EP0901476A4 - Pyridines et pyrimidines a fusion aryloxy et arylthio et derives de ces dernieres - Google Patents
Pyridines et pyrimidines a fusion aryloxy et arylthio et derives de ces dernieresInfo
- Publication number
- EP0901476A4 EP0901476A4 EP97916985A EP97916985A EP0901476A4 EP 0901476 A4 EP0901476 A4 EP 0901476A4 EP 97916985 A EP97916985 A EP 97916985A EP 97916985 A EP97916985 A EP 97916985A EP 0901476 A4 EP0901476 A4 EP 0901476A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- pyrimidines
- arylthio
- aryloxy
- derivatives
- fused pyridines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1409096P | 1996-03-26 | 1996-03-26 | |
US14090P | 1996-03-26 | ||
US64661196A | 1996-05-08 | 1996-05-08 | |
US646611 | 1996-05-08 | ||
PCT/US1997/004828 WO1997035846A1 (fr) | 1996-03-26 | 1997-03-25 | Pyridines et pyrimidines a fusion aryloxy et arylthio et derives de ces dernieres |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0901476A1 EP0901476A1 (fr) | 1999-03-17 |
EP0901476A4 true EP0901476A4 (fr) | 2001-08-16 |
Family
ID=26685647
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97916985A Withdrawn EP0901476A4 (fr) | 1996-03-26 | 1997-03-25 | Pyridines et pyrimidines a fusion aryloxy et arylthio et derives de ces dernieres |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0901476A4 (fr) |
JP (1) | JP2000507552A (fr) |
AU (1) | AU725254B2 (fr) |
CA (1) | CA2249598A1 (fr) |
NZ (1) | NZ331647A (fr) |
WO (1) | WO1997035846A1 (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19653646A1 (de) * | 1996-12-20 | 1998-06-25 | Hoechst Ag | Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung |
NZ511267A (en) | 1998-11-12 | 2002-12-20 | Neurocrine Biosciences Inc | Tricyclic heterocyclic CRF receptor antagonists and their use in treatment |
IL142893A0 (en) | 1998-11-12 | 2002-04-21 | Neurocrine Biosciences Inc | Fused polyclic heterocyclic compounds and pharmaceutical compositions containing the same |
US6432989B1 (en) | 1999-08-27 | 2002-08-13 | Pfizer Inc | Use of CRF antagonists to treat circadian rhythm disorders |
AU2001276903A1 (en) | 2000-07-14 | 2002-01-30 | Bristol-Myers Squibb Pharma Company | Imidazo(1,2-a)pyrazines for the treatment of neurological disorders |
DK1368094T3 (da) | 2001-03-13 | 2007-07-02 | Bristol Myers Squibb Pharma Co | 4-(2-Butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl)-pyrazolo[1,5-a]-1,3,5-triazin, dens enantiomerer og farmaceutisk acceptable salte som corticotropin-frigivende faktor-receptor- ligander |
EP1392309B1 (fr) | 2001-05-14 | 2007-01-17 | Bristol-Myers Squibb Company | Pyrazinones, pyridines et pyrimidines substitues en tant que ligands de la corticoliberine |
US6894045B2 (en) | 2001-07-12 | 2005-05-17 | Bristol-Myers Squibb Pharma Company | Tetrahydropurinones and derivatives thereof as corticotropin releasing factor receptor ligands |
US7276526B2 (en) | 2001-07-13 | 2007-10-02 | Bristol-Myers Squibb Pharma Company | Substituted thiazoles and oxazoles as corticotropin releasing hormone ligands |
WO2003043637A1 (fr) | 2001-11-20 | 2003-05-30 | Bristol-Myers Squibb Pharma Company | Derives de 3,7-dihydro-purine-2,6-dione utilises comme ligands du recepteur de crf |
