DE69824090D1 - Verfahren zur Herstellung von 2,5-disubstituierten Pyridinen - Google Patents
Verfahren zur Herstellung von 2,5-disubstituierten PyridinenInfo
- Publication number
- DE69824090D1 DE69824090D1 DE69824090T DE69824090T DE69824090D1 DE 69824090 D1 DE69824090 D1 DE 69824090D1 DE 69824090 T DE69824090 T DE 69824090T DE 69824090 T DE69824090 T DE 69824090T DE 69824090 D1 DE69824090 D1 DE 69824090D1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- compound
- chem
- signifies
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- -1 2,5-disubstituted pyridines Chemical class 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000012433 hydrogen halide Substances 0.000 abstract 1
- 229910000039 hydrogen halide Inorganic materials 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/08—Preparation by ring-closure
- C07D213/09—Preparation by ring-closure involving the use of ammonia, amines, amine salts, or nitriles
- C07D213/10—Preparation by ring-closure involving the use of ammonia, amines, amine salts, or nitriles from acetaldehyde or cyclic polymers thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97114269 | 1997-08-19 | ||
| EP97114269 | 1997-08-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69824090D1 true DE69824090D1 (de) | 2004-07-01 |
| DE69824090T2 DE69824090T2 (de) | 2005-07-07 |
Family
ID=8227241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69824090T Expired - Lifetime DE69824090T2 (de) | 1997-08-19 | 1998-08-10 | Verfahren zur Herstellung von 2,5-disubstituierter Pyridine |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6080866A (de) |
| EP (1) | EP0897914B1 (de) |
| JP (1) | JP3025239B2 (de) |
| KR (1) | KR100275663B1 (de) |
| CN (1) | CN1103335C (de) |
| AT (1) | ATE267808T1 (de) |
| CA (1) | CA2245169C (de) |
| DE (1) | DE69824090T2 (de) |
| DK (1) | DK0897914T3 (de) |
| ES (1) | ES2221696T3 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6743783B1 (en) * | 1993-12-01 | 2004-06-01 | Marine Polymer Technologies, Inc. | Pharmaceutical compositions comprising poly-β-1→4-N-acetylglucosamine |
| US6417360B1 (en) | 1999-03-03 | 2002-07-09 | Hoffmann-La Roche Inc. | Heterocyclic sulfonamides |
| ZA200002318B (en) * | 1999-05-22 | 2000-11-16 | Actelion Pharmaceuticals Ltd | Aqueous pharmaceutical composition. |
| ES2621018T3 (es) * | 2007-02-19 | 2017-06-30 | Marine Polymer Technologies, Inc. | Composiciones hemostáticas y regímenes terapéuticos |
| MX342912B (es) | 2010-04-15 | 2016-10-19 | Marine Polymer Tech Inc | Aplicaciones antibacterianas de nanofibras de poli-n-acetilglucosamina. |
| US20140127310A1 (en) | 2011-04-15 | 2014-05-08 | Marine Polymer Technologies, Inc. | Treatment of disease with poly-n-acetylglucosamine nanofibers |
| KR20230104232A (ko) | 2020-11-05 | 2023-07-07 | 이도르시아 파마슈티컬스 리미티드 | 클라조센탄 디소듐 염의 안정한 결정성 수화물 |
| TW202329952A (zh) | 2021-12-17 | 2023-08-01 | 瑞士商愛杜西亞製藥有限公司 | 克拉生坦(clazosentan)二鈉鹽之製備方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU571683B2 (en) * | 1984-05-23 | 1988-04-21 | Zeneca Ag Products Inc. | 2-substituted-5-methylpyridines from methylcyclobutane- carbonitrile, valeronitrile and pentenonitrile intermediates |
| DE4223013A1 (de) * | 1992-07-13 | 1994-01-20 | Bayer Ag | Verfahren zur Herstellung von 2,5-disubstituierten Pyridinen |
