CZ20033477A3 - Conjugates of an antibody to CD44 and a maytansinoid - Google Patents
Conjugates of an antibody to CD44 and a maytansinoid Download PDFInfo
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- CZ20033477A3 CZ20033477A3 CZ20033477A CZ20033477A CZ20033477A3 CZ 20033477 A3 CZ20033477 A3 CZ 20033477A3 CZ 20033477 A CZ20033477 A CZ 20033477A CZ 20033477 A CZ20033477 A CZ 20033477A CZ 20033477 A3 CZ20033477 A3 CZ 20033477A3
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- compound
- antibody
- antibody molecule
- conjugate
- maytansinoid
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| US8071072B2 (en) * | 1999-10-08 | 2011-12-06 | Hoffmann-La Roche Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
| US6441163B1 (en) * | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
| US7084257B2 (en) | 2001-10-05 | 2006-08-01 | Amgen Inc. | Fully human antibody Fab fragments with human interferon-gamma neutralizing activity |
| EP1417974A1 (en) * | 2002-11-08 | 2004-05-12 | Boehringer Ingelheim International GmbH | Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and radiotherapy |
| US7384744B2 (en) | 2002-11-29 | 2008-06-10 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | Expression vector, methods for the production of heterologous gene products and for the selection of recombinant cells producing high levels of such products |
| DE10256083A1 (de) * | 2002-11-29 | 2004-08-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Expressionsvektor, Verfahren zur Herstellung von heterologen Genprodukten und Selektionsverfahren für hochproduzierende rekombinante Zellen |
| US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
| PL1651162T3 (pl) * | 2003-05-20 | 2016-04-29 | Immunogen Inc | Maitansynoidy w leczeniu nowotworów |
| ATE496944T1 (de) * | 2003-07-21 | 2011-02-15 | Immunogen Inc | Ca6-antigenspezifisches zytotoxisches konjugat und verfahren zu dessen anwendung |
| AU2005214331B2 (en) | 2004-02-12 | 2011-09-15 | Eisai, Inc. | Monoclonal antibodies that specifically bind to folate receptor alpha |
| WO2006062779A2 (en) * | 2004-12-09 | 2006-06-15 | Centocor, Inc. | Anti-integrin immunoconjugates, methods and uses |
| US20060182750A1 (en) * | 2005-02-11 | 2006-08-17 | Immunogen, Inc. | Process for preparing stable drug conjugates |
| ES2429340T3 (es) | 2005-03-10 | 2013-11-14 | Morphotek, Inc. | Anticuerpos anti-mesotelina |
| CN101374545B (zh) * | 2005-04-15 | 2012-03-28 | 免疫基因公司 | 消除肿瘤中的异质或混合细胞群体 |
| AU2006241099B2 (en) | 2005-04-22 | 2012-04-19 | Eisai, Inc. | Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells |
| CA2893252C (en) | 2005-08-24 | 2018-05-29 | Immunogen, Inc. | Process for preparing antibody maytansinoid conjugates |
| EP1806365A1 (en) * | 2006-01-05 | 2007-07-11 | Boehringer Ingelheim International GmbH | Antibody molecules specific for fibroblast activation protein and immunoconjugates containing them |
| AR059900A1 (es) * | 2006-03-17 | 2008-05-07 | Genentech Inc | Anticuerpos anti-tat226 e inmunoconjugados |
| ME03479B (me) | 2009-06-03 | 2020-01-20 | Immunogen Inc | Metodi konjugacije |
| UY32913A (es) * | 2009-10-02 | 2011-04-29 | Sanofi Aventis | Nuevos maitansinoides y el uso de dichos maitansinoides para preparar conjugados con un anticuero |
| ME03353B (me) | 2011-03-29 | 2019-10-20 | Immunogen Inc | Priprema konjugata antitela i majtanzinoida jednostepenim postupkom |
| CN102337298B (zh) * | 2011-08-19 | 2013-11-06 | 黄开红 | 一种输送siRNA的免疫纳米载体及其制备方法和应用 |
| AU2013326881B2 (en) | 2012-10-04 | 2018-08-02 | Immunogen, Inc. | Use of a PVDF membrane to purify cell-binding agent cytotoxic agent conjugates |
| GB201220889D0 (en) * | 2012-11-21 | 2013-01-02 | Kit Karlsrusher Inst Fuer Technologie Und Inst Fuer Toxikologie Und Genetik And Amcure Gmbh | CD44v6-derived peptides for treating metastasizing cancers |
| GB201220891D0 (en) | 2012-11-21 | 2013-01-02 | Kit Karlsrusher Inst Fuer Technologie Und Inst Fuer Toxikologie Und Genetik And Amcure Gmbh | CD44v6-derived peptides for treating breast cancers |