GB0219746D0 (en) | 2002-08-23 | 2002-10-02 | Inst Of Ex Botany Ascr | Azapurine derivatives |
KR20210061202A (ko) * | 2019-11-19 | 2021-05-27 | 일동제약(주) | 벤조나이트릴이 치환된 축합 피리미딘 유도체 및 그의 의약 용도 |
Citations (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4076711A (en) * | 1976-04-05 | 1978-02-28 | Schering Corporation | Triazolo [4,5-d]-pyrimidines |
JPS56131587A (en) * | 1980-03-18 | 1981-10-15 | Ss Pharmaceut Co Ltd | 7-substituted triazolopyrimidine derivative and its preparation |
JPS5962595A (ja) * | 1982-09-30 | 1984-04-10 | Ss Pharmaceut Co Ltd | 3,5,7―トリ置換―トリアゾロピリミジン誘導体 |
EP0298467A2 (fr) * | 1987-07-10 | 1989-01-11 | Hoechst Aktiengesellschaft | 2-Amino-8-azapurines substituées en positions 6 et 9, leur utilisation, médicament contenant les purines et procédé pour la préparation des purines |
EP0458519A2 (fr) * | 1990-05-24 | 1991-11-27 | Efamol Holdings Plc | Synthèse des dérivés de nucléotides et nucléosides |
US5075445A (en) * | 1983-08-18 | 1991-12-24 | Beecham Group P.L.C. | Guanine derivatives |
WO1994013676A1 (fr) * | 1992-12-17 | 1994-06-23 | Pfizer Inc. | Pyrrolopyrimidines en tant qu'antagonistes du facteur liberateur de corticotrophine (crf) |
WO1994013677A1 (fr) * | 1992-12-17 | 1994-06-23 | Pfizer Inc. | Pyrazolopyrimidines employes comme antagonistes du facteur de liberation de corticotropine |
WO1995010506A1 (fr) * | 1993-10-12 | 1995-04-20 | The Du Pont Merck Pharmaceutical Company | 1n-alkyle-n-arylpyrimidinamines et leurs derives |
EP0664294A1 (fr) * | 1994-01-19 | 1995-07-26 | Colin Reese | Production d'analogues de nucléoside |
WO1995033750A1 (fr) * | 1994-06-08 | 1995-12-14 | Pfizer Inc. | Antagonistes du facteur liberant la corticotrophine |
WO1995033727A1 (fr) * | 1994-06-06 | 1995-12-14 | Pfizer Inc. | Pyrazoles substitues ayant une activite antagoniste du facteur liberant la corticotropine (flc) |
WO1995034563A1 (fr) * | 1994-06-16 | 1995-12-21 | Pfizer Inc. | Pyrazolo et pyrrolopyridines |
EP0778277A1 (fr) * | 1995-12-08 | 1997-06-11 | Pfizer Inc. | Derivés hétérocycliques substitués comme CRF antagonistes |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56131586A (en) * | 1980-03-18 | 1981-10-15 | Ss Pharmaceut Co Ltd | Triazolopyrimidine derivative and its preparation |
US4916224A (en) * | 1988-01-20 | 1990-04-10 | Regents Of The University Of Minnesota | Dideoxycarbocyclic nucleosides |
-
1997
- 1997-03-25 CA CA002249598A patent/CA2249598A1/fr not_active Abandoned
- 1997-03-25 NZ NZ331647A patent/NZ331647A/xx unknown
- 1997-03-25 EP EP97916985A patent/EP0901476A4/fr not_active Withdrawn
- 1997-03-25 AU AU25453/97A patent/AU725254B2/en not_active Ceased
- 1997-03-25 JP JP9534562A patent/JP2000507552A/ja active Pending
- 1997-03-25 WO PCT/US1997/004828 patent/WO1997035846A1/fr not_active Application Discontinuation
Patent Citations (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4076711A (en) * | 1976-04-05 | 1978-02-28 | Schering Corporation | Triazolo [4,5-d]-pyrimidines |
JPS56131587A (en) * | 1980-03-18 | 1981-10-15 | Ss Pharmaceut Co Ltd | 7-substituted triazolopyrimidine derivative and its preparation |
JPS5962595A (ja) * | 1982-09-30 | 1984-04-10 | Ss Pharmaceut Co Ltd | 3,5,7―トリ置換―トリアゾロピリミジン誘導体 |
