GR80121B - Compounds - Google Patents

Compounds

Info

Publication number
GR80121B
GR80121B GR80121A GR840180121A GR80121B GR 80121 B GR80121 B GR 80121B GR 80121 A GR80121 A GR 80121A GR 840180121 A GR840180121 A GR 840180121A GR 80121 B GR80121 B GR 80121B
Authority
GR
Greece
Prior art keywords
compounds
Prior art date
Application number
GR80121A
Other languages
Greek (el)
Inventor
Jarvest Lewis Richard
Harnden Raymond Michael
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838322199A external-priority patent/GB8322199D0/en
Priority claimed from GB838325271A external-priority patent/GB8325271D0/en
Priority claimed from GB848408322A external-priority patent/GB8408322D0/en
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of GR80121B publication Critical patent/GR80121B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/18Polyhydroxylic acyclic alcohols
    • C07C31/22Trihydroxylic alcohols, e.g. glycerol
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/03Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14Unsaturated ethers
    • C07C43/178Unsaturated ethers containing hydroxy or O-metal groups
    • C07C43/1782Unsaturated ethers containing hydroxy or O-metal groups containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/007Esters of unsaturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/041,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/061,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
GR80121A 1983-08-18 1984-08-16 Compounds GR80121B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB838322199A GB8322199D0 (en) 1983-08-18 1983-08-18 Pharmaceutical composition
GB838325271A GB8325271D0 (en) 1983-09-21 1983-09-21 Compounds
GB848408322A GB8408322D0 (en) 1984-03-30 1984-03-30 Compounds

Publications (1)

Publication Number Publication Date
GR80121B true GR80121B (en) 1984-12-17

Family

ID=27262187

Family Applications (1)

Application Number Title Priority Date Filing Date
GR80121A GR80121B (en) 1983-08-18 1984-08-16 Compounds

Country Status (14)