| GB201220899D0 (en) * | 2012-11-21 | 2013-01-02 | Kit Karlsrusher Inst Fuer Technologie Und Inst Fuer Toxikologie Und Genetik And Amcure Gmbh | CD44v6-derived pegylated peptides |
| GB201220901D0 (en) * | 2012-11-21 | 2013-01-02 | Kit Karlsrusher Inst Fuer Technologie Und Inst Fuer Toxikologie Und Genetik And Amcure Gmbh | CD44v6-derived peptides for treating pancreatic cancer |
| KR102306490B1 (ko) | 2013-03-15 | 2021-09-28 | 리제너론 파아마슈티컬스, 인크. | 생물학적 활성 분자, 그의 접합체 및 치료 용도 |
| SG11201601230RA (en) | 2013-08-26 | 2016-03-30 | Regeneron Pharma | Pharmaceutical compositions comprising macrolide diastereomers, methods of their synthesis and therapeutic uses |
| GB201421647D0 (en) | 2014-12-05 | 2015-01-21 | Amcure Gmbh And Ruprecht-Karls-Universitat And Karlsruher Institut F�R Technologie | CD44v6-derived cyclic peptides for treating cancers and angiogenesis related diseases |
| WO2016150521A1 (en) * | 2015-03-26 | 2016-09-29 | Fundación Imdea Nanociencia | Functionalised magnetic nanoparticle |
| CN107995912A (zh) | 2015-03-27 | 2018-05-04 | 里珍纳龙药品有限公司 | 美登素类衍生物、其偶联物和使用方法 |
| WO2017214151A1 (en) | 2016-06-06 | 2017-12-14 | Northwestern University | Fusion protein construct |
| EP3755717A4 (en) * | 2018-02-22 | 2022-01-26 | Multitude Inc. | THERAPEUTIC ANTIBODIES AND ASSOCIATED USES |
| CN114057874B (zh) * | 2020-07-31 | 2023-05-05 | 北京市神经外科研究所 | 抗cd44的单链抗体及其在制备治疗肿瘤的药物中的用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5208020A (en) * | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| CA2026147C (en) * | 1989-10-25 | 2006-02-07 | Ravi J. Chari | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| UY24389A1 (es) * | 1995-12-06 | 2001-10-25 | Karlsruhe Forschzent | Composición farmacéutica para el tratamiento de carcinoma de epitelio plano |
| DE19648209A1 (de) * | 1996-11-21 | 1998-05-28 | Boehringer Ingelheim Int | Verfahren zur Tumorzelldepletion CD34-positiver Zellen |
| DE19708713C2 (de) * | 1997-03-04 | 2002-11-28 | Boehringer Ingelheim Int | Verwendung von anti-CD44 Antikörpern enthaltenden Präparationen zur Behandlung bestimmter Tumore und zur Unterdrückung von Immunreaktionen |
| EP2977063A1 (en) * | 1999-06-25 | 2016-01-27 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
| EP1229934B1 (en) * | 1999-10-01 | 2014-03-05 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
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- 2002-05-16 KR KR10-2003-7015037A patent/KR20030097883A/ko not_active Withdrawn
- 2002-05-16 EE EEP200300568A patent/EE200300568A/xx unknown
- 2002-05-16 WO PCT/EP2002/005413 patent/WO2002094325A2/en not_active Ceased
- 2002-05-16 YU YU91503A patent/YU91503A/sh unknown
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- 2002-05-16 IL IL15796502A patent/IL157965A0/xx unknown
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- 2002-05-16 PL PL02365480A patent/PL365480A1/xx not_active Application Discontinuation
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- 2002-05-16 BR BR0209862-8A patent/BR0209862A/pt not_active IP Right Cessation
- 2002-05-16 EA EA200301159A patent/EA200301159A1/ru unknown
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| NZ530167A (en) | 2005-10-28 |
| CN1509187A (zh) | 2004-06-30 |
| EE200300568A (et) | 2004-04-15 |
| IL157965A0 (en) | 2004-03-28 |
| ZA200307364B (en) | 2004-04-20 |
| PL365480A1 (en) | 2005-01-10 |
| CO5550468A2 (es) | 2005-08-31 |
| WO2002094325A2 (en) | 2002-11-28 |
| JP2004529963A (ja) | 2004-09-30 |
| EP1395290A2 (en) | 2004-03-10 |
| KR20030097883A (ko) | 2003-12-31 |
| BG108366A (bg) | 2004-09-30 |
| PE20021097A1 (es) | 2003-02-13 |
| BR0209862A (pt) | 2004-06-08 |
| MXPA03010432A (es) | 2004-04-02 |
| EA200301159A1 (ru) | 2004-06-24 |
| NO20035108L (no) | 2003-11-17 |
| EP1258255A1 (en) | 2002-11-20 |
| HUP0400046A2 (hu) | 2004-04-28 |
| AR035977A1 (es) | 2004-07-28 |
| CA2443438A1 (en) | 2002-11-28 |
| HRP20030932A2 (en) | 2004-04-30 |
| HUP0400046A3 (en) | 2006-02-28 |
| WO2002094325A3 (en) | 2003-04-17 |
| YU91503A (sh) | 2006-05-25 |
| SK15582003A3 (sk) | 2004-04-06 |
| NO20035108D0 (no) | 2003-11-17 |
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