US5075445A (en) * | 1983-08-18 | 1991-12-24 | Beecham Group P.L.C. | Guanine derivatives |
EP0298467A2 (fr) * | 1987-07-10 | 1989-01-11 | Hoechst Aktiengesellschaft | 2-Amino-8-azapurines substituées en positions 6 et 9, leur utilisation, médicament contenant les purines et procédé pour la préparation des purines |
EP0458519A2 (fr) * | 1990-05-24 | 1991-11-27 | Efamol Holdings Plc | Synthèse des dérivés de nucléotides et nucléosides |
WO1994013676A1 (fr) * | 1992-12-17 | 1994-06-23 | Pfizer Inc. | Pyrrolopyrimidines en tant qu'antagonistes du facteur liberateur de corticotrophine (crf) |
WO1994013677A1 (fr) * | 1992-12-17 | 1994-06-23 | Pfizer Inc. | Pyrazolopyrimidines employes comme antagonistes du facteur de liberation de corticotropine |
WO1995010506A1 (fr) * | 1993-10-12 | 1995-04-20 | The Du Pont Merck Pharmaceutical Company | 1n-alkyle-n-arylpyrimidinamines et leurs derives |
EP0664294A1 (fr) * | 1994-01-19 | 1995-07-26 | Colin Reese | Production d'analogues de nucléoside |
WO1995033727A1 (fr) * | 1994-06-06 | 1995-12-14 | Pfizer Inc. | Pyrazoles substitues ayant une activite antagoniste du facteur liberant la corticotropine (flc) |
WO1995033750A1 (fr) * | 1994-06-08 | 1995-12-14 | Pfizer Inc. | Antagonistes du facteur liberant la corticotrophine |
WO1995034563A1 (fr) * | 1994-06-16 | 1995-12-21 | Pfizer Inc. | Pyrazolo et pyrrolopyridines |
EP0778277A1 (fr) * | 1995-12-08 | 1997-06-11 | Pfizer Inc. | Derivés hétérocycliques substitués comme CRF antagonistes |
Non-Patent Citations (3)
Title |
---|
PATENT ABSTRACTS OF JAPAN vol. 006, no. 007 (C - 087) 16 January 1982 (1982-01-16) * |
PATENT ABSTRACTS OF JAPAN vol. 008, no. 162 (C - 235) 26 July 1984 (1984-07-26) * |
See also references of WO9735846A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP0901476A1 (fr) | 1999-03-17 |
WO1997035846A1 (fr) | 1997-10-02 |
CA2249598A1 (fr) | 1997-10-02 |
AU2545397A (en) | 1997-10-17 |
AU725254B2 (en) | 2000-10-12 |
JP2000507552A (ja) | 2000-06-20 |
NZ331647A (en) | 2000-03-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19980914 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: OLSON, RICHARD, ERIC Inventor name: GILLIGAN, PAUL, JOSEPH Inventor name: BECK, JAMES, PETER Inventor name: BAKTHAVATCHALAM, RAJAGOPAL Inventor name: CHORVAT, ROBERT, JOHN Inventor name: RAJAGOPALAN, PARTHASARATHI |
|
RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7C 07D 487/04 A, 7C 07D 471/04 B, 7C 07D 473/30 B, 7C 07D 473/00 B, 7C 07D 239/46 B, 7C 07D 239/48 B, 7A 61K 31/44 B, 7A 61K 31/505 B, 7A 61K 31/52 B, 7A 61K 31/53 B, 7C 07D 487/04 J, 7C 07D 249:00 J, 7C 07D 239:00 J, 7C 07D 487/04 K, 7C 07D 239:00 K, 7C 07D 231:00 K, 7C 07D 471/04 L, 7C 07D 235:00 L, 7C 07D 221:00 L, 7C 07D 471/04 M, 7C 07D 231:00 M, 7C 07D 221:00 M, 7C 07D 471/04 N, 7C 07D 249:00 N, 7C 07D 221:00 N |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20010625 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE |
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RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: BRISTOL-MYERS SQUIBB PHARMA COMPANY |
|
17Q | First examination report despatched |
Effective date: 20030930 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20040211 |