CZ20011486A3 - Způsob výroby 4-[(2`,5`-diamino-6`-halogenpyrimidin-4`-yl)amino]-cyklopent-2-enylmethanolu - Google Patents
Způsob výroby 4-[(2`,5`-diamino-6`-halogenpyrimidin-4`-yl)amino]-cyklopent-2-enylmethanoluInfo
- Publication number
- CZ20011486A3 CZ20011486A3 CZ20011486A CZ20011486A CZ20011486A3 CZ 20011486 A3 CZ20011486 A3 CZ 20011486A3 CZ 20011486 A CZ20011486 A CZ 20011486A CZ 20011486 A CZ20011486 A CZ 20011486A CZ 20011486 A3 CZ20011486 A3 CZ 20011486A3
- Authority
- CZ
- Czechia
- Prior art keywords
- diamino
- enylmethanol
- cyclopent
- amino
- halopyrimidin
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title abstract 2
- UXKZFJDNFBNQHE-UHFFFAOYSA-N (4-aminocyclopent-2-en-1-yl)methanol Chemical compound NC1CC(CO)C=C1 UXKZFJDNFBNQHE-UHFFFAOYSA-N 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003586 protic polar solvent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98120529 | 1998-10-30 | ||
| US14610599P | 1999-07-29 | 1999-07-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CZ20011486A3 true CZ20011486A3 (cs) | 2001-10-17 |
| CZ300155B6 CZ300155B6 (cs) | 2009-02-25 |
Family
ID=56289961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ20011486A CZ300155B6 (cs) | 1998-10-30 | 1999-10-29 | Zpusob výroby 4-[(2',5'-diamino-6'-halogenpyrimidin-4'-yl)amino]-cyklopent-2-enylmethanolu |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1124805B1 (cs) |
| JP (1) | JP4457496B2 (cs) |
| CN (1) | CN1115338C (cs) |
| AT (1) | ATE240945T1 (cs) |
| AU (1) | AU1158000A (cs) |
| CA (1) | CA2348374C (cs) |
| CZ (1) | CZ300155B6 (cs) |
| DK (1) | DK1124805T3 (cs) |
| ES (1) | ES2200594T3 (cs) |
| HU (1) | HU227559B1 (cs) |
| IL (1) | IL142760A (cs) |
| PL (1) | PL198180B1 (cs) |
| SK (1) | SK285271B6 (cs) |
| WO (1) | WO2000026193A1 (cs) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6433170B1 (en) | 1998-10-30 | 2002-08-13 | Lonza Group | Method for producing 4-[2',5'-diamino-6'-halopyrimidine-4'-yl)amino]- cyclopent-2-enylmethanols |
| WO2008084261A1 (en) | 2007-01-10 | 2008-07-17 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors |
| WO2009087381A1 (en) | 2008-01-08 | 2009-07-16 | Merck Sharp & Dohme Ltd | Pharmaceutically acceptable salts of 2-{4-[(3s)-piperidin-3- yl]phenyl} -2h-indazole-7-carboxamide |
| CN103626745B (zh) * | 2013-12-04 | 2016-02-24 | 青岛黄海制药有限责任公司 | 一种替卡格雷中间体的制备方法 |
| EP3860988A1 (en) | 2018-10-03 | 2021-08-11 | Tesaro, Inc. | Crystalline forms of niraparib freebase |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3901502C2 (de) * | 1988-01-20 | 2002-06-13 | Univ Minnesota | Didesoxydehydrocarbocyclische Nucleoside, diese enthaltende pharmazeutische Formulierungen und Pyrimidinylamino-cyclopentenylcarbinol-Derivate |
| GB8916698D0 (en) * | 1989-07-21 | 1989-09-06 | Beecham Group Plc | Novel process |
| MY104575A (en) * | 1989-12-22 | 1994-04-30 | The Wellcome Foundation Ltd | Therapeutic nucleosides. |
| CA2145928C (en) * | 1994-04-27 | 2007-10-09 | Gerhard Stucky | N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide, and a process for its preparation |
| HU226141B1 (en) * | 1996-05-30 | 2008-05-28 | Lonza Ag | Process for the preparation of amino alcohols and derivatives thereof |
-
1999
- 1999-10-29 CN CN99812845A patent/CN1115338C/zh not_active Expired - Fee Related
- 1999-10-29 AU AU11580/00A patent/AU1158000A/en not_active Abandoned
- 1999-10-29 SK SK569-2001A patent/SK285271B6/sk not_active IP Right Cessation
- 1999-10-29 AT AT99971416T patent/ATE240945T1/de active
- 1999-10-29 HU HU0104045A patent/HU227559B1/hu not_active IP Right Cessation
- 1999-10-29 WO PCT/EP1999/008270 patent/WO2000026193A1/de active IP Right Grant
- 1999-10-29 IL IL14276099A patent/IL142760A/en not_active IP Right Cessation
- 1999-10-29 ES ES99971416T patent/ES2200594T3/es not_active Expired - Lifetime
- 1999-10-29 CZ CZ20011486A patent/CZ300155B6/cs not_active IP Right Cessation
- 1999-10-29 EP EP99971416A patent/EP1124805B1/de not_active Expired - Lifetime
- 1999-10-29 CA CA002348374A patent/CA2348374C/en not_active Expired - Fee Related
- 1999-10-29 PL PL347503A patent/PL198180B1/pl unknown
- 1999-10-29 DK DK99971416T patent/DK1124805T3/da active
- 1999-10-29 JP JP2000579582A patent/JP4457496B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE240945T1 (de) | 2003-06-15 |
| HU227559B1 (en) | 2011-08-29 |
| CA2348374C (en) | 2009-04-07 |
| PL198180B1 (pl) | 2008-06-30 |
| DK1124805T3 (da) | 2003-09-15 |
| CN1325386A (zh) | 2001-12-05 |
| IL142760A0 (en) | 2002-03-10 |
| CN1115338C (zh) | 2003-07-23 |
| PL347503A1 (en) | 2002-04-08 |
| IL142760A (en) | 2005-12-18 |
| JP2003500333A (ja) | 2003-01-07 |
| HUP0104045A2 (hu) | 2002-05-29 |
| EP1124805A1 (de) | 2001-08-22 |
| CA2348374A1 (en) | 2000-05-11 |
| CZ300155B6 (cs) | 2009-02-25 |
| AU1158000A (en) | 2000-05-22 |
| SK285271B6 (sk) | 2006-10-05 |
| WO2000026193A1 (de) | 2000-05-11 |
| SK5692001A3 (en) | 2001-12-03 |
| EP1124805B1 (de) | 2003-05-21 |
| JP4457496B2 (ja) | 2010-04-28 |
| HUP0104045A3 (en) | 2002-07-29 |
| ES2200594T3 (es) | 2004-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed due to non-payment of fee |
Effective date: 20131029 |