Country Link
US (3) US5075445A (en)
EP (1) EP0141927B1 (en)
JP (2) JP2519882B2 (en)
BG (1) BG61325B2 (en)
CA (1) CA1339818C (en)
CY (1) CY1746A (en)
CZ (1) CZ283182B6 (en)
DE (1) DE3485225D1 (en)
ES (3) ES8602791A1 (en)
GR (1) GR80121B (en)
HK (1) HK126093A (en)
IE (1) IE58334B1 (en)
MX (1) MX160431A (en)
NZ (1) NZ209248A (en)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5684153A (en) * 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
DE3485225D1 (en) * 1983-08-18 1991-12-05 Beecham Group Plc ANTIVIRAL GUANINE DERIVATIVES.
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
EP0152316B1 (en) * 1984-01-26 1989-07-26 Merck & Co. Inc. Substituted butyl guanines and their utilization in antiviral compositions
EP0182024B1 (en) * 1984-09-20 1991-04-03 Beecham Group Plc Purine derivatives and their pharmaceutical use
GB8507606D0 (en) 1985-03-23 1985-05-01 Beecham Group Plc Process
EP0216459B1 (en) * 1985-07-27 1990-05-16 Beecham Group Plc 9-substituted guanine monohydrates
GB8628826D0 (en) * 1986-12-02 1987-01-07 Beecham Group Plc Pharmaceutical products
DE3855774T2 (en) * 1987-08-01 1997-06-12 Beecham Group Plc Purine compounds and their production
US5175288A (en) * 1987-08-01 1992-12-29 Beecham Group P.L.C. Process for preparing purine derivatives and intermediates thereof
US5284837A (en) * 1988-05-06 1994-02-08 Medivir Ab Derivatives of purine, process for their preparation and a pharmaceutical preparation
GB8817607D0 (en) * 1988-07-23 1988-09-01 Beecham Group Plc Novel process
CA2009109A1 (en) * 1989-02-02 1990-08-02 John Hannah Antiviral acyclonucleosides and acyclonucleotides
US4966895A (en) * 1989-02-02 1990-10-30 Merck & Co. Inc. Cyclic monophosphates of purine and pyrimidine acyclonucleosides as anti-retroviral agents
GB8904855D0 (en) * 1989-03-03 1989-04-12 Beecham Group Plc Pharmaceutical treatment
GB8917959D0 (en) * 1989-08-05 1989-09-20 Beecham Group Plc Pharmaceutical formulation
US6469015B1 (en) 1990-01-26 2002-10-22 Novartis International Pharmaceutical Ltd Pharmaceutical formulation
GB9001886D0 (en) * 1990-01-26 1990-03-28 Beecham Group Plc Pharmaceutical formulation
GB9004647D0 (en) * 1990-03-01 1990-04-25 Beecham Group Plc Pharmaceuticals
US5674869A (en) * 1990-07-07 1997-10-07 Beecham Group Plc Pharmaceutical treatment
GB9015051D0 (en) * 1990-07-07 1990-08-29 Beecham Group Plc Pharmaceutical treatment
GB9102127D0 (en) * 1991-01-31 1991-03-13 Smithkline Beecham Plc Pharmaceuticals
CA2076886C (en) * 1991-11-22 2002-06-11 Masami Igi Method for production of 2-amino-6-halogenopurine and synthesis intermediate therefor
GB9201961D0 (en) 1992-01-30 1992-03-18 Smithkline Beecham Plc Pharmaceuticals
GB9326177D0 (en) * 1993-12-22 1994-02-23 Smithkline Beecham Plc Pharmaceuticals
US6124304A (en) * 1993-10-05 2000-09-26 Smithkline Beecham Plc Penciclovir for the treatment of zoster associated pain
IL111138A (en) * 1993-10-05 1997-04-15 Smithkline Beecham Plc Pharmaceutical compositions comprising penciclovir and/or its bioprecursor and/or its derivatives for the treatment and prophylaxis of post-herpetic neuralgia
GB9323404D0 (en) * 1993-11-12 1994-01-05 Smithkline Beecham Plc Pharmaceuticals
US6683084B1 (en) 1993-11-12 2004-01-27 Novartis International Pharmaceutical Ltd. Use of 2-amino purine derivatives for the treatment and prophylaxis of human herpes virus 6 infections
GB9323403D0 (en) * 1993-11-12 1994-01-05 Smithkline Beecham Plc Pharmaceuticals
GB9402161D0 (en) * 1994-02-04 1994-03-30 Wellcome Found Chloropyrimidine intermediates
GB9407698D0 (en) * 1994-04-19 1994-06-15 Smithkline Beecham Plc Pharmaceuticals
US5525606A (en) 1994-08-01 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines
KR100382707B1 (en) * 1994-12-12 2003-08-19 노파르티스 인터내셔널 파마슈티칼 리미티드 Use of Aminopurine Antiviral Agents for the Treatment and Prophylaxis of Latent Herpesvirus Infections
US5840763A (en) * 1994-12-12 1998-11-24 Smithkline Beecham Plc Treatment of a latent infection of herpes viruses
US5559114A (en) * 1994-12-16 1996-09-24 Exley; Ray W. Treatment of autoimmune disease using 2-amino purine derivatives
GB9504497D0 (en) * 1995-03-07 1995-04-26 Smithkline Beecham Plc Pharmaceuticals
WO1997035846A1 (en) * 1996-03-26 1997-10-02 Dupont Pharmaceuticals Company Aryloxy- and arylthio-fused pyridines and pyrimidines and derivatives
GB9615253D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
GB9615275D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
PT102030B (en) * 1996-07-20 1999-04-30 Smithkline Beecham Plc PROCESS FOR THE PRESENTATION OF PENCICLOVIR OR FAMCICLOVIR COMPOUNDS WHICH IS UTESI AS ANTI-AGING AGENTS
GB9615276D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
KR19980028023A (en) * 1996-10-19 1998-07-15 김준웅 Ο-acyl-Ο-amino acid 9- (4-hydroxy-3-hydroxymethylbut-1-ylguanine ester derivative
US6060458A (en) * 1998-02-13 2000-05-09 The United States Of America As Represented By The Department Of Health And Human Services Oligodeoxyribonucleotides comprising O6 -benzylguanine and their use
GB9807116D0 (en) 1998-04-02 1998-06-03 Smithkline Beecham Plc Novel process
DE69923338T2 (en) 1998-11-02 2006-04-06 Gilead Sciences, Inc., Foster City COMBINATION THERAPY FOR THE TREATMENT OF HEPATITIS B INFECTIONS
US6407077B1 (en) 1998-11-05 2002-06-18 Emory University β-L nucleosides for the treatment of HIV infection
US6107303A (en) * 1999-03-15 2000-08-22 Demarco; Charlene C. Treatment of Epstein Barr infection
AUPQ806700A0 (en) * 2000-06-08 2000-07-06 Commonwealth Scientific And Industrial Research Organisation Antiviral agents
AU2002335489B2 (en) 2001-03-01 2008-06-05 Abbott Laboratories Polymorphic and other crystalline forms of cis-FTC
ITMI20021533A1 (en) * 2002-07-12 2004-01-12 Recordati Chem Pharm PROCESS FOR THE PREPARATION OF 2-ACETOXY-METHYL-4-HALO-BUT-1-IL ACETATES
EA015145B1 (en) * 2003-01-14 2011-06-30 Джилид Сайэнс, Инк. Pharmaceutical compositions and oral pharmaceutical dosage form (variants), exhibiting activity relative to a hiv infection, a patient pack and a tablet
AU2005311534B2 (en) * 2004-12-03 2011-02-17 F. Hoffmann-La Roche Ag 3-substituted pyridine derivatives as H3 antagonists
WO2006063718A1 (en) * 2004-12-16 2006-06-22 F.Hoffmann-La Roche Ag Piperazinyl pyridine derivatives as anti-obesity agents
AU2006230269A1 (en) 2005-03-30 2006-10-05 Novartis Ag Penciclovir or famciclovir for the treatment of recurrent genital herpes with a one-day application
GB2426247A (en) 2005-05-20 2006-11-22 Arrow Int Ltd Methods of preparing purine derivatives such as famciclovir
TWI471145B (en) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc Unitary pharmaceutical dosage form
TWI375560B (en) * 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
US20100137592A1 (en) * 2007-06-21 2010-06-03 Asif Parvez Sayyed Process for preparing purine derivative
US20110105434A1 (en) 2007-11-21 2011-05-05 Exley Ray W 2-amino purine derivatives and their use as anti-herpetic agents
US20110059921A1 (en) * 2008-03-27 2011-03-10 Ektar Therapeutics Oligomer-Nitrogenous Base Conjugates
WO2009129385A1 (en) * 2008-04-16 2009-10-22 Abbott Laboratories Cationic lipids and uses thereof
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
PA8855601A1 (en) * 2008-12-23 2010-07-27 NUCLEOSID FORFORMIDATES
CN102753563A (en) * 2008-12-23 2012-10-24 吉利德制药有限责任公司 Nucleoside analogs
WO2010075554A1 (en) 2008-12-23 2010-07-01 Pharmasset, Inc. Synthesis of purine nucleosides
US20110065655A1 (en) * 2009-09-17 2011-03-17 Karry Whitten Therapeutic composition to treat lesions caused by herpes simplex virus
JP6058528B2 (en) 2010-03-31 2017-01-11 ギリアド ファーマセット エルエルシー Nucleoside phosphoramidate
AU2013257951A1 (en) 2012-05-11 2015-01-22 Akron Molecules Ag Use of compounds for the treatment of pain
US9474400B2 (en) 2012-07-27 2016-10-25 Anthony C. Farris Combination bracket and garment hanger system and assembly mountable to an overhead trim piece associated with a doorway such as for rotatably supporting a garment during steam cleaning
US10342372B2 (en) 2012-07-27 2019-07-09 Anthony C. Farris Combination bracket and garment hanger system and assembly mountable to an overhead trim piece associated with a doorway such as for rotatably supporting a garment during steam cleaning
WO2014068265A1 (en) 2012-10-29 2014-05-08 Cipla Limited Antiviral phosphonate analogues and process for preparation thereof
CN104086552B (en) * 2014-07-31 2016-01-13 济南兆康医药科技有限公司 A kind of process for purification of Penciclovir
MY197408A (en) * 2016-08-29 2023-06-16 Hoffmann La Roche 7-substituted sulfonimidoylpurinone compounds for the treatment and prophylaxis of virus infection
CN108314685B (en) * 2018-03-16 2020-08-25 上药康丽(常州)药业有限公司 Preparation method of 2-amino-6-chloro-9- (4-acetoxyl-3-acetoxymethyl butyl) purine

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3624251A (en) * 1970-01-16 1971-11-30 Diagnostic Data Inc Orgotein purification process by heating above 65{20 {0 c.
US3706181A (en) * 1970-11-20 1972-12-19 Tenneco Chem Process for the safe handling of c{11 {11 and c{11 {11 acetylenic hydrocarbons
US3688438A (en) * 1970-12-28 1972-09-05 Texaco Development Corp Production of a methane-rich synthesis gas
US3790365A (en) * 1971-06-21 1974-02-05 Ethyl Corp Method of making metal foams by sequential expansion
US4146715A (en) * 1975-08-27 1979-03-27 Burroughs Wellcome Co. 2-amido-9-(2-acyloxyethoxymethyl)hypoxanthines
IL64501A (en) * 1980-12-22 1985-07-31 Astra Laekemedel Ab 9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use
US4507305A (en) * 1981-05-21 1985-03-26 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
AU569462B2 (en) * 1981-08-11 1988-02-04 Wellcome Foundation Limited, The Antiviral purine derivatives
US4451478A (en) * 1982-03-12 1984-05-29 Newport Pharmaceuticals International, Inc. Imidazole compounds
US4461757A (en) * 1983-02-23 1984-07-24 Ens Bio Logicals Inc. Dimethylaminomethylenated anti-herpes compounds
DE3485225D1 (en) * 1983-08-18 1991-12-05 Beecham Group Plc ANTIVIRAL GUANINE DERIVATIVES.
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
US4565867A (en) * 1984-01-05 1986-01-21 Melamine Chemicals, Inc. Anhydrous high-pressure melamine synthesis
US4845084A (en) * 1984-01-26 1989-07-04 Merck & Co., Inc. Phosphate derivatives of substituted butyl guanines, antiviral compositions containing them, and methods of treating viral infections with them
EP0152316B1 (en) * 1984-01-26 1989-07-26 Merck & Co. Inc. Substituted butyl guanines and their utilization in antiviral compositions
US4689129A (en) * 1985-07-16 1987-08-25 The Dow Chemical Company Process for the preparation of submicron-sized titanium diboride
EP0216459B1 (en) * 1985-07-27 1990-05-16 Beecham Group Plc 9-substituted guanine monohydrates
US4714787A (en) * 1985-09-03 1987-12-22 Mobil Oil Corporation Production of ethers from linear olefins
US4910035A (en) * 1989-03-08 1990-03-20 Consolidated Flavor Corporation Process and product for making flavored milk
US5401861A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
US5185365A (en) * 1992-06-24 1993-02-09 Cornell Research Foundation, Inc. Insect deterrent azamcrolides
US5670668A (en) * 1996-07-03 1997-09-23 Eastman Chemical Company Crystalline tocotrienol esters