| US5837708A (en) * | 1994-11-25 | 1998-11-17 | Hoffmann-La Roche Inc. | Sulphonamides |
| CA2162630C (en) * | 1994-11-25 | 2007-05-01 | Volker Breu | Sulfonamides |
| TW313568B (de) * | 1994-12-20 | 1997-08-21 | Hoffmann La Roche |
-
1998
- 1998-08-10 DE DE69824090T patent/DE69824090T2/de not_active Expired - Lifetime
- 1998-08-10 ES ES98114969T patent/ES2221696T3/es not_active Expired - Lifetime
- 1998-08-10 DK DK98114969T patent/DK0897914T3/da active
- 1998-08-10 AT AT98114969T patent/ATE267808T1/de active
- 1998-08-10 EP EP98114969A patent/EP0897914B1/de not_active Expired - Lifetime
- 1998-08-17 CN CN98118370A patent/CN1103335C/zh not_active Expired - Lifetime
- 1998-08-18 US US09/136,118 patent/US6080866A/en not_active Expired - Lifetime
- 1998-08-18 CA CA002245169A patent/CA2245169C/en not_active Expired - Lifetime
- 1998-08-18 JP JP10231239A patent/JP3025239B2/ja not_active Expired - Lifetime
- 1998-08-18 KR KR1019980033472A patent/KR100275663B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US6080866A (en) | 2000-06-27 |
| CN1103335C (zh) | 2003-03-19 |
| EP0897914A1 (de) | 1999-02-24 |
| KR19990023680A (ko) | 1999-03-25 |
| CA2245169A1 (en) | 1999-02-19 |
| JPH11116554A (ja) | 1999-04-27 |
| ATE267808T1 (de) | 2004-06-15 |
| ES2221696T3 (es) | 2005-01-01 |
| DK0897914T3 (da) | 2004-09-27 |
| EP0897914B1 (de) | 2004-05-26 |
| KR100275663B1 (ko) | 2000-12-15 |
| CN1210105A (zh) | 1999-03-10 |
| JP3025239B2 (ja) | 2000-03-27 |
| CA2245169C (en) | 2004-08-10 |
| DE69824090T2 (de) | 2005-07-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1254883T3 (da) | Fremgangsmåde til fremstilling af substitueret 1,1,1-trifluoro-3-butene-2-oner | |
| DE69029334T2 (de) | Verfahren zur Herstellung von Alkoxyiminoacetamid-Derivaten und ein Zwischenproduckt dafür | |
| DK0733621T3 (da) | Hidtil ukendte imidazolderivater og fremgangsmåde til fremstilling af disse | |
| DK539589A (da) | Fremgangsmaade til fremstilling af 3-oxo-4-azasteroider | |
| DE69824090D1 (de) | Verfahren zur Herstellung von 2,5-disubstituierten Pyridinen | |
| GR3003776T3 (de) | ||
| DK0781764T3 (da) | Fremgangsmåde til fremstilling af alkoxyiminoacetamid-derivater | |
| TW357056B (en) | Herbicides | |
| ATE115567T1 (de) | Verfahren zur herstellung von halogensulfonyl- substituierten pyridinen. | |
| DE69119714D1 (de) | Verfahren zur Herstellung von Benzylphthalazinonderivaten und von deren Salzen | |
| DK0953564T3 (da) | Fremgangsmåde til fremstilling af en 2-cyanobiphenylforbindelse | |
| DK0412529T3 (da) | Hidtil ukendte imidazolderivater, fremgangsmåde til fremstilling deraf og midler mod mavesår indeholdende disse | |
| DE69733716D1 (de) | Verfahren zur herstellung von imidazolderivaten | |
| DK0662475T3 (da) | Fremgangsmåde til fremstilling af 2-perfluoralkyl-3-oxazolin-5-on. | |
| PL347503A1 (en) | Method for producing 4- [(2',5'- diamino-6'- halopyrimidine- 4'-yl)amino]- cyclopent- 2-enylmethanols | |
| DE69706504D1 (de) | Verfahren zur herstellung von 3,4-dihydroxy-3-cyclobuten-1,2-dion | |
| DE68926016D1 (de) | Halogeno-4-Methylpyrazole und Verfahren zu ihrer Herstellung | |
| DK0644183T3 (da) | Fremgangsmåde til fremstilling af N-alkylacetamider |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |