KR20030097883A - 세포독성 ｃｄ44 항체 면역접합체 - Google Patents
세포독성 ｃｄ44 항체 면역접합체 Download PDFInfo
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- KR20030097883A KR20030097883A KR10-2003-7015037A KR20037015037A KR20030097883A KR 20030097883 A KR20030097883 A KR 20030097883A KR 20037015037 A KR20037015037 A KR 20037015037A KR 20030097883 A KR20030097883 A KR 20030097883A
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01112227A EP1258255A1 (en) | 2001-05-18 | 2001-05-18 | Conjugates of an antibody to CD44 and a maytansinoid |
| EP01112227.2 | 2001-05-18 | ||
| PCT/EP2002/005413 WO2002094325A2 (en) | 2001-05-18 | 2002-05-16 | Cytotoxic cd44 antibody immunoconjugates |
Publications (1)
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| KR20030097883A true KR20030097883A (ko) | 2003-12-31 |
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| EA (1) | EA200301159A1 (enExample) |
| EE (1) | EE200300568A (enExample) |
| HR (1) | HRP20030932A2 (enExample) |
| HU (1) | HUP0400046A3 (enExample) |
| IL (1) | IL157965A0 (enExample) |
| MX (1) | MXPA03010432A (enExample) |
| NO (1) | NO20035108L (enExample) |
| NZ (1) | NZ530167A (enExample) |
| PE (1) | PE20021097A1 (enExample) |
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| US8071072B2 (en) * | 1999-10-08 | 2011-12-06 | Hoffmann-La Roche Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
| US6441163B1 (en) * | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
| US7084257B2 (en) | 2001-10-05 | 2006-08-01 | Amgen Inc. | Fully human antibody Fab fragments with human interferon-gamma neutralizing activity |
| EP1417974A1 (en) * | 2002-11-08 | 2004-05-12 | Boehringer Ingelheim International GmbH | Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and radiotherapy |
| DE10256083A1 (de) * | 2002-11-29 | 2004-08-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Expressionsvektor, Verfahren zur Herstellung von heterologen Genprodukten und Selektionsverfahren für hochproduzierende rekombinante Zellen |
| US7384744B2 (en) | 2002-11-29 | 2008-06-10 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | Expression vector, methods for the production of heterologous gene products and for the selection of recombinant cells producing high levels of such products |
| US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
| EP1651162B1 (en) * | 2003-05-20 | 2015-10-21 | ImmunoGen, Inc. | Improved cytotoxic agents comprising new maytansinoids |
| EA014640B1 (ru) * | 2003-07-21 | 2010-12-30 | Иммьюноджен, Инк. | Антитело или его эпитоп-связывающий фрагмент, которые связываются с гликотопом са6, и способы их применения |
| CA2556027C (en) * | 2004-02-12 | 2015-11-24 | Morphotek, Inc. | Monoclonal antibodies that specifically block biological activity of a tumor antigen |
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| DE19648209A1 (de) * | 1996-11-21 | 1998-05-28 | Boehringer Ingelheim Int | Verfahren zur Tumorzelldepletion CD34-positiver Zellen |
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| JP4776843B2 (ja) * | 1999-10-01 | 2011-09-21 | イムノゲン インコーポレーティッド | 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法 |
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- 2002-05-16 SK SK1558-2003A patent/SK15582003A3/sk not_active Application Discontinuation
- 2002-05-16 CN CNA028101634A patent/CN1509187A/zh active Pending
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- 2002-05-16 JP JP2002591041A patent/JP2004529963A/ja active Pending
- 2002-05-16 BR BR0209862-8A patent/BR0209862A/pt not_active IP Right Cessation
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- 2002-05-16 PL PL02365480A patent/PL365480A1/xx not_active Application Discontinuation
- 2002-05-16 WO PCT/EP2002/005413 patent/WO2002094325A2/en not_active Ceased
- 2002-05-16 EA EA200301159A patent/EA200301159A1/ru unknown
- 2002-05-16 CA CA002443438A patent/CA2443438A1/en not_active Abandoned
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| WO2002094325A3 (en) | 2003-04-17 |
| HUP0400046A3 (en) | 2006-02-28 |
| PL365480A1 (en) | 2005-01-10 |
| WO2002094325A2 (en) | 2002-11-28 |
| NO20035108D0 (no) | 2003-11-17 |
| EP1258255A1 (en) | 2002-11-20 |
| EP1395290A2 (en) | 2004-03-10 |
| EE200300568A (et) | 2004-04-15 |
| NO20035108L (no) | 2003-11-17 |
| CN1509187A (zh) | 2004-06-30 |
| CA2443438A1 (en) | 2002-11-28 |
| AR035977A1 (es) | 2004-07-28 |
| CO5550468A2 (es) | 2005-08-31 |
| MXPA03010432A (es) | 2004-04-02 |
| HRP20030932A2 (en) | 2004-04-30 |
| SK15582003A3 (sk) | 2004-04-06 |
| CZ20033477A3 (en) | 2004-05-12 |
| NZ530167A (en) | 2005-10-28 |
| IL157965A0 (en) | 2004-03-28 |
| BG108366A (bg) | 2004-09-30 |
| ZA200307364B (en) | 2004-04-20 |
| YU91503A (sh) | 2006-05-25 |
| BR0209862A (pt) | 2004-06-08 |
| EA200301159A1 (ru) | 2004-06-24 |
| PE20021097A1 (es) | 2003-02-13 |
| HUP0400046A2 (hu) | 2004-04-28 |
| JP2004529963A (ja) | 2004-09-30 |
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