Also Published As

Publication number Publication date
ES535283A0 (en) 1985-12-01
ES543214A0 (en) 1986-01-01
ES8602791A1 (en) 1985-12-01
CZ283182B6 (en) 1998-01-14
IE842123L (en) 1985-02-18
ES8603887A1 (en) 1986-01-01
CZ391491A3 (en) 1993-01-13
JP2519882B2 (en) 1996-07-31
CA1339818C (en) 1998-04-14
ES543213A0 (en) 1986-01-01
US5075445A (en) 1991-12-24
IE58334B1 (en) 1993-09-08
DE3485225D1 (en) 1991-12-05
US6573378B1 (en) 2003-06-03
JPH06293764A (en) 1994-10-21
US6579981B1 (en) 2003-06-17
HK126093A (en) 1993-11-19
JPS6058982A (en) 1985-04-05
BG61325B2 (en) 1997-05-30
NZ209248A (en) 1988-01-08
EP0141927A3 (en) 1986-03-12
MX160431A (en) 1990-02-22
EP0141927A2 (en) 1985-05-22
JP2543822B2 (en) 1996-10-16
ES8603888A1 (en) 1986-01-01
EP0141927B1 (en) 1991-10-30
CY1746A (en) 1994-06-03

Similar Documents

Publication Publication Date Title
GR80121B (en) Compounds
GB8323034D0 (en) 7-substituted-3-vinyl-3-cephem compounds
GB8319538D0 (en) Compounds
GB8302483D0 (en) Compounds
DE3460772D1 (en) Distyrene compounds
GB8305316D0 (en) Compounds
GB8304647D0 (en) Compounds
GB8310556D0 (en) Compounds
DE3468412D1 (en) Trihalochalcogenpropenone compounds
GB8322137D0 (en) Compounds
GB8311426D0 (en) Compounds
GB8320184D0 (en) Compounds
GB8306481D0 (en) Compounds
GB8313590D0 (en) Compounds
GB8320183D0 (en) Compounds
GB8305701D0 (en) Compounds
GB8308846D0 (en) Compounds
GB8304648D0 (en) Compounds
GB8310842D0 (en) Compounds
GB8304645D0 (en) Compounds
GB8313588D0 (en) Compounds
GB8313589D0 (en) Compounds
GB8315963D0 (en) Compounds
GB8319875D0 (en) Compounds
GB8304644D0 (en) Compounds