CY1746A - Antiviral guanine derivatives - Google Patents

Antiviral guanine derivatives

Info

Publication number
CY1746A
CY1746A CY174694A CY174694A CY1746A CY 1746 A CY1746 A CY 1746A CY 174694 A CY174694 A CY 174694A CY 174694 A CY174694 A CY 174694A CY 1746 A CY1746 A CY 1746A
Authority
CY
Cyprus
Prior art keywords
guanine derivatives
antiviral
antiviral guanine
derivatives
guanine
Prior art date
Application number
CY174694A
Other languages
English (en)
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838322199A external-priority patent/GB8322199D0/en
Priority claimed from GB838325271A external-priority patent/GB8325271D0/en
Priority claimed from GB848408322A external-priority patent/GB8408322D0/en
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of CY1746A publication Critical patent/CY1746A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/18—Polyhydroxylic acyclic alcohols
    • C07C31/22—Trihydroxylic alcohols, e.g. glycerol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C07C43/1782—Unsaturated ethers containing hydroxy or O-metal groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/007—Esters of unsaturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
CY174694A 1983-08-18 1994-06-03 Antiviral guanine derivatives CY1746A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB838322199A GB8322199D0 (en) 1983-08-18 1983-08-18 Pharmaceutical composition
GB838325271A GB8325271D0 (en) 1983-09-21 1983-09-21 Compounds
GB848408322A GB8408322D0 (en) 1984-03-30 1984-03-30 Compounds

Publications (1)

Publication Number Publication Date
CY1746A true CY1746A (en) 1994-06-03

Family

ID=27262187

Family Applications (1)

Application Number Title Priority Date Filing Date
CY174694A CY1746A (en) 1983-08-18 1994-06-03 Antiviral guanine derivatives

Country Status (14)

Country Link
US (3) US5075445A (fr)
EP (1) EP0141927B1 (fr)
JP (2) JP2519882B2 (fr)
BG (1) BG61325B2 (fr)
CA (1) CA1339818C (fr)
CY (1) CY1746A (fr)
CZ (1) CZ283182B6 (fr)
DE (1) DE3485225D1 (fr)
ES (3) ES535283A0 (fr)
GR (1) GR80121B (fr)
HK (1) HK126093A (fr)
IE (1) IE58334B1 (fr)
MX (1) MX160431A (fr)
NZ (1) NZ209248A (fr)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5684153A (en) 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
DE3485225D1 (de) * 1983-08-18 1991-12-05 Beecham Group Plc Antivirale guanin-derivate.
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
EP0152316B1 (fr) * 1984-01-26 1989-07-26 Merck & Co. Inc. Butylguanines substituées et leur utilisation dans des compositions antivirales
DE3582399D1 (de) * 1984-09-20 1991-05-08 Beecham Group Plc Purin-derivate und ihre pharmazeutische verwendung.
GB8507606D0 (en) 1985-03-23 1985-05-01 Beecham Group Plc Process
DE3671227D1 (de) 1985-07-27 1990-06-21 Beecham Group Plc 9-substituierte guaninmonohydrate.
GB8628826D0 (en) * 1986-12-02 1987-01-07 Beecham Group Plc Pharmaceutical products
ES2098219T3 (es) * 1987-08-01 1997-05-01 Beecham Group Plc Compuestos de purina y su preparacion.
US5175288A (en) * 1987-08-01 1992-12-29 Beecham Group P.L.C. Process for preparing purine derivatives and intermediates thereof
US5284837A (en) * 1988-05-06 1994-02-08 Medivir Ab Derivatives of purine, process for their preparation and a pharmaceutical preparation
GB8817607D0 (en) * 1988-07-23 1988-09-01 Beecham Group Plc Novel process
US4966895A (en) * 1989-02-02 1990-10-30 Merck & Co. Inc. Cyclic monophosphates of purine and pyrimidine acyclonucleosides as anti-retroviral agents
CA2009109A1 (fr) * 1989-02-02 1990-08-02 John Hannah Acyclonucleosides et acyclonucleotides antiviraux
GB8904855D0 (en) * 1989-03-03 1989-04-12 Beecham Group Plc Pharmaceutical treatment
GB8917959D0 (en) * 1989-08-05 1989-09-20 Beecham Group Plc Pharmaceutical formulation
US6469015B1 (en) 1990-01-26 2002-10-22 Novartis International Pharmaceutical Ltd Pharmaceutical formulation
GB9001886D0 (en) * 1990-01-26 1990-03-28 Beecham Group Plc Pharmaceutical formulation
GB9004647D0 (en) * 1990-03-01 1990-04-25 Beecham Group Plc Pharmaceuticals
US5674869A (en) * 1990-07-07 1997-10-07 Beecham Group Plc Pharmaceutical treatment
GB9015051D0 (en) * 1990-07-07 1990-08-29 Beecham Group Plc Pharmaceutical treatment
GB9102127D0 (en) * 1991-01-31 1991-03-13 Smithkline Beecham Plc Pharmaceuticals
CA2076886C (fr) * 1991-11-22 2002-06-11 Masami Igi Methode d'obtention de 2-amino-6-halogenopurine et intermediaires de synthese
GB9201961D0 (en) 1992-01-30 1992-03-18 Smithkline Beecham Plc Pharmaceuticals
US6124304A (en) * 1993-10-05 2000-09-26 Smithkline Beecham Plc Penciclovir for the treatment of zoster associated pain
IL111138A (en) * 1993-10-05 1997-04-15 Smithkline Beecham Plc Pharmaceutical compositions comprising penciclovir and/or its bioprecursor and/or its derivatives for the treatment and prophylaxis of post-herpetic neuralgia
GB9326177D0 (en) * 1993-12-22 1994-02-23 Smithkline Beecham Plc Pharmaceuticals
US6683084B1 (en) 1993-11-12 2004-01-27 Novartis International Pharmaceutical Ltd. Use of 2-amino purine derivatives for the treatment and prophylaxis of human herpes virus 6 infections
GB9323404D0 (en) * 1993-11-12 1994-01-05 Smithkline Beecham Plc Pharmaceuticals
GB9323403D0 (en) * 1993-11-12 1994-01-05 Smithkline Beecham Plc Pharmaceuticals
GB9402161D0 (en) 1994-02-04 1994-03-30 Wellcome Found Chloropyrimidine intermediates
GB9407698D0 (en) 1994-04-19 1994-06-15 Smithkline Beecham Plc Pharmaceuticals
US5525606A (en) * 1994-08-01 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines
US5840763A (en) * 1994-12-12 1998-11-24 Smithkline Beecham Plc Treatment of a latent infection of herpes viruses
KR100382707B1 (ko) * 1994-12-12 2003-08-19 노파르티스 인터내셔널 파마슈티칼 리미티드 잠재적허피스바이러스감염의치료및예방을위한아미노퓨린항바이러스제의용도
