CY2067A - Stereoselective glycosylation process - Google Patents

Stereoselective glycosylation process

Info

Publication number
CY2067A
CY2067A CY206793A CY206793A CY2067A CY 2067 A CY2067 A CY 2067A CY 206793 A CY206793 A CY 206793A CY 206793 A CY206793 A CY 206793A CY 2067 A CY2067 A CY 2067A
Authority
CY
Cyprus
Prior art keywords
glycosylation process
stereoselective glycosylation
stereoselective
anomer
fluorocarbohydrate
Prior art date
Application number
CY206793A
Other languages
English (en)
Inventor
Ta-Sen Chou
Laurie Michelle Poteet
Douglas Patton Kjell
Cora Sue Grossman
Larry Wayne Hertel
Richard Elmer Holmes
Charles David Jones
Thomas Edward Mabry
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27583678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2067(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/902,312 external-priority patent/US5371210A/en
Priority claimed from US08/044,312 external-priority patent/US5426183A/en
Priority claimed from US08/044,996 external-priority patent/US5821357A/en
Priority claimed from US08/044,343 external-priority patent/US5401838A/en
Priority claimed from US08/044,345 external-priority patent/US5594124A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CY2067A publication Critical patent/CY2067A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CY206793A 1992-06-22 1993-06-21 Stereoselective glycosylation process CY2067A (en)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US90230292A 1992-06-22 1992-06-22
US90213592A 1992-06-22 1992-06-22
US90231392A 1992-06-22 1992-06-22
US90211292A 1992-06-22 1992-06-22
US90215092A 1992-06-22 1992-06-22
US07/902,312 US5371210A (en) 1992-06-22 1992-06-22 Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US4430993A 1993-04-07 1993-04-07
US4431593A 1993-04-07 1993-04-07
US08/044,312 US5426183A (en) 1992-06-22 1993-04-07 Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US08/044,996 US5821357A (en) 1992-06-22 1993-04-07 Stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoropurine and triazole nucleosides
US08/044,343 US5401838A (en) 1992-06-22 1993-04-07 Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US08/044,345 US5594124A (en) 1992-06-22 1993-04-07 Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof

Publications (1)

Publication Number Publication Date
CY2067A true CY2067A (en) 1993-06-21

Family

ID=27583678

Family Applications (1)

Application Number Title Priority Date Filing Date
CY206793A CY2067A (en) 1992-06-22 1993-06-21 Stereoselective glycosylation process

Country Status (20)

Country Link
EP (1) EP0577303B1 (fr)
JP (1) JP3313191B2 (fr)
KR (1) KR100252452B1 (fr)
AT (1) ATE158799T1 (fr)
BR (1) BR9302434A (fr)
CA (1) CA2098881C (fr)
CY (1) CY2067A (fr)
DE (1) DE69314239C5 (fr)
DK (1) DK0577303T3 (fr)
ES (1) ES2107624T3 (fr)
FI (1) FI108643B (fr)
GR (1) GR3025689T3 (fr)
HU (2) HUT64358A (fr)
IL (1) IL106071A (fr)
MX (1) MX9303707A (fr)
MY (1) MY115775A (fr)
NO (1) NO180235B3 (fr)
NZ (1) NZ247939A (fr)
PL (1) PL172348B1 (fr)
UA (1) UA41261C2 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5606048A (en) * 1992-06-22 1997-02-25 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5424416A (en) * 1993-08-25 1995-06-13 Eli Lilly And Company Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides
US5637688A (en) * 1994-12-13 1997-06-10 Eli Lilly And Company Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
US5559222A (en) * 1995-02-03 1996-09-24 Eli Lilly And Company Preparation of 1-(2'-deoxy-2',2'-difluoro-D-ribo-pentofuranosyl)-cytosine from 2-deoxy-2,2-difluoro-β-D-ribo-pentopyranose
JP2000501738A (ja) 1995-12-13 2000-02-15 イーライ・リリー・アンド・カンパニー α，α―ジフルオロ―β―ヒドロキシチオールエステル及びその合成
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
WO2001060383A1 (fr) 2000-02-18 2001-08-23 Southern Research Institute Procedes de synthese de 2-chloro-9-(2-deoxy-2-fluoro-$g(b)-d-arabinofuranosyl)-9h-purine-6-amine
US7435755B2 (en) 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
JP4593917B2 (ja) * 2001-08-02 2010-12-08 アイレックス オンコロジー， インコーポレイテッド プリンヌクレオシドを調製する方法
US7176237B2 (en) 2002-01-15 2007-02-13 The Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
US6884880B2 (en) * 2002-08-21 2005-04-26 Ash Stevens, Inc. Process for the preparation of 9-β-anomeric nucleoside analogs
AU2003291726A1 (en) 2002-11-04 2004-06-07 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
US8148505B2 (en) 2003-05-22 2012-04-03 Japan Science And Technology Agency Method of α-selective glycosylation
WO2006070985A1 (fr) * 2004-12-30 2006-07-06 Hanmi Pharm. Co., Ltd. Méthode de synthèse de la 2’-désoxy-2’,2’-difluorocytidine
GEP20094822B (en) * 2005-03-04 2009-11-10 Dabur Pharma Ltd Intermediate and process for preparing of beta- anomer enriched 21-deoxy, 21, 21-difluoro-d-ribofuranosyl nucleosides
MX2007015174A (es) * 2005-06-03 2008-04-22 Scinopharm Taiwan Ltd Proceso para elaborar un sulfonato de 2-desoxi-2,2-difluoro-d-ribo furanosilo enriquecido con alfa-anomero y su uso para elaborar beta nucleosido.
CN100391966C (zh) * 2005-06-17 2008-06-04 华东师范大学 一种2’-脱氧-2’，2’-二氟-胞苷合成的方法
US8299046B2 (en) 2006-11-17 2012-10-30 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
WO2008064133A1 (fr) 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthèse et activités biologiques de nouveaux composés tricycliques-bis-énones (tbe)
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
CN100475832C (zh) 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
EP2048151A1 (fr) * 2007-10-10 2009-04-15 Cilag AG Procédé pour la production de nucléosides par glycosylation directe de la base nucléosidique
EP2050757A1 (fr) * 2007-10-10 2009-04-22 Cilag AG Procédé de fabrication de 2' -désoxy-5-azacytidine (Décitabine)
JP4923146B2 (ja) 2008-01-11 2012-04-25 リアタ ファーマシューティカルズ インコーポレイテッド 合成トリテルペノイドおよび疾患の治療における使用方法
WO2009146216A2 (fr) 2008-04-18 2009-12-03 Reata Pharmaceuticals. Inc. Modulateurs d’inflammation antioxydant : nouveaux dérivés d’acide oléanolique
EP2271658B1 (fr) 2008-04-18 2016-11-09 Reata Pharmaceuticals, Inc. Modulateurs d'inflammation antioxydants : dérivés d'acide oléanolique c-17 homologués
JP5564490B2 (ja) 2008-04-18 2014-07-30 リアタ ファーマシューティカルズ インコーポレイテッド 抗炎症性ファルマコアを含む化合物および使用法
ES2703274T3 (es) 2008-04-18 2019-03-07 Reata Pharmaceuticals Inc Moduladores de la inflamación antioxidantes: derivados del ácido oleanólico con modificaciones amino y otras en C-17
CN102164941B (zh) 2008-04-18 2015-05-27 里亚塔医药公司 抗氧化剂炎症调节剂:具有饱和c环的齐墩果酸衍生物
SI2833905T1 (en) 2012-04-04 2018-08-31 Halozyme, Inc. Combination therapy with hyaluronidase and tumane-directed taxane
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
CA2906284A1 (fr) * 2013-03-15 2014-09-18 Epigenetics Pharma Llc Analogues de pyrimidine fluores et methodes d'utilisation correspondantes
CN110831605A (zh) 2017-04-26 2020-02-21 托马斯·I.·卡尔曼 多靶标的核苷衍生物
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1295998C (fr) * 1985-07-29 1992-02-18 Sai P. Sunkara Nucleosides et leur utilisation en tant qu'agents antineoplasiques
ATE202113T1 (de) * 1987-08-28 2001-06-15 Lilly Co Eli Verfahren zur herstellung von 2'-deoxy-2',2'- difluornukleosiden
JPH0217199A (ja) * 1988-07-05 1990-01-22 Japan Tobacco Inc ２’−デオキシ−β−アデノシンの製造方法
GB8816345D0 (en) * 1988-07-08 1988-08-10 Hoffmann La Roche Purine derivatives
HU906976D0 (en) * 1989-11-13 1991-05-28 Bristol Myers Squibb Co Process for producing 2', 3'-didesoxy-2'-fluoarabinonucleoside analogues
AU7558491A (en) * 1990-04-04 1991-10-30 Nycomed Imaging As Nucleoside derivatives
US5817799A (en) * 1990-07-23 1998-10-06 The United States Of America As Represented By The Department Of Health And Human Services 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides
US5256798A (en) * 1992-06-22 1993-10-26 Eli Lilly And Company Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
US5371210A (en) * 1992-06-22 1994-12-06 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides

Also Published As

Publication number Publication date
NO180235C (no) 1997-03-12
NO180235B (no) 1996-12-02
DE69314239T2 (de) 1998-02-19
GR3025689T3 (en) 1998-03-31
HU223837B1 (hu) 2005-02-28
FI108643B (fi) 2002-02-28
NZ247939A (en) 1996-02-27
FI932869A (fi) 1993-12-23
JPH06157570A (ja) 1994-06-03
KR100252452B1 (en) 2000-04-15
CA2098881A1 (fr) 1993-12-23
EP0577303B1 (fr) 1997-10-01
JP3313191B2 (ja) 2002-08-12
NO932288D0 (no) 1993-06-21
FI932869A0 (fi) 1993-06-21
IL106071A0 (en) 1993-10-20
KR940005658A (ko) 1994-03-22
ATE158799T1 (de) 1997-10-15
IL106071A (en) 2006-08-20
NO180235B3 (no) 2007-10-01
EP0577303A1 (fr) 1994-01-05
HU9301822D0 (en) 1993-09-28
DE69314239C5 (de) 2012-11-29
DK0577303T3 (da) 1997-10-27
PL299415A1 (en) 1994-03-07
MX9303707A (es) 1994-06-30
HU0201196D0 (fr) 2002-06-29
DE69314239D1 (de) 1997-11-06
ES2107624T3 (es) 1997-12-01
MY115775A (en) 2003-09-30
CA2098881C (fr) 2005-06-07
BR9302434A (pt) 1994-02-16
UA41261C2 (uk) 2001-09-17
HUT64358A (en) 1993-12-28
PL172348B1 (pl) 1997-09-30
NO932288A (no) 1993-12-23

Similar Documents

Publication Publication Date Title
CY2067A (en) Stereoselective glycosylation process
GB8803405D0 (en) Lightweight refractory & process for producing same
HUT43619A (en) Process for producing 5-amino-4-hydroxy-valeril-derivatives substituted with sulfur-containing groups
AU7224887A (en) Process for the printing of shaped articles derived from aramid fibers
EP0223199A3 (en) Process for producing high-strenght, high-modulus carbon fibers
EP0439184A3 (en) Carbon fiber structure and process for producing the same
EP0165465A3 (en) Process for producing carbon fibers
HU9301826D0 (en) Method for separing 2-desoxi-2,2-difluorine-d-ribofuranosyle-alkyl-sulfonate anomers
EP0331753A4 (fr) Procede de production d'organopolysiloxanes comportant un groupe alkenyle a son extremite.
HU891329D0 (en) Process for producing beta silicion carbide
HUT58341A (en) Process for producing 2',3'4'-tris(acetyl)-4,6'-ethylidene-beta-d-glycopyranizides
HU208300B (en) Process for producing alpha-halogenated carbonates
PT84628A (en) Process for producing antibiotic a42125
EP0242401A4 (fr) Procede de production de fibres de carbone.
EP0272674A3 (en) Process for producing 2,6-dichlorobenzyl alcohol
GB8828861D0 (en) Process for producing nucleosides
PT85445B (en) Process for producing antibiotic ll-42067 alpha
IL83976A0 (en) Process for producing glycopeptide antibiotic
IL102144A0 (en) Process for producing 2'-deoxy-2',2'-difluoro nucleosides
RU93046709A (ru) Способ получения нуклеозидов
AU2321188A (en) Process for producing organopolysiloxanes having alkenyl group at its end
IE872065L (en) Process for producing antibiotic ll-d42067
PL240921A1 (en) Process for preparing erythromycin 2'-esters