TWI296931B (en) | 2008-05-21 |
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