US5559114A (en) * 1994-12-16 1996-09-24 Exley; Ray W. Treatment of autoimmune disease using 2-amino purine derivatives
GB9504497D0 (en) 1995-03-07 1995-04-26 Smithkline Beecham Plc Pharmaceuticals
EP0901476A4 (fr) * 1996-03-26 2001-08-16 Du Pont Pharm Co Pyridines et pyrimidines a fusion aryloxy et arylthio et derives de ces dernieres
PT102030B (pt) * 1996-07-20 1999-04-30 Smithkline Beecham Plc Processo para a apreparacao dos compostos penciclovir ou famciclovir que sao utesi como agentes antivirais
GB9615275D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
GB9615276D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
GB9615253D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
KR19980028023A (ko) * 1996-10-19 1998-07-15 김준웅 Ο-아실-ο-아미노산 9-(4-하이드록시-3-하이드록시메틸부트-1-일구아닌 에스테르 유도체
US6060458A (en) * 1998-02-13 2000-05-09 The United States Of America As Represented By The Department Of Health And Human Services Oligodeoxyribonucleotides comprising O6 -benzylguanine and their use
GB9807116D0 (en) * 1998-04-02 1998-06-03 Smithkline Beecham Plc Novel process
CN1891221A (zh) 1998-11-02 2007-01-10 三角药物公司 对乙型肝炎病毒的联合治疗
US6407077B1 (en) 1998-11-05 2002-06-18 Emory University β-L nucleosides for the treatment of HIV infection
US6107303A (en) * 1999-03-15 2000-08-22 Demarco; Charlene C. Treatment of Epstein Barr infection
AUPQ806700A0 (en) * 2000-06-08 2000-07-06 Commonwealth Scientific And Industrial Research Organisation Antiviral agents
ATE383355T1 (de) 2001-03-01 2008-01-15 Abbott Lab Polymorph und andere kristallinische formen von zusammen-ftc
ITMI20021533A1 (it) * 2002-07-12 2004-01-12 Recordati Chem Pharm Processo per la preparazione di 2-acetossimetil-4-alo-but-1-il acetati
AU2004206827A1 (en) * 2003-01-14 2004-08-05 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
RU2389721C2 (ru) * 2004-12-03 2010-05-20 Ф.Хоффманн-Ля Рош Аг 3-замещенные производные пиридина в качестве антагонистов гистаминовых н3 рецепторов
WO2006063718A1 (fr) * 2004-12-16 2006-06-22 F.Hoffmann-La Roche Ag Derives de piperazinyl-pyridine utilises comme agents de lutte contre l'obesite
AU2006230269A1 (en) 2005-03-30 2006-10-05 Novartis Ag Penciclovir or famciclovir for the treatment of recurrent genital herpes with a one-day application
GB2426247A (en) 2005-05-20 2006-11-22 Arrow Int Ltd Methods of preparing purine derivatives such as famciclovir
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
EP2170840A1 (fr) * 2007-06-21 2010-04-07 Aurobindo Pharma Ltd Procédé perfectionné pour la préparation d'un dérivé de la purine
CN101951911A (zh) 2007-11-21 2011-01-19 雷·W·埃克斯利 2-氨基嘌呤衍生物和其作为抗疱疹剂的用途
US20110059921A1 (en) * 2008-03-27 2011-03-10 Ektar Therapeutics Oligomer-Nitrogenous Base Conjugates
WO2009129385A1 (fr) * 2008-04-16 2009-10-22 Abbott Laboratories Lipides cationiques et utilisations de ceux-ci
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
CL2009002206A1 (es) 2008-12-23 2011-08-26 Gilead Pharmasset Llc Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales.
EP2376514A2 (fr) * 2008-12-23 2011-10-19 Pharmasset, Inc. Analogues de nucléoside
NZ593648A (en) * 2008-12-23 2013-09-27 Gilead Pharmasset Llc Nucleoside phosphoramidates
US20110065655A1 (en) * 2009-09-17 2011-03-17 Karry Whitten Therapeutic composition to treat lesions caused by herpes simplex virus
KR101715981B1 (ko) 2010-03-31 2017-03-13 길리애드 파마셋 엘엘씨 뉴클레오사이드 포스포르아미데이트
JP2015520144A (ja) 2012-05-11 2015-07-16 アクロン・モレキュールズ・アクチェンゲゼルシャフトＡｋｒｏｎ Ｍｏｌｅｃｕｌｅｓ Ａｇ 疼痛の治療のための化合物の使用
US10342372B2 (en) 2012-07-27 2019-07-09 Anthony C. Farris Combination bracket and garment hanger system and assembly mountable to an overhead trim piece associated with a doorway such as for rotatably supporting a garment during steam cleaning
US9474400B2 (en) 2012-07-27 2016-10-25 Anthony C. Farris Combination bracket and garment hanger system and assembly mountable to an overhead trim piece associated with a doorway such as for rotatably supporting a garment during steam cleaning
WO2014068265A1 (fr) 2012-10-29 2014-05-08 Cipla Limited Analogues de phosphonate antiviraux et leur procédé de préparation
CN104086552B (zh) * 2014-07-31 2016-01-13 济南兆康医药科技有限公司 一种喷昔洛韦的精制方法
WO2018041763A1 (fr) * 2016-08-29 2018-03-08 F. Hoffmann-La Roche Ag Composés de sulfonimidoylpurinone substitués dans la position 7 pour le traitement et la prophylaxie d'infection virale
CN108314685B (zh) * 2018-03-16 2020-08-25 上药康丽（常州）药业有限公司 一种2-氨基-6-氯-9-(4-乙酰氧基-3-乙酰氧甲基丁基)嘌呤的制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3624251A (en) * 1970-01-16 1971-11-30 Diagnostic Data Inc Orgotein purification process by heating above 65{20 {0 c.
US3706181A (en) * 1970-11-20 1972-12-19 Tenneco Chem Process for the safe handling of c{11 {11 and c{11 {11 acetylenic hydrocarbons
US3688438A (en) * 1970-12-28 1972-09-05 Texaco Development Corp Production of a methane-rich synthesis gas
US3790365A (en) * 1971-06-21 1974-02-05 Ethyl Corp Method of making metal foams by sequential expansion
US4146715A (en) * 1975-08-27 1979-03-27 Burroughs Wellcome Co. 2-amido-9-(2-acyloxyethoxymethyl)hypoxanthines
IL64501A (en) * 1980-12-22 1985-07-31 Astra Laekemedel Ab 9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use
US4507305A (en) * 1981-05-21 1985-03-26 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
CS594082A2 (en) * 1981-08-11 1989-08-14 Wellcome Found Method of antiviral effective 2-amino-9-/(2-hydroxy-1-hydroxymethyl-ethoxy)methyl/purines production
US4451478A (en) * 1982-03-12 1984-05-29 Newport Pharmaceuticals International, Inc. Imidazole compounds
US4461757A (en) * 1983-02-23 1984-07-24 Ens Bio Logicals Inc. Dimethylaminomethylenated anti-herpes compounds
DE3485225D1 (de) * 1983-08-18 1991-12-05 Beecham Group Plc Antivirale guanin-derivate.
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
US4565867A (en) * 1984-01-05 1986-01-21 Melamine Chemicals, Inc. Anhydrous high-pressure melamine synthesis
US4845084A (en) * 1984-01-26 1989-07-04 Merck & Co., Inc. Phosphate derivatives of substituted butyl guanines, antiviral compositions containing them, and methods of treating viral infections with them
EP0152316B1 (fr) * 1984-01-26 1989-07-26 Merck & Co. Inc. Butylguanines substituées et leur utilisation dans des compositions antivirales
US4689129A (en) * 1985-07-16 1987-08-25 The Dow Chemical Company Process for the preparation of submicron-sized titanium diboride
DE3671227D1 (de) * 1985-07-27 1990-06-21 Beecham Group Plc 9-substituierte guaninmonohydrate.
US4714787A (en) * 1985-09-03 1987-12-22 Mobil Oil Corporation Production of ethers from linear olefins
US4910035A (en) * 1989-03-08 1990-03-20 Consolidated Flavor Corporation Process and product for making flavored milk
US5401861A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
US5185365A (en) * 1992-06-24 1993-02-09 Cornell Research Foundation, Inc. Insect deterrent azamcrolides
US5670668A (en) * 1996-07-03 1997-09-23 Eastman Chemical Company Crystalline tocotrienol esters

Also Published As

Publication number Publication date
JP2519882B2 (ja) 1996-07-31
US6573378B1 (en) 2003-06-03
ES8603887A1 (es) 1986-01-01
CZ283182B6 (cs) 1998-01-14
ES543214A0 (es) 1986-01-01
EP0141927A2 (fr) 1985-05-22
JP2543822B2 (ja) 1996-10-16
US5075445A (en) 1991-12-24
NZ209248A (en) 1988-01-08
IE842123L (en) 1985-02-18
JPS6058982A (ja) 1985-04-05
ES8603888A1 (es) 1986-01-01
DE3485225D1 (de) 1991-12-05
EP0141927A3 (en) 1986-03-12
US6579981B1 (en) 2003-06-17
HK126093A (en) 1993-11-19
IE58334B1 (en) 1993-09-08
BG61325B2 (bg) 1997-05-30
ES543213A0 (es) 1986-01-01
GR80121B (en) 1984-12-17
EP0141927B1 (fr) 1991-10-30
CA1339818C (fr) 1998-04-14
ES8602791A1 (es) 1985-12-01
JPH06293764A (ja) 1994-10-21
MX160431A (es) 1990-02-22
CZ391491A3 (en) 1993-01-13
ES535283A0 (es) 1985-12